About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 38092809 Journal: Scientific Reports Year: 2023 Reference: Sci Rep. 2023 Dec 13;13(1):22109. doi: 10.1038/s41598-023-48480-z. Impact factor: Publication type: Paper in international publication Authors: Alberti, Piero; Altintas, Engin; Aparicio, David; Aslan, Rahmi; Aveiro, Debora; Aykut, Umut Emre; Bajor, Judit; Balaban, Vasile-Daniel; Balci, Hatice Rizaoglu; Banovcin, Peter et al. DOI: 10.1038/s41598-023-48480-z
PMID: 38099264 Journal: Year: 2023 Reference: Stroke Res Treat. 2023 Dec 7;2023:6655772. doi: 10.1155/2023/6655772. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Alberti, Piero; Altintas, Engin; Amaya Pascasio, Laura; Aparicio, David; Arjona Padillo, Antonio; Aslan, Rahmi; Aveiro, Debora; Aykut, Umut Emre; Bajor, Judit; Balaban, Vasile-Daniel et al. DOI: 10.1155/2023/6655772
PMID: 38108358 Journal: Journal of neuromuscular diseases Year: 2023 Reference: J Neuromuscul Dis. 2023 Dec 15. doi: 10.3233/JND-230027. Impact factor: Publication type: Paper in international publication Authors: Bhai, Salman; Bloemen, Bart; Canalda-Baltrons, Aleix; Coppers, Jacqueline; Cup, Edith; d'Enfert, Christophe; Groothuis, Jan T; Karazi, Walaa; Lokken, Nicoline; Maas, Daphne et al. DOI: 10.3233/JND-230027
PMID: 35641109 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2022 Reference: Neurogastroenterol Motil. 2022 May 31:e14413. doi: 10.1111/nmo.14413. Impact factor: 3.598 Publication type: Letter or abstract Authors: Serra, Jordi, Aguilar, Ariadna et al. DOI: 10.1111/nmo.14413
PMID: 35465165 Journal: Computational and Structural Biotechnology Journal Year: 2022 Reference: Comput Struct Biotechnol J. 2022 Apr 5;20:1632-1641. doi: 10.1016/j.csbj.2022.04.001. eCollection 2022. Impact factor: 7.271 Publication type: Paper in international publication Authors: Oyarzun, Inigo, Le Neve, Boris, Yanez, Francisca, Xie, Zixuan, Pichaud, Matthieu, Serrano-Gomez, Gerard, Roca, Joaquim, Veiga, Patrick, Azpiroz, Fernando, Tap, Julien et al. DOI: 10.1016/j.csbj.2022.04.001
PMID: 35431513 Journal: WORLD JOURNAL OF GASTROENTEROLOGY Year: 2022 Reference: World J Gastroenterol. 2022 Mar 28;28(12):1204-1219. doi: 10.3748/wjg.v28.i12.1204. Impact factor: 5.742 Publication type: Review in international publication Authors: Ivashkin, Vladimir, Guarner, Francisco, Shifrin, Oleg, Svistushkin, Valery, Mamieva, Zarina, Poluektova, Elena, Sobolev, Vasily et al. DOI: 10.3748/wjg.v28.i12.1204
PMID: 35355100 Journal: WORLD JOURNAL OF SURGERY Year: 2022 Reference: World J Surg. 2022 Jul;46(7):1758-1767. doi: 10.1007/s00268-022-06533-w. Epub 2022 Mar 30. Impact factor: 3.352 Publication type: Paper in international publication Authors: Charco, Ramon, Balsells, Joaquim, Molero, Xavier, Tasayco, Stephanie, Blanco, Laia, Hidalgo, Nils Jimmy, Pando, Elizabeth, Alberti, Piero, Vidal, Laura, Mata, Rodrigo et al. DOI: 10.1007/s00268-022-06533-w
PMID: 34944998 Journal: Cancers Year: 2021 Reference: Cancers (Basel). 2021 Dec 20;13(24). pii: cancers13246378. doi: 10.3390/cancers13246378. Impact factor: 6.639 Publication type: Paper in international publication Authors: Sanchez, Ariadna, Bujanda, Luis, Cuatrecasas, Miriam, Bofill, Alex, Alvarez-Urturi, Cristina, Hernandez, Goretti, Aguilera, Lara, Carballal, Sabela, Llach, Joan, Herrera-Pariente, Cristina et al. DOI: 10.3390/cancers13246378
