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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Loss of humoral response 3 months after SARS-CoV-2 vaccination in the CKD spectrum: the multicentric SENCOVAC study.

PMID: 35022757
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Apr 25;37(5):994-999. doi: 10.1093/ndt/gfac007.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Adriana Restrepo; Agraz, Irene; Aguilera, Esther Torres; Alarcon, Walter Lopez; Alea, Rolando Tello; Alexandru, Simona; Alfaro, Georgina; Alonso, Fernanda Arroyo; Alonso, Juan Carlos; Alonso, Pablo Otero et al.
DOI: 10.1093/ndt/gfac007

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells.

PMID: 35025963
Journal: PLoS Pathogens
Year: 2022
Reference: PLoS Pathog. 2022 Jan 13;18(1):e1010171. doi: 10.1371/journal.ppat.1010171. eCollection 2022 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Alcami, Jose; Blanco, Julia; Buzon, Maria J; Falco, Vicenc; Garcia-Perez, Javier; Genesca, Meritxell; Grau-Exposito, Judith; Massana, Nuria; Perea, David; Rosado, Joel et al.
DOI: 10.1371/journal.ppat.1010171

Disarming the Old Foe. Restoring T-Cell Immune Function with mTor-Inhibitors to Tackle Cytomegalovirus Infection.

PMID: 34969818
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2022
Reference: J Am Soc Nephrol. 2022 Jan;33(1):6-8. doi: 10.1681/ASN.2021111471.
Impact factor:
Publication type: Editorail in international publication
Authors: Bestard, Oriol; Crespo, Elena et al.
DOI: 10.1681/ASN.2021111471

Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus.

PMID: 36614945
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Dec 24;12(1):145. doi: 10.3390/jcm12010145.
Impact factor:
Publication type: Paper in international publication
Authors: Carretero-Gomez, Juana; Castro, Almudena; Cebrian-Cuenca, Ana; de Torres-Sanchez, Alejandra; Garcia-de-Lucas, Maria Dolores; Gorgojo-Martinez, Juan J; Gorriz, Jose Luis; Mezquita-Raya, Pedro; Nunez, Julio; Obaya, Juan Carlos et al.
DOI: 10.3390/jcm12010145

Endothelial ADAM17 Expression in the Progression of Kidney Injury in an Obese Mouse Model of Pre-Diabetes.

PMID: 35008648
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Dec 25;23(1). pii: ijms23010221. doi: 10.3390/ijms23010221.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Palau, Vanesa, Jarrin, Josue, Villanueva, Sofia, Benito, David, Marquez, Eva, Rodriguez, Eva, Soler, Maria Jose, Oliveras, Anna, Gimeno, Javier, Sans, Laia et al.
DOI: 10.3390/ijms23010221

Funding kidney research as a public health priority: challenges and opportunities.

PMID: 32888017
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Dec 31;37(1):21-28. doi: 10.1093/ndt/gfaa163.
Impact factor: 5.992
Publication type: Review in international publication
Authors: Zoccali, Carmine, Vanholder, Raymond, Wagner, Carsten A, Anders, Hans-Joachim, Blankestijn, Peter J, Bruchfeld, Annette, Capasso, Giovambattista, Cozzolino, Mario, Dekker, Friedo W, Fliser, Danilo et al.
DOI: 10.1093/ndt/gfaa163

Corrigendum to "Transjugular Kidney Biopsy as a Safe Method to Increase the Etiological Diagnosis in Kidney Disease" Kidney Int. Rep. 2021;6:2535-2536.

PMID: 34901580
Journal: Kidney International Reports
Year: 2021
Reference: Kidney Int Rep. 2021 Oct 20;6(12):3095. doi: 10.1016/j.ekir.2021.10.013. eCollection 2021 Dec.
Impact factor: 4.164
Publication type: Letter or abstract
Authors: Cardona, Monica Bolufer, Soler, Maria Jose, McMahon, Gearoid M et al.
DOI: 10.1016/j.ekir.2021.10.013

Redefining the Role of ADAM17 in Renal Proximal Tubular Cells and Its Implications in an Obese Mouse Model of Pre-Diabetes.

PMID: 34884897
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Dec 3;22(23). pii: ijms222313093. doi: 10.3390/ijms222313093.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Palau, Vanesa, Villanueva, Sofia, Jarrin, Josue, Benito, David, Marquez, Eva, Rodriguez, Eva, Soler, Maria Jose, Oliveras, Anna, Gimeno, Javier, Sans, Laia et al.
DOI: 10.3390/ijms222313093

GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists.

PMID: 32235471
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Mar 30;9(4). pii: jcm9040947. doi: 10.3390/jcm9040947.
Impact factor: 3.303
Publication type: Review in international publication
Authors: Navarro-Gonzalez, Juan F, Gorriz, Jose Luis, Soler, Maria Jose, D'Marco, Luis, Martinez Castelao, Alberto, Fernandez-Fernandez, Beatriz, Ortiz, Alberto, Gorriz-Zambrano, Carmen, Navarro-Perez, Jorge, Gorgojo-Martinez, Juan Jose et al.
DOI: 10.3390/jcm9040947

Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19.

PMID: 32220930
Journal: Clinical Journal of the American Society of Nephrology
Year: 2020
Reference: Clin J Am Soc Nephrol. 2020 May 7;15(5):714-716. doi: 10.2215/CJN.03530320. Epub 2020 Mar 27.
Impact factor: 6.628
Publication type: Paper in international publication
Authors: Swaminathan, Sundar, Sparks, Matthew A, South, Andrew, Welling, Paul, Luther, J Matt, Cohen, Jordana, Byrd, James Brian, Burrell, Louise M, Batlle, Daniel, Tomlinson, Laurie et al.
DOI: 10.2215/CJN.03530320

Transcriptome Analysis in Renal Transplant Biopsies Not Fulfilling Rejection Criteria.

PMID: 32213927
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Mar 24;21(6). pii: ijms21062245. doi: 10.3390/ijms21062245.
Impact factor: 4.556
Publication type: Review in international publication
Authors: Moreso, Francesc, Sellares, Joana, Soler, Maria Jose, Seron, Daniel et al.
DOI: 10.3390/ijms21062245

SGLT2i and postglomerular vasodilation.

PMID: 32200864
Journal: KIDNEY INTERNATIONAL
Year: 2020
Reference: Kidney Int. 2020 Apr;97(4):805-806. doi: 10.1016/j.kint.2020.01.007.
Impact factor: 8.945
Publication type: Letter or abstract
Authors: Soler, Maria Jose, Porrini, Esteban, Fernandez-Fernandez, Beatriz, Ortiz, Alberto et al.
DOI: 10.1016/j.kint.2020.01.007

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.