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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells.

PMID: 37907090
Journal: Open Biology
Year: 2023
Reference: Open Biol. 2023 Nov;13(11):230258. doi: 10.1098/rsob.230258. Epub 2023 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Aasen, Trond; Campoy, Desiree; Canals Pernas, Tania; Caramelo, Francisco; Carreira, Isabel Marques; Catarino, Steve; Cerezo Manchado, Juan Jose; Flores Aparco, Katia Jessica; Garcia de Guadiana-Romualdo, Luis; Gil Ortega, Ignacio et al.
DOI: 10.1098/rsob.230258

Large vessel occlusion prediction scale thresholds that are sensitive for DAWN Trial patients.

PMID: 37915142
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2023
Reference: Interv Neuroradiol. 2023 Nov 1:15910199231203266. doi: 10.1177/15910199231203266.
Impact factor:
Publication type: Paper in international publication
Authors: Aasen, Trond; Bhuva, Parita; Bonafe, Alain; Budzik, Ronald F; Caramelo, Francisco; Carreira, Isabel Marques; Catarino, Steve; Cognard, Christophe; Girao, Henrique; Goncalves, Lino et al.
DOI: 10.1177/15910199231203266

Glyoxal acid-free (GAF) histological fixative is a suitable alternative to formalin: results from an open-label comparative non-inferiority study.

PMID: 37996705
Journal: VIRCHOWS ARCHIV
Year: 2023
Reference: Virchows Arch. 2023 Nov 24. doi: 10.1007/s00428-023-03692-6.
Impact factor:
Publication type: Paper in international publication
Authors: Barbash, Olena; Bussolati, Benedetta; Bussolati, Gianni; Cajal, Santiago Ramon Y; Cescon, David W; Detillo, Paolo; Dhar, Arindam; Frexia, Francesca; Hicks, Kirsty; Hilton, John et al.
DOI: 10.1007/s00428-023-03692-6

Adverse renal effects of check-point inhibitors (ICI) in cancer patients: Recommendations of the Onco-nephrology Working Group of the Spanish Society of Nephrology.

PMID: 38000944
Journal: Nefrologia
Year: 2023
Reference: Nefrologia (Engl Ed). 2023 Nov 23:S2013-2514(23)00170-0. doi: 10.1016/j.nefroe.2023.11.001.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Aunon, Pilar; Bussolati, Benedetta; Bussolati, Gianni; Cajal, Santiago Ramon Y; Detillo, Paolo; Frexia, Francesca; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo et al.
DOI: 10.1016/j.nefroe.2023.11.001

A faecal microbiota signature with high specificity for pancreatic cancer.

PMID: 35260444
Journal: GUT
Year: 2022
Reference: Gut. 2022 Jul;71(7):1359-1372. doi: 10.1136/gutjnl-2021-324755. Epub 2022 Mar 8.
Impact factor: 23.059
Publication type: Paper in international publication
Authors: Maistrenko, Oleksandr M, Kartal, Ece, Schmidt, Thomas S B, Molina-Montes, Esther, Rodriguez-Perales, Sandra, Wirbel, Jakob, Malats, Nuria, Bork, Peer, Malats, Nuria, Real, Francisco X et al.
DOI: 10.1136/gutjnl-2021-324755

Safety of Obtaining an Extra Biobank Kidney Biopsy Core.

PMID: 35268550
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Mar 7;11(5). pii: jcm11051459. doi: 10.3390/jcm11051459.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Mast, Richard, Vergara, Ander, Agraz, Irene, Leon, Juan Carlos, Bolufer, Monica, Gabaldon, Maria-Alejandra, Seron, Daniel, Bestard, Oriol, Soler, Maria Jose, Garcia-Carro, Clara et al.
DOI: 10.3390/jcm11051459

Histological Findings in Transbronchial Cryobiopsies Obtained From Patients After COVID-19.

PMID: 34582842
Journal: CHEST
Year: 2022
Reference: Chest. 2022 Mar;161(3):647-650. doi: 10.1016/j.chest.2021.09.016. Epub 2021 Sep 25.
Impact factor: 9.41
Publication type: Letter whit IF
Authors: Alvarez, Antonio, Andreu, Jordi, Arjona, Marta, Berastegui, Cristina, Barrecheguren, Miriam, Cardoso, Jose, Cruz, Ma Jesus, De Souza, Ma Luiza, Espejo, David, Granados, Galo et al.
DOI: 10.1016/j.chest.2021.09.016

Sinusoidal Obstruction Syndrome after Liver Transplantation: A Multicenter Observational Study.

