Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
The role of MNK kinases in cellular stress resistance.
The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Projects

New therapeutic approaches in head and neck cancer

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Jordi Temprana Salvador, Angel García Jiménez, Josep Castellví Vives, Laia Josa Culleré, Marina Bataller Fernández
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI20/00556
Duration: 01/01/2021 - 30/06/2025

Implicaction of proteins associated with vascular beta-amyloid in Cerebral Amyloid Angiopathy

IP: Maria Mar Hernandez Guillamon
Collaborators: Jessica Camacho Soriano, Olga Maisterra Santos, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI20/00465
Duration: 01/01/2021 - 30/06/2025

Protuberancias intercelulares reguladas por Cx43 en cáncer: elucidación funcional, descubrimiento de objetivos, desarrollo de biomarcadores y detección de tumores

IP: Trond Aasen
Collaborators: Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino, Irene Sansano Valero, Stefan Hummer
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI21/00470
Duration: 01/01/2022 - 30/06/2026

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Lorena Valero Arrese, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 30/06/2026

Publications

[SEAP-IAP recommendations for the collection, storage and use of biological materials of human origin and related data intended for research. Generic biobank consideration and ethical-legal review (Part II)].

PMID: 39393892
Journal:
Year: 2024
Reference: Rev Esp Patol. 2024 Oct-Dec;57(4):250-257. doi: 10.1016/j.patol.2024.04.005. Epub 2024 Jul 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre Anda, Jose Javier; Alfaro-Cervello, Clara; Alvarez Alegret, Ramiro; Aso Manso, Sonsoles; Azua Romeo, Javier; Bejar Valera, Javier; Centeno Haro, Macarena; Chappuis de Oliveira, Cesar; Dinares Fernandez, Carme; Fernandez Figueras, Maite et al.
DOI: 10.1016/j.patol.2024.04.005

Neuropilin-1 as a Key Molecule for Renal Recovery in Lupus Nephritis: Insights from an NZB/W F1 Mouse Model.

PMID: 39518917
Journal:
Year: 2024
Reference: Int J Mol Sci. 2024 Oct 22;25(21):11364. doi: 10.3390/ijms252111364.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes-Hernandez, Josefina; Gabaldon, Alejandra; Joseph-Mullol, Blanca; Moline, Teresa; Royo, Maria; Sandoval, Sebastian; Sole, Cristina et al.
DOI: 10.3390/ijms252111364

Effectiveness of trichloroacetic acid versus electrocautery for the treatment of anal high-grade squamous intraepithelial lesions in persons with HIV.

PMID: 38217494
Journal:
Year: 2024
Reference: Infect Dis (Lond). 2024 Jan 13:1-9. doi: 10.1080/23744235.2024.2303021.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Joaquin; Curran, Adria; Falco, Vicenc; Garcia, Jorge; Hernandez-Losa, Javier; Landolfi, Stefania; Navarro, Jordi; Suanzes, Paula et al.
DOI: 10.1080/23744235.2024.2303021

Effectiveness and Safety of Trabectedin and Radiotherapy for Patients With Myxoid Liposarcoma: A Nonrandomized Clinical Trial.

PMID: 36995731
Journal: JAMA Oncology
Year: 2023
Reference: JAMA Oncol. 2023 May 1;9(5):656-663. doi: 10.1001/jamaoncol.2023.0056.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Rosa; Blay, Jean-Yves; Casali, Paolo G; Cruz Jurado, Josefina; Dei Tos, Angelo P; Fabbroni, Chiara; Gronchi, Alessandro; Gutierrez, Antonio; Hindi, Nadia; Italiano, Antoine et al.
DOI: 10.1001/jamaoncol.2023.0056

Nutritional status associates with immunotherapy clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma patients.

PMID: 36989964
Journal: ORAL ONCOLOGY
Year: 2023
Reference: Oral Oncol. 2023 May;140:106364. doi: 10.1016/j.oraloncology.2023.106364. Epub 2023 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Aguilar, Susana; Alberola, Margarita; Alberola, Margarita; Assaf Pastrana, Juan David; Assaf Pastrana, Juan David; Benavente, Sergi; Bescos, Coro; Brana, Irene; Dienstmann, Rodrigo et al.
DOI: 10.1016/j.oraloncology.2023.106364

Impact of the COVID-19 pandemic in the early-onset colorectal cancer.

