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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up.

PMID: 38008809
Journal: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Year: 2023
Reference: J Cancer Res Clin Oncol. 2023 Nov 26. doi: 10.1007/s00432-023-05500-9.
Impact factor:
Publication type: Paper in international publication
Authors: Aldamiz, Teresa; Alonso, Lucia; Alvarez-Lopez, Patricia; Amador Prous, Concha; Asensi, Victor; Blanco, Jose Luis; Bruguera, Andreu; Calzado Isbert, Sonia; Casabona, Jordi; Curran, Adrian et al.
DOI: 10.1007/s00432-023-05500-9

How do cytopathologists learn fine needle aspiration techniques? An international survey.

PMID: 38146771
Journal: CYTOPATHOLOGY
Year: 2023
Reference: Cytopathology. 2023 Dec 26. doi: 10.1111/cyt.13352.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz-Mateos, Eduardo; Exposito-Afonso, Idaira Jael; Jiang, Xiaoyin Sara; Labiano-Miravalles, Tania; Pijuan, Lara; Temprana-Salvador, Jordi; Zhao, Qing et al.
DOI: 10.1111/cyt.13352

A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort.

PMID: 35245746
Journal: BREAST
Year: 2022
Reference: Breast. 2022 Jun;63:1-8. doi: 10.1016/j.breast.2022.02.010. Epub 2022 Feb 22.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Gunda, Aparna, Basavaraj, Chetana, Serkad V, Chandra Prakash, Adinarayan, Manjula, Kolli, Ramu, Siraganahalli Eshwaraiah, Mallikarjuna, Saura, Cristina, Ruiz, Fiorella, Gomez, Patricia, Peg, Vicente et al.
DOI: 10.1016/j.breast.2022.02.010

Are Temporal Artery Biopsy Findings Related to PET/CT Findings in Giant Cell Arteritis?

PMID: 35234202
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2022
Reference: Clin Nucl Med. 2022 May 1;47(5):387-393. doi: 10.1097/RLU.0000000000004097.
Impact factor: 7.794
Publication type: Paper in international publication
Authors: Navales-Mateu, Ignacio, Mestre-Torres, Jaume, Martinez-Valle, Fernando, Gabaldon, Alejandra, Simo-Perdigo, Marc, Salcedo-Allende, M Teresa, Solans-Laque, Roser et al.
DOI: 10.1097/RLU.0000000000004097

Prognostic value of ctDNA detection in patients with early breast cancer undergoing neoadjuvant therapy: A systematic review and meta-analysis.

PMID: 35219090
Journal: CANCER TREATMENT REVIEWS
Year: 2022
Reference: Cancer Treat Rev. 2022 Mar;104:102362. doi: 10.1016/j.ctrv.2022.102362. Epub 2022 Feb 18.
Impact factor: 12.111
Publication type: Review in international publication
Authors: Peg, Vicente, Vivancos, Ana, Saura, Cristina, Villacampa, Guillermo, Oliveira, Mafalda, Espinosa-Bravo, Martin, Ortiz, Carolina, Zamora, Esther, Sunol, Anna, Papakonstantinou, Andri et al.
DOI: 10.1016/j.ctrv.2022.102362

Podocytopathy in patients with monoclonal gammopathy: three patients and literature review.

PMID: 35211301
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Sep 28;15(3):417-424. doi: 10.1093/ckj/sfab176. eCollection 2022 Mar.
Impact factor: 4.452
Publication type: Review in international publication
Authors: Crespo, Marta, Rodriguez, Eva, Gabaldon, Alejandra, Soler, Maria Jose, Lop, Joan, Ribas, Andres, Puche, Adrian, Gimeno, Javier, Sans, Laia, Barrios, Clara et al.
DOI: 10.1093/ckj/sfab176

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer.

PMID: 33342055
Journal: Molecular Oncology
Year: 2021
Reference: Mol Oncol. 2021 Apr;15(4):887-900. doi: 10.1002/1878-0261.12891. Epub 2021 Jan 6.
Impact factor: 6.603
Publication type: Paper in international publication
Authors: Frigola, Joan, Navarro, Alejandro, Carbonell, Caterina, Callejo, Ana, Iranzo, Patricia, Cedres, Susana, Martinez-Marti, Alex, Pardo, Nuria, Saoudi-Gonzalez, Nadia, Martinez, Debora et al.
DOI: 10.1002/1878-0261.12891

ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity.

