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Microbiology

The Microbiology research group of the Vall d'Hebron Research Institute (VHIR) focuses on the study of microbiological aspects —in basic, translational and clinical research— that could improve the outcome of patients with infectious diseases.

Our priority research areas are:

  • Microbiological surveillance of emerging and re-emerging infectious diseases.
    • Diseases due to viral infections of the respiratory tract
    • Microorganisms that cause vaccine-preventable diseases
    • Infectious diseases of sexual transmission
  • Antimicrobial resistance
  • Sepsis
  • Development and validation of rapid microbiological diagnostic devices.
  • International Health
  • Hepatitis 

We actively collaborate with other microbiology laboratories, health services, national and international centres and organizations, as well as with the different research networks of the Carlos III Health Institute in Spain.

In addition, we carry out an important activity in the surveillance of the genotypic and phenotypic evolution of microorganisms present in the community in terms of their virulence, transmissibility, antigenic escape and antimicrobial resistance, in collaboration with public administrations, both at the national and international level.
 

Publications

Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab.

PMID: 34544604
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcli.2021.06.012. Epub 2021 Jun 18.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Espinosa-Pereiro, Juan, Fernandez-Hidalgo, Nuria, Perez-Hoyos, Santiago, Salvador, Fernando, Dura, Xavier, Miarons, Marta, Anton, Andres, Eremiev-Eremiev, Simeon, Sempere-Gonzalez, Abiu, Monforte-Pallares, Arnau et al.
DOI: 10.1016/j.medcli.2021.06.012

Evolution, geographic spreading, and demographic distribution of Enterovirus D68.

PMID: 35639811
Journal: PLoS Pathogens
Year: 2022
Reference: PLoS Pathog. 2022 May 31;18(5):e1010515. doi: 10.1371/journal.ppat.1010515. eCollection 2022 May.
Impact factor: 6.823
Publication type: Paper in international publication
Authors: Andres, Cristina, Egli, Adrian, Reist, Josiane, Garcia Martinez de Artola, Diego, Alcoba-Florez, Julia, Niesters, Hubert G M, Anton, Andres, Poelman, Randy, Reynders, Marijke, Wollants, Elke et al.
DOI: 10.1371/journal.ppat.1010515

Staphylococcus aureus surface protein G (sasG) allelic variants: correlation between biofilm formation and their prevalence in methicillin-resistant S. aureus (MRSA) clones.

PMID: 35091030
Journal: RESEARCH IN MICROBIOLOGY
Year: 2022
Reference: Res Microbiol. 2022 Mar-Apr;173(3):103921. doi: 10.1016/j.resmic.2022.103921. Epub 2022 Jan 26.
Impact factor: 3.992
Publication type: Paper in international publication
Authors: Fontanals, D, Loza, E, Rodriguez-Lopez, F, Olarte, I, Mirelis, B, Ruiz de Gopegui, E, Lepe, J A, Larrosa, N, Xercavins, M, Tapiol, J et al.
DOI: 10.1016/j.resmic.2022.103921

Association of HLA-B*35 and moderate or severe cutaneous reactions secondary to benznidazole treatment in chronic Chagas disease patients.

PMID: 34863919
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2022
Reference: Clin Microbiol Infect. 2022 Jun;28(6):881.e1-881.e5. doi: 10.1016/j.cmi.2021.11.021. Epub 2021 Dec 1.
Impact factor: 8.067
Publication type: Paper in international publication
Authors: Bosch-Nicolau, P, Salvador, F, Sanchez-Montalva, A, Franco-Jarava, C, Arrese-Munoz, I, Sulleiro, E, Roure, S, Valerio, Ll, Oliveira-Souto, I, Serre-Delcor, N et al.
DOI: 10.1016/j.cmi.2021.11.021

Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability.

