Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.

Projects

Aquest any no hi ha projectes actius.

Publications

Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry.

PMID: 35318777
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2022
Reference: Neurogastroenterol Motil. 2022 Mar 22:e14351. doi: 10.1111/nmo.14351.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Alcala, Luis G, Malagelada, Carolina, Livovsky, Dan M, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.14351

Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak.

PMID: 35297257
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2022
Reference: Rev Esp Enferm Dig. 2022 Mar 17. doi: 10.17235/reed.2022.8668/2022.
Impact factor: 2.086
Publication type: Paper in international publication
Authors: Perez Martinez, Zahira, Casellas, Francesc, Ibarz, Arantxa, Borruel Sainz, Natalia, Serra Ruiz, Xavier, Herrera-de Guise, Claudia, Mayorga Ayala, Luis Fernando, Robles Alonso, Virginia et al.
DOI: 10.17235/reed.2022.8668/2022

Pancreatitis crónica para el clínico. Parte 2: Tratamiento y seguimiento. Documento de posicionamiento interdisciplinar de la Societat Catalana de Digestologia y la Societat Catalana de Pàncrees (versión castellana)

PMID: 34171422
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Apr;45(4):304-314. doi: 10.1016/j.gastrohep.2021.05.016. Epub 2021 Jun 23.
Impact factor: 2.102
Publication type: Paper in national publication
Authors: Molero, Xavier, Ayuso, Juan Ramon, Balsells, Joaquim, Boadas, Jaume, Busquets, Juli, Casteras, Anna, Concepcion, Mar, Cuatrecasas, Miriam, Esparrach, Gloria Fernandez, Fort, Esther et al.
DOI: 10.1016/j.gastrohep.2021.05.016

Percutaneous angiographic arterial embolization of a vascular lesion in the colon of a patient on anticoagulant therapy.

PMID: 33248176
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Apr;45(4):282-283. doi: 10.1016/j.gastrohep.2020.11.011. Epub 2020 Nov 25.
Impact factor: 2.102
Publication type: Paper in national publication
Authors: Serra-Ruiz, Xavier, Tasayco, Stephanie, Gonzalez-Junyent, Carla, Alonso-Cotoner, Carmen et al.
DOI: 10.1016/j.gastrohep.2020.11.011

Integrating Dietary Data into Microbiome Studies: A Step Forward for Nutri-Metaomics.

PMID: 34578856
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Aug 27;13(9). pii: nu13092978. doi: 10.3390/nu13092978.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Serrano-Gomez, Gerard, Manichanh, Chaysavanh, Oyarzun, Inigo, Xie, Zixuan, Oliero, Manon, Soler, Zaida, Yanez, Francisca et al.
DOI: 10.3390/nu13092978

Differential Effects of Western and Mediterranean-Type Diets on Gut Microbiota: A Metagenomics and Metabolomics Approach.

PMID: 34444797
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082638. doi: 10.3390/nu13082638.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Barber, Claudia, Mego, Marianela, Sabater, Carlos, Vallejo, Fernando, Bendezu, Rogger Alvaro, Masihy, Marcela, Guarner, Francisco, Espin, Juan Carlos, Margolles, Abelardo, Azpiroz, Fernando et al.
DOI: 10.3390/nu13082638

Propagation patterns of jejunal motor activity measured by high-resolution water-perfused manometry.

PMID: 34378830
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2021
Reference: Neurogastroenterol Motil. 2021 Dec;33(12):e14240. doi: 10.1111/nmo.14240. Epub 2021 Aug 11.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis Gerardo, Malagelada, Carolina, Galan, Carmen, Nieto, Adoracion, Accarino, Anna, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.14240

Effectiveness of a Telephone-Based Motivational Intervention for Smoking Cessation in Patients With Crohn Disease: A Randomized, Open-Label, Controlled Clinical Trial.

