About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 34254522 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2022 Reference: Rev Esp Enferm Dig. 2022 Mar;114(3):156-165. doi: 10.17235/reed.2021.8130/2021. Impact factor: 2.086 Publication type: Paper in national publication Authors: Bella Castillo, Pablo, Barreiro-de Acosta, Manuel, Gomez, Susana, Fortes, Pilar, Camacho, Laura, Casellas, Francesc, Gonzalez-Lama, Yago, Ginard Vicens, Daniel, Garcia-Lopez, Santiago, Munoz, Fernando et al. DOI: 10.17235/reed.2021.8130/2021
PMID: 35260444 Journal: GUT Year: 2022 Reference: Gut. 2022 Jul;71(7):1359-1372. doi: 10.1136/gutjnl-2021-324755. Epub 2022 Mar 8. Impact factor: 23.059 Publication type: Paper in international publication Authors: Maistrenko, Oleksandr M, Kartal, Ece, Schmidt, Thomas S B, Molina-Montes, Esther, Rodriguez-Perales, Sandra, Wirbel, Jakob, Malats, Nuria, Bork, Peer, Malats, Nuria, Real, Francisco X et al. DOI: 10.1136/gutjnl-2021-324755
PMID: 35262306 Journal: Minerva gastroenterology Year: 2022 Reference: Minerva Gastroenterol (Torino). 2022 Mar 8. pii: S2724-5985.22.03127-8. doi: 10.23736/S2724-5985.22.03127-8. Impact factor: 0 Publication type: Paper in international publication Authors: Casteras, Anna, Concepcion, Mar, Cuatrecasas, Miriam, Fernandez Esparrach, Gloria, Fort, Esther, Garcia Borobia, Francisco, Gines, Angels, Ilzarbe, Lucas, Loras, Carme, Masachs, Miquel et al. DOI: 10.23736/S2724-5985.22.03127-8
PMID: 35256061 Journal: Endocrinologia Diabetes y Nutricion Year: 2022 Reference: Endocrinol Diabetes Nutr (Engl Ed). 2022 Feb;69(2):155-156. doi: 10.1016/j.endien.2022.02.004. Impact factor: 1.417 Publication type: Letter or abstract Authors: Cordero-Vazquez, Efrain, Filippi-Arriaga, Francesca, Hernandez, Irene Hernandez, Haman, Stephanie Solange Tasayco, Ciudin, Andreea et al. DOI: 10.1016/j.endien.2022.02.004
PMID: 34131474 Journal: World journal of hepatology Year: 2021 Reference: World J Hepatol. 2021 May 27;13(5):611-619. doi: 10.4254/wjh.v13.i5.611. Impact factor: 0 Publication type: Letter or abstract Authors: Riveiro-Barciela, Mar, Mirallas, Oriol, Saoudi, Nadia, Gomez-Puerto, Diego, Landolfi, Stefania, Blanco, Laia, Garcia-Burillo, Amparo, Molero, Xavier, Salcedo-Allende, Maria Teresa, Capdevila, Jaume et al. DOI: 10.4254/wjh.v13.i5.611
PMID: 34104210 Journal: Therapeutic Advances in Gastroenterology Year: 2021 Reference: Therap Adv Gastroenterol. 2021 May 30;14:17562848211016567. doi: 10.1177/17562848211016567. eCollection 2021. Impact factor: 4.409 Publication type: Paper in international publication Authors: Campos-Varela, Isabel, Villagrasa, Ares, Simon-Talero, Macarena, Riveiro-Barciela, Mar, Ventura-Cots, Meritxell, Aguilera-Castro, Lara, Alvarez-Lopez, Patricia, Nordahl, Emilie A, Rivera-Esteban, Jesus M, Romero, Alba et al. DOI: 10.1177/17562848211016567
PMID: 33213168 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2021 Reference: Rev Esp Enferm Dig. 2021 May;113(5):313-317. doi: 10.17235/reed.2020.6941/2020. Impact factor: 2.086 Publication type: Paper in national publication Authors: Marques Cami, Miquel, Robles Alonso, Virginia, Borruel Sainz, Natalia, Herrera de Guise, Claudia, Mayorga Ayala, Luis, Casellas Jorda, Francesc et al. DOI: 10.17235/reed.2020.6941/2020
