About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our research group is focused on studying the pathophysiology of migraine and other primary headaches using preclinical, translational and clinical research.
Migraine will allow us to define the brain’s adaptive, sensory/cognitive functions, through genetics, epigenetics, neurophysiology, neuromolecular and neuroanatomical information with an interest in developing clinical therapeutic solutions, with the goal on having an impact on suffering and increasing the well-being.
PMID: 39314064 Journal: CEPHALALGIA Year: 2024 Reference: Cephalalgia. 2024 Sep;44(9):3331024241273966. doi: 10.1177/03331024241273966. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Elosua-Bayes, Iker; Melgarejo, Laura; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1177/03331024241273966
PMID: 39380339 Journal: CEPHALALGIA Year: 2024 Reference: Cephalalgia. 2024 Oct;44(10):3331024241287224. doi: 10.1177/03331024241287224. Impact factor: Publication type: Paper in international publication Authors: Atalar, Arife Cimen; Caronna, Edoardo; Cetta, Ilaria; Farham, Fatemeh; Fitzek, Mira; Karatas-Kursun, Hulya; Kholodova, Marharyta; Kukumagi, Kadri-Hebo; Montisano, Danilo Antonio; Onan, Dilara et al. DOI: 10.1177/03331024241287224
PMID: 39558611 Journal: CEPHALALGIA Year: 2024 Reference: Cephalalgia. 2024 Nov;44(11):3331024241297652. doi: 10.1177/03331024241297652. Impact factor: Publication type: Paper in international publication Authors: Ashraf, Usman; Caronna, Edoardo; Cerrahoglu Sirin, Tuba; Dantes, Mia Catherine; Gonzalez-Martinez, Alicia; Gosalia, Helin; Haghdoost, Faraidoon; Hwang, Heewon; Jennysdotter Olofsgard, Felicia; Kim, Jee Min et al. DOI: 10.1177/03331024241297652
PMID: 37516125 Journal: LANCET Year: 2023 Reference: Lancet. 2023 Jul 26:S0140-6736(23)01049-8. doi: 10.1016/S0140-6736(23)01049-8. Impact factor: Publication type: Paper in international publication Authors: Ailani, Jessica; Ashina, Messoud; Boinpally, Ramesh; De Abreu Ferreira, Rosa; Finnegan, Michelle; Goadsby, Peter J; Guo, Hua; Lipton, Richard B; Lu, Kaifeng; McCusker, Emily et al. DOI: 10.1016/S0140-6736(23)01049-8
PMID: 37665495 Journal: Current Neurology and Neuroscience Reports Year: 2023 Reference: Curr Neurol Neurosci Rep. 2023 Sep 4. doi: 10.1007/s11910-023-01296-w. Impact factor: Publication type: Review in international publication Authors: Caronna, Edoardo; Gomez-Dabo, Laura; Gomez-Dabo, Laura; Melgarejo-Martinez, Laura; Pozo-Rosich, Patricia; Pozo-Rosich, Patricia et al. DOI: 10.1007/s11910-023-01296-w
PMID: 37691118 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2023 Reference: J Headache Pain. 2023 Sep 11;24(1):125. doi: 10.1186/s10194-023-01644-8. Impact factor: Publication type: Review in international publication Authors: Braniste, Diana; Burstein, Rami; Caronna, Edoardo; Chkhitunidze, Nino; Dapkute, Austeja; Gollion, Cedric; Gudadze, Tamari; Hoffmann, Jan; Labastida-Ramirez, Alejandro; Meksa, Liga et al. DOI: 10.1186/s10194-023-01644-8
PMID: 37728577 Journal: CEPHALALGIA Year: 2023 Reference: Cephalalgia. 2023 Sep;43(9):3331024231201577. doi: 10.1177/03331024231201577. Impact factor: Publication type: Review in international publication Authors: Choi, So Youn; Kim, Seung Ae; Lee, Mi Ji; Pozo-Rosich, Patricia; Pozo-Rosich, Patricia; Youn, Michelle Sojung et al. DOI: 10.1177/03331024231201577
PMID: 35928182 Journal: Future healthcare journal Year: 2022 Reference: Future Healthc J. 2022 Jul;9(2):194-199. doi: 10.7861/fhj.2022-0005. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Anna Ochoa de Echaguen; Carbonell-Cobo, Marta; de Castro, Rodolfo; Hueto-Madrid, Juan Antonio; Paradell, Raquel Canovas; Pozo-Rosich, Patricia; Pozo-Rosich, Patricia; Rovira-Simon, Jordi; Sales-I-Coll, Marc; Shaw, Genevieve et al. DOI: 10.7861/fhj.2022-0005
PMID: 35815637 Journal: CEPHALALGIA Year: 2022 Reference: Cephalalgia. 2022 Nov;42(13):1305-1316. doi: 10.1177/03331024221111772. Epub 2022 Jul 9. Impact factor: Publication type: Paper in international publication Authors: Caronna, Edoardo; Cerda-Company, Xim; Gallardo, Victor Jose; Ikumi, Nara; Marti-Marca, Angela; Pozo-Rosich, Patricia; Vila-Ballo, Adria et al. DOI: 10.1177/03331024221111772
