Aging may be considered as an accumulation of changes in cells and tissues that increases the risk of disease and death. The senescence-accelerated prone mice SAMP8 is an aging model with brain histopathological signs and other aging-related disorders, such as ß-amyloid and tau protein aggregates and increased oxidative stress. If hyperphosphorylated, tau protein contributes to the development of a tauopathy, process linked to neurodegenerative diseases of the aging brain such as Alzheimer disease. Several kinases (PKC, ERK, CDK5 or GSK3ß) perform this tau protein post-transcriptional modification. We plan to determine the effect that inhibitors of these kinases such as lithium, in vivo and in vitro, could have in slowing down the brain neurodegenerative processes. Besides, we will study the role of a newly described protein family, sirtuins.

Sirtuins are ontogenically preserved proteins related to longevity. We will evaluate the gene and protein expression of Sirt 1, 2 and 3 in cultured neurons and in the brain of this mouse strain. We seek to elucidate the participation of sirtuins in cerebral ageing using as a tools resveratrol, a flavonoid described as activator of these proteins, and caloric restriction, two paradigms that lead to an elongation of lifespan and neuroprotection in several animal models. In the in vitro studies, the role of GDNF in maintaining neuronal functionality and its correlation with sirtuins will be investigated because this trophic factor decreases with aging and shows a lesser expression in SAMP8 mice. These studies will contribute to the development of new therapeutic strategies to prevent age-related neurodegeneratives diseases.

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.

Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.

Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.

Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.

Current research:

1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).

A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.

Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.

3. 3D Planification / Printing

3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.

Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.

Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.

Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.

Current research:

1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).

A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.

Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.

3. 3D Planification / Printing

3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.

Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.

Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.

Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.

Current research:

1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).

A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.

Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.

3. 3D Planification / Printing

3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.