About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
PMID: 35464398 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Apr 8;13:881206. doi: 10.3389/fimmu.2022.881206. eCollection 2022. Impact factor: Publication type: Paper in international publication Authors: Aguilo-Cucurull, Aina; Antolin, Maria; Colobran, Roger; Franco-Jarava, Clara; Garcia-Prat, Marina; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Parra-Martinez, Alba; Salgado-Perandres, Sandra et al. DOI: 10.3389/fimmu.2022.881206
PMID: 35453934 Journal: Diagnostics Year: 2022 Reference: Diagnostics (Basel). 2022 Apr 1;12(4). pii: diagnostics12040886. doi: 10.3390/diagnostics12040886. Impact factor: Publication type: Paper in international publication Authors: Barquin-DelPino, Raquel; Castillo-Ribelles, Laura; Diaz-Troyano, Noelia; Esteban, Angels; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Hernandez-Gonzalez, Manuel; Klammer, Martin; Pumarola, Tomas; Rodriguez-Frias, Francisco et al. DOI: 10.3390/diagnostics12040886
PMID: 35460231 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Oct 6;61(10):3887-3888. doi: 10.1093/rheumatology/keac252. Impact factor: Publication type: Paper in international publication Authors: Sanz-Martinez, Maria Teresa; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al. DOI: 10.1093/rheumatology/keac252
PMID: 35433311 Journal: World journal of critical care medicine Year: 2022 Reference: World J Crit Care Med. 2022 Jan 9;11(1):1-21. doi: 10.5492/wjccm.v11.i1.1. eCollection 2022 Jan 9. Impact factor: Publication type: Review in international publication Authors: Chiscano-Camon, Luis; Ferrer, Ricard; Gonzalez-Lopez, Juan J; Hernandez-Gonzalez, Manuel; Larrosa, Nieves; Martinez-Gallo, Monica; Palmada, Clara; Perez-Carrasco, Marcos; Plata-Menchaca, Erika P; Ribas, Vicent et al. DOI: 10.5492/wjccm.v11.i1.1
PMID: 32896249 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 May-Jun;39(3):519-524. Epub 2020 Sep 3. Impact factor: Publication type: Paper in international publication Authors: Baucells, Andres; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Hosono, Yuji; Mammen, Andrew L; Marin-Sanchez, Ana; Pak, Katherine; Pinal-Fernandez, Iago; Sanz-Martinez, Maria Teresa et al. DOI:
PMID: 33950194 Journal: NUCLEIC ACIDS RESEARCH Year: 2021 Reference: Nucleic Acids Res. 2021 May 21;49(9):5057-5073. doi: 10.1093/nar/gkab322. Impact factor: Publication type: Paper in international publication Authors: Abolhassani, Hassan; Alvarez-Prado, Angel F; Ballestar, Esteban; Catala-Moll, Francesc; Ciudad, Laura; Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Durandy, Anne; Ferrete-Bonastre, Anna G et al. DOI: 10.1093/nar/gkab322
PMID: 33904890 Journal: JOURNAL OF EXPERIMENTAL MEDICINE Year: 2021 Reference: J Exp Med. 2021 Jun 7;218(6). pii: 212029. doi: 10.1084/jem.20210446. Impact factor: Publication type: Paper in international publication Authors: Abel, Laurent; Abolhassani, Hassan; Abou Tayoun, Ahmad; Aguilera-Albesa, Sergio; Aiuti, Alessandro; Akcan, Ozge Metin; Al-Mulla, Fahd; Alkan, Gulsum; Almuhsen, Saleh Zaid; Alsina, Laia et al. DOI: 10.1084/jem.20210446
PMID: 33900188 Journal: EMERGING INFECTIOUS DISEASES Year: 2021 Reference: Emerg Infect Dis. 2021 May;27(5):1513-1516. doi: 10.3201/eid2705.204675. Impact factor: Publication type: Paper in international publication Authors: Alamo-Junquera, Dolores; Andres, Cristina; Anton, Andres; Borrell, Ricardo Pujol; Campins, Magda; Codina, Maria Gema; Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Esperalba, Juliana et al. DOI: 10.3201/eid2705.204675