PMID: 35791285 Journal: CEPHALALGIA Year: 2022 Reference: Cephalalgia. 2022 Nov;42(13):1387-1396. doi: 10.1177/03331024221110102. Epub 2022 Jul 5. Impact factor: Publication type: Paper in international publication Authors: Dell'Agnello, Grazia; Gantenbein, Andreas R; Katsarava, Zaza; Pozo-Rosich, Patricia; Roche, Sarah L; Steiner, Timothy J; Tassorelli, Cristina; Terwindt, Gisela M et al. DOI: 10.1177/03331024221110102
PMID: 35735024 Journal: BRAIN Year: 2022 Reference: Brain. 2022 Sep 14;145(9):3214-3224. doi: 10.1093/brain/awac105. Impact factor: Publication type: Paper in international publication Authors: Adams, Hieab H H; Anttila, Verneri; Aromaa, Arpo J; Artto, Ville; Belin, Andrea C; Bivol, Svetlana; Boomsma, Dorret I; Borck, Guntram; Borte, Sigrid; Buring, Julie E et al. DOI: 10.1093/brain/awac105
PMID: 34180076 Journal: ANNALS OF NEUROLOGY Year: 2021 Reference: Ann Neurol. 2021 Aug;90(2):203-216. doi: 10.1002/ana.26146. Epub 2021 Jul 14. Impact factor: Publication type: Paper in international publication Authors: Borte, Sigrid; de Boer, Irene; Ferrari, Michel D; Fourier, Carmen; Fronczek, Rolf; Hansen, Thomas F; Harder, Aster V E; Jensen, Rigmor H; Kogelman, Lisette J A; Kristoffersen, Espen S et al. DOI: 10.1002/ana.26146
PMID: 34173301 Journal: EUROPEAN JOURNAL OF PAIN Year: 2021 Reference: Eur J Pain. 2021 Nov;25(10):2177-2189. doi: 10.1002/ejp.1831. Epub 2021 Jul 13. Impact factor: Publication type: Paper in international publication Authors: Afridi, S; Donnet, A; Gendolla, A; Gil-Gouveia, R; Poole, A C; Pozo-Rosich, P; Sanchez-De la Rosa, R; Tassorelli, C; Terwindt, G M et al. DOI: 10.1002/ejp.1831
PMID: 34180043 Journal: REVISTA DE NEUROLOGIA Year: 2021 Reference: Rev Neurol. 2021 Jun 30;72(s02):S1-S19. doi: 10.33588/rn.72s02.2021155. Impact factor: Publication type: Review in national publication Authors: Ashina, M; Belvis, R; Diaz-Insa, S; Ezpeleta, D; Garcia-Azorin, D; Gonzalez-Oria, C; Guerrero, A L; Guillem, A; Holle-Lee, D; Huerta-Villanueva, M et al. DOI: 10.33588/rn.72s02.2021155
PMID: 34138860 Journal: PLoS One Year: 2021 Reference: PLoS One. 2021 Jun 17;16(6):e0251528. doi: 10.1371/journal.pone.0251528. eCollection 2021. Impact factor: Publication type: Review in international publication Authors: Abdul Rashid, Anna Misyail; Baharin, Janudin; Basri, Hamidon; Fernandez, Aaron; Hoo, Fan Kee; Inche Mat, Liyana Najwa; Lee, Kai Wei; Loh, Wei Chao; Mohamad Safiai, Nabil Izzaatie; Mohamad, Nur Afiqah et al. DOI: 10.1371/journal.pone.0251528
PMID: 32546227 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2020 Reference: J Headache Pain. 2020 Jun 16;21(1):76. doi: 10.1186/s10194-020-01130-5. Impact factor: Publication type: Paper in international publication Authors: Braschinsky, Mark; de la Torre, Elena Ruiz; Del Rio, Margarita Sanchez; Ducros, Anne; Katsarava, Zaza; Lampl, Christian; Little, Patrick; Martelletti, Paolo; Pozo-Rosich, Patricia; Reuter, Uwe et al. DOI: 10.1186/s10194-020-01130-5
PMID: 32522142 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2020 Reference: J Headache Pain. 2020 Jun 10;21(1):74. doi: 10.1186/s10194-020-01147-w. Impact factor: Publication type: Paper in international publication Authors: Bailon, Cristina; Ignacio, Emilio; Layos-Romero, Almudena; Martin-Delgado, Jimmy; Mira, Jose Joaquin; Pascual, Julio; Pozo-Rosich, Patricia; Santiago, Alejandro; Tentor, Ana; Torres, Antonio et al. DOI: 10.1186/s10194-020-01147-w
PMID: 32421912 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2020 Reference: Eur J Neurol. 2020 Oct;27(10):2102-2108. doi: 10.1111/ene.14331. Epub 2020 Jun 17. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Del Rio, Margarita Sanchez; Gago-Veiga, Ana; Gallardo, Victor Jose; Guerrero, Angel; Irimia, Pablo; Lainez, Jose Miguel; Pozo-Rosich, Patricia; Santos-Lasaosa, Sonia; Torres-Ferrus, Marta et al. DOI: 10.1111/ene.14331