PMID: 33801924 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Mar 10;13(3). pii: nu13030893. doi: 10.3390/nu13030893. Impact factor: 5.719 Publication type: Review in international publication Authors: Livovsky, Dan M, Azpiroz, Fernando et al. DOI: 10.3390/nu13030893
PMID: 31634907 Journal: INFLAMMATORY BOWEL DISEASES Year: 2020 Reference: Inflamm Bowel Dis. 2020 Apr 11;26(5):782-791. doi: 10.1093/ibd/izz126. Impact factor: 4.261 Publication type: Paper in international publication Authors: Casellas, Fransesc, Marin, Laura, Julia, Berta, Vera, Isabel, Calvet, Xavier, Saldana, Roberto, Carpio, Daniel, Minguez, Miguel et al. DOI: 10.1093/ibd/izz126
PMID: 32252402 Journal: Nutrients Year: 2020 Reference: Nutrients. 2020 Apr 2;12(4). pii: nu12040986. doi: 10.3390/nu12040986. Impact factor: 4.546 Publication type: Paper in international publication Authors: Livovsky, Dan M, Pribic, Teorora, Azpiroz, Fernando et al. DOI: 10.3390/nu12040986
PMID: 31726116 Journal: JOURNAL OF HEPATOLOGY Year: 2020 Reference: J Hepatol. 2020 Apr;72(4):702-710. doi: 10.1016/j.jhep.2019.10.027. Epub 2019 Nov 11. Impact factor: 20.582 Publication type: Paper in international publication Authors: Tellez, Luis, Rodriguez de Santiago, Enrique, Minguez, Beatriz, Payance, Audrey, Clemente, Ana, Baiges, Anna, Morales-Arraez, Dalia, La Mura, Vincenzo, Llop, Elba, Garrido, Elena et al. DOI: 10.1016/j.jhep.2019.10.027
PMID: 32176761 Journal: Journal of Gastrointestinal and Liver Diseases Year: 2020 Reference: J Gastrointestin Liver Dis. 2020 Mar 13;29(1):65-68. doi: 10.15403/jgld-806. Impact factor: 2.351 Publication type: Paper in international publication Authors: Pribic, Teodora, Lopez, Quiro, Lucas, Eduardo, Livovsky, Dan M, Rovira, Alex, Accarino, Anna, Azpiroz, Fernando, Pareto, Deborah et al. DOI: 10.15403/jgld-806
PMID: 29329392 Journal: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Year: 2018 Reference: Int J Epidemiol. 2018 Apr 1;47(2):473-483. doi: 10.1093/ije/dyx269. Impact factor: 8.36 Publication type: Paper in international publication Authors: O'Rorke, M, Tardon, A, Gress, T, Barbera, V M, Crnogorac-Jurcevic, T, Dominguez-Munoz, E, Munoz-Bellvis, L, Balsells, J, Costello, E, Huang, J et al. DOI: 10.1093/ije/dyx269
PMID: 27477485 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2017 Reference: Neurogastroenterol Motil. 2017 Feb;29(2). doi: 10.1111/nmo.12911. Epub 2016 Jul 31. Impact factor: 3.617 Publication type: Paper in international publication Authors: Azpiroz, F, Dubray, C, Bernalier-Donadille, A, Cardot, J-M, Accarino, A, Serra, J, Wagner, A, Respondek, F, Dapoigny, M et al. DOI: 10.1111/nmo.12911
PMID: 27717791 Journal: DIGESTIVE AND LIVER DISEASE Year: 2017 Reference: Dig Liver Dis. 2017 Feb;49(2):152-156. doi: 10.1016/j.dld.2016.09.009. Epub 2016 Sep 21. Impact factor: 3.061 Publication type: Paper in international publication Authors: Casellas, Francesc, Herrera-de Guise, Claudia, Robles, Virginia, Navarro, Ester, Borruel, Natalia et al. DOI: 10.1016/j.dld.2016.09.009
PMID: 28054426 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2017 Reference: Neurogastroenterol Motil. 2017 May;29(5). doi: 10.1111/nmo.13011. Epub 2017 Jan 5. Impact factor: 3.617 Publication type: Paper in international publication Authors: Ciccantelli, B, Pribic, T, Malagelada, C, Accarino, A, Azpiroz, F et al. DOI: 10.1111/nmo.13011
