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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas.

PMID: 35172160
Journal: Cell Reports
Year: 2022
Reference: Cell Rep. 2022 Feb 15;38(7):110385. doi: 10.1016/j.celrep.2022.110385.
Impact factor: 9.423
Publication type: Paper in international publication
Authors: Lazaro, Conxi, Gel, Bernat, Carrio, Meritxell, Serra, Eduard, Romagosa, Cleofe, Heyn, Holger, Raya, Angel, Mazuelas, Helena, Magallon-Lorenz, Miriam, Fernandez-Rodriguez, Juana et al.
DOI: 10.1016/j.celrep.2022.110385

Hepatic sinusoidal obstruction syndrome associated with nivolumab: an uncommon adverse event related to immune checkpoint inhibitors.

PMID: 33723557
Journal: Journal of Gastrointestinal and Liver Diseases
Year: 2021
Reference: J Gastrointestin Liver Dis. 2021 Mar 13;30(1):171-172. doi: 10.15403/jgld-3207.
Impact factor: 2.008
Publication type: Letter whit IF
Authors: Riveiro-Barciela, Mar, Gonzalez-Sans, Didac, Marmolejo, David, Salcedo, Maria-Teresa, Munoz-Couselo, Eva et al.
DOI: 10.15403/jgld-3207

Differential Characteristics and Outcomes of Asian and non-Asian Patients with HBV-related Hepatocellular Carcinoma.

PMID: 33713386
Journal: LIVER INTERNATIONAL
Year: 2021
Reference: Liver Int. 2021 Aug;41(8):1922-1932. doi: 10.1111/liv.14877. Epub 2021 Apr 1.
Impact factor: 5.828
Publication type: Paper in international publication
Authors: Huang, Daniel Q, Hoang, Joseph K, Leong, Jennifer, Riveiro-Barciela, Mar, Yang, Ju Dong, Accarino, Elena Vargas, Thin, Khin, Trinh, Lindsey, Cheung, Ramsey C, Roberts, Lewis R et al.
DOI: 10.1111/liv.14877

Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas.

PMID: 32079701
Journal: HAEMATOLOGICA
Year: 2021
Reference: Haematologica. 2021 Feb 1;106(2):513-521. doi: 10.3324/haematol.2019.241208.
Impact factor: 9.941
Publication type: Paper in international publication
Authors: Raheja, Priyanka, Carpio, Cecilia, Rubio-Perez, Carlota, Tazon-Vega, Barbara, Palacio, Carlos, Carabia, Julia, Jimenez, Isabel, Nieto, Juan C, Montoro, Julia, Martinez-Ricarte, Francisco et al.
DOI: 10.3324/haematol.2019.241208

Spiral Arteries in Second Trimester of Pregnancy: When Is It Possible to Define Expected Physiological Remodeling as Abnormal?

PMID: 33237514
Journal: Reproductive Sciences
Year: 2021
Reference: Reprod Sci. 2021 Apr;28(4):1185-1193. doi: 10.1007/s43032-020-00403-3. Epub 2020 Nov 25.
Impact factor: 3.06
Publication type: Paper in international publication
Authors: Franco, Jorge Andres, Rodriguez, Jorge Luis, Vargas, Magda Jimena, Aula-Olivar, Ana, Quintero, Laura, Ramon Y Cajal, Santiago, Garrido, Marta, Olaya-C, Mercedes et al.
DOI: 10.1007/s43032-020-00403-3

Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A Nonrandomized Phase 1/2 Clinical Trial.

PMID: 32077895
Journal: JAMA Oncology
Year: 2020
Reference: JAMA Oncol. 2020 Apr 1;6(4):535-541. doi: 10.1001/jamaoncol.2019.6584.
Impact factor: 24.799
Publication type: Paper in international publication
Authors: Luna, Pablo, Alastuey, Ignacio, Redondo, Andres, Belinchon, Belen, Martinez-Serra, Jordi, Sunyach, Marie-Pierre, Coindre, Jean-Michel, Dei Tos, Angelo P, Romero, Jesus, Gronchi, Alessandro et al.
DOI: 10.1001/jamaoncol.2019.6584

Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report.

PMID: 32028116
Journal: Multiple Sclerosis and Related Disorders
Year: 2020
Reference: Mult Scler Relat Disord. 2020 May;40:101973. doi: 10.1016/j.msard.2020.101973. Epub 2020 Jan 31.
Impact factor: 2.889
Publication type: Letter or abstract
Authors: Romero, A, Midaglia, L, Salcedo, M T, Viladomiu, L, Guillen, E, Bajana, I, Escola-Verge, L, Tintore, M, Montalban, X, Len, O et al.
DOI: 10.1016/j.msard.2020.101973

Efficacy and safety of bortezomib in refractory lupus nephritis: a single-center experience.

PMID: 31865857
Journal: LUPUS
Year: 2020
Reference: Lupus. 2020 Feb;29(2):118-125. doi: 10.1177/0961203319896018. Epub 2019 Dec 22.
Impact factor: 2.251
Publication type: Paper in international publication
Authors: Segarra, A, Arredondo, K V, Jaramillo, J, Jatem, E, Salcedo, M T, Agraz, I, Ramos, N, Carnicer, C, Valtierra, N, Ostos, E et al.
DOI: 10.1177/0961203319896018

Clinical implications of intratumor heterogeneity: challenges and opportunities.

PMID: 31970428
Journal: JOURNAL OF MOLECULAR MEDICINE-JMM
Year: 2020
Reference: J Mol Med (Berl). 2020 Feb;98(2):161-177. doi: 10.1007/s00109-020-01874-2. Epub 2020 Jan 22.
Impact factor: 4.427
Publication type: Review in international publication
Authors: Castellvi, Josep, Diaz-Cano, Salvador J, Ramon Y Cajal, Santiago, Sese, Marta, Capdevila, Claudia, Aasen, Trond, De Mattos-Arruda, Leticia, Hernandez-Losa, Javier et al.
DOI: 10.1007/s00109-020-01874-2

Blog

News

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

Vall d’Hebron ha celebrat avui la Jornada del Dia Mundial contra el Càncer, una malaltia cada cop més freqüent que patiran al llarg de la vida un de cada dos homes i una de cada tres dones del nostre entorn.

The multidisciplinary paper on papillary thyroid cancer has been considered the best original article of 2021 in the journal Endocrinología, Diabetes y Nutrición

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Rates

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Rates 2016-2020

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