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Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice.

PMID: 35602059
Journal: Frontiers in Microbiology
Year: 2022
Reference: Front Microbiol. 2022 May 4;13:840757. doi: 10.3389/fmicb.2022.840757. eCollection 2022.
Impact factor: 5.64
Publication type: Paper in international publication
Authors: Anton, Andres, Tarres-Freixas, Ferran, Trinite, Benjamin, Pons-Grifols, Anna, Romero-Durana, Miguel, Riveira-Munoz, Eva, Avila-Nieto, Carlos, Perez, Monica, Garcia-Vidal, Edurne, Perez-Zsolt, Daniel et al.
DOI: 10.3389/fmicb.2022.840757

Surveillance of influenza B severe hospitalized cases during ten seasons in Catalonia. Does the lineage make a difference?

PMID: 35593301
Journal: JOURNAL OF MEDICAL VIROLOGY
Year: 2022
Reference: J Med Virol. 2022 Sep;94(9):4417-4424. doi: 10.1002/jmv.27876. Epub 2022 Jun 4.
Impact factor: 2.327
Publication type: Paper in international publication
Authors: Torner, Nuria, Marcos, M Angeles, Mosquera, MMar, Anton, Andres, Andres, Cristina, Rius, Cristina, Pumarola, Tomas, Dominguez, Angela, Martinez, Ana, Basile, Luca et al.
DOI: 10.1002/jmv.27876

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

PMID: 35576468
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF
Year: 2022
Reference: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16.
Impact factor: 11.205
Publication type: Paper in international publication
Authors: Garcia-Prat, Marina, Manry, Jeremy, Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jeremie, Philippot, Quentin, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei et al.
DOI: 10.1073/pnas.2200413119

Empirical use of beta-lactam/beta-lactamase inhibitor combinations does not increase mortality compared with cloxacillin and cefazolin in methicillin-susceptible Staphylococcus aureus bacteraemia: a propensity-weighted cohort study.

PMID: 35552420
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2022
Reference: J Antimicrob Chemother. 2022 May 12. pii: 6584695. doi: 10.1093/jac/dkac152.
Impact factor: 5.79
Publication type: Paper in international publication
Authors: Pigrau, Carles, Almirante, Benito, Rodriguez-Pardo, Dolors, Gonzalez-Lopez, Juan J, Larrosa, Maria N, Fernandez-Hidalgo, Nuria, Willekens, Rein, Puig-Asensio, Mireia, Suanzes, Paula et al.
DOI: 10.1093/jac/dkac152

Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season.

PMID: 34193898
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Jun 30;11(1):13587. doi: 10.1038/s41598-021-92895-5.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Espejo, E, Barrabeig, I, Camps, N, Carol, M, Ferras, J, Ferrus, G, Follia, N, Bach, P, Minguell, S, Parron, I et al.
DOI: 10.1038/s41598-021-92895-5

One-quarter of chronic hepatitis D patients reach HDV-RNA decline or undetectability during the natural course of the disease.

PMID: 34181772
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2021
Reference: Aliment Pharmacol Ther. 2021 Aug;54(4):462-469. doi: 10.1111/apt.16485. Epub 2021 Jun 28.
Impact factor: 8.171
Publication type: Paper in international publication
Authors: Roade, Luisa, Palom, Adriana, Sopena, Sara, Riveiro-Barciela, Mar, Carvalho-Gomes, Angela, Madejon, Antonio, Rodriguez-Tajes, Sergio, Lens, Sabela, Berenguer-Hayme, Marina, Rodriguez-Frias, Francisco et al.
DOI: 10.1111/apt.16485

Circulation of multidrug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019.

PMID: 34157402
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2021
Reference: Int J Antimicrob Agents. 2021 Sep;58(3):106378. doi: 10.1016/j.ijantimicag.2021.106378. Epub 2021 Jun 23.
Impact factor: 5.283
Publication type: Paper in international publication
Authors: Moreno-Mingorance, Albert, Espinal, Paula, Rodriguez, Virginia, Goterris, Lidia, Fabrega, Anna, Serra-Pladevall, Judit, Barbera, M Jesus, Alberny, M, Martin-Gonzalez, Hector, Cornejo-Sanchez, Thais et al.
DOI: 10.1016/j.ijantimicag.2021.106378

Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study.

PMID: 34153457
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2021
Reference: Clin Microbiol Infect. 2021 Oct;27(10):1521.e1-1521.e5. doi: 10.1016/j.cmi.2021.06.016. Epub 2021 Jun 19.
Impact factor: 8.067
Publication type: Paper in international publication
Authors: Garcia-Ruiz, Itziar, Sulleiro, Elena, Serrano, Berta, Fernandez-Buhigas, Irene, Rodriguez-Gomez, Leire, Sanchez-Nieves, David, Anton-Pagarolas, Andres, Esperalba-Esquerra, Juliana, Frick, Marie Antoinette, Camba, Fatima et al.
DOI: 10.1016/j.cmi.2021.06.016

Clinical Features Associated with Strongyloidiasis in Migrants and the Potential Impact of Immunosuppression: A Case Control Study.