PMID: 34269705
Journal: Gastroenterology Nursing
Year: 2021
Reference: Gastroenterol Nurs. 2021 Nov-Dec 01;44(6):418-425. doi: 10.1097/SGA.0000000000000572.
Impact factor: 0.978
Publication type: Paper in international publication
Authors: Robles Alonso, Virginia, Navarro Correal, Ester, Casellas Jorda, Francesc, Borruel Sainz, Natalia, Sanchez Garcia, Josep Maria, Vila Morte, Genoveva, Fuentelsaz Gallego, Carmen, Ibarz Casas, Arantxa, Herrera de Guise, Claudia et al.
DOI: 10.1097/SGA.0000000000000572

International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

PMID: 32376198
Journal: PANCREATOLOGY
Year: 2020
Reference: Pancreatology. 2020 Jun;20(4):579-585. doi: 10.1016/j.pan.2020.03.014. Epub 2020 Apr 8.
Impact factor: 3.629
Publication type: Review in international publication
Authors: Hegyi, Peter, Parniczky, Andrea, Lerch, Markus M, Sheel, Andrea R G, Rebours, Vinciane, Forsmark, Chris E, Del Chiaro, Marco, Rosendahl, Jonas, de-Madaria, Enrique, Szucs, Akos et al.
DOI: 10.1016/j.pan.2020.03.014

A scalable approach to T2-MRI colon segmentation.

PMID: 32353758
Journal: MEDICAL IMAGE ANALYSIS
Year: 2020
Reference: Med Image Anal. 2020 Jul;63:101697. doi: 10.1016/j.media.2020.101697. Epub 2020 Apr 13.
Impact factor: 11.148
Publication type: Paper in international publication
Authors: Azpiroz, Fernando, Orellana, Bernat, Monclus, Eva, Brunet, Pere, Navazo, Isabel, Bendezu, Alvaro et al.
DOI: 10.1016/j.media.2020.101697

National survey on the experiences of people with celiac disease in Spain. The CELIAC-SPAIN project.

PMID: 32338009
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2020
Reference: Rev Esp Enferm Dig. 2020 May;112(5):343-354. doi: 10.17235/reed.2020.6929/2020.
Impact factor: 1.591
Publication type: Paper in international publication
Authors: Casellas Jorda, Francesc, Arguelles Arias, Federico, Burgos, Rosa, van der Hofstadt Rovira, Maria et al.
DOI: 10.17235/reed.2020.6929/2020

Early postoperative endoscopic recurrence in Crohn's disease is characterized by distinct microbiota recolonization.

PMID: 32333762
Journal: Journal of Crohns & Colitis
Year: 2020
Reference: J Crohns Colitis. 2020 Nov 7;14(11):1535-1546. doi: 10.1093/ecco-jcc/jjaa081.
Impact factor: 8.658
Publication type: Paper in international publication
Authors: Machiels, Kathleen, Pozuelo Del Rio, Marta, Martinez-De la Torre, Adrian, Xie, Zixuan, Pascal Andreu, Victoria, Sabino, Joao, Santiago, Alba, Wolthuis, Albert, D'Hoore, Andre, De Hertogh, Gert et al.
DOI: 10.1093/ecco-jcc/jjaa081

Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis.

PMID: 28834270
Journal: LIVER INTERNATIONAL
Year: 2018
Reference: Liver Int. 2018 Feb;38(2):295-302. doi: 10.1111/liv.13551. Epub 2017 Sep 13.
Impact factor: 4.5
Publication type: Paper in international publication
Authors: Gomez-Hurtado, Isabel, Gimenez, Paula, Garcia, Irma, Zapater, Pedro, Frances, Ruben, Gonzalez-Navajas, Jose Manuel, Manichahn, Chaysavanh, Ramos, Jose Manuel, Bellot, Pablo, Guarner, Francisco et al.
DOI: 10.1111/liv.13551

Education of the postprandial experience by a sensory-cognitive intervention.

PMID: 28836716
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13197. Epub 2017 Aug 24.
Impact factor: 3.842
Publication type: Paper in international publication
Authors: Azpiroz, F, Pribic, T, Vilaseca, H, Nieto, A, Hernandez, L, Malagelada, C, Accarino, A, Roca, J et al.
DOI: 10.1111/nmo.13197

Effects of meal palatability on postprandial sensations.

PMID: 29105893
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13248. Epub 2017 Nov 6.
Impact factor: 3.842
Publication type: Paper in international publication
Authors: Nieto, A, Malagelada, C, Accarino, A, Azpiroz, F, Hernandez, L, Pribic, T et al.
DOI: 10.1111/nmo.13248

Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans.

