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Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS)

CRIPS is a research group focusing on severe acute respiratory infections and sepsis. 

The objective is to develop projects on clinical and translational research in hospital-acquired pneumonia, community-acquired pneumonia, and severe viral respiratory infections, such as influenza and COVID-19. CRIPS also develop epidemiological studies focused on risk and prognostic factors for multi-resistant pathogens, validation of ventilator-associated events in ventilated adult and pediatric patients, incorporating artificial intelligence techniques. It also highlights evidence-based medicine (EBM) research, evaluating therapies and prevention strategies and participating in the formulation of clinical practice guidelines, as part of CIBERES and the European Society for Clinical Microbiology and Infections. The EBM research focuses on knowledge translation to get research findings to the point of decision making, providing health-related recommendations, focusing on clinical research and relevance of care. 

CRIPS collaborate on a Local (UIC, IDIAP), National (CIBERES), and International level (CHU Nimes, Uolo University, ISARIC and Pneumo-Inspire Networks).

Publications

Screening for Antimicrobial-Resistant Gram-negative bacteria in hospitalised patients, and risk of progression from colonisation to infection: Systematic review.

PMID: 34793762
Journal: JOURNAL OF INFECTION
Year: 2022
Reference: J Infect. 2022 Feb;84(2):119-130. doi: 10.1016/j.jinf.2021.11.007. Epub 2021 Nov 15.
Impact factor: 6.072
Publication type: Review in international publication
Authors: Scardina, Giuditta, Casigliani, Virginia, Petri, Davide, Porretta, Andrea, Moi, Marco, Lucenteforte, Ersilia, Rello, Jordi, Lopalco, Pierluigi, Baggiani, Angelo, Privitera, Gaetano Pierpaolo et al.
DOI: 10.1016/j.jinf.2021.11.007

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study.

PMID: 35169585
Journal: ERJ open research
Year: 2022
Reference: ERJ Open Res. 2022 Feb 14;8(1). pii: 00552-2021. doi: 10.1183/23120541.00552-2021. eCollection 2022 Jan.
Impact factor: 0
Publication type: Paper in international publication
Authors: Kartsonaki, Christiana, Aragao, Irene, Barrett, Peter W, Beane, Abigail, Burrell, Aidan, Cheng, Matthew Pellan, Christian, Michael D, Cidade, Jose Pedro, Citarella, Barbara Wanjiru, Donnelly, Christl A et al.
DOI: 10.1183/23120541.00552-2021

Plasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department.

PMID: 35055399
Journal: Journal of Personalized Medicine
Year: 2022
Reference: J Pers Med. 2022 Jan 10;12(1). pii: jpm12010084. doi: 10.3390/jpm12010084.
Impact factor: 4.945
Publication type: Paper in international publication
Authors: Valenzuela-Mendez, Blanca, Valenzuela-Sanchez, Francisco, Rodriguez-Gutierrez, Juan Francisco, Bohollo-de-Austria, Rafael, Estella, Angel, Martinez-Garcia, Pilar, Gonzalez-Garcia, Maria Angela, Rello, Jordi et al.
DOI: 10.3390/jpm12010084

Critical appraisal of international adult bronchiectasis guidelines using the AGREE II tool.

PMID: 35074245
Journal: European Journal of Internal Medicine
Year: 2022
Reference: Eur J Intern Med. 2022 Apr;98:4-11. doi: 10.1016/j.ejim.2022.01.023. Epub 2022 Jan 21.
Impact factor: 4.624
Publication type: Paper in international publication
Authors: Tejada, Sofia, Ramirez-Estrada, Sergio, Tejo, Alexandre M, Forero, Carlos G, Pomares, Xavier, Gallego, Miguel, Soriano, Joan B, Chalmers, James D, Rello, Jordi et al.
DOI: 10.1016/j.ejim.2022.01.023

Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma.