PMID: 34342438
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Year: 2021
Reference: J Med Chem. 2021 Aug 12;64(15):11472-11482. doi: 10.1021/acs.jmedchem.1c00795. Epub 2021 Aug 3.
Impact factor: 7.446
Publication type: Paper in international publication
Authors: Sandin, Daniel, Valle, Javier, Chaves-Arquero, Belen, Prats-Ejarque, Guillem, Larrosa, Maria Nieves, Gonzalez-Lopez, Juan Jose, Jimenez, Maria Angeles, Boix, Ester, Andreu, David, Torrent, Marc et al.
DOI: 10.1021/acs.jmedchem.1c00795

Viral populations of SARS-CoV-2 in upper respiratory tract, placenta, amniotic fluid and umbilical cord blood support viral replication in placenta.

PMID: 34260951
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2021
Reference: Clin Microbiol Infect. 2021 Oct;27(10):1542-1544. doi: 10.1016/j.cmi.2021.07.008. Epub 2021 Jul 11.
Impact factor: 8.067
Publication type: Letter or abstract
Authors: Pinana, Maria, Abril, Josep F, Andres, Cristina, Silgado, Aroa, Navarro, Alexandra, Suy, Anna, Sulleiro, Elena, Pumarola, Tomas, Quer, Josep, Anton, Andres et al.
DOI: 10.1016/j.cmi.2021.07.008

Invasive pneumococcal disease in children under 60 months before and after availability of 13-valent conjugate vaccine.

PMID: 34238710
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Jul 6. pii: S2341-2879(21)00113-7. doi: 10.1016/j.anpede.2021.06.005.
Impact factor: 1.5
Publication type: Paper in national publication
Authors: de Sevilla, Mariona F, Munoz-Almagro, Carmen, Dominguez, Angela, Salleras, Luis, Ciruela, Pilar, Martinez-Osorio, Johanna, Garcia-Garcia, Juan Jose, Diaz, Alvaro, Hernandez, Sergi, Sole-Ribalta, Anna et al.
DOI: 10.1016/j.anpede.2021.06.005

[Invasive pneumococcal disease in children under 60 months before and after availability of 13-valent conjugate vaccine].

PMID: 34217675
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Jun 30. pii: S1695-4033(21)00206-X. doi: 10.1016/j.anpedi.2021.05.018.
Impact factor: 1.5
Publication type: Paper in national publication
Authors: Planes, Ana Maria, Martinez-Osorio, Johanna, Garcia-Garcia, Juan Jose, Moraga-Llop, Fernando, Diaz, Alvaro, Hernandez, Sergi, Sole-Ribalta, Anna, Gonzalez-Peris, Sebastia, Izquierdo, Conchita, Esteva, Cristina et al.
DOI: 10.1016/j.anpedi.2021.05.018

A European multi-centre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts.

PMID: 31883139
Journal: JOURNAL OF MEDICAL VIROLOGY
Year: 2020
Reference: J Med Virol. 2020 Aug;92(8):1065-1074. doi: 10.1002/jmv.25659. Epub 2020 Jan 17.
Impact factor: 2.021
Publication type: Paper in international publication
Authors: Hayes, A, Nguyen, D, Andersson, M, Anton, A, Bailly, J-L, Beard, S, Benschop, K S M, Berginc, N, Blomqvist, S, Cunningham, E et al.
DOI: 10.1002/jmv.25659

Comparative evaluation of community interventions for the immigrant population of Latin American origin at risk for Chagas disease in the city of Barcelona.

PMID: 32663211
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Jul 14;15(7):e0235466. doi: 10.1371/journal.pone.0235466. eCollection 2020.
Impact factor: 2.74
Publication type: Paper in international publication
Authors: de Los Santos, Juan Jose, Gomez I Prat, Jordi, Peremiquel-Trillas, Paula, Claveria Guiu, Isabel, Caro Mendivelso, Johanna, Choque, Estefa, Albajar Vinas, Pedro, Ascaso Terren, Carlos, Ouaarab Essadek, Hakima, Sulleiro, Elena et al.
DOI: 10.1371/journal.pone.0235466

Fetal Transient Skin Edema in Two Pregnant Women With Coronavirus Disease 2019 (COVID-19).