PMID: 35255179
Journal: LIVER TRANSPLANTATION
Year: 2022
Reference: Liver Transpl. 2022 Jul;28(7):1257-1261. doi: 10.1002/lt.26452. Epub 2022 Apr 28.
Impact factor: 5.799
Publication type: Paper in international publication
Authors: Romero-Cristobal, Mario, Caballero-Marcos, Aranzazu, Peligros, Isabel, Perez-Rojas, Judith, Campos-Varela, Isabel, Colmenero, Jordi, Gomez-Bravo, Miguel Angel, Justo, Iago, Otero, Alejandra, Molina-Perez, Esther et al.
DOI: 10.1002/lt.26452

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience.

PMID: 33986388
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 May 13;11(1):10171. doi: 10.1038/s41598-021-89562-0.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Ramon, Maria Antonia, Gomez-Olles, Susana, Roman, Antonio, Bello, Irene, Burgos, Rosa, Escobar, Roser, Ferrandiz-Pulido, Carla, Gomez, Alba, Pallisa, Esther, Palomares, Gloria et al.
DOI: 10.1038/s41598-021-89562-0

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.

PMID: 33983674
Journal: Molecular Oncology
Year: 2021
Reference: Mol Oncol. 2021 Dec;15(12):3691-3705. doi: 10.1002/1878-0261.12996. Epub 2021 Jun 30.
Impact factor: 6.603
Publication type: Paper in international publication
Authors: Valverde, Claudia, Ramos, Rafael, Ortega-Medina, Luis, Martin-Davila, Francisco, Castilla-Ramirez, Carolina, Hernandez-Leon, Carmen Nieves, Romagosa, Cleofe, Vaz Salgado, Maria Angeles, Lavernia, Javier, Bague, Silvia et al.
DOI: 10.1002/1878-0261.12996

Focal and segmental glomerulosclerosis associated with COVID-19 infection.

PMID: 33888348
Journal: NEFROLOGIA
Year: 2021
Reference: Nefrologia (Engl Ed). 2021 Apr 19. pii: S0211-6995(21)00058-8. doi: 10.1016/j.nefro.2021.03.002.
Impact factor: 2.033
Publication type: Letter or abstract
Authors: LeonRoman, Juan, Vergara, Ander, Agraz, Irene, Garcia-Carro, Clara, Bermejo, Sheila, Gabaldon, Alejandra, Soler, Maria Jose et al.
DOI: 10.1016/j.nefro.2021.03.002

Cytokeratin Expression in Plasmablastic Lymphoma - a Possible Diagnostic Pitfall in the Routine Work-Up of Tumors.

PMID: 33165992
Journal: HISTOPATHOLOGY
Year: 2021
Reference: Histopathology. 2021 May;78(6):831-837. doi: 10.1111/his.14300. Epub 2020 Dec 25.
Impact factor: 5.087
Publication type: Paper in international publication
Authors: Frontzek, Fabian, Goodlad, John R, Tapia, Gustavo, Rosenwald, Andreas, Klapper, Wolfram, Fend, Falko, Climent, Fina, Castellvi, Josep, Tzankov, Alexandar, Dirnhofer, Stefan et al.
DOI: 10.1111/his.14300

Parvovirus B19 Myocarditis: Looking Beyond the Heart.

PMID: 31335286
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Year: 2020
Reference: Pediatr Dev Pathol. 2020 Mar-Apr;23(2):158-162. doi: 10.1177/1093526619865641. Epub 2019 Jul 23.
Impact factor: 0.885
Publication type: Paper in international publication
Authors: Izquierdo-Blasco, Jaume, Salcedo Allende, Maria Teresa, Codina Grau, Maria Gemma, Gran, Ferran, Martinez Saez, Elena, Balcells, Joan et al.
DOI: 10.1177/1093526619865641

The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1.

PMID: 32183023
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Mar 13;12(3). pii: cancers12030670. doi: 10.3390/cancers12030670.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Nadal-Serrano, Mercedes, Morancho, Beatriz, Escriva-de-Romani, Santiago, Morales, Cristina Bernado, Luque, Antonio, Escorihuela, Marta, Espinosa Bravo, Martin, Peg, Vicente, Dijcks, Fred A, Dokter, Wim H A et al.
DOI: 10.3390/cancers12030670

Cyclophilins A and B Oppositely Regulate Renal Tubular Epithelial Cell Phenotype.