PMID: 29330618
Journal: Annals of Intensive Care
Year: 2018
Reference: Ann Intensive Care. 2018 Jan 9;8(1):1. doi: 10.1186/s13613-017-0346-6.
Impact factor: 3.771
Publication type: Paper in international publication
Authors: de-Madaria, Enrique, Molero, Xavier, Bonjoch, Laia, Casas, Josefina, Cardenas-Jaen, Karina, Montenegro, Andrea, Closa, Daniel et al.
DOI: 10.1186/s13613-017-0346-6

Colonic gas homeostasis: Mechanisms of adaptation following HOST-G904 galactooligosaccharide use in humans.

PMID: 28418214
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13080. Epub 2017 Apr 18.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Mego, M, Accarino, A, Tzortzis, G, Vulevic, J, Gibson, G, Guarner, F, Azpiroz, F et al.
DOI: 10.1111/nmo.13080

A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk.

PMID: 28383714
Journal: ANNALS OF ONCOLOGY
Year: 2017
Reference: Ann Oncol. 2017 Jul 1;28(7):1618-1624. doi: 10.1093/annonc/mdx167.
Impact factor: 11.855
Publication type: Paper in international publication
Authors: Barbera, V M, Gomez-Rubio, P, Rosato, V, Marquez, M, Bosetti, C, Molina-Montes, E, Rava, M, Pinero, J, Michalski, C W, Farre, A et al.
DOI: 10.1093/annonc/mdx167

Appetite influences the responses to meal ingestion.

PMID: 28370941
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Aug;29(8). doi: 10.1111/nmo.13072. Epub 2017 Mar 31.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Pribic, T, Nieto, A, Hernandez, L, Malagelada, C, Accarino, A, Azpiroz, F et al.
DOI: 10.1111/nmo.13072

Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study.

PMID: 27477485
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Feb;29(2). doi: 10.1111/nmo.12911. Epub 2016 Jul 31.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Azpiroz, F, Dubray, C, Bernalier-Donadille, A, Cardot, J-M, Accarino, A, Serra, J, Wagner, A, Respondek, F, Dapoigny, M et al.
DOI: 10.1111/nmo.12911

Development and Validation of the Short Crohn's Disease Work Disability Questionnaire.

PMID: 26933747
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2016
Reference: Inflamm Bowel Dis. 2016 Apr;22(4):955-62. doi: 10.1097/MIB.0000000000000678.
Impact factor: 4.358
Publication type: Paper in international publication
Authors: Vergara, Mercedes, Sicilia, Beatriz, Prieto, Luis, Casellas, Francesc, Ramos, Alexis, Gomollon, Fernando, Calvet, Xavier et al.
DOI: 10.1097/MIB.0000000000000678

[Efficacy and effectiveness of biologic therapy in inflammatory bowel disease. EFIFECT study].

PMID: 27005800
Journal: Gastroenterologia y Hepatologia
Year: 2016
Reference: Gastroenterol Hepatol. 2016 Jun-Jul;39(6):369-76. doi: 10.1016/j.gastrohep.2016.02.004. Epub 2016 Apr 20.
Impact factor: 0.8
Publication type: Paper in national publication
Authors: Ginard, Daniel, Khorrami, Sam, Perez-Carazo, Leticia, Tavio-Hernandez, Eduardo, Lopez-Sanroman, Antonio, Garcia-Alvarado, Maria, Munoz, Fernando, Ibanez-Samaniego, Luis, Marin-Jimenez, Ignacio, Guevara, Jorge et al.
DOI: 10.1016/j.gastrohep.2016.02.004

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery.

PMID: 27045859
Journal: ANNALS OF SURGERY
Year: 2016
Reference: Ann Surg. 2016 Dec;264(6):949-958.
Impact factor: 8.569
Publication type: Paper in international publication
Authors: Marra-Lopez, Carlos, Sabater, Luis, Ausania, Fabio, Bakker, Olaf J, Boadas, Jaume, Dominguez-Munoz, J Enrique, Falconi, Massimo, Fernandez-Cruz, Laureano, Frulloni, Luca, Gonzalez-Sanchez, Victor et al.
DOI: 10.1097/SLA.0000000000001732

Perception of lactose intolerance impairs health-related quality of life.