PMID: 32585975
Journal: Pathogens
Year: 2020
Reference: Pathogens. 2020 Jun 23;9(6). pii: pathogens9060507. doi: 10.3390/pathogens9060507.
Impact factor: 3.018
Publication type: Paper in international publication
Authors: Quinto, Llorenc, Munoz, Jose, Requena-Mendez, Ana, Strong-Semtsi Working Group, On Behalf Of The, Lozano-Serrano, Ana Belen, Llaberia-Marcual, Jaume, Pecorelli, Rosangela, Trevino, Begona, Soriano-Perez, Manuel Jesus, Salvador, Fernando et al.
DOI: 10.3390/pathogens9060507

Association between biomass formation and the prognosis of infective endocarditis due to Staphylococcus aureus.

PMID: 31806416
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Jun - Jul;38(6):263-266. doi: 10.1016/j.eimc.2019.10.008. Epub 2019 Dec 2.
Impact factor: 1.654
Publication type: Paper in national publication
Authors: Chaves, Fernando, Fernandez-Hidalgo, Nuria, Basas, Jana, Viedma, Ester, Ribera, Aida, Larrosa, Nieves, Perez-Montarelo, Dafne, Almirante, Benito, Gavalda, Joan et al.
DOI: 10.1016/j.eimc.2019.10.008

Conservation and variability of hepatitis B core at different chronic hepatitis stages.

PMID: 32523313
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: World J Gastroenterol. 2020 May 28;26(20):2584-2598. doi: 10.3748/wjg.v26.i20.2584.
Impact factor: 3.665
Publication type: Paper in international publication
Authors: Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Yll, Marcal, Cortese, Maria Francesca, Guerrero-Murillo, Mercedes, Orriols, Gerard, Gregori, Josep, Casillas, Rosario, Gonzalez, Carolina et al.
DOI: 10.3748/wjg.v26.i20.2584

Quantification of parasite burden of Trypanosoma cruzi and identification of Discrete Typing Units (DTUs) in blood samples of Latin American immigrants residing in Barcelona, Spain.

PMID: 32497037
Journal: PLoS Neglected Tropical Diseases
Year: 2020
Reference: PLoS Negl Trop Dis. 2020 Jun 4;14(6):e0008311. doi: 10.1371/journal.pntd.0008311. eCollection 2020 Jun.
Impact factor: 3.885
Publication type: Paper in international publication
Authors: Tavares de Oliveira, Maykon, Sulleiro, Elena, Silgado Gimenez, Aroa, de Lana, Marta, Zingales, Bianca, Santana da Silva, Joao, Marin-Neto, J Antonio, Molina, Israel et al.
DOI: 10.1371/journal.pntd.0008311

Treatment Outcomes and Adverse Events from a Standardized Multidrug-Resistant Tuberculosis Regimen in a Rural Setting in Angola.

PMID: 31333153
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2019
Reference: Am J Trop Med Hyg. 2019 Sep;101(3):502-509. doi: 10.4269/ajtmh.19-0175.
Impact factor: 2.315
Publication type: Paper in international publication
Authors: Bocanegra, Cristina, Olivas, Eva Gil, Eugenio, Arlete Nindia, Zacarias, Adriano, Katimba, Domingos, Gabriel, Estevao, Mendioroz, Jacobo, Lopez Garcia, Maria Teresa, Sune, Tomas Pumarola, Tortola Fernandez, Maria Teresa et al.
DOI: 10.4269/ajtmh.19-0175

Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing.

PMID: 31318908
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Jul 18;14(7):e0219701. doi: 10.1371/journal.pone.0219701. eCollection 2019.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Carratala, Jordi, Sabe, Nuria, Niubo, Jordi, Cervera, Carlos, Capon, Alicia, Cervilla, Anna, Santos, Marta, Bodro, Marta, Munoz, Patricia, Farinas, Maria Carmen et al.
DOI: 10.1371/journal.pone.0219701

Rapid Influenza Testing in Infants and Children Younger than 6 Years in Primary Care: Impact on Antibiotic Treatment and Use of Health Services.

PMID: 31310597
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2019
Reference: Pediatr Infect Dis J. 2019 Aug;38(8):e187-e189. doi: 10.1097/INF.0000000000002287.
Impact factor: 2.317
Publication type: Paper in international publication
Authors: van Esso, Diego L, Valente, Ana Marta, Vila, Monica, de Quixano, Marta, Rodrigo, Carlos, Anton, Andres, Pumarola, Tomas, Casanovas, Josep M et al.
DOI: 10.1097/INF.0000000000002287

Extensively drug-resistant Pseudomonas Aeruginosa outbreak in a burn unit: management and solutions.

PMID: 31285735
Journal: Annals of burns and fire disasters
Year: 2019
Reference: Ann Burns Fire Disasters. 2019 Mar 31;32(1):47-55.
Impact factor: 0
Publication type: Paper in international publication
Authors: Larrosa Escartin, N, Rodriguez Garrido, V, Armadans Gil, L, Sanchez Garcia, J M, Campins, M, Baena Caparros, J, Barret, J P, Andreu-Sola, V, Aguilera-Saez, J et al.
DOI:

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