PMID: 32162654
Journal: Journal of Molecular Cell Biology
Year: 2020
Reference: J Mol Cell Biol. 2020 Jul 1;12(7):499-514. doi: 10.1093/jmcb/mjaa005.
Impact factor: 4
Publication type: Paper in international publication
Authors: Gundelach, Justin H, Sarro, Eduard, Duran, Monica, Rico, Ana, Bou-Teen, Diana, Fernandez-Majada, Vanesa, Croatt, Anthony J, Nath, Karl A, Salcedo, Maria Teresa, Meseguer, Anna et al.
DOI: 10.1093/jmcb/mjaa005

Insights into new mechanisms and models of cancer stem cell multidrug resistance.

PMID: 31369817
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2020
Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
Impact factor: 11.09
Publication type: Review in international publication
Authors: Garcia-Mayea, Y, Mir, C, Masson, F, Paciucci, R, LLeonart, M E et al.
DOI: 10.1016/j.semcancer.2019.07.022

ONE-STEP NUCLEIC ACID AMPLIFICATION FOR INTRAOPERATIVE ANALYSIS OF SENTINEL LYMPH NODE IN PAPILLARY THYROID CARCINOMA.

PMID: 30400049
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2019
Reference: Eur J Endocrinol. 2019 Jan 1;180(1):21-29. doi: 10.1530/EJE-18-0624.
Impact factor: 5.107
Publication type: Paper in international publication
Authors: Fort, Jose M, Pujol-Borrell, Ricardo, Ramon Y Cajal, Santiago, Gonzalez, Oscar, Castell, Joan, Mesa, Jordi, Roca, Isabel, Caubet, Enric, Iglesias Felip, Carmela, Zafon, Carles et al.
DOI: 10.1530/EJE-18-0624

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.

PMID: 30373788
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2019
Reference: Mol Cell Proteomics. 2019 Feb;18(2):231-244. doi: 10.1074/mcp.RA118.001102. Epub 2018 Oct 29.
Impact factor: 4.828
Publication type: Paper in international publication
Authors: Abad, Etna, Garcia-Mayea, Yoelsis, Mir, Cristina, Sebastian, David, Zorzano, Antonio, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex, Lleonart, Matilde et al.
DOI: 10.1074/mcp.RA118.001102

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: Tissunomics.

PMID: 30667539
Journal: HISTOPATHOLOGY
Year: 2019
Reference: Histopathology. 2019 Jul;75(1):4-19. doi: 10.1111/his.13828. Epub 2019 May 14.
Impact factor: 3.294
Publication type: Editorail in international publication
Authors: Ramon Y Cajal, S, Hummer, S, Peg, V, Matias Guiu, X, De Torres, I, Castellvi, J, Martinez-Saez, E, Hernandez-Losa, J et al.
DOI: 10.1111/his.13828

Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms.

PMID: 30655613
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Jan 17;9(1):150. doi: 10.1038/s41598-018-36931-x.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Manubens, Marta, Alvarez, Yolanda, Barquinero, Joan Francesc, Ramon Y Cajal, Santiago, Ortega, Margarita, Blanco, Adoracion, Caballin, Maria Rosa, Armengol, Gemma, Alonso, Cintia, Garcia-Quevedo, Lydia et al.
DOI: 10.1038/s41598-018-36931-x

Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.

PMID: 29464030
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2017 Dec 19;9(5):5736-5751. doi: 10.18632/oncotarget.23422. eCollection 2018 Jan 19.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vilardell, Jordi, Alcaraz, Estefania, Sarro, Eduard, Trilla, Enric, Cuadros, Thais, de Torres, Ines, Plana, Maria, Ramon Y Cajal, Santiago, Pinna, Lorenzo A, Ruzzene, Maria et al.
DOI: 10.18632/oncotarget.23422

Beyond molecular tumor heterogeneity: protein synthesis takes control.

PMID: 29463861
Journal: ONCOGENE
Year: 2018
Reference: Oncogene. 2018 May;37(19):2490-2501. doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21.
Impact factor: 6.854
Publication type: Review in national publication
Authors: Ramon Y Cajal, Santiago, Castellvi, Josep, Hummer, Stefan, Peg, Vicente, Pelletier, Jerry, Sonenberg, Nahum et al.
DOI: 10.1038/s41388-018-0152-0

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis.

PMID: 29433983
Journal: EBioMedicine
Year: 2018
Reference: EBioMedicine. 2018 Mar;29:112-127. doi: 10.1016/j.ebiom.2018.02.001. Epub 2018 Feb 5.
Impact factor: 6.183
Publication type: Paper in international publication
Authors: Karachaliou, Niki, Chaib, Imane, Cardona, Andres Felipe, Rosell, Rafael, Cao, Peng, Cajal, Santiago Ramon Y, Cui, Jean, Berenguer, Jordi, Bracht, Jillian Wilhelmina Paulina, Yang, Jie et al.
DOI: 10.1016/j.ebiom.2018.02.001

Promising activity of selinexor in the treatment of a patient with refractory diffuse large B-cell lymphoma and central nervous system involvement.