PMID: 34938418 Journal: Computational and Structural Biotechnology Journal Year: 2021 Reference: Comput Struct Biotechnol J. 2021 Dec 2;19:6481-6489. doi: 10.1016/j.csbj.2021.11.037. eCollection 2021. Impact factor: 7.271 Publication type: Paper in international publication Authors: Serrano-Gomez, Gerard, Mayorga, Luis, Oyarzun, Inigo, Roca, Joaquim, Borruel, Natalia, Casellas, Francesc, Varela, Encarna, Pozuelo, Marta, Machiels, Kathleen, Guarner, Francisco et al. DOI: 10.1016/j.csbj.2021.11.037
PMID: 34778332 Journal: Frontiers in Nutrition Year: 2021 Reference: Front Nutr. 2021 Oct 28;8:718093. doi: 10.3389/fnut.2021.718093. eCollection 2021. Impact factor: 6.576 Publication type: Review in international publication Authors: Fortea, Marina, Albert-Bayo, Merce, Abril-Gil, Mar, Ganda Mall, John-Peter, Serra-Ruiz, Xavier, Henao-Paez, Alejandro, Exposito, Elba, Gonzalez-Castro, Ana Maria, Guagnozzi, Danila, Lobo, Beatriz et al. DOI: 10.3389/fnut.2021.718093
PMID: 34586707 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2021 Reference: Neurogastroenterol Motil. 2021 Sep;33(9):e14238. doi: 10.1111/nmo.14238. Impact factor: 3.598 Publication type: Paper in international publication Authors: Wauters, Lucas, Dickman, Ram, Drug, Vasile, Mulak, Agata, Serra, Jordi, Smet, Annemieke, Stengel, Andreas, Storonova, Olga, Storr, Martin, Tornblom, Hans et al. DOI: 10.1111/nmo.14238
PMID: 32492812 Journal: Nutrients Year: 2020 Reference: Nutrients. 2020 Jun 1;12(6). pii: nu12061627. doi: 10.3390/nu12061627. Impact factor: 4.546 Publication type: Paper in international publication Authors: Kilpatrick, Lisa, Pribic, Teodora, Ciccantelli, Barbara, Malagelada, Carolina, Livovsky, Dan M, Accarino, Anna, Pareto, Deborah, Azpiroz, Fernando, Mayer, Emeran A et al. DOI: 10.3390/nu12061627
PMID: 32496109 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2020 Reference: Rev Esp Enferm Dig. 2020 Sep;112(9):712-715. doi: 10.17235/reed.2020.6600/2019. Impact factor: 1.591 Publication type: Paper in international publication Authors: Armengol Bertroli, Jordi, Pascasio-Hernandez, Mario Jose, Benages Curell, Anna, Castillo Cejas, Maria Dolores, Pigrau Pastor, Marc, Sihuay Diburga, Denisse, Guevara Cubas, Jorge, Castro-Reyes, Luz Maria, Jimenez Hernandez, Cesar, Tasayco Huaman, Stephanie et al. DOI: 10.17235/reed.2020.6600/2019
PMID: 32475007 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2020 Reference: Neurogastroenterol Motil. 2020 Sep;32(9):e13883. doi: 10.1111/nmo.13883. Epub 2020 May 31. Impact factor: 2.946 Publication type: Paper in international publication Authors: Malagelada, Carolina, Bendezu, R-Alvaro, Segui, Santi, Vitria, Jordi, Merino, Xavier, Nieto, Adoracion, Sihuay, Denisse, Accarino, Anna, Molero, Xavier, Azpiroz, Fernando et al. DOI: 10.1111/nmo.13883
PMID: 32420499 Journal: Heliyon Year: 2020 Reference: Heliyon. 2020 May 8;6(5):e03940. doi: 10.1016/j.heliyon.2020.e03940. eCollection 2020 May. Impact factor: 0 Publication type: Paper in international publication Authors: Guillen, M Carmen, Alcover, M Magdalena, Borruel, Natalia, Sulleiro, Elena, Salvador, Fernando, Berenguer, Diana, Herrera-de Guise, Claudia, Rodriguez, Veronica, Moure, Zaira, Sanchez-Montalva, Adrian et al. DOI: 10.1016/j.heliyon.2020.e03940
