About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
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People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
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The Biomedical Research in Melanoma group is interested in skin cancer. We investigate the molecular causes for these diseases to design effective therapies against them. Our research is done in close proximity to patients, where our goal is to translate our discoveries as fast as possible to the clinic. To that end, we have a multidisciplinary group that associate dermatologists, oncologists, pathologists and basic-scientists that ask relevant clinical questions that need biological answers. Our workflow contemplates information obtained from patients (genetic information, clinical history, functional data…) that is translated into animal models (genetic modified mouse models, PDX…) and in vitro experiments to answer the formulated questions. These results are used to design novel therapeutic approaches, including drug development and preclinical studies that ultimately will be translated to patients.
The main lines of investigation are: • Molecular mechanisms involved in melanoma development and progression, • Targeting metabolism for melanoma treatment, • The mechanisms of resistance to immunotherapy.
Metabolic settings of aggressive tumor cells adapt to their energetic and anabolic demands. While limited success in cancer treatment using targeted therapy has been accomplished, the altered metabolism of tumor cells compared to normal cells, provides a viable novel target for a non-toxic chemotherapeutic approach. Since tumor cells can utilize different metabolic strategies that have only now being elucidated, deciphering which metabolic settings are associated to a particular mutational status would be helpful to both design novel therapeutic strategies and stratify patients for treatment. In melanoma ~50% of tumors present activating mutations in BRAF (BRAFV600E) and another 20% present activating mutations in NRAS (NRASQ61L). While targeted therapy of BRAFV600E mutant tumors has been partially successful there is no therapeutic alternative for patients harboring NRASQ61L mutant tumors. Despite the fact that these molecules affect the same pathway (RAS-ERK1/2), BRAFV600E and NRASQ61L mutant cells behave and respond differently to therapy and to metabolic stress. Understanding the metabolic settings of BRAFV600E and NRASQ61L mutant melanoma tumors would help to sensitize them, overcome resistance mechanisms to therapy and target them according to their genetic alterations. This project is been supported by Marie Curie actions.
Expected results: After execution of this project the main expected results are:
1. To define the different metabolic settings of melanomas harboring diferent oncogenic mutations
2. To identify the biochemical mechanism responsible for the differential metabolic stress response acconding to their genotype
3. To design of novel therapeutic alternatives to treat melanoma tumors.
IP: -
To translate our reseach into the clinic is one of our main objetives. We are currently conducting a preclinical study in colaboration with the Industry to test the therapeutic capabilities of ALDH isoform-specific inhibidors in melanoma, lung and breast tumors. The aims of this project are:
To identify the ALDH isoforms and the metabolic settings associated to oncògenes
To verify a cause and effect relationship between the increased activity of a specific ALDH isoform and the resistance to cell death manifest