PMID: 33619748
Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY
Year: 2021
Reference: Pediatr Allergy Immunol. 2021 Jul;32(5):980-991. doi: 10.1111/pai.13484. Epub 2021 Mar 20.
Impact factor: 6.377
Publication type: Paper in international publication
Authors: Valdesoiro Navarrete, Laura, Ballester Asensio, Esther, Sanz Santiago, Veronica, Romero Garcia, Raquel, Gimeno Diaz de Atauri, Alvaro, Valenzuela Soria, Alfredo, Sanchez Mateos, Mercedes, Batlles Garrido, Jose, Andres Martin, Anselmo, Campos Alonso, Elena et al.
DOI: 10.1111/pai.13484

Transverse orange nail lesions following SARS-CoV-2 infection.

PMID: 33340203
Journal: Dermatologic Therapy
Year: 2021
Reference: Dermatol Ther. 2021 Jan;34(1):e14688. doi: 10.1111/dth.14688. Epub 2020 Dec 22.
Impact factor: 2.851
Publication type: Letter or abstract
Authors: Tammaro, Antonella, Adebanjo, Ganiyat Adenike Ralitsa, Erasmus, Hans-Peter, Chello, Camilla, Pezzuto, Aldo, Ramirez-Estrada, Sergio, Rello, Jordi et al.
DOI: 10.1111/dth.14688

Nebulized antibiotics for ventilator-associated pneumonia: methodological framework for future multicenter randomized controlled trials.

PMID: 33605620
Journal: CURRENT OPINION IN INFECTIOUS DISEASES
Year: 2021
Reference: Curr Opin Infect Dis. 2021 Apr 1;34(2):156-168. doi: 10.1097/QCO.0000000000000720.
Impact factor: 4.915
Publication type: Review in international publication
Authors: Torres, Antoni, Zhu, Yinggang, Pugin, Jerome, Rello, Jordi, Rouby, Jean-Jacques, Monsel, Antoine et al.
DOI: 10.1097/QCO.0000000000000720

Cutaneous Endothelial Dysfunction and Complement Deposition in COVID-19.

PMID: 33055532
Journal: AMERICAN JOURNAL OF DERMATOPATHOLOGY
Year: 2021
Reference: Am J Dermatopathol. 2021 Mar 1;43(3):237-238. doi: 10.1097/DAD.0000000000001825.
Impact factor: 1.533
Publication type: Paper in international publication
Authors: Tammaro, Antonella, Adebanjo, Ganiyat Adenike Ralitsa, Del Nonno, Franca, Pezzuto, Aldo, Ramirez-Estrada, Sergio, Parisella, Francesca Romana, Rello, Jordi, Scarabello, Alessandra et al.
DOI: 10.1097/DAD.0000000000001825

Antibiotic use in patients with COVID-19: a 'snapshot' Infectious Diseases International Research Initiative (ID-IRI) survey.

PMID: 32766706
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2020
Reference: J Antimicrob Chemother. 2020 Nov 1;75(11):3386-3390. doi: 10.1093/jac/dkaa326.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Beovic, Bojana, Dousak, May, Ferreira-Coimbra, Joao, Nadrah, Kristina, Rubulotta, Francesca, Belliato, Mirko, Berger-Estilita, Joana, Rello, Jordi, Erdem, Hakan, Ayoade, Folusakin et al.
DOI: 10.1093/jac/dkaa326

Adult ICU Triage During the Coronavirus Disease 2019 Pandemic: Who Will Live and Who Will Die? Recommendations to Improve Survival.

PMID: 32697491
Journal: CRITICAL CARE MEDICINE
Year: 2020
Reference: Crit Care Med. 2020 Aug;48(8):1196-1202. doi: 10.1097/CCM.0000000000004410.
Impact factor: 7.414
Publication type: Review in international publication
Authors: Sprung, Charles L, Joynt, Gavin M, Christian, Michael D, Truog, Robert D, Rello, Jordi, Nates, Joseph L et al.
DOI: 10.1097/CCM.0000000000004410

Necrotic acral lesions and lung failure in a fatal case of COVID-19.