PMID: 32649505
Journal: OBSTETRICS AND GYNECOLOGY
Year: 2020
Reference: Obstet Gynecol. 2020 Nov;136(5):1016-1020. doi: 10.1097/AOG.0000000000004059.
Impact factor: 5.524
Publication type: Paper in international publication
Authors: Garcia-Manau, Pablo, Garcia-Ruiz, Itziar, Rodo, Carlota, Sulleiro, Elena, Maiz, Nerea, Catalan, Marina, Fernandez-Hidalgo, Nuria, Balcells, Joan, Anton, Andres, Carreras, Elena et al.
DOI: 10.1097/AOG.0000000000004059

Asymptomatic SARS-CoV-2 Infection in Nursing Homes, Barcelona, Spain, April 2020.

PMID: 32574139
Journal: EMERGING INFECTIOUS DISEASES
Year: 2020
Reference: Emerg Infect Dis. 2020 Sep;26(9). doi: 10.3201/eid2609.202603. Epub 2020 Jun 23.
Impact factor: 6.259
Publication type: Paper in international publication
Authors: Abadias, Maria Jose, Roman, Antonio, Pumarola, Tomas, Campins, Magda, Almirante, Benito, Selvi, Marta, Martin, Elisabet, Anton, Andres, Esperalba, Juliana, Borras-Bermejo, Blanca et al.
DOI: 10.3201/eid2609.202603

Usefulness of FDG PET/CT in the management of tuberculosis.

PMID: 31454368
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Aug 27;14(8):e0221516. doi: 10.1371/journal.pone.0221516. eCollection 2019.
Impact factor: 2.776
Publication type: Paper in international publication
Authors: Sanchez-Montalva, Adrian, Barios, Marta, Salvador, Fernando, Villar, Ana, Tortola, Teresa, Molina-Morant, Daniel, Lorenzo-Bosquet, Carles, Espinosa-Pereiro, Juan, Molina, Israel et al.
DOI: 10.1371/journal.pone.0221516

The high genetic similarity between rhinoviruses and enteroviruses remains as a pitfall for molecular diagnostic tools: A three-year overview.

PMID: 31401308
Journal: INFECTION GENETICS AND EVOLUTION
Year: 2019
Reference: Infect Genet Evol. 2019 Nov;75:103996. doi: 10.1016/j.meegid.2019.103996. Epub 2019 Aug 8.
Impact factor: 2.611
Publication type: Paper in international publication
Authors: Vila, Jorgina, Esperalba, Juliana, Trejo-Zahinos, Jesus, Codina, Maria Gema, Martin, Maria Carmen, Fuentes, Francisco, Rubio, Susana, Pumarola, Tomas, Anton, Andres, Pinana, Maria et al.
DOI: 10.1016/j.meegid.2019.103996

Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.

PMID: 31382453
Journal: Vaccines
Year: 2019
Reference: Vaccines (Basel). 2019 Aug 2;7(3). pii: vaccines7030078. doi: 10.3390/vaccines7030078.
Impact factor: 4.76
Publication type: Paper in international publication
Authors: Joseph, Joan, Brander, Christian, Hanke, Tomas, Kilpelainen, Athina, Saubi, Narcis, Guitart, Nuria, Olvera, Alex et al.
DOI: 10.3390/vaccines7030078

Role of Nucleic Acid Amplification assays in monitoring treatment response in Chagas disease: Usefulness in clinical trials.

PMID: 31376368
Journal: ACTA TROPICA
Year: 2019
Reference: Acta Trop. 2019 Nov;199:105120. doi: 10.1016/j.actatropica.2019.105120. Epub 2019 Jul 31.
Impact factor: 2.629
Publication type: Review in international publication
Authors: Sulleiro, Elena, Munoz-Calderon, Arturo, Schijman, Alejandro G et al.
DOI: 10.1016/j.actatropica.2019.105120

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The new diagnostic method, designed for use in endemic regions, combines a mobile application with a low-cost robotic microscope.