PMID: 37031602
Journal: Translational Oncology
Year: 2023
Reference: Transl Oncol. 2023 Jun;32:101668. doi: 10.1016/j.tranon.2023.101668. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Baraibar, Iosune; Capdevila, Jaume; Castells, Marta R; Castillo, Gloria; Comas, Raquel; Comas, Raquel; Dopazo, Cristina; Elez, Elena; Espin, Eloy; Garcia, Ariadna et al.
DOI: 10.1016/j.tranon.2023.101668

[Rapidly progressive intracranial large artery aterosclerosis, a rare stroke etiology].

PMID: 37046396
Journal: REVISTA DE NEUROLOGIA
Year: 2023
Reference: Rev Neurol. 2023 Apr 16;76(8):273-275. doi: 10.33588/rn.7608.2022328.
Impact factor:
Publication type: Letter or abstract
Authors: Anton-Jimenez, A; Martinez-Saez, E; Rovira, A; Sarria-Estrada, S; Tortajada-Bustelo, J C; Tortajada-Bustelo, J C et al.
DOI: 10.33588/rn.7608.2022328

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.

PMID: 35841910
Journal: LANCET NEUROLOGY
Year: 2022
Reference: Lancet Neurol. 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Shahi Salman, Rustam; Albucher, Jean Francois; Banerjee, Gargi; Barbato, Carmen; Baron, Jean-Claude; Bonneville, Fabrice; Boulouis, Gregoire; Brandner, Sebastian; Calviere, Lionel; Caparros, Francois et al.
DOI: 10.1016/S1474-4422(22)00208-3

Secondary organising pneumonia to persistent SARS-CoV-2 infection in immunocompromised patient.

PMID: 35786522
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Oct 14;159(7):349. doi: 10.1016/j.medcli.2022.04.008. Epub 2022 Jun 10.
Impact factor:
Publication type: Letter or abstract
Authors: Granados, Galo David; Sansano, Irene; Villar, Ana et al.
DOI: 10.1016/j.medcli.2022.04.008

Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.

PMID: 35762039
Journal: JOURNAL OF CELLULAR PHYSIOLOGY
Year: 2022
Reference: J Cell Physiol. 2022 Sep;237(9):3598-3613. doi: 10.1002/jcp.30818. Epub 2022 Jun 27.
Impact factor:
Publication type: Paper in international publication
Authors: Brianso-Llort, Laura; Fuertes-Rioja, Lidia; Hernandez, Cristina; Ramos-Perez, Lorena; Salcedo-Allende, Maria Teresa; Selva, David M; Simo, Rafael et al.
DOI: 10.1002/jcp.30818

Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.

PMID: 35739348
Journal: Clinical & Translational Oncology
Year: 2022
Reference: Clin Transl Oncol. 2022 Jun 23. pii: 10.1007/s12094-022-02856-1. doi: 10.1007/s12094-022-02856-1.
Impact factor:
Publication type: Paper in international publication
Authors: Alberola-Ferranti, Margarita; Brana-Garcia, Irene; Castillo, Paola; Garcia-Castano, Almudena; Garcia-Cosio, Monica; Goma, Montserrat; Mesia-Nin, Ricard; Ruiz-Bravo, Elena; Soria-Rivas, Ainara; Trigo, Jose et al.
DOI: 10.1007/s12094-022-02856-1

Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.

PMID: 34359597
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Jul 23;13(15). pii: cancers13153696. doi: 10.3390/cancers13153696.
Impact factor:
Publication type: Review in international publication
Authors: Alberola Ferranti, Margarita; Bescos Atin, Coro; Bossi, Paolo; Brana Garcia, Irene; de Pablo Garcia-Cuenca, Alba; Lorini, Luigi; Muller-Richter, Urs; Nuciforo, Paolo; Pamias Romero, Jorge; Saez Barba, Manel et al.
DOI: 10.3390/cancers13153696

Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study.

PMID: 34329836
Journal: PATHOLOGY RESEARCH AND PRACTICE
Year: 2021
Reference: Pathol Res Pract. 2021 Sep;225:153562. doi: 10.1016/j.prp.2021.153562. Epub 2021 Jul 22.
Impact factor:
Publication type: Paper in international publication
Authors: Arana, Estanislao; Cruz, Julia; di Bernardo, Andrea; Elisabetta, Armiraglio; Ferrari, Cristina; Gambarotti, Marco; Garcia Del Muro, Francisco Javier; Garcia, Jose Antonio Narvaez; Giner, Francisco; Gomez-Mateo, M Carmen et al.
DOI: 10.1016/j.prp.2021.153562

Acute interstitial nephritis associated with immune checkpoint inhibitors: a single-centre experience.