PMID: 33807672
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Mar 5;13(5). pii: cancers13051110. doi: 10.3390/cancers13051110.
Impact factor: 6.639
Publication type: Paper in international publication
Authors: Avila, Matias A, Minguez, Beatriz, Soriano, Eduardo, Villarroya, Francesc, Berasain, Carmen, Uriarte, Iker, Santamaria, Eva, Balibrea, Jose Maria, Mirra, Serena, Gavalda-Navarro, Aleix et al.
DOI: 10.3390/cancers13051110

Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC).

PMID: 33772065
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Mar 26;11(1):6957. doi: 10.1038/s41598-021-86218-x.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Arevalo, Jazmine, Lorente, David, Trilla, Enrique, Salcedo, Maria Teresa, Morote, Juan, Meseguer, Anna et al.
DOI: 10.1038/s41598-021-86218-x

Immune analysis of lymph nodes in relation to the presence or absence of tumor infiltrating lymphocytes in triple-negative breast cancer.

PMID: 33743482
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2021
Reference: Eur J Cancer. 2021 May;148:134-145. doi: 10.1016/j.ejca.2021.01.037. Epub 2021 Mar 17.
Impact factor: 9.162
Publication type: Paper in international publication
Authors: Munoz-Couselo, Eva, Perez-Garcia, Jose, Marti, Merce, Blanco-Heredia, Juan, Anjos, Carla Dos, Vazquez, Miguel, De Mattos-Arruda, Leticia, Cortes, Javier, Curigliano, Giuseppe, Schmid, Peter et al.
DOI: 10.1016/j.ejca.2021.01.037

Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation OF OF 783 cases with Emphasis on histological features.

PMID: 32145220
Journal: HUMAN PATHOLOGY
Year: 2020
Reference: Hum Pathol. 2020 Apr;98:98-109. doi: 10.1016/j.humpath.2020.02.005. Epub 2020 Mar 5.
Impact factor: 2.735
Publication type: Paper in international publication
Authors: Dalurzo, Liliana, Langman, Gerald, Jang, Se Jin, Spagnolo, Dominic, Chai, Siaw Ming, Laycock, Andrew, Falconieri, Giovanni, Pizzolitto, Stefano, de Pellegrin, Alessandro, Medeiros, Filomena et al.
DOI: 10.1016/j.humpath.2020.02.005

A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation.

PMID: 31383960
Journal: MODERN PATHOLOGY
Year: 2020
Reference: Mod Pathol. 2020 Mar;33(3):404-419. doi: 10.1038/s41379-019-0323-8. Epub 2019 Aug 5.
Impact factor: 5.988
Publication type: Paper in international publication
Authors: Baud, Jessica, Le Loarer, Francois, Cleven, Arjen H G, Bouvier, Corinne, Castex, Marie-Pierre, Romagosa, Cleofe, Moreau, Anne, Salas, Sebastien, Bonhomme, Benjamin, Gomez-Brouchet, Anne et al.
DOI: 10.1038/s41379-019-0323-8

A Multidisciplinary Proposal for a Diagnostic Algorithm in Idiopathic Pulmonary Fibrosis: The Role of Transbronchial Cryobiopsy.

PMID: 31420183
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2020
Reference: Arch Bronconeumol. 2020 Feb;56(2):99-105. doi: 10.1016/j.arbres.2019.07.001. Epub 2019 Aug 13.
Impact factor: 4.957
Publication type: Paper in national publication
Authors: Llatjos, Roger, Sansano, Irene, Sellares, Jacobo, Centeno, Carmen, Fibla, Juan J, Sanchez, Marcelo, Ramirez, Jose, Moreno, Amalia, Trujillo-Reyes, Juan Carlos, Barbeta, Enric et al.
DOI: 10.1016/j.arbres.2019.07.001

Pulmonary Adenofibromas: A Clinicopathologic Correlation of 13 Cases.

PMID: 32091433
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2020
Reference: Am J Surg Pathol. 2020 Jul;44(7):917-921. doi: 10.1097/PAS.0000000000001456.
Impact factor: 4.958
Publication type: Paper in international publication
Authors: Lindholm, Kaleigh E, Sansano-Valero, Irene, Rodriguez, Jorge L, Ramon Y Cajal, Santiago, Moran, Cesar A et al.
DOI: 10.1097/PAS.0000000000001456

The Role of Molecular Techniques for the Detection of Mycobacterium Tuberculosis Complex in Paraffin-embedded Biopsies.