PMID: 29588085 Journal: Gastroenterologia y Hepatologia Year: 2019 Reference: Gastroenterol Hepatol. 2019 Feb;42(2):111-112. doi: 10.1016/j.gastrohep.2018.02.004. Epub 2018 Mar 24. Impact factor: 1.126 Publication type: Letter or abstract Authors: Rivera Esteban, Jesus Manuel, Espin Basany, Eloy, Santos Vicente, Javier, Alonso-Cotoner, Carmen et al. DOI: 10.1016/j.gastrohep.2018.02.004
PMID: 30229903 Journal: INTERNATIONAL JOURNAL OF CANCER Year: 2019 Reference: Int J Cancer. 2019 Apr 1;144(7):1540-1549. doi: 10.1002/ijc.31866. Epub 2018 Oct 26. Impact factor: 4.982 Publication type: Paper in international publication Authors: Kleeff, Jorg, Kong, Bo, Mora, Josefina, Murray, Liam, O'Driscoll, Damian, Poves, Ignasi, Lawlor, Rita T, Ye, Weimin, Hidalgo, Manuel, Scarpa, Aldo et al. DOI: 10.1002/ijc.31866
PMID: 30626147 Journal: Nutrients Year: 2019 Reference: Nutrients. 2019 Jan 8;11(1). pii: nu11010119. doi: 10.3390/nu11010119. Impact factor: 4.171 Publication type: Paper in international publication Authors: Galan, Carmen, Nieto, Adoracion, Amigo, Nuria, Accarino, Anna, Correig, Xavier, Azpiroz, Fernando, Pribic, Teodora, Monrroy, Hugo et al. DOI: 10.3390/nu11010119
PMID: 29158237 Journal: GUT Year: 2019 Reference: Gut. 2019 Jan;68(1):130-139. doi: 10.1136/gutjnl-2017-314828. Epub 2017 Nov 20. Impact factor: 17.943 Publication type: Paper in international publication Authors: Molina-Montes, Esther, Babaei, Masoud, van der Geest, Lydia, Lemmens, Valery, Van Eycken, Liesbet, De Schutter, Harlinde, Johannesen, Tom B, Fristrup, Claus W, Mortensen, Michael B, Primic-Zakelj, Maja et al. DOI: 10.1136/gutjnl-2017-314828
PMID: 29490942 Journal: CANCER RESEARCH Year: 2018 Reference: Cancer Res. 2018 May 15;78(10):2624-2637. doi: 10.1158/0008-5472.CAN-17-1882. Epub 2018 Feb 28. Impact factor: 9.13 Publication type: Paper in international publication Authors: Sangrador, Irene, Molero, Xavier, Campbell, Fiona, Franch-Exposito, Sebastia, Rovira-Rigau, Maria, Samper, Esther, Dominguez Fraile, Manuel, Fillat, Cristina, Castells, Antoni, Vaquero, Eva C et al. DOI: 10.1158/0008-5472.CAN-17-1882
PMID: 29465251 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2018 Reference: Rev Esp Enferm Dig. 2018 Mar;110(3):172-178. doi: 10.17235/reed.2018.5354/2017. Impact factor: 1.632 Publication type: Paper in international publication Authors: Casellas Jorda, Francesc, Vera Mendoza, Isabel, Barreiro-de Acosta, Manuel, Vazquez Moron, Juan Maria, Lopez Roman, Javier, Judez Gutierrez, Javier et al. DOI: 10.17235/reed.2018.5354/2017
PMID: 29396473 Journal: Scientific Reports Year: 2018 Reference: Sci Rep. 2018 Feb 2;8(1):2255. doi: 10.1038/s41598-018-20540-9. Impact factor: 4.122 Publication type: Paper in international publication Authors: Martinez, Cristina, Fortea, Marina, Lobo, Beatriz, Pigrau, Marc, Nieto, Adoracion, Gonzalez-Castro, Ana Maria, Salvo-Romero, Eloisa, Guagnozzi, Danila, Pardo-Camacho, Cristina, Iribarren, Cristina et al. DOI: 10.1038/s41598-018-20540-9