PMID: 34221369
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Feb 10;14(5):1364-1370. doi: 10.1093/ckj/sfaa008. eCollection 2021 May.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Bolufer, Monica; Bury, Roxana; Espinel, Eugenia; Felip, Enriqueta; Gabaldon, Alejandra; Garcia-Carro, Clara; Munoz, Eva; Oleas, Diana; Seron, Daniel et al.
DOI: 10.1093/ckj/sfaa008

GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma.

PMID: 34212338
Journal: Clinical & Translational Oncology
Year: 2021
Reference: Clin Transl Oncol. 2021 Dec;23(12):2460-2473. doi: 10.1007/s12094-021-02654-1. Epub 2021 Jul 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bernabeu, D; Bernabeu, D; Gallego, S; Gallego, S; Garrido-Pontnou, M; Guillen, G; Hindi, N; Hindi, N; Juan-Ribelles, A; Juan-Ribelles, A et al.
DOI: 10.1007/s12094-021-02654-1

Lung cancer biomarker testing: perspective from Europe.

PMID: 32676354
Journal: Translational Lung Cancer Research
Year: 2020
Reference: Transl Lung Cancer Res. 2020 Jun;9(3):887-897. doi: 10.21037/tlcr.2020.04.07.
Impact factor:
Publication type: Review in international publication
Authors: Anttila, Sisko; Brcic, Luka; Calabrese, Fiorella; Carvallo, Lina; Dale, Vibeke G; Eri, Zivka; Haragan, Alex; Hofman, Paul; Kern, Izidor; Leonte, Diana et al.
DOI: 10.21037/tlcr.2020.04.07

Topographical distribution of microscopic colitis and the importance of orientation of paraffin embedded biopsies.

PMID: 32673680
Journal: HUMAN PATHOLOGY
Year: 2020
Reference: Hum Pathol. 2020 Sep;103:63-71. doi: 10.1016/j.humpath.2020.07.011. Epub 2020 Jul 13.
Impact factor:
Publication type: Paper in international publication
Authors: Goudkade, Danny; Heiberg Engel, Peter Johan; Kanstrup Fiehn, Anne-Marie; Landolfi, Stefania; Lanzarotto, Francesco; Munck, Lars Kristian; Villanacci, Vincenzo et al.
DOI: 10.1016/j.humpath.2020.07.011

Utility of transjugular renal biopsy as an alternative to percutaneous biopsy.

PMID: 32660793
Journal: NEFROLOGIA
Year: 2020
Reference: Nefrologia. 2020 Nov - Dec;40(6):634-639. doi: 10.1016/j.nefro.2020.04.018. Epub 2020 Jul 11.
Impact factor:
Publication type: Paper in national publication
Authors: Agraz, Irene; Arredondo, Karla; Azancot, Maria A; Azancot, Maria A; Bolufer, Monica; Bury, Roxana; Diez Miranda, Iratxe; Espinel, Eugenia; Gabaldon, Alejandra; Garcia-Carro, Clara et al.
DOI: 10.1016/j.nefro.2020.04.018

Efficacy of Thalidomide in Discoid Lupus Erythematosus: Insights into the Molecular Mechanisms.

PMID: 32659758
Journal: DERMATOLOGY
Year: 2020
Reference: Dermatology. 2020;236(5):467-476. doi: 10.1159/000508672. Epub 2020 Jul 13.
Impact factor:
Publication type: Review in international publication
Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina et al.
DOI: 10.1159/000508672

Impact of delayed and prolonged fixation on the evaluation of immunohistochemical staining on lung carcinoma resection specimen.

PMID: 31264038
Journal: VIRCHOWS ARCHIV
Year: 2019
Reference: Virchows Arch. 2019 Aug;475(2):191-199. doi: 10.1007/s00428-019-02595-9. Epub 2019 Jul 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bendek, Matyas; Brcic, Iva; Brcic, Luka; Geiger, Thomas; Gonzales, Atilio Navarro; Kammler, Rosita; Korkmaz, H Ibrahim; Lissenberg-Witte, Birgit; Sansano, Irene; Stahel, Rolf et al.
DOI: 10.1007/s00428-019-02595-9

Optimization of Transbronchial Cryobiopsy in Lung Transplant Recipients.

