Acerca del VHIR
El Vall d'Hebron Instituto de Investigación (VHIR) promueve la investigación biomédica, la innovación y la docencia. Más de 1.800 personas buscan comprender las enfermedades hoy con el objetivo de mejorar su tratamiento mañana.
Investigación
Trabajamos para entender las enfermedades, saber cómo funcionan y crear mejores tratamientos para los pacientes. Conoce nuestros grupos y sus líneas de investigación.
Personas
Las personas son el centro del Vall d'Hebron Instituto de Investigación (VHIR). Por eso nos vinculamos con los principios de libertad de investigación, igualdad de género y actitud profesional que promueve la HRS4R.
Ensayos clínicos
Nuestra tarea no es solo básica o traslacional; somos líderes en investigación clínica. Entra para saber qué ensayos clínicos estamos llevando a cabo y por qué somos referente mundial en este campo.
Progreso
Queremos que la investigación que se efectúa en el Vall d'Hebron Instituto de Investigación (VHIR) sea un motor de transformación. ¿Cómo? Identificando nuevas vías y soluciones para fomentar la salud y el bienestar de las personas.
Core facilities
Ofrecemos un apoyo especializado a los investigadores tanto internos como externos, desde un servicio concreto hasta la elaboración de un proyecto en su totalidad. Todo ello, con una perspectiva de calidad y agilidad de respuesta.
Actualidad
Te damos una puerta de entrada para estar al día de todo lo que sucede en el Vall d'Hebron Instituto de Investigación (VHIR), desde las últimas noticias hasta las actividades e iniciativas solidarias futuras que estamos organizando.
Dr. Ruth Rodríguez Barrueco, Principal Investigator, Molecular Oncology Center, Oncologic Research Institute - Bellvitge Biomedical Research Institute-IDIBELL
Breast cancer is the most frequently diagnosed tumor among women, and the leading cause of female cancer death. Mammographic screening coupled with improved treatments have led to a striking increase of survival in both early and advanced settings. However, most patients presenting advanced disease will eventually progress, with more than 90% of the patients dying from metastatic breast cancer. Tumor progression and metastatic spread require high cell plasticity to quickly adapt to new scenarios and escape the immune system. Cellular metabolism largely influences the promotion and maintenance of stemness in breast cancer. The specific events, and the mechanisms by which they are controlled, require further exploration. Previous work of our laboratory demonstrated that decreased levels of the cluster of miRNAs 424(322)/503 induce stem characteristics to normal mammary cells. Accordingly, we have recently reported that the miR-424(322)/302 cluster is a novel modulator of canonical Wnt signaling in the mammary epithelium that exerts its function by decreasing the expression of the LRP6 co-receptor. Moreover, the cluster is required for Wnt-mediated MaSC expansion induced by the ovarian cycles. In the context of breast cancer, the suppression of the expression of these two miRNAs in a murine model promotes hyperplasia in the mammary glands and multifocal thickening of the TDLUs (Terminal Ductal Lobular Units). We have also described that the cluster of mi-R-424(322)/503 is deleted in a group of aggressive breast tumors and reported that miR-424(322)/503 knockout mice develop mammary tumors over time which are promoted by pregnancy. These are undifferentiated tumors that resist to chemotherapeutic agents thanks to the increased expression of their target genes BCL-2 and IGF1R. We have also associated the loss of expression of miR-424(322)/503 to the acquisition of plasticity necessary to switch amongst stages and to the rewiring of major energy-producing pathways. Mechanistically, miR-424(322)/503 regulates pluripotency and metabolism via direct targeting of zinc finger protein 217 (ZNF217). Repression of this transcription factor was sufficient to reverse the stem-like and metabolic phenotypes revealing a new role of ZNF217 in mammary epithelial cells and opening the avenue to new targeted therapies for aggressive breast tumors.
Host: Dr. Miquel Segura, Senior researcher Childhood Cancer and Blood Disorders (VHIR)