Model generated by administration of monocrotaline pyrrole and aorto-caval shunt surgery

The RCS rat strain provides a model of inherited outer retinal degenerative diseases. At 4 weeks of age, the RCS rat retina appears normal. However, by 8 weeks of age, and under low light conditions, RCS rats have impaired retinal function and disorganized and thinned retina. Standard lighting conditions accelerated the degenerative process while low lighting conditions slow the process thereby enabling a broader window for therapeutic intervention. The RCS rat strain is a good model for evaluating efficacy of gene based therapies and/or retinal prosthesis devices. July 2019. Volume 60, Issue 9. OPEN ACCESS. ARVO Annual Meeting Abstract. July 2019. Characterization of the Royal College of Surgeon’s Rat Model Endpoints for Use in Preclinical Ophthalmic Studies Justin Prater; Vicky Peele; David Culp; Brian C Gilger. Availability: Cryopreserved

With this model, cirrhosis is caused by biliary poisoning. At 2 weeks the model has mild portal hypertension. The appearance of the animal at 28 days is characterized by jaundice, dark urine and, in 20% of the rats, by some degree of ascites. The model will stop at 4 weeks, at which time the rat has been shown to have established cirrhosis.

Neonatal mice between two and five days of age are exposed to a UVB irradiation dose of 9 KJ/m2

Transient or permanent proximal occlusion of middle cerebral artery by nylon filament is conducted, through the external carotid artery. Biodistribution of some treatments is monitored in vivo and ex vivo over time with molecular imaging. Functional (grip strength test) and neurological status of the animals are evaluated

Transient or permanent proximal occlusion of middle cerebral artery by nylon filament is conducted, through the external carotid artery. Biodistribution of some treatments is monitored in vivo and ex vivo over time with molecular imaging. Functional (grip strength test) and neurological status of the animals are evaluated

Transient or permanent proximal occlusion of middle cerebral artery by blood clot insertion, through the external carotid artery. t-PA-induced thrombolysis could be induced. Biodistribution of some treatments is monitored in vivo and ex vivo over time with molecular imaging. Functional (grip strength test) and neurological status of the animals are evaluated

Transient or permanent occlusion of the distal portion of the middle cerebral artery in conducted with a 30G rounded tip needle above the artery held with a micromanipulator (with electrocoagulation for the permanent model). The biodistribution of some treatments is monitored in vivo and ex vivo over time with molecular imaging.Functional (grip strength test) and neurological status of the animals are evaluated

Orthotopic intrauterine tumor cells injection or subcutaneous injection of commercial cell lines of endometrial and/or ovarian cancer

Injection of HuH-7 cells (5x10 (6) cells) (100ul) subcutaneously in the dorsal area of the mouse