PMID: 31229481
Journal: ANNALS OF THORACIC SURGERY
Year: 2019
Reference: Ann Thorac Surg. 2019 Oct;108(4):1052-1058. doi: 10.1016/j.athoracsur.2019.04.096. Epub 2019 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Antonio; Berastegui, Cristina; Culebras, Mario; de Gracia, Javier; Loor, Karina; Loor, Karina; Sansano, Irene et al.
DOI: 10.1016/j.athoracsur.2019.04.096

Salvage surgery after definitive chemo-radiotherapy for patients with Non-Small Cell Lung Cancer.

PMID: 31200817
Journal: LUNG CANCER
Year: 2019
Reference: Lung Cancer. 2019 Jul;133:117-122. doi: 10.1016/j.lungcan.2019.05.010. Epub 2019 May 13.
Impact factor:
Publication type: Paper in international publication
Authors: Maestre-Alcacer, Jose Antonio; Moya-Horno, Irene; Ramon Y Cajal, Santiago; Romero-Vielva, Laura; Rosell, Rafael; Toscas, Jose Ignacio; Viteri, Santiago et al.
DOI: 10.1016/j.lungcan.2019.05.010

Analysis of the PD-1/PD-L1 axis in human autoimmune thyroid disease: Insights into pathogenesis and clues to immunotherapy associated thyroid autoimmunity.

PMID: 31182340
Journal: JOURNAL OF AUTOIMMUNITY
Year: 2019
Reference: J Autoimmun. 2019 Sep;103:102285. doi: 10.1016/j.jaut.2019.05.013. Epub 2019 Jun 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sierra, Daniel; Casteras, Anna; Colobran, Roger; Costa, Roser Ferrer; de Jesus Gil, Carmen; Gonzalez, Oscar; Iglesias-Felip, Carmela; Marin-Sanchez, Ana; Nuciforo, Paolo; Pujol-Borrell, Ricardo et al.
DOI: 10.1016/j.jaut.2019.05.013

Extracellular HMGA1 promotes tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

PMID: 30135148
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Arribas, Joaquin; Cortes, Javier; Fernandez, Yolanda; Gregori, Josep; Matres, Ana; Mendez, Olga; Peg, Vicente; Perez, Jose; Pujals, Mireia et al.
DOI: 10.1158/1078-0432.CCR-18-0517

High Resolution Computed Tomography and Fiberoptic Bronchoscopy in the Study of Severe Asthma.

PMID: 30054117
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2018
Reference: Arch Bronconeumol. 2018 Dec;54(12):627. doi: 10.1016/j.arbres.2018.05.018. Epub 2018 Jul 24.
Impact factor:
Publication type: Paper in national publication
Authors: Clofent, David; Ojanguren, Inigo; Sansano, Irene et al.
DOI: 10.1016/j.arbres.2018.05.018

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence.

PMID: 29944140
Journal: JOURNAL OF CLINICAL INVESTIGATION
Year: 2018
Reference: J Clin Invest. 2018 Aug 31;128(9):3887-3905. doi: 10.1172/JCI96393. Epub 2018 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Argiles, Guillem; Arques, Oriol; Arroyo, Alicia G; Caratu, Ginevra; Casanovas, Oriol; Chicote, Irene; Cuesta-Borras, Estefania; Dienstmann, Rodrigo; Eguizabal, Cristina et al.
DOI: 10.1172/JCI96393

Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC).

PMID: 29931469
Journal: VIRCHOWS ARCHIV
Year: 2018
Reference: Virchows Arch. 2018 Aug;473(2):209-217. doi: 10.1007/s00428-018-2389-y. Epub 2018 Jun 21.
Impact factor:
Publication type: Paper in international publication
Authors: de Torres, Ines; Gutierrez, Francisco Javier Queipo; Panizo, Angel; Pardo-Mindan, Javier; Rodriguez, Irene; Sola, Jesus Javier; Temprana-Salvador, Jordi; Tienza, Antonio et al.
DOI: 10.1007/s00428-018-2389-y

Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants.

