About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 35105687 Journal: Neurology-Neuroimmunology & Neuroinflammation Year: 2022 Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Feb 1;9(2). pii: 9/2/e1143. doi: 10.1212/NXI.0000000000001143. Print 2022 Mar. Impact factor: Publication type: Paper in international publication Authors: Arrambide, Georgina; Beltran, Jordina; Bonastre, Merce; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Espejo, Carmen et al. DOI: 10.1212/NXI.0000000000001143
PMID: 34844263 Journal: Blood Advances Year: 2022 Reference: Blood Adv. 2022 Feb 8;6(3):774-784. doi: 10.1182/bloodadvances.2021006101. Impact factor: Publication type: Paper in international publication Authors: Abrisqueta, Pau; Barba, Pere; Bosch, Francesc; Cabirta, Alba; Campins, Magda; Catala, Eva; Crespo, Marta; Esperalba, Juliana; Fernandez-Naval, Candela; Fox, Maria Laura et al. DOI: 10.1182/bloodadvances.2021006101
PMID: 35043109 Journal: Year: 2022 Reference: Res Sq. 2022 Jan 14. doi: 10.21203/rs.3.rs-1225906/v1. Impact factor: Publication type: Letter or abstract Authors: Abel, Laurent; Aiuti, Alessandro; AlKhater, Suzan; Amador-Borrero, Blanca; Anaya, Juan-Manuel; Anderson, Mark; Andreakos, Evangelos; Anglicheau, Dany; Arias, Andres; Arrestier, Romain et al. DOI: 10.21203/rs.3.rs-1225906/v1
PMID: 35999826 Journal: Medicina clinica (English ed.) Year: 2022 Reference: Med Clin (Engl Ed). 2022 Aug 12;159(3):116-123. doi: 10.1016/j.medcle.2021.09.028. Epub 2022 Aug 19. Impact factor: Publication type: Paper in international publication Authors: Anton, Andres; Arrese-Munoz, Iria; Cardona, Victoria; Esperalba, Juliana; Fernandez-Naval, Candela; Hernandez-Gonzalez, Manuel; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Pujol-Borrell, Ricardo; Pumarola, Tomas et al. DOI: 10.1016/j.medcle.2021.09.028
PMID: 33620072 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Dec 1;60(12):5647-5658. doi: 10.1093/rheumatology/keab170. Impact factor: Publication type: Paper in international publication Authors: Loureiro-Amigo, Jose; Martinez-Gallo, Monica; Martinez-Valle, Fernando; Palacio-Garcia, Carlos; Ramentol-Sintas, Marc; Solans-Laque, Roser et al. DOI: 10.1093/rheumatology/keab170
PMID: 33422078 Journal: MALARIA JOURNAL Year: 2021 Reference: Malar J. 2021 Jan 9;20(1):35. doi: 10.1186/s12936-021-03580-x. Impact factor: Publication type: Paper in international publication Authors: Abdelrahim, Mutasim; Adam, Ishag; Franco-Jarava, Clara; Molina, Israel; Noureldien, Ali; Omer, Mona; Omer, Samia et al. DOI: 10.1186/s12936-021-03580-x
PMID: 33417088 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2021 Reference: J Clin Immunol. 2021 Apr;41(3):639-657. doi: 10.1007/s10875-020-00930-3. Epub 2021 Jan 8. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Alejo, Noe Ramirez; Ardeniz, Fatma Omur; Arias, Andres Augusto; Bellanne-Chantelot, Christine; Berron-Ruiz, Laura; Boisson-Dupuis, Stephanie; Branco, Lidia; Brunel, Anne-Sophie; Bustamante, Jacinta et al. DOI: 10.1007/s10875-020-00930-3
PMID: 38279410 Journal: Lancet Rheumatology Year: 2021 Reference: Lancet Rheumatol. 2021 Apr;3(4):e262-e269. doi: 10.1016/S2665-9913(20)30425-2. Epub 2021 Feb 1. Impact factor: Publication type: Paper in international publication Authors: Alataris, Konstantinos; Baker, Matthew C; Borrell, Helena; Corominas, Hector; de Agustin, Juan Jose; Franco-Jarava, Clara; Genovese, Mark C; Lopez-Lasanta, Maria; Marsal, Sara; Narvaez, Javier et al. DOI: 10.1016/S2665-9913(20)30425-2
PMID: 32802142 Journal: Immunity & Ageing Year: 2020 Reference: Immun Ageing. 2020 Aug 14;17:22. doi: 10.1186/s12979-020-00194-w. eCollection 2020. Impact factor: 2.804 Publication type: Paper in international publication Authors: Boix, Francisco, Martinez-Caceres, Eva, Hernandez, Manuel, Perurena-Prieto, Janire, Gil, Juana, Cantenys, Sergi, Gonzalez-Martinez, Gema, Martinez-Saavedra, Maria T, Rojo, Ricardo, Marco, Francisco M et al. DOI: 10.1186/s12979-020-00194-w
PMID: 32465574 Journal: JOURNAL OF HEART AND LUNG TRANSPLANTATION Year: 2020 Reference: J Heart Lung Transplant. 2020 Apr;39(4S):S380. doi: 10.1016/j.healun.2020.01.485. Epub 2020 Mar 30. Impact factor: 7.865 Publication type: Paper in international publication Authors: Sandiumenge, A, Bello, I, Coll, E, Franco, C, Perez, M, Crowley, S, Minambres, E, Naranjo, S, Penafiel, S, Sacanell, J et al. DOI: 10.1016/j.healun.2020.01.485
PMID: 32431704 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 May 5;11:771. doi: 10.3389/fimmu.2020.00771. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Urcelay, Elena, Espino-Paisan, Laura, Agudo-Jimenez, Teresa, Rosales-Martinez, Isabel, Lopez-Cotarelo, Pilar, Garcia-Martinez, Maria Angel, Dominguez-Mozo, Maria Inmaculada, Perez-Perez, Silvia, Dieli-Crimi, Romina, Comabella, Manuel et al. DOI: 10.3389/fimmu.2020.00771
PMID: 31599728 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Investig Allergol Clin Immunol. 2020 Apr 24;30(2):143-145. doi: 10.18176/jiaci.0459. Epub 2019 Oct 10. Impact factor: 3.488 Publication type: Paper in international publication Authors: Labrador Horrillo, M, Cardona, V, Sala Cunill, A, Guilarte, M, Luengo, O, Molina Molina, G J, Carrasco Gonzalez, M D, Vinas Gimenez, L, Sanz Martinez, M, Galvan Blasco, P et al. DOI: 10.18176/jiaci.0459
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
