About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 34145682 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2022 Reference: Neurogastroenterol Motil. 2022 Mar;34(3):e14202. doi: 10.1111/nmo.14202. Epub 2021 Jun 18. Impact factor: 3.598 Publication type: Paper in international publication Authors: Duracinsky, Martin, Archbold, Sharon, Lobo, Beatriz, Bessonneau, Pascal, Thonon, Frederique, Santos, Javier, Guagnozzi, Danila, Payakachat, Nalin, Coffin, Benoit, Azpiroz, Fernando et al. DOI: 10.1111/nmo.14202
PMID: 34051313 Journal: Gastroenterologia y Hepatologia Year: 2022 Reference: Gastroenterol Hepatol. 2022 Mar;45(3):165-176. doi: 10.1016/j.gastrohep.2021.04.010. Epub 2021 May 27. Impact factor: 2.102 Publication type: Paper in national publication Authors: Marin-Jimenez, Ignacio, de Acosta, Manuel Barreiro, Esteve, Maria, Castro-Laria, Luisa, Garcia-Lopez, Santiago, Ceballos, Daniel, Echarri, Ana, Martin-Arranz, Maria Dolores, Busquets, David, Llao, Jordina et al. DOI: 10.1016/j.gastrohep.2021.04.010
PMID: 34157366 Journal: Gastroenterologia y Hepatologia Year: 2022 Reference: Gastroenterol Hepatol. 2022 Mar;45(3):231-248. doi: 10.1016/j.gastrohep.2021.05.017. Epub 2021 Jun 19. Impact factor: 2.102 Publication type: Paper in national publication Authors: Vaquero, Eva Cristina, Serrano, Teresa, Salord, Silvia, Puig-Divi, Valenti, Molero, Xavier, Ayuso, Juan Ramon, Balsells, Joaquim, Boadas, Jaume, Busquets, Juli, Casteras, Anna et al. DOI: 10.1016/j.gastrohep.2021.05.017
PMID: 35086339 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2022 Reference: Rev Esp Enferm Dig. 2022 Jan 28. doi: 10.17235/reed.2022.8388/2021. Impact factor: 2.086 Publication type: Paper in international publication Authors: Alcala-Gonzalez, Luis, Cortina, Vicente, Jimenez, Alba, Cerda, Maria, Johansson, Erik, Olivera, Pavel, Santamaria, Amparo, Alonso-Cotoner, Carmen, Jimenez, Cesar et al. DOI: 10.17235/reed.2022.8388/2021
PMID: 32898308 Journal: JOURNAL OF INHERITED METABOLIC DISEASE Year: 2021 Reference: J Inherit Metab Dis. 2021 Mar;44(2):376-387. doi: 10.1002/jimd.12300. Epub 2020 Sep 8. Impact factor: 4.982 Publication type: Review in international publication Authors: Hirano, Michio, Carelli, Valerio, De Giorgio, Roberto, Pironi, Loris, Accarino, Anna, Cenacchi, Giovanna, D'Alessandro, Roberto, Filosto, Massimiliano, Marti, Ramon, Nonino, Francesco et al. DOI: 10.1002/jimd.12300
PMID: 33758031 Journal: mSystems Year: 2021 Reference: mSystems. 2021 Mar 23;6(2). pii: 6/2/e01277-20. doi: 10.1128/mSystems.01277-20. Impact factor: 6.496 Publication type: Paper in international publication Authors: Sarrabayrouse, G, Elias, A, Yanez, F, Mayorga, L, Varela, E, Bartoli, C, Casellas, F, Borruel, N, Herrera de Guise, C, Machiels, K et al. DOI: 10.1128/mSystems.01277-20
PMID: 33738725 Journal: ADVANCES IN THERAPY Year: 2021 Reference: Adv Ther. 2021 May;38(5):2054-2076. doi: 10.1007/s12325-021-01676-z. Epub 2021 Mar 18. Impact factor: 3.847 Publication type: Review in international publication Authors: Alonso-Cotoner, Carmen, Abril-Gil, Mar, Albert-Bayo, Merce, Mall, John-P Ganda, Exposito, Elba, Gonzalez-Castro, Ana M, Lobo, Beatriz, Santos, Javier et al. DOI: 10.1007/s12325-021-01676-z
PMID: 33709214 Journal: Patient-Patient Centered Outcomes Research Year: 2021 Reference: Patient. 2021 Sep;14(5):625-634. doi: 10.1007/s40271-021-00500-8. Epub 2021 Mar 12. Impact factor: 3.883 Publication type: Paper in international publication Authors: Calvet, Xavier, Casellas, Fransesc, Saldana, Roberto, Carpio, Daniel, Minguez, Miguel, Vera, Isabel, Marin, Laura, Julia, Berta et al. DOI: 10.1007/s40271-021-00500-8
PMID: 32114574 Journal: DIGESTIVE DISEASES Year: 2020 Reference: Dig Dis. 2020;38(4):293-298. doi: 10.1159/000505810. Epub 2020 Feb 28. Impact factor: 2.493 Publication type: Review in international publication Authors: Malagelada, Juan R et al. DOI: 10.1159/000505810
PMID: 32051190 Journal: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION Year: 2020 Reference: Cancer Epidemiol Biomarkers Prev. 2020 May;29(5):1009-1018. doi: 10.1158/1055-9965.EPI-19-1027. Epub 2020 Feb 12. Impact factor: 4.344 Publication type: Paper in international publication Authors: Barbera, Victor M, Molina-Montes, Esther, Van Hoogstraten, Lisa, Gomez-Rubio, Paulina, Lohr, Matthias, Sharp, Linda, Molero, Xavier, Marquez, Mirari, Michalski, Christoph W, Farre, Antoni et al. DOI: 10.1158/1055-9965.EPI-19-1027