PMID: 28667664
Journal: TRANSPLANT INTERNATIONAL
Year: 2017
Reference: Transpl Int. 2017 Nov;30(11):1119-1131. doi: 10.1111/tri.13002. Epub 2017 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Asberg, Anders; Azancot, Maria A; Azancot, Maria A; Castella, Eva; Dorje, Christina; Garcia-Carro, Clara; Holdaas, Hallvard; Midtvedt, Karsten; Moreso, Francesc; Perello, Manel et al.
DOI: 10.1111/tri.13002

Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.

PMID: 28618197
Journal: Molecular Oncology
Year: 2017
Reference: Mol Oncol. 2017 Sep;11(9):1263-1272. doi: 10.1002/1878-0261.12099. Epub 2017 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Maria; Argiles, Guillem; Capdevila, Jaume; Dienstmann, Rodrigo; Elez, Elena; Garcia, Ariadna; Landolfi, Stefania; Macarulla, Teresa; Matos, Ignacio; Nuciforo, Paolo et al.
DOI: 10.1002/1878-0261.12099

Pancreatic cancer heterogeneity and response to Mek inhibition.

PMID: 28581516
Journal: ONCOGENE
Year: 2017
Reference: Oncogene. 2017 Oct 5;36(40):5639-5647. doi: 10.1038/onc.2017.174. Epub 2017 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, M; Allende, E; Arribas, J; Balsells, J; Bernado Morales, C; Bilal, F; Carreras, M-J; Macarulla, T; Masso-Valles, D; Mohan, V et al.
DOI: 10.1038/onc.2017.174

Isolation, characterization, and differentiation of multipotent neural progenitor cells from human cerebrospinal fluid in fetal cystic myelomeningocele.

PMID: 28578005
Journal: Stem Cell Research
Year: 2017
Reference: Stem Cell Res. 2017 Jul;22:33-42. doi: 10.1016/j.scr.2017.05.003. Epub 2017 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Belfort, Michael A; Carreras, Elena; Fernandez-Martin, Alejandra; Fontecha, Cesar G; Gine, Carles; Marotta, Mario; Martinez-Ibanez, Vicente; Oria, Marc; Peiro, Jose L; Pelizzo, Gloria et al.
DOI: 10.1016/j.scr.2017.05.003

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.

PMID: 27462779
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Aug 30;7(35):56295-56308. doi: 10.18632/oncotarget.10787.
Impact factor:
Publication type: Paper in international publication
Authors: Arribas, Joaquin; Bernado-Morales, Cristina; Cano, Amparo; Castilla, M Angeles; Cortes, Javier; Gonzalez-Martin, Antonio; Hergueta-Redondo, Marta; Martinez, Lidia; Martinez-Ramirez, Angel; Molina-Crespo, Angela et al.
DOI: 10.18632/oncotarget.10787

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.

PMID: 27440383
Journal: Cancer Medicine
Year: 2016
Reference: Cancer Med. 2016 Sep;5(9):2501-12. doi: 10.1002/cam4.817. Epub 2016 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Camacho, Jessica; Ferreres Pinas, Joan Carles; Hernandez-Losa, Javier; Martinez-Ricarte, Francisco; Martinez-Saez, Elena; Ortega-Aznar, Arantxa; Peg, Vicente; Ramon Y Cajal, Santiago et al.
DOI: 10.1002/cam4.817

The cancer stem-cell signaling network and resistance to therapy.

PMID: 27434881
Journal: CANCER TREATMENT REVIEWS
Year: 2016
Reference: Cancer Treat Rev. 2016 Sep;49:25-36. doi: 10.1016/j.ctrv.2016.07.001. Epub 2016 Jul 9.
Impact factor:
Publication type: Review in international publication
Authors: Carnero, A; Garcia-Mayea, Y; LLeonart, M E; Lorente, J; Mir, C; Rubio, I T et al.
DOI: 10.1016/j.ctrv.2016.07.001

The hypoxic microenvironment: A determinant of cancer stem cell evolution.

PMID: 27417124
Journal: BIOESSAYS
Year: 2016
Reference: Bioessays. 2016 Jul;38 Suppl 1:S65-74. doi: 10.1002/bies.201670911.
Impact factor:
Publication type: Review in national publication
Authors: Carnero, Amancio; Lleonart, Matilde et al.
DOI: 10.1002/bies.201670911

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.

