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Rheumatology

The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.

At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.

Publications

Multidisciplinary models for pregnancy care in patients with rheumatic diseases: Clinical experiences and experts opinion.

PMID: 35156620
Journal: European journal of rheumatology
Year: 2022
Reference: Eur J Rheumatol. 2022 Oct;9(4):191-196. doi: 10.5152/eujrheum.2022.20012.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Laia; Baniandres, Ofelia; Caliz, Rafael; Casellas, Manel; Grados, Dolors; Martinez Lopez, Juan Antonio; Pego Reigosa, Jose Maria; Perez, Erika Padron; Pluma, Andrea; Polo, Ana et al.
DOI: 10.5152/eujrheum.2022.20012

What can we learn from DNA methylation studies in lupus?

PMID: 34973429
Journal: CLINICAL IMMUNOLOGY
Year: 2022
Reference: Clin Immunol. 2022 Jan;234:108920. doi: 10.1016/j.clim.2021.108920. Epub 2021 Dec 29.
Impact factor:
Publication type: Review in international publication
Authors: Ballestar, Esteban; Cortes-Hernandez, Josefina; Ferrete-Bonastre, Anna Guiomar et al.
DOI: 10.1016/j.clim.2021.108920

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.

PMID: 34861974
Journal: Biological Psychiatry
Year: 2022
Reference: Biol Psychiatry. 2022 Feb 1;91(3):313-327. doi: 10.1016/j.biopsych.2021.05.029. Epub 2021 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Abdellaoui, Abdel; Abramova, Liliya; Adams, Mark; Adams, Mark J; Adan, Roger A H; Adolfsson, Rolf; Adolfsson, Rolf; Adorjan, Kristina; Agartz, Ingrid; Agartz, Ingrid et al.
DOI: 10.1016/j.biopsych.2021.05.029

Characterising the axial phenotype of psoriatic arthritis: a study comparing axial psoriatic arthritis and ankylosing spondylitis with psoriasis from the REGISPONSER registry.

PMID: 36597989
Journal: RMD Open
Year: 2022
Reference: RMD Open. 2022 Dec;8(2):e002513. doi: 10.1136/rmdopen-2022-002513.
Impact factor:
Publication type: Paper in international publication
Authors: Collantes, Eduardo; Erra, Alba; Font-Ugalde, Pilar; Juanola, Xavier; Lopez-Medina, Clementina; Marzo-Ortega, Helena; Michelena, Xabier et al.
DOI: 10.1136/rmdopen-2022-002513

Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients.

PMID: 33603102
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Feb 18;11(1):4215. doi: 10.1038/s41598-021-83762-4.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Carioti, Luca; Casillas, Rosario; Cortese, Maria Francesca; Esteban-Mur, Rafael; Garcia-Garcia, Selene; Godoy, Cristina; Gonzalez, Carolina; Gregori, Josep; Guerrero-Murillo, Mercedes et al.
DOI: 10.1038/s41598-021-83762-4

Are Circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

PMID: 33353469
Journal: ANTIOXIDANTS & REDOX SIGNALING
Year: 2021
Reference: Antioxid Redox Signal. 2021 Jun 20;34(18):1420-1427. doi: 10.1089/ars.2020.8230. Epub 2021 Feb 11.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Martin, Jose; Castro-Marrero, Jesus; Cordobilla, Begona; Domingo, Joan Carles; Ferrer, Roser; Giralt, Marina et al.
DOI: 10.1089/ars.2020.8230

Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients.

PMID: 33217613
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2021
Reference: J Allergy Clin Immunol Pract. 2021 Feb;9(2):803-818.e11. doi: 10.1016/j.jaip.2020.11.007. Epub 2020 Nov 18.
Impact factor:
Publication type: Paper in international publication
Authors: Bader-Meunier, Brigitte; Barnabei, Laura; Belot, Alexandre; Berteloot, Laureline; Blanche, Stephane; Bondet, Vincent; Bresson, Violaine; Breton, Sylvain; Brocq, Olivier; Chan, Damien et al.
DOI: 10.1016/j.jaip.2020.11.007

Performance of the 2019 ACR/EULAR classification criteria for IgG4-related disease and clinical phenotypes in a Spanish multicentre registry (REERIGG4).

