About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 35105687 Journal: Neurology-Neuroimmunology & Neuroinflammation Year: 2022 Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Feb 1;9(2). pii: 9/2/e1143. doi: 10.1212/NXI.0000000000001143. Print 2022 Mar. Impact factor: 8.485 Publication type: Paper in international publication Authors: Arrambide, Georgina; Zabalza, Ana; Nos, Carlos; Sastre-Garriga, Jaume; Tintore, Mar; Montalban, Xavier; Comabella, Manuel; Espejo, Carmen; Castillo, Joaquin; Otero-Romero, Susana et al. DOI: 10.1212/NXI.0000000000001143
PMID: 35255492 Journal: NATURE Year: 2022 Reference: Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Impact factor: 49.962 Publication type: Paper in international publication Authors: Tsinaslanidis, George; Birkinshaw, Isobel; Carter, Joseph; Howard, Kate; Ingham, Joanne; Joy, Rosie; Pearson, Harriet; Roche, Samantha; Scott, Zoe; Bancroft, Hollie et al. DOI: 10.1038/s41586-022-04576-6
PMID: 35770252 Journal: EClinicalMedicine Year: 2022 Reference: EClinicalMedicine. 2022 Jun 25;50:101515. doi: 10.1016/j.eclinm.2022.101515. eCollection 2022 Aug. Impact factor: 0 Publication type: Paper in international publication Authors: Davalos, Veronica; Garcia-Prieto, Carlos A; Alegria, Iosune; Aguilera-Albesa, Sergio; Valencia-Ramos, Juan; Rodriguez-Palmero, Agusti; Ruiz, Montserrat; Planas-Serra, Laura; Jordan, Iolanda; Ferrer, Gerardo et al. DOI: 10.1016/j.eclinm.2022.101515
PMID: 35784294 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Jun 17;13:897975. doi: 10.3389/fimmu.2022.897975. eCollection 2022. Impact factor: 7.561 Publication type: Letter or abstract Authors: Valenzuela, Irene; Franco-Jarava, Clara; Colobran, Roger; Batlle-Maso, Laura; Castells, Neus; Dieli-Crimi, Romina; Martinez-Gallo, Monica; Garcia-Prat, Marina; Riviere, Jacques G; Soler-Palacin, Pere et al. DOI: 10.3389/fimmu.2022.897975
PMID: 35083241 Journal: Frontiers in Medicine Year: 2021 Reference: Front Med (Lausanne). 2022 Jan 10;8:779038. doi: 10.3389/fmed.2021.779038. eCollection 2021. Impact factor: 5.093 Publication type: Paper in international publication Authors: Palmada, Clara, Paola Plata-Menchaca, Erika, Franco-Jarava, Clara, Perez-Carrasco, Marcos, Hernandez-Gonzalez, Manuel, Ferrer, Ricard, Ruiz-Sanmartin, Adolf, Chiscano-Camon, Luis, Ruiz-Rodriguez, Juan Carlos et al. DOI: 10.3389/fmed.2021.779038
PMID: 34943483 Journal: Diagnostics Year: 2021 Reference: Diagnostics (Basel). 2021 Nov 30;11(12). pii: diagnostics11122246. doi: 10.3390/diagnostics11122246. Impact factor: 3.706 Publication type: Paper in international publication Authors: Mahler, Michael, Malyavantham, Kishore, Seaman, Andrea, Bentow, Chelsea, Anunciacion-Llunell, Ariadna, Sanz-Martinez, Maria Teresa, Vinas-Gimenez, Laura, Selva-O'Callaghan, Albert et al. DOI: 10.3390/diagnostics11122246
PMID: 34919042 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):131-139. Epub 2021 Dec 15. Impact factor: 4.473 Publication type: Paper in international publication Authors: Loureiro-Amigo, Jose, Franco-Jarava, Clara, Perurena-Prieto, Janire, Palacio, Carlos, Martinez-Valle, Fernando, Solans-Laque, Roser et al. DOI:
PMID: 34140949 Journal: Frontiers in Immunology Year: 2021 Reference: Front Immunol. 2021 Jun 1;12:665824. doi: 10.3389/fimmu.2021.665824. eCollection 2021. Impact factor: 7.561 Publication type: Letter or abstract Authors: Ruiz-Rodriguez, Juan Carlos, Chiscano-Camon, Luis, Palmada, Clara, Ruiz-Sanmartin, Adolf, Garcia-de-Acilu, Marina, Plata-Menchaca, Erika, Perurena-Prieto, Janire, Hernandez-Gonzalez, Manuel, Perez-Carrasco, Marcos, Soler-Palacin, Pere et al. DOI: 10.3389/fimmu.2021.665824
PMID: 31799703 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2020 Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19. Impact factor: 3.532 Publication type: Paper in international publication Authors: Alonso, Laura, Riviere, Jacques G, Soler-Palacin, Pere, Colobran, Roger, Sayos, Joan, Martinez-Gallo, Monica, Franco-Jarava, Clara, Ossowski, Stephan, Drechsel, Oliver, Magallon-Lorenz, Miriam et al. DOI: 10.1111/cei.13405
PMID: 32256498 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Mar 17;11:455. doi: 10.3389/fimmu.2020.00455. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Truedsson, Lennart, Hara, Toshiro, Nonoyama, Shigeaki, Schwenk, Jochen M, Nilsson, Peter, Hammarstrom, Lennart, von Dobeln, Ulrika, Hernandez-Gonzalez, Manuel, Rezaei, Nima, Aghamohammadi, Asghar et al. DOI: 10.3389/fimmu.2020.00455
PMID: 32206630 Journal: Pediatric gastroenterology, hepatology & nutrition Year: 2020 Reference: Pediatr Gastroenterol Hepatol Nutr. 2020 Mar;23(2):174-179. doi: 10.5223/pghn.2020.23.2.174. Epub 2020 Mar 4. Impact factor: 0 Publication type: Letter or abstract Authors: Quintero, Jesus, Juamperez, Javier, Gonzales, Emmanuel, Julio, Ecaterina, Mercadal-Hally, Maria, Collado-Hilly, Mauricette, Marin-Sanchez, Ana, Charco, Ramon et al. DOI: 10.5223/pghn.2020.23.2.174
PMID: 32117230 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Riviere, Jacques G, Franco-Jarava, Clara, Martinez-Gallo, Monica, Aguilo-Cucurull, Aina, Blasco-Perez, Laura, Paramonov, Ida, Antolin, Maria, Martin-Nalda, Andrea, Soler-Palacin, Pere, Colobran, Roger et al. DOI: 10.3389/fimmu.2020.00046
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