PMID: 26432853
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Nov;21(13):1632-43. doi: 10.1177/1352458515599848. Epub 2015 Oct 2.
Impact factor:
Publication type: Paper in international publication
Authors: Castro, Z; Costa, C; Eixarch, H; Espejo, C; Gutierrez-Franco, A; Martinez-Saez, E; Montalban, X; Ortega-Aznar, A; Ramon Y Cajal, S et al.
DOI: 10.1177/1352458515599848

Identification of somatic gene mutations in penile squamous cell carcinoma.

PMID: 26216163
Journal: GENE CHROMOSOME CANC
Year: 2015
Reference: Genes Chromosomes Cancer. 2015 Oct;54(10):629-37. doi: 10.1002/gcc.22274. Epub 2015 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Cajal, Y; de Torres, Ines; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Mares, Roso; Masferrer, Emili; Morote, Juan; Placer, Jose; Pujol, Ramon M et al.
DOI: 10.1002/gcc.22274

Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine.

PMID: 26047065
Journal: J DERMATOL
Year: 2015
Reference: J Dermatol. 2015 Dec;42(12):1172-5. doi: 10.1111/1346-8138.12967. Epub 2015 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Ferrer, Berta; Garcia-Patos, Vicente; Gemigniani, Franco; Hernandez-Losa, Javier et al.
DOI: 10.1111/1346-8138.12967

A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain.

PMID: 25740605
Journal: AMINO ACIDS
Year: 2015
Reference: Amino Acids. 2015 Jun;47(6):1127-34. doi: 10.1007/s00726-015-1941-1. Epub 2015 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Dierssen, Mara; Lubec, Gert; Pollak, Arnold; Subramaniyan, Saraswathi; Toran, Nuria; Weitzdoerfer, Rachel et al.
DOI: 10.1007/s00726-015-1941-1

The role of subscapularis muscle denervation in the pathogenesis of shoulder internal rotation contracture after neonatal brachial plexus palsy: A study in a rat model.

PMID: 25124991
Journal: JOURNAL OF ORTHOPAEDIC RESEARCH
Year: 2014
Reference: J Orthop Res. 2014 Dec;32(12):1675-9. doi: 10.1002/jor.22709. Epub 2014 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Casaccia, Marcelo; Fernandez-Martin, Alejandra; Fontecha, Cesar G; Haddad, Sleiman; Knorr, Jorge; Marotta, Mario; Mascarenhas, Vasco V; Soldado, Francisco et al.
DOI: 10.1002/jor.22709

Detection of sentinel lymph node in breast cancer recurrence may change adjuvant treatment decision in patients with breast cancer recurrence and previous axillary surgery.

PMID: 24726837
Journal: Breast Journal
Year: 2014
Reference: Breast. 2014 Aug;23(4):460-5. doi: 10.1016/j.breast.2014.03.007. Epub 2014 Apr 13.
Impact factor:
Publication type: Editorail in international publication
Authors: Cordoba, Octavi; Cortadellas, Tomas; Esgueva, Antonio; Espinosa-Bravo, Martin; Peg, Vicente; Perez-Ceresuela, Francesc; Reyes, Victoria; Rodriguez-Revuelto, Robert; Rubio, Isabel T; Xercavins, Jordi et al.
DOI: 10.1016/j.breast.2014.03.007

Breast-Conservative Surgery Followed by Radiofrequency Ablation of Margins Decreases the Need for a Second Surgical Procedure for Close or Positive Margins.

PMID: 24703804
Journal: Clinical Breast Cancer
Year: 2014
Reference: Clin Breast Cancer. 2014 Oct;14(5):346-51. doi: 10.1016/j.clbc.2014.02.002. Epub 2014 Feb 21.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes, Javier; Landolfi, Stefania; Molla, Meritxell; Rubio, Isabel T; Xercavins, Jordi et al.
DOI: 10.1016/j.clbc.2014.02.002

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

PMID: 24684754
Journal: Molecular Cancer
Year: 2014
Reference: Mol Cancer. 2014 Mar 31;13:74. doi: 10.1186/1476-4598-13-74.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alana, Lide; Bigas, Anna; Canovas, Veronica; Corominas, Montserrat; de Torres, Ines; Espinosa, Lluis; Fernandez, Pedro L; Fernandez, Yolanda; Paciucci, Rosanna et al.
DOI: 10.1186/1476-4598-13-74

Oxidative stress and cancer: an overview.