PMID: 32671827
Journal: AUSTRALASIAN JOURNAL OF DERMATOLOGY
Year: 2020
Reference: Australas J Dermatol. 2020 Nov;61(4):e467-e468. doi: 10.1111/ajd.13400. Epub 2020 Jul 16.
Impact factor: 1.789
Publication type: Letter whit IF
Authors: Tammaro, Antonella, Chello, Camilla, Sernicola, Alvise, Magri, Francesca, Adebanjo, Ganiyat Adenike Ralitsa, Parisella, Francesca Romana, Scarabello, Alessandra, Pezzuto, Aldo, Ramirez-Estrada, Sergio, Rello, Jordi et al.
DOI: 10.1111/ajd.13400

Quality of Evidence Supporting Surviving Sepsis Campaign Recommendations.

PMID: 32650126
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2020
Reference: Anaesth Crit Care Pain Med. 2020 Aug;39(4):497-502. doi: 10.1016/j.accpm.2020.06.015. Epub 2020 Jul 7.
Impact factor: 2.707
Publication type: Paper in international publication
Authors: Elena, Xu, Sole-Lleonart, Candela, Campogiani, Laura, Koulenti, Despoina, Ferreira-Coimbra, Joao, Lipman, Jeff, Tejada, Sofia, Rello, Jordi et al.
DOI: 10.1016/j.accpm.2020.06.015

Infectious diseases: the 10 common truths I never believed.

PMID: 29934924
Journal: INTENSIVE CARE MEDICINE
Year: 2019
Reference: Intensive Care Med. 2019 Feb;45(2):243-245. doi: 10.1007/s00134-018-5272-z. Epub 2018 Jun 22.
Impact factor: 18.967
Publication type: Editorail in international publication
Authors: Rello, Jordi, Alp, Emine, Vandana, Kalwaje Eshwara et al.
DOI: 10.1007/s00134-018-5272-z

An international perspective on hospitalized patients with viral community-acquired pneumonia.

PMID: 30401576
Journal: European Journal of Internal Medicine
Year: 2019
Reference: Eur J Intern Med. 2019 Feb;60:54-70. doi: 10.1016/j.ejim.2018.10.020. Epub 2018 Nov 4.
Impact factor: 3.66
Publication type: Paper in international publication
Authors: Ceccato, Adrian, Radovanovic, Dejan, Sotgiu, Giovanni, Jankovic, Mateja, Mahesh, Padukudru Anand, Marcos, Pedro Jorge, Abdalla, Mohamed I, Di Pasquale, Marta Francesca, Gramegna, Andrea, Terraneo, Silvia et al.
DOI: 10.1016/j.ejim.2018.10.020

Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials.

PMID: 30722013
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2019
Reference: Clin Infect Dis. 2019 Nov 13;69(11):1912-1918. doi: 10.1093/cid/ciz093.
Impact factor: 9.055
Publication type: Paper in international publication
Authors: Rello, Jordi, Rex, John H, Shorr, Andrew F, Talbot, George H, Thamlikitkul, Visanu, Torres, Antoni, Wunderink, Richard G, Timsit, Jean-Francois, Prokocimer, Philippe, Poulakou, Garyphallia et al.
DOI: 10.1093/cid/ciz093

A global priority list of the TOp TEn resistant Microorganisms (TOTEM) study at intensive care: a prioritization exercise based on multi-criteria decision analysis.

PMID: 30426331
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2019
Reference: Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):319-323. doi: 10.1007/s10096-018-3428-y. Epub 2018 Nov 13.
Impact factor: 2.591
Publication type: Paper in international publication
Authors: Wunderink, Richard G, Conway-Morris, Andrew, Rojas, Jose Nicolas, Alp, Emine, Zhang, Zhongheng, Alves, Joana, Lagunes, Leo, Kalwaje Eshwara, Vandana, Rello, Jordi et al.
DOI: 10.1007/s10096-018-3428-y

Role of biomarkers in the differential diagnosis of acute respiratory failure in the immediate postoperative period of lung transplantation.