PMID: 28078750 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2017 Reference: Aliment Pharmacol Ther. 2017 Mar;45(5):670-680. doi: 10.1111/apt.13931. Epub 2017 Jan 12. Impact factor: 7.286 Publication type: Clinical Trials Authors: Manichanh, C, Accarino, A, Campos, D, Pozuelo, M, Varela, E, Vulevic, J, Tzortzis, G, Gibson, G, Guarner, F, Azpiroz, F et al. DOI: 10.1111/apt.13931
PMID: 27726847 Journal: MEDICINA CLINICA Year: 2016 Reference: Med Clin (Barc). 2016 Nov 18;147(10):465.e1-465.e8. doi: 10.1016/j.medcli.2016.07.033. Epub 2016 Oct 7. Impact factor: 1.267 Publication type: Paper in national publication Authors: Martin-Richard, Marta, Gines, Angels, Ayuso, Juan Ramon, Sabater, Luis, Fabregat, Joan, Mendez, Ramiro, Fernandez-Esparrach, Gloria, Molero, Xavier, Vaquero, Eva C, Cuatrecasas, Miriam et al. DOI: 10.1016/j.medcli.2016.07.033
PMID: 26871593 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2016 Reference: Neurogastroenterol Motil. 2016 Jun;28(6):849-54. doi: 10.1111/nmo.12782. Epub 2016 Feb 12. Impact factor: 3.31 Publication type: Paper in international publication Authors: Bendezu, R A, Barba, E, Burri, E, Cisternas, D, Accarino, A, Quiroga, S, Monclus, E, Navazo, I, Malagelada, J-R, Azpiroz, F et al. DOI: 10.1111/nmo.12782
PMID: 26901502 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2016 Reference: Rev Esp Enferm Dig. 2016 Apr;108(4):181-9. doi: 10.17235/reed.2016.4094/2015. Impact factor: 1.455 Publication type: Paper in international publication Authors: Rodriguez Almagro, Julian, Hernandez Martinez, Antonio, Lucendo, Alfredo Jose, Casellas, Francesc, Solano Ruiz, Maria Carmen, Siles Gonzalez, Jose et al. DOI: 10.17235/reed.2016.4094/2015
PMID: 26610769 Journal: Gastroenterologia y Hepatologia Year: 2016 Reference: Gastroenterol Hepatol. 2016 Oct;39(8):535-59. doi: 10.1016/j.gastrohep.2015.09.018. Epub 2015 Nov 21. Impact factor: 0.8 Publication type: Review in national publication Authors: Fernandez-Banares, Fernando, Accarino, Anna, Balboa, Agustin, Domenech, Eugeni, Esteve, Maria, Garcia-Planella, Esther, Guardiola, Jordi, Molero, Xavier, Rodriguez-Luna, Alba, Ruiz-Cerulla, Alexandra et al. DOI: 10.1016/j.gastrohep.2015.09.018
PMID: 25458544 Journal: Gastroenterologia y Hepatologia Year: 2015 Reference: Gastroenterol Hepatol. 2015 Feb;38(2):82-96. doi: 10.1016/j.gastrohep.2014.09.006. Epub 2014 Nov 6. Impact factor: 0.838 Publication type: Paper in national publication Authors: Gines, Angels, Gornals, Joan, Gruartmoner, Guillem, Ilzarbe, Lucas, Merino, Xavier, Oms, Lluis, Puig, Ignasi, Puig-Divi, Valenti, Vaquero, Eva, Vida, Francesc et al. DOI: 10.1016/j.gastrohep.2014.09.006
PMID: 24768808 Journal: Clinical Gastroenterology and Hepatology Year: 2015 Reference: Clin Gastroenterol Hepatol. 2015 Jan;13(1):100-6.e1. doi: 10.1016/j.cgh.2014.04.018. Epub 2014 Apr 24. Impact factor: 7.896 Publication type: Paper in international publication Authors: Barba, Elizabeth, Burri, Emanuel, Accarino, Anna, Malagelada, Carolina, Rodriguez-Urrutia, Amanda, Soldevilla, Alfredo, Malagelada, Juan-R, Azpiroz, Fernando et al. DOI: 10.1016/j.cgh.2014.04.018
PMID: 25304690 Journal: Beneficial Microbes Year: 2015 Reference: Benef Microbes. 2015 Mar;6(1):3-17. doi: 10.3920/BM2014.0079. Impact factor: 2.614 Publication type: Paper in international publication Authors: Van den Nieuwboer, M, Brummer, R J, Guarner, F, Morelli, L, Cabana, M, Claassen, E et al. DOI: 10.3920/BM2014.0079
A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