PMID: 23123177
Journal: AGEING RESEARCH REVIEWS
Year: 2013
Reference: Ageing Res Rev. 2013 Jan;12(1):376-90. doi: 10.1016/j.arr.2012.10.004. Epub 2012 Oct 31.
Impact factor:
Publication type: Review in international publication
Authors: Kondoh, Hiroshi; Lleonart, Matilde E; Moline, Teresa; Paciucci, Rosanna; Somoza, Rosa; Sosa, Venus et al.
DOI: 10.1016/j.arr.2012.10.004

Atypical neuropathological sCJD-MM phenotype with abundant white matter Kuru-type plaques sparing the cerebellar cortex.

PMID: 22862687
Journal: NEUROPATHOLOGY
Year: 2013
Reference: Neuropathology. 2013 Apr;33(2):204-8. doi: 10.1111/j.1440-1789.2012.01341.x. Epub 2012 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Ferrer, Isidre; Gelpi, Ellen; Martinez-Saez, Elena; Nos, Carlos; Parchi, Piero; Ribalta, Teresa; Sanchez-Valle, Raquel; Saverioni, Daniela; Soler Insa, Josep Ma; Yague, Jordi et al.
DOI: 10.1111/j.1440-1789.2012.01341.x

Preventive midline laparotomy closure with a new bioabsorbable mesh: An experimental study.

PMID: 22687881
Journal: JOURNAL OF SURGICAL RESEARCH
Year: 2013
Reference: J Surg Res. 2013 May 1;181(1):160-9. doi: 10.1016/j.jss.2012.05.041. Epub 2012 Jun 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jss.2012.05.041

Multidisciplinary management of a giant plexiform neurofibroma by double sequential preoperative embolization and surgical resection.

PMID: 23607010
Journal: Case Reports in Neurological Medicine
Year: 2013
Reference: Case Rep Neurol Med. 2013;2013:987623. doi: 10.1155/2013/987623. Epub 2013 Mar 28.
Impact factor:
Publication type: Letter or abstract
Authors: Barastegui, David; Barrera-Ochoa, Sergi; Perez, Manuel; Perez-Lafuente, Mercedes; Romagosa, Cleofe; Velez, Roberto et al.
DOI: 10.1155/2013/987623

beta-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.

PMID: 22610277
Journal: NATURE MEDICINE
Year: 2012
Reference: Nat Med. 2012 Jun;18(6):892-901. doi: 10.1038/nm.2772.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/nm.2772

Analysis of gene expression regulated by the ETV5 transcription factor in OV90 ovarian cancer cells identifies FoxM1 over-expression in ovarian cancer.

PMID: 22589409
Journal: MOLECULAR CANCER RESEARCH
Year: 2012
Reference: Mol Cancer Res. 2012 Jul;10(7):914-24. doi: 10.1158/1541-7786.MCR-11-0449. Epub 2012 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1158/1541-7786.MCR-11-0449

Folliculocystic and collagen hamartoma of tuberous sclerosis complex.

PMID: 21839539
Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Year: 2012
Reference: J Am Acad Dermatol. 2012 Apr;66(4):617-21. Epub 2011 Aug 12.
Impact factor:
Publication type: Paper in international publication
Authors: Azorin, Daniel; Bodemer, Christine; Colmenero, Isabel; de Salamanca, Javier Enriquez; Ferreres, Joan C; Fraitag, Sylvie; Garcia-Patos, Vicente; Hadj-Rabia, Smail; Happle, Rudolf; Hernandez-Martin, Angela et al.
DOI: 10.1016/j.jaad.2011.04.002

Ten Novel Mutations in the NR5A1 Gene Cause Disordered Sex Development in 46,XY and Ovarian Insufficiency in 46,XX Individuals.

PMID: 22549935
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2012
Reference: J Clin Endocrinol Metab. 2012 Jul;97(7):E1294-306. doi: 10.1210/jc.2011-3169. Epub 2012 May 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1210/jc.2011-3169

Molecular markers of endometrial carcinoma detected in uterine aspirates.

PMID: 21207424
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2011
Reference: Int J Cancer. 2011 Nov 15;129(10):2435-44. doi: 10.1002/ijc.25901. Epub 2011 Apr 8.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/ijc.25901

A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain.