PMID: 29242296
Journal: HAEMATOLOGICA
Year: 2018
Reference: Haematologica. 2018 Feb;103(2):e92-e93. doi: 10.3324/haematol.2017.181636. Epub 2017 Dec 14.
Impact factor: 9.09
Publication type: Paper in international publication
Authors: Raheja, Priyanka, Bobillo, Sabela, Abrisqueta, Pau, Carpio, Cecilia, Bosch, Francesc, Crespo, Marta, Castellvi, Josep et al.
DOI: 10.3324/haematol.2017.181636

Epidemiology and diagnosis of tuberculous lymphadenitis in a tuberculosis low-burden country.

PMID: 25634205
Journal: MEDICINE
Year: 2015
Reference: Medicine (Baltimore). 2015 Jan;94(4):e509. doi: 10.1097/MD.0000000000000509.
Impact factor: 4.867
Publication type: Paper in international publication
Authors: Salvador, Fernando, Los-Arcos, Ibai, Sanchez-Montalva, Adrian, Tortola, Teresa, Curran, Adrian, Villar, Ana, Saborit, Nuria, Castellvi, Josep, Molina, Israel et al.
DOI: 10.1097/MD.0000000000000509

Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.

PMID: 25373533
Journal: Clinical & Translational Oncology
Year: 2015
Reference: Clin Transl Oncol. 2015 Apr;17(4):264-73. doi: 10.1007/s12094-014-1252-0. Epub 2014 Nov 6.
Impact factor: 2.077
Publication type: Paper in international publication
Authors: Navarro, S, Ramon Y Cajal, S, Landolfi, S, Garcia-Alfonso, P, Garcia-Foncillas, J, Salazar, R, Perez-Segura, P, Garcia-Carbonero, R, Musulen-Palet, E, Cuatrecasas, M et al.
DOI: 10.1007/s12094-014-1252-0

Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1.

PMID: 23455324
Journal: ONCOGENE
Year: 2014
Reference: Oncogene. 2014 Feb 27;33(9):1124-34. doi: 10.1038/onc.2013.51. Epub 2013 Mar 4.
Impact factor: 8.559
Publication type: Paper in international publication
Authors: Marques, N, Sese, M, Canovas, V, Valente, F, Bermudo, R, de Torres, I, Fernandez, Y, Abasolo, I, Fernandez, P L, Contreras, H et al.
DOI: 10.1038/onc.2013.51

The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors.

PMID: 24284518
Journal: KIDNEY INT
Year: 2014
Reference: Kidney Int. 2014 May;85(5):1161-8. doi: 10.1038/ki.2013.461. Epub 2013 Nov 27.
Impact factor: 8.52
Publication type: Paper in international publication
Authors: Trilla, Enric, Sellares, Joana, Morote, Joan, Seron, Daniel, Montero, Angeles, Torres, Irina B, Perello, Manel, Cantarell, Carme, Antonieta Azancot, M, Moreso, Francesc et al.
DOI: 10.1038/ki.2013.461

Early predictors of antiviral treatment response in liver transplant recipients with recurrent hepatitis C genotype 1.

PMID: 24620835
Journal: J VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12.
Impact factor: 3.307
Publication type: Paper in international publication
Authors: Campos-Varela, I, Esteban, J I, Bes, M, Caralt, M, Allende, H, Rodriguez-Frias, F, Salcedo, M T, Sauleda, S, Charco, R, Guardia, J et al.
DOI: 10.1111/jvh.12246

Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein.

PMID: 24618734
Journal: LEUKEMIA
Year: 2014
Reference: Leukemia. 2014 Oct;28(10):1993-2004. doi: 10.1038/leu.2014.96. Epub 2014 Mar 12.
Impact factor: 9.379
Publication type: Paper in international publication
Authors: Purroy, N, Abrisqueta, P, Carabia, J, Carpio, C, Calpe, E, Palacio, C, Castellvi, J, Crespo, M, Bosch, F et al.
DOI: 10.1038/leu.2014.96

Blog

News

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

Vall d’Hebron ha celebrat avui la Jornada del Dia Mundial contra el Càncer, una malaltia cada cop més freqüent que patiran al llarg de la vida un de cada dos homes i una de cada tres dones del nostre entorn.

The multidisciplinary paper on papillary thyroid cancer has been considered the best original article of 2021 in the journal Endocrinología, Diabetes y Nutrición

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