PMID: 32658963
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Jan 5;60(1):217-223. doi: 10.1093/rheumatology/keaa247.
Impact factor:
Publication type: Paper in international publication
Authors: Carballo, Iago; de Miguel-Campo, Borja; Feijoo-Masso, Carlos; Fernandez-Codina, Andreu; Fonseca-Aizpuru, Eva; Hernandez-Rodriguez, Jose; Lopez-Dupla, Miguel; Martinez-Valle, Fernando; Pinal-Fernandez, Iago; Pinilla, Blanca et al.
DOI: 10.1093/rheumatology/keaa247

Influence of MUC5B gene on antisynthetase syndrome.

PMID: 31996780
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Jan 29;10(1):1415. doi: 10.1038/s41598-020-58400-0.
Impact factor:
Publication type: Paper in international publication
Authors: Balsa, Alejandro; Bonilla, Gema; Calvo-Alen, Jaime; Castaneda, Santos; Cavagna, Lorenzo; Cifrian, Jose M; Cuesta, Victor M Mora; Fernandez, David Iturbe; Gafas, Alicia De Pablo; Genre, Fernanda et al.
DOI: 10.1038/s41598-020-58400-0

Efficacy of a Multicomponent Intervention for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): Study Protocol of a Randomized Controlled Trial.

PMID: 31963773
Journal: International Journal of Environmental Research and Public Health
Year: 2020
Reference: Int J Environ Res Public Health. 2020 Jan 19;17(2). pii: ijerph17020634. doi: 10.3390/ijerph17020634.
Impact factor:
Publication type: Paper in international publication
Authors: Almirall, Miriam; Feliu-Soler, Albert; Fontcuberta, Anna; Garcia-Troiteiro, Elna; Luciano, Juan V; Mateo-Canedo, Corel; Mendez-Ulrich, Jorge Luis; Sanabria-Mazo, Juan P; Sanz, Antoni; Serrat, Mayte et al.
DOI: 10.3390/ijerph17020634

Emerging PD-1 and PD-1L inhibitors-associated myopathy with a characteristic histopathological pattern.

PMID: 31838162
Journal: AUTOIMMUNITY REVIEWS
Year: 2020
Reference: Autoimmun Rev. 2020 Feb;19(2):102455. doi: 10.1016/j.autrev.2019.102455. Epub 2019 Dec 12.
Impact factor:
Publication type: Review in international publication
Authors: Antoniol, Maria Noelia; Cabrera, Carlos; Castrejon, Natalia; Grau, Josep Maria; Matas-Garcia, Ana; Milisenda, Jose C; Padrosa, Joan; Prieto-Gonzalez, Sergio; Reguart, Noemi; Ros, Javier et al.
DOI: 10.1016/j.autrev.2019.102455

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis.

PMID: 31906988
Journal: Journal of Translational Medicine
Year: 2020
Reference: J Transl Med. 2020 Jan 6;18(1):4. doi: 10.1186/s12967-019-02184-z.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre, Jose; Capdevila, Lluis; Castro, Juan Ramos; Castro-Marrero, Jesus; Escorihuela, Rosa Maria; Maurel, Sara; Zaragoza, Maria Cleofe et al.
DOI: 10.1186/s12967-019-02184-z

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News

Funded by the European Union, this project coordinated by the Vall d'Hebron Research Institute (VHIR) seeks to develop more effective therapies by creating new combinations of existing drugs

The head of the Rheumatology Service at Vall d'Hebron University Hospital and of the Rheumatology research group at VHIR is a highly accomplished rheumatologist with a distinguished career in the field.

It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.