PMID: 21262400
Journal: Journal of Proteomics
Year: 2011
Reference: J Proteomics. 2011 Apr 1;74(4):547-57. Epub 2011 Jan 22.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.jprot.2011.01.009

Frequent hSNF5/INI1 germline mutations in patients with rhabdoid tumor.

PMID: 21208904
Journal: CLINICAL CANCER RESEARCH
Year: 2011
Reference: Clin Cancer Res. 2011 Jan 1;17(1):31-8.
Impact factor:
Publication type: Paper in international publication
Authors: Andre, Nicolas; Audry, Georges; Bergeron, Christophe; Bourdeaut, Franck; Brugieres, Laurence; Capra, Valeria; Coupier, Isabelle; Delattre, Olivier; Doz, Francois; Dufour, Christelle et al.
DOI: 10.1158/1078-0432.CCR-10-1795

RSK4 Inhibition Results in Bypass of Stress-Induced and Oncogene-Induced Senescence.

PMID: 21239520
Journal: CARCINOGENESIS
Year: 2011
Reference: Carcinogenesis. 2011 Apr;32(4):470-6. Epub 2011 Jan 14.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1093/carcin/bgr003

Effects of birth advancement in Chiari malformation in a surgical myelomeningocele model in rabbits.

PMID: 20223326
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2010
Reference: J Pediatr Surg. 2010 Mar;45(3):594-599.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jpedsurg.2009.08.003

[Endobronchial chondromesenchymal hamartoma.]

PMID: 20206588
Journal: ANALES DE PEDIATRIA
Year: 2010
Reference: An Pediatr (Barc). 2010 Apr;72(4):263-6. Epub 2010 Mar 4.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.anpedi.2009.12.011

The dual PI3K/mTOR inhibitor (PI-103) promotes immunosupression, in vivo tumor growth and increases survival of sorafenib treated melanoma cells.

PMID: 19810100
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2010
Reference: Int J Cancer. 2010 Apr 1;126(7):1549-61.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1002/ijc.24926

Novel (60%) and Recurrent (40%) Androgen Receptor Gene Mutations in a Series of 59 Patients with a 46,XY Disorder of Sex Development.

PMID: 20150575
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2010
Reference: J Clin Endocrinol Metab. 2010 Apr;95(4):1876-88. Epub 2010 Feb 11.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1210/jc.2009-2146

Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.

PMID: 19443906
Journal: CARCINOGENESIS
Year: 2009
Reference: Carcinogenesis. 2009 Aug;30(8):1288-97.
Impact factor:
Publication type: Paper in international publication
Authors: Abal, Miguel; Alameda, Francesc; Canals, Francesc; Carreras, Ramon; Castellvi, Josep; Colas, Eva; Diaz, Berta; Doll, Andreas; Gabrielli, Franco; Gil-Moreno, Antonio et al.
DOI: 10.1093/carcin/bgp119

Lymphocyte-rich classical Hodgkin's lymphoma: distinctive tumor and microenvironment markers.

PMID: 19465900
Journal: MODERN PATHOLOGY
Year: 2009
Reference: Mod Pathol. 2009 Aug;22(8):1006-15.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia, Juan F; Montes-Moreno, Santiago; Nam-Cha, Syong H; Piris, Miguel A; Salcedo, Maria T; Sanjuan, Josefina et al.
DOI: 10.1038/modpathol.2009.54

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

PMID: 19738063
Journal: CANCER RESEARCH
Year: 2009
Reference: Cancer Res. 2009 Sep 15;69(18):7430-8.
Impact factor:
Publication type: Paper in international publication
Authors: Arango, Diego; Castano, Julio; Ceron, Julian; Dopeso, Higinio; Esteves, Marielle; Hernandez-Losa, Javier; Lagares-Tena, Laura; Landolfi, Stefania; Mariadason, John M; Mateo-Lozano, Silvia et al.
DOI: 10.1158/0008-5472.CAN-09-0706

Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH-IGF) axis gene expression in human fetal epiphyseal chondrocytes.

PMID: 19056306
Journal: GROWTH HORMONE & IGF RESEARCH
Year: 2009
Reference: Growth Horm IGF Res. 2009 Jun;19(3):232-7.
Impact factor:
Publication type: Paper in international publication
Authors: Andaluz, P; Audi, L; Carrascosa, A; Esteban, C; Fernandez-Cancio, M; Granada, M L; Toran, N et al.
DOI: 10.1016/j.ghir.2008.10.004

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