PMID: 23462428
Journal: Medicina Intensiva
Year: 2013
Reference: Med Intensiva. 2013 Aug-Sep;37(6):416-22. doi: 10.1016/j.medin.2013.01.005. Epub 2013 Feb 22.
Impact factor: 1.323
Publication type: Paper in national publication
Authors: Sacanell, J, Roman, A, Ruano, L, Rello, J et al.
DOI: 10.1016/j.medin.2013.01.005

Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors.

PMID: 23358539
Journal: INTENSIVE CARE MEDICINE
Year: 2013
Reference: Intensive Care Med. 2013 Apr;39(4):672-81. doi: 10.1007/s00134-012-2808-5. Epub 2013 Jan 29.
Impact factor: 5.258
Publication type: Paper in international publication
Authors: Martin-Loeches, Ignacio, Deja, Maria, Dimopoulos, George, Marsh, Brian, Torres, Antonio, Niederman, Michael S, Rello, Jordi, Koulenti, Despoina et al.
DOI: 10.1007/s00134-012-2808-5

[Life after the Intensive Care Unit: The hidden face from the moon.]

PMID: 23332621
Journal: MEDICINA CLINICA
Year: 2013
Reference: Med Clin (Barc). 2013 Jun 4;140(11):500-1. doi: 10.1016/j.medcli.2012.11.020. Epub 2013 Jan 18.
Impact factor: 1.399
Publication type: Editorial in national publication
Authors: Rello, Jordi, Gallart, Elisabet et al.
DOI: 10.1016/j.medcli.2012.11.020

Early non-invasive ventilation treatment for severe influenza pneumonia.

PMID: 22404211
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2013
Reference: Clin Microbiol Infect. 2013 Mar;19(3):249-256. doi: 10.1111/j.1469-0691.2012.03797.x. Epub 2012 Mar 8.
Impact factor: 4.578
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1469-0691.2012.03797.x

Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A.

PMID: 21385717
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2011
Reference: J Antimicrob Chemother. 2011 May;66(5):1140-9. Epub 2011 Jan 7.
Impact factor: 4.659
Publication type: Paper in international publication
Authors: García-López, Fernando, Rodriguez, Alejandro, Emili Diaz, Martin Loeches, Ignacio, Sandiumenge, Alberto, Canadell, Laura, Diaz, Juan J., Figueira, Juan C., Marques, Asuncion, Alvarez-Lerma, Francisco et al.
DOI: 10.1093/jac/dkq511

A European care bundle for management of ventilator-associated pneumonia.

PMID: 20537504
Journal: JOURNAL OF CRITICAL CARE
Year: 2011
Reference: J Crit Care. 2011 Feb;26(1):3-10.
Impact factor: 2.077
Publication type: Paper in international publication
Authors: , , , et al.
DOI: 10.1016/j.jcrc.2010.04.001

The Effects of Hypoalbuminaemia on Optimizing Antibacterial Dosing in Critically Ill Patients.

PMID: 21142293
Journal: CLINICAL PHARMACOKINETICS
Year: 2011
Reference: Clin Pharmacokinet. 2011 Feb 1;50(2):99-110. doi: 10.2165/11539220-000000000-00000.
Impact factor: 4.513
Publication type: Review in international publication
Authors: , , , , et al.
DOI: 10.2165/11539220-000000000-00000

Community-Acquired Respiratory Co-infection (CARC) in Critically Ill Patients Infected With Pandemic 2009 Influenza A (H1N1) Virus Infection.

PMID: 20930007
Journal: CHEST
Year: 2011
Reference: Chest. 2011 Mar;139(3):555-62. Epub 2010 Oct 7.
Impact factor: 6.519
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1378/chest.10-1396

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