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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Publications

Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma.

PMID: 33411965
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2021
Reference: Int J Cancer. 2021 Apr 15;148(8):2048-2058. doi: 10.1002/ijc.33464. Epub 2021 Jan 15.
Impact factor: 7.396
Publication type: Paper in international publication
Authors: Nilsson, Magnus, Evangelina Lopez de Maturana, Maria, Estudillo Garcia, Lidia, Renz, Harald, Carrato, Alfredo, Molero, Xavier, Real, Francisco X, Malats, Nuria, Ye, Weimin, Lohr, Matthias et al.
DOI: 10.1002/ijc.33464

Transportome profiling identifies profound alterations in Crohn's disease partially restored by commensal bacteria.

PMID: 26874350
Journal: Journal of Crohns & Colitis
Year: 2016
Reference: J Crohns Colitis. 2016 Jul;10(7):850-9. doi: 10.1093/ecco-jcc/jjw042. Epub 2016 Feb 13.
Impact factor: 6.585
Publication type: Paper in international publication
Authors: Perez-Torras, Sandra, Iglesias, Ingrid, Llopis, Marta, Lozano, Juan J, Antolin, Maria, Guarner, Francisco, Pastor-Anglada, Marcal et al.
DOI: 10.1093/ecco-jcc/jjw042

High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation.

PMID: 26848957
Journal: PLoS Neglected Tropical Diseases
Year: 2016
Reference: PLoS Negl Trop Dis. 2016 Feb 5;10(2):e0004416. doi: 10.1371/journal.pntd.0004416. eCollection 2016 Feb.
Impact factor: 3.948
Publication type: Paper in international publication
Authors: Moris, Maria, Sanchez-Montalva, Adrian, Accarino, Anna, Ramirez, Kathleen, Azpiroz, Fernando, Ruiz-de-Leon, Antonio, Molina, Israel, Salvador, Fernando, Mego, Marianela et al.
DOI: 10.1371/journal.pntd.0004416

Diabetic neuropathy in the gut: pathogenesis and diagnosis.

PMID: 26643877
Journal: DIABETOLOGIA
Year: 2016
Reference: Diabetologia. 2016 Mar;59(3):404-8. doi: 10.1007/s00125-015-3831-1. Epub 2015 Dec 7.
Impact factor: 6.206
Publication type: Paper in international publication
Authors: Azpiroz, Fernando, Malagelada, Carolina et al.
DOI: 10.1007/s00125-015-3831-1

Blog

News

A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.