PMID: 27188918
Journal: EUROPEAN JOURNAL OF CLINICAL NUTRITION
Year: 2016
Reference: Eur J Clin Nutr. 2016 Sep;70(9):1068-72. doi: 10.1038/ejcn.2016.80. Epub 2016 May 18.
Impact factor: 2.935
Publication type: Paper in international publication
Authors: Casellas, F, Aparici, A, Perez, M J, Rodriguez, P et al.
DOI: 10.1038/ejcn.2016.80

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome.

PMID: 26239401
Journal: Scientific Reports
Year: 2015
Reference: Sci Rep. 2015 Aug 4;5:12693. doi: 10.1038/srep12693.
Impact factor: 5.578
Publication type: Paper in international publication
Authors: Pozuelo, Marta, Panda, Suchita, Santiago, Alba, Mendez, Sara, Accarino, Anna, Santos, Javier, Guarner, Francisco, Azpiroz, Fernando, Manichanh, Chaysavanh et al.
DOI: 10.1038/srep12693

Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy.

PMID: 26264513
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Oct;138(Pt 10):2847-58. doi: 10.1093/brain/awv226. Epub 2015 Aug 10.
Impact factor: 9.196
Publication type: Paper in international publication
Authors: Accarino, Anna, Ferra, Christelle, Illa, Isabel, Beguin, Yves, Bakker, Jaap A, Boelens, Jaap J, de Coo, Irenaeus F M, Fay, Keith, Sue, Carolyn M, Nachbaur, David et al.
DOI: 10.1093/brain/awv226

Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.

PMID: 25037190
Journal: GUT
Year: 2015
Reference: Gut. 2015 Jun;64(6):937-47. doi: 10.1136/gutjnl-2013-306068. Epub 2014 Jul 18.
Impact factor: 14.66
Publication type: Paper in international publication
Authors: Cendrowski, Jaroslaw, Lobo, Victor J Sanchez-Arevalo, Sendler, Matthias, Salas, Antonio, Kuhn, Jens-Peter, Molero, Xavier, Fukunaga, Rikiro, Mayerle, Julia, Lerch, Markus M, Real, Francisco X et al.
DOI: 10.1136/gutjnl-2013-306068

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability.

PMID: 25537677
Journal: Journal of Neurogastroenterology and Motility
Year: 2015
Reference: J Neurogastroenterol Motil. 2015 Jan 1;21(1):33-50. doi: 10.5056/jnm14084.
Impact factor: 2.296
Publication type: Paper in international publication
Authors: Santos, Javier, Rodino-Janeiro, Bruno K, Alonso-Cotoner, Carmen, Pigrau, Marc, Lobo, Beatriz, Vicario, Maria et al.
DOI: 10.5056/jnm14084

Understanding the microbiota in the midst of Renaissance architecture and olive groves.

PMID: 23334821
Journal: NATURE IMMUNOLOGY
Year: 2013
Reference: Nat Immunol. 2013 Feb;14(2):101-5. doi: 10.1038/ni.2512.
Impact factor: 26.199
Publication type: Paper in international publication
Authors: Guarner, Francisco, Hooper, Lora V, Nunez, Gabriel et al.
DOI: 10.1038/ni.2512

Dietary and lifestyle factors in functional dyspepsia.

PMID: 23296252
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2013
Reference: Nat Rev Gastroenterol Hepatol. 2013 Mar;10(3):150-7. doi: 10.1038/nrgastro.2012.246. Epub 2013 Jan 8.
Impact factor: 10.426
Publication type: Review in international publication
Authors: Feinle-Bisset, Christine, Azpiroz, Fernando et al.
DOI: 10.1038/nrgastro.2012.246

Gut microbiota and gastrointestinal health: current concepts and future directions.

PMID: 23279728
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2013
Reference: Neurogastroenterol Motil. 2013 Jan;25(1):4-15. doi: 10.1111/nmo.12046.
Impact factor: 2.935
Publication type: Review in international publication
Authors: Aziz, Q, Dore, J, Emmanuel, A, Guarner, F, Quigley, E M M et al.
DOI: 10.1111/nmo.12046

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