PMID: 32117230 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020. Impact factor: Publication type: Paper in international publication Authors: Aguilo-Cucurull, Aina; Antolin, Maria; Blasco-Perez, Laura; Colobran, Roger; Franco-Jarava, Clara; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Paramonov, Ida; Riviere, Jacques G; Soler-Palacin, Pere et al. DOI: 10.3389/fimmu.2020.00046
PMID: 32094085 Journal: ANALES DE PEDIATRIA Year: 2020 Reference: An Pediatr (Barc). 2020 Dec;93(6):417-419. doi: 10.1016/j.anpedi.2020.01.008. Epub 2020 Feb 21. Impact factor: Publication type: Letter whit IF Authors: Clemente Leon, Maria; Ferrer Costa, Roser; Puerto Carranza, Elsa; Pujol Borrell, Ricard; Scatti Regas, Aina et al. DOI: 10.1016/j.anpedi.2020.01.008
PMID: 32076423 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 Jan 31;11:107. doi: 10.3389/fimmu.2020.00107. eCollection 2020. Impact factor: Publication type: Paper in international publication Authors: Batlle-Maso, Laura; Casals, Ferran; Colobran, Roger; de la Cruz, Xavier; Martinez-Gallo, Monica; Padilla, Natalia; Riviere, Jacques G; Vinas-Gimenez, Laura et al. DOI: 10.3389/fimmu.2020.00107
PMID: 31865540 Journal: INTERNATIONAL JOURNAL OF HEMATOLOGY Year: 2020 Reference: Int J Hematol. 2020 Mar;111(3):440-450. doi: 10.1007/s12185-019-02796-7. Epub 2019 Dec 21. Impact factor: Publication type: Paper in international publication Authors: Alsina, Laia; Catala, Albert; Colobran, Roger; de la Campa, Elena Alvarez; de la Cruz, Xavier; Donadeu, Laura; Esteve-Sole, Ana; Martinez-Gallo, Monica; Rincon, Rafael; Sayos, Joan et al. DOI: 10.1007/s12185-019-02796-7
PMID: 31182340 Journal: JOURNAL OF AUTOIMMUNITY Year: 2019 Reference: J Autoimmun. 2019 Sep;103:102285. doi: 10.1016/j.jaut.2019.05.013. Epub 2019 Jun 8. Impact factor: 7.543 Publication type: Paper in international publication Authors: Alvarez-Sierra, Daniel, Marin-Sanchez, Ana, Ruiz-Blazquez, Paloma, de Jesus Gil, Carmen, Gonzalez, Oscar, Casteras, Anna, Costa, Roser Ferrer, Nuciforo, Paolo, Colobran, Roger, Pujol-Borrell, Ricardo et al. DOI: 10.1016/j.jaut.2019.05.013
PMID: 30334372 Journal: CYTOMETRY PART B-CLINICAL CYTOMETRY Year: 2019 Reference: Cytometry B Clin Cytom. 2019 May;96(3):223-233. doi: 10.1002/cyto.b.21728. Epub 2018 Oct 17. Impact factor: 2.938 Publication type: Paper in international publication Authors: Garcia-Prat, Marina, Alvarez-Sierra, Daniel, Aguilo-Cucurull, Aina, Salgado-Perandres, Sandra, Briongos-Sebastian, Sara, Franco-Jarava, Clara, Montserrat, Isabel, Hernandez-Gonzalez, Manuel, Pujol-Borrell, Ricardo, Soler-Palacin, Pere et al. DOI: 10.1002/cyto.b.21728
PMID: 30767873 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 Jul-Aug;37 Suppl 119(4):41-48. Epub 2019 Feb 11. Impact factor: 3.238 Publication type: Paper in international publication Authors: Callejas-Moraga, Eduardo Luis, Guillen-Del-Castillo, Alfredo, Marin-Sanchez, Ana Maria, Roca-Herrera, Maria, Balada, Eva, Tolosa-Vilella, Carles, Fonollosa-Pla, Vicente, Simeon-Aznar, Carmen Pilar et al. DOI:
PMID: 30738005 Journal: ALLERGY Year: 2019 Reference: Allergy. 2019 Jul;74(7):1384-1386. doi: 10.1111/all.13735. Epub 2019 Mar 14. Impact factor: 6.771 Publication type: Letter whit IF Authors: Gil-Serrano, Ingrid Johana, Galvan-Blasco, Paula, Guilarte, Mar, Cardona, Victoria, Labrador-Horrillo, Moises, Sala-Cunill, Anna, Luengo, Olga et al. DOI: 10.1111/all.13735
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