PMID: 28870393 Journal: NEUROLOGIA Year: 2020 Reference: Neurologia. 2020 Apr;35(3):176-184. doi: 10.1016/j.nrl.2017.08.001. Epub 2017 Sep 1. Impact factor: Publication type: Review in national publication Authors: Gago-Veiga, A B; Garcia-Azorin, D; Mas-Sala, N; Ordas, C M; Pozo-Rosich, P; Ruiz-Pinero, M; Santos-Lasaosa, S; Torres-Ferrus, M; Viguera Romero, J et al. DOI: 10.1016/j.nrl.2017.08.001
PMID: 30834194 Journal: Epilepsy & behavior case reports Year: 2019 Reference: Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019. Impact factor: Publication type: Paper in international publication Authors: Abraira, Laura; Alpuente, Alicia; Guzman, Lorena; Maisterra, Olga; Salas-Puig, Javier; Santamarina, Estevo; Sarria, Silvana; Sueiras, Maria; Toledo, Manuel et al. DOI: 10.1016/j.ebcr.2019.01.008
PMID: 30824632 Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Year: 2019 Reference: J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):796-804. doi: 10.1136/jnnp-2018-320113. Epub 2019 Mar 1. Impact factor: Publication type: Review in national publication Authors: Liebler, Eric; McClure, Candace; Pozo-Rosich, Patricia; Reuter, Uwe et al. DOI: 10.1136/jnnp-2018-320113
PMID: 30806518 Journal: CEPHALALGIA Year: 2019 Reference: Cephalalgia. 2019 May;39(6):687-710. doi: 10.1177/0333102419828967. Epub 2019 Feb 26. Impact factor: Publication type: Paper in international publication Authors: Ashina, Messoud; Becker, Werner J; Diener, Hans-Christoph; Dodick, David W; Ferrari, Michel D; Goadsby, Peter J; Lipton, Richard B; Mandrekar, Jay; Pozo-Rosich, Patricia; Silberstein, Stephen D et al. DOI: 10.1177/0333102419828967
PMID: 29771141 Journal: CEPHALALGIA Year: 2019 Reference: Cephalalgia. 2019 Jan;39(1):91-99. doi: 10.1177/0333102418777509. Epub 2018 May 17. Impact factor: Publication type: Paper in international publication Authors: Ajanovic, Sara; Alvarez-Sabin, Jose; Gallardo, Victor Jose; Gomez, Juan Bernardo; Macaya, Alfons; Pozo-Rosich, Patricia; Quintana, Manuel; Torres-Ferrus, Marta; Vila-Sala, Carme et al. DOI: 10.1177/0333102418777509
PMID: 29504482 Journal: CEPHALALGIA Year: 2018 Reference: Cephalalgia. 2018 Apr;38(5):815-832. doi: 10.1177/0333102418758283. Epub 2018 Mar 4. Impact factor: Publication type: Paper in international publication Authors: Ashina, Messoud; Becker, Werner J; Diener, Hans-Christoph; Dodick, David W; Ferrari, Michel D; Goadsby, Peter J; Lipton, Richard B; Pozo-Rosich, Patricia; Silberstein, Stephen D; Tassorelli, Cristina et al. DOI: 10.1177/0333102418758283
PMID: 29493566 Journal: Nature Reviews Disease Primers Year: 2018 Reference: Nat Rev Dis Primers. 2018 Mar 1;4:18006. doi: 10.1038/nrdp.2018.6. Impact factor: Publication type: Review in international publication Authors: Evers, Stefan; Magis, Delphine; May, Arne; Pozo-Rosich, Patricia; Schwedt, Todd J; Wang, Shuu-Jiun et al. DOI: 10.1038/nrdp.2018.6
PMID: 29339147 Journal: BIOLOGICAL PSYCHOLOGY Year: 2018 Reference: Biol Psychol. 2018 Feb;132:233-243. doi: 10.1016/j.biopsycho.2018.01.007. Epub 2018 Jan 12. Impact factor: Publication type: Paper in international publication Authors: Laine, Matti; Lehtonen, Minna; Rodriguez-Fornells, Antoni; Salmi, Juha; Soveri, Anna; Vila-Ballo, Adria et al. DOI: 10.1016/j.biopsycho.2018.01.007
PMID: 29171146 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2018 Reference: Eur J Neurol. 2018 Feb;25(2):411-416. doi: 10.1111/ene.13523. Epub 2017 Dec 18. Impact factor: Publication type: Paper in international publication Authors: Alvaro, Luis Carlos; Belvis, Roberto; Dominguez, Clara; Gago, Ana; Gallego, Mercedes; Garcia-Alhama, Jessica; Gonzalez-Oria, Carmen; Hernandez-Beltran, Natalia; Huerta, Mariano; Jurado-Cobo, Carmen et al. DOI: 10.1111/ene.13523
Two international studies led by Vall d'Hebron recommend early administration of specific drugs to prevent migraine to achieve a better response to therapy.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
The study, conducted in more than 770 people, concludes that atogepant reduces the frequency of migraine attacks and the need to take medication.