PMID: 29392797 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2018 Reference: Neurogastroenterol Motil. 2018 Jul;30(7):e13309. doi: 10.1111/nmo.13309. Epub 2018 Feb 2. Impact factor: 3.842 Publication type: Review in international publication Authors: Pribic, T, Azpiroz, F et al. DOI: 10.1111/nmo.13309
PMID: 28712415 Journal: JOURNAL OF PSYCHOSOMATIC RESEARCH Year: 2017 Reference: J Psychosom Res. 2017 Aug;99:112-119. doi: 10.1016/j.jpsychores.2017.06.005. Epub 2017 Jun 9. Impact factor: 2.809 Publication type: Paper in international publication Authors: Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose, Accarino, Anna, Malagelada, Carolina, Azpiroz, Fernando et al. DOI: 10.1016/j.jpsychores.2017.06.005
PMID: 28705783 Journal: Clinical Gastroenterology and Hepatology Year: 2017 Reference: Clin Gastroenterol Hepatol. 2017 Dec;15(12):1922-1929. doi: 10.1016/j.cgh.2017.06.052. Epub 2017 Jul 11. Impact factor: 7.398 Publication type: Paper in international publication Authors: Barba, Elizabeth, Accarino, Anna, Azpiroz, Fernando et al. DOI: 10.1016/j.cgh.2017.06.052
PMID: 28508867 Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Year: 2017 Reference: Am J Gastroenterol. 2017 Aug;112(8):1221-1231. doi: 10.1038/ajg.2017.129. Epub 2017 May 16. Impact factor: 9.566 Publication type: Review in national publication Authors: Malagelada, Juan R, Accarino, Anna, Azpiroz, Fernando et al. DOI: 10.1038/ajg.2017.129
PMID: 28429202 Journal: Current gastroenterology reports Year: 2017 Reference: Curr Gastroenterol Rep. 2017 Jun;19(6):26. doi: 10.1007/s11894-017-0565-x. Impact factor: 0 Publication type: Review in national publication Authors: Malagelada, Carolina, Malagelada, Juan R et al. DOI: 10.1007/s11894-017-0565-x
PMID: 27057682 Journal: INFLAMMATORY BOWEL DISEASES Year: 2016 Reference: Inflamm Bowel Dis. 2016 Jun;22(6):1450-5. doi: 10.1097/MIB.0000000000000768. Impact factor: 4.358 Publication type: Paper in international publication Authors: Herrera-deGuise, Claudia, Casellas, Francesc, Robles, Virginia, Navarro, Ester, Borruel, Natalia et al. DOI: 10.1097/MIB.0000000000000768
PMID: 27271780 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2016 Reference: Neurogastroenterol Motil. 2016 Dec;28(12):1806-1814. doi: 10.1111/nmo.12879. Epub 2016 Jun 7. Impact factor: 3.31 Publication type: Paper in international publication Authors: Azpiroz, F, Santos, J, Malagelada, C, Barba, I, Accarino, A, Molne, L, Mendez, S, Campos, E, Gonzalez, A, Alonso-Cotoner, C et al. DOI: 10.1111/nmo.12879
PMID: 27286570 Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY Year: 2016 Reference: Eur J Gastroenterol Hepatol. 2016 Sep;28(9):1094-9. doi: 10.1097/MEG.0000000000000678. Impact factor: 2.093 Publication type: Paper in international publication Authors: Fernandez-Esparrach, Gloria, Boadas, Jaume, Busquets, Juli, Fernandez-Cruz, Laureano, Ferrer, Joana, Vaquero, Eva C, Molero, Xavier, Navarro, Salvador, Sanchez-Cabus, Santiago, Araujo, Isis K et al. DOI: 10.1097/MEG.0000000000000678
PMID: 27474198 Journal: DIGESTIVE AND LIVER DISEASE Year: 2016 Reference: Dig Liver Dis. 2016 Oct;48(10):1172-9. doi: 10.1016/j.dld.2016.06.036. Epub 2016 Jul 14. Impact factor: 2.719 Publication type: Paper in international publication Authors: Casellas, Francesc, Ginard, Daniel, Riestra, Sabino et al. DOI: 10.1016/j.dld.2016.06.036
PMID: 25778503 Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Year: 2015 Reference: Am J Trop Med Hyg. 2015 May;92(5):898-902. doi: 10.4269/ajtmh.14-0546. Epub 2015 Mar 16. Impact factor: 2.699 Publication type: Paper in international publication Authors: Salvador, Fernando, Mego, Marianela, Sanchez-Montalva, Adrian, Moris, Maria, Ramirez, Kathleen, Accarino, Ana, Malagelada, Juan-Ramon, Azpiroz, Fernando, Molina, Israel et al. DOI: 10.4269/ajtmh.14-0546
PMID: 25659055 Journal: Nutricion Hospitalaria Year: 2015 Reference: Nutr Hosp. 2015 Feb 7;31 Suppl 1:59-63. doi: 10.3305/nh.2015.31.sup1.8708. Impact factor: 1.04 Publication type: Paper in national publication Authors: Azpiroz, Fernando, Alvarez Calatayud, Guillermo et al. DOI: 10.3305/nh.2015.31.sup1.8708
PMID: 26383484 Journal: PSYCHONEUROENDOCRINOLOGY Year: 2015 Reference: Psychoneuroendocrinology. 2015 Nov;61:75-6. doi: 10.1016/j.psyneuen.2015.07.599. Epub 2015 Aug 8. Impact factor: 4.944 Publication type: Paper in international publication Authors: Gonzalez-Castro, Ana M, Pardo-Camacho, Cristina, Lobo, Beatriz, Alonso-Cotoner, Carmen, Fortea, Marina, Salvo-Romero, Eloisa, Casado-Bedmar, Maite, Rodino-Janeiro, Bruno K, Azpiroz, Fernando, Santos, Javier et al. DOI: 10.1016/j.psyneuen.2015.07.599
PMID: 26251472 Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Year: 2015 Reference: Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G413-9. doi: 10.1152/ajpgi.00193.2015. Epub 2015 Aug 6. Impact factor: 3.798 Publication type: Paper in international publication Authors: Malagelada, Carolina, Drozdzal, Michal, Segui, Santi, Mendez, Sara, Vitria, Jordi, Radeva, Petia, Santos, Javier, Accarino, Anna, Malagelada, Juan-R, Azpiroz, Fernando et al. DOI: 10.1152/ajpgi.00193.2015
PMID: 23395564 Journal: PANCREATOLOGY Year: 2013 Reference: Pancreatology. 2013 Jan-Feb;13(1):8-17. doi: 10.1016/j.pan.2012.11.309. Epub 2012 Nov 27. Impact factor: 2.043 Publication type: Paper in international publication Authors: Martinez, J, Abad-Gonzalez, A, Aparicio, J R, Aparisi, L, Boadas, J, Boix, E, Farre, A, Fernandez-Cruz, L, Gomez, L, Iglesias-Garcia, J et al. DOI: 10.1016/j.pan.2012.11.309
PMID: 23360877 Journal: BRITISH JOURNAL OF NUTRITION Year: 2013 Reference: Br J Nutr. 2013 Jan;109 Suppl 2:S21-6. doi: 10.1017/S0007114512005235. Impact factor: 3.302 Publication type: Review in international publication Authors: Robles Alonso, Virginia, Guarner, Francisco et al. DOI: 10.1017/S0007114512005235
PMID: 23385241 Journal: INFLAMMATORY BOWEL DISEASES Year: 2013 Reference: Inflamm Bowel Dis. 2013 Mar;19(3):481-8. doi: 10.1097/MIB.0b013e31827fec6d. Impact factor: 5.119 Publication type: Paper in international publication Authors: Rajilic-Stojanovic, Mirjana, Shanahan, Fergus, Guarner, Francisco, de Vos, Willem M et al. DOI: 10.1097/MIB.0b013e31827fec6d
PMID: 23360536 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2013 Reference: Neurogastroenterol Motil. 2013 Apr;25(4):339-e253. doi: 10.1111/nmo.12068. Epub 2013 Jan 29. Impact factor: 2.935 Publication type: Paper in international publication Authors: Burri, E, Cisternas, D, Villoria, A, Accarino, A, Soldevilla, A, Malagelada, J-R, Azpiroz, F et al. DOI: 10.1111/nmo.12068
A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