PMID: 28549036
Journal: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
Year: 2019
Reference: Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):77-80. doi: 10.1097/PAI.0000000000000533.
Impact factor: 1.863
Publication type: Paper in international publication
Authors: Castellvi, Josep, Moure, Zaira, Tortola, M Teresa, Pumarola, Tomas, Sanchez-Montalva, Adrian et al.
DOI: 10.1097/PAI.0000000000000533

Intraoperative Ultrasound-Guided Excision of Axillary Clip in Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Therapy (ILINA Trial) : A New Tool to Guide the Excision of the Clipped Node After Neoadjuvant Treatment.

PMID: 29197044
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2018
Reference: Ann Surg Oncol. 2018 Mar;25(3):784-791. doi: 10.1245/s10434-017-6270-z. Epub 2017 Dec 1.
Impact factor: 3.857
Publication type: Paper in international publication
Authors: Siso, Christian, de Torres, Juan, Esgueva-Colmenarejo, Antonio, Espinosa-Bravo, Martin, Rus, Neus, Cordoba, Octavi, Rodriguez, Roberto, Peg, Vicente, Rubio, Isabel T et al.
DOI: 10.1245/s10434-017-6270-z

Advances in endometrial cancer protein biomarkers for use in the clinic.

PMID: 29183259
Journal: Expert Review of Proteomics
Year: 2018
Reference: Expert Rev Proteomics. 2018 Jan;15(1):81-99. doi: 10.1080/14789450.2018.1410061. Epub 2017 Nov 30.
Impact factor: 3.489
Publication type: Paper in international publication
Authors: Martinez-Garcia, Elena, Lopez-Gil, Carlos, Campoy, Irene, Vallve, Julia, Coll, Eva, Cabrera, Silvia, Ramon Y Cajal, Santiago, Matias-Guiu, Xavier, van Oostrum, Jan, Reventos, Jaume et al.
DOI: 10.1080/14789450.2018.1410061

[Value of soluble urokinase receptor serum levels in the differential diagnosis between idiopathic and secondary focal segmental glomerulosclerosis].

PMID: 24463863
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(1):53-61. doi: 10.3265/Nefrologia.pre2013.Oct.12272.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Segarra, Alfons, Jatem, Elias, Quiles, M Teresa, Arbos, M Antonia, Ostos, Helena, Valtierra, Naiara, Carnicer, Clara, Salcedo, M Teresa et al.
DOI: 10.3265/Nefrologia.pre2013.Oct.12272

[Diagnostic value of soluble urokinase-type plasminogen activator receptor serum levels in adults with idiopathic nephrotic syndrome].

PMID: 24463862
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(1):46-52. doi: 10.3265/Nefrologia.pre2013.Oct.12256.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Agraz, Irene, Segarra, Alfons, Jatem, Elias, Quiles, M Teresa, Arbos, M Antonia, Ostos, Helena, Valtierra, Naiara, Carnicer, Clara, Salcedo, M Teresa et al.
DOI: 10.3265/Nefrologia.pre2013.Oct.12256

Association of BRCA1 germline mutations in young onset triple-negative breast cancer (TNBC).

PMID: 23982851
Journal: CLIN TRANSL ONCOL
Year: 2014
Reference: Clin Transl Oncol. 2014 Mar;16(3):280-4. doi: 10.1007/s12094-013-1070-9. Epub 2013 Aug 27.
Impact factor: 1.6
Publication type: Paper in international publication
Authors: Robles, L, Andres, R, Pajares, I, Balmana, J, Llort, G, Ramon Y Cajal, T, Chirivella, I, Aguirre, E, Bosch, N, Yague, C et al.
DOI: 10.1007/s12094-013-1070-9

HAVCR/KIM-1 activates the IL-6/STAT-3 Pathway in ccRCC and Determines Tumor Progression and Patient Outcome.

PMID: 24390735
Journal: CANCER RES
Year: 2014
Reference: Cancer Res. 2014 Mar 1;74(5):1416-28. doi: 10.1158/0008-5472.CAN-13-1671. Epub 2014 Jan 3.
Impact factor: 9.284
Publication type: Paper in international publication
Authors: Cuadros, Thais, Trilla, Enric, Sarro, Eduard, Vila, Maya R, Vilardell, Jordi, de Torres, Ines, Salcedo, Mayte, Lopez-Hellin, Joan, Sanchez, Alex, Ramon Y Cajal, Santiago et al.
DOI: 10.1158/0008-5472.CAN-13-1671

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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