PMID: 31211875 Journal: HEPATOLOGY Year: 2020 Reference: Hepatology. 2020 Feb;71(2):658-669. doi: 10.1002/hep.30817. Epub 2019 Aug 19. Impact factor: 14.679 Publication type: Paper in international publication Authors: Tellez, Luis, Martinez, Javier, Alvarez-Navascues, Carmen, Fraile, Miguel, Procopet, Bogdan, Piscaglia, Fabio, de Koning, Barbara, Llop, Elba, Romero Cristobal, Mario, Tjwa, Eric et al. DOI: 10.1002/hep.30817
PMID: 31756783 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2020 Reference: Neurogastroenterol Motil. 2020 Feb;32(2):e13762. doi: 10.1111/nmo.13762. Epub 2019 Nov 22. Impact factor: 2.946 Publication type: Review in international publication Authors: Mendive, Juan-Manuel, Pfeifer, Johann, Rogler, Gerhard, Scott, S Mark, Simren, Magnus, Whorwell, Peter, Layer, Peter, Hungin, A Pali S, Gourcerol, Guillaume, Ducrotte, Philippe et al. DOI: 10.1111/nmo.13762
PMID: 28116817 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2017 Reference: Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13031. Epub 2017 Jan 23. Impact factor: 3.617 Publication type: Paper in international publication Authors: Pribic, T, Kilpatrick, L, Ciccantelli, B, Malagelada, C, Accarino, A, Rovira, A, Pareto, D, Mayer, E, Azpiroz, F et al. DOI: 10.1111/nmo.13031
PMID: 28164346 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2017 Reference: Aliment Pharmacol Ther. 2017 Apr;45(7):909-922. doi: 10.1111/apt.13958. Epub 2017 Feb 6. Impact factor: 7.286 Publication type: Clinical Trials Authors: Cremon, C, Stanghellini, V, Barbaro, M R, Cogliandro, R F, Bellacosa, L, Santos, J, Vicario, M, Pigrau, M, Alonso Cotoner, C, Lobo, B et al. DOI: 10.1111/apt.13958
PMID: 28179361 Journal: GUT Year: 2017 Reference: Gut. 2017 May;66(5):813-822. doi: 10.1136/gutjnl-2016-313235. Epub 2017 Feb 7. Impact factor: 16.658 Publication type: Paper in international publication Authors: Machiels, Kathleen, Vermeire, Severine, Sokol, Harry, Guarner, Francisco, Manichanh, Chaysavanh, Sarrabayrouse, Guillaume, Varela, Encarna, Santiago, Alba, Pascal, Victoria, Pozuelo, Marta et al. DOI: 10.1136/gutjnl-2016-313235
PMID: 28175097 Journal: Journal of Crohns & Colitis Year: 2017 Reference: J Crohns Colitis. 2017 Feb 1;11(suppl_1):S291-S292. doi: 10.1093/ecco-jcc/jjx002.548. Impact factor: 5.813 Publication type: Letter or abstract Authors: Casellas, F, Barreiro-de Acosta, M, Esteve, M, Castro-Laria, L, Vicente, R, Ceballos, D, Echarri, A, Martin-Arranz, M D, Busquets, D, Llaomicron, J et al. DOI: 10.1093/ecco-jcc/jjx002.548
PMID: 27810622 Journal: COMPUTERS IN BIOLOGY AND MEDICINE Year: 2016 Reference: Comput Biol Med. 2016 Dec 1;79:163-172. doi: 10.1016/j.compbiomed.2016.10.011. Epub 2016 Oct 19. Impact factor: 1.521 Publication type: Paper in international publication Authors: Segui, Santi, Drozdzal, Michal, Pascual, Guillem, Radeva, Petia, Malagelada, Carolina, Azpiroz, Fernando, Vitria, Jordi et al. DOI: 10.1016/j.compbiomed.2016.10.011
PMID: 27741951 Journal: Parasites & Vectors Year: 2016 Reference: Parasit Vectors. 2016 Oct 14;9(1):548. Impact factor: 3.234 Publication type: Paper in international publication Authors: Salvador, Fernando, Sulleiro, Elena, Sanchez-Montalva, Adrian, Alonso, Carmen, Santos, Javier, Fuentes, Isabel, Molina, Israel et al. DOI: 10.1186/s13071-016-1827-4
PMID: 27564131 Journal: Nature Microbiology Year: 2016 Reference: Nat Microbiol. 2016 Aug 26;1:16152. doi: 10.1038/nmicrobiol.2016.152. Impact factor: 0 Publication type: Paper in international publication Authors: Rettedal, Elizabeth, Plichta, Damian Rafal, Juncker, Agnieszka Sierakowska, Bertalan, Marcelo, Manichanh, Chaysavanh, Fouqueray, Charlene, Levenez, Florence, Nielsen, Trine, Dore, Joel, Machado, Ana Manuel Dantas et al. DOI: 10.1038/nmicrobiol.2016.152
PMID: 27242727 Journal: Frontiers in Microbiology Year: 2016 Reference: Front Microbiol. 2016 May 11;7:705. doi: 10.3389/fmicb.2016.00705. eCollection 2016. Impact factor: 4.165 Publication type: Paper in international publication Authors: Jose Fabrega, Maria, Aguilera, Laura, Gimenez, Rosa, Varela, Encarna, Alexandra Canas, Maria, Antolin, Maria, Badia, Josefa, Baldoma, Laura et al. DOI: 10.3389/fmicb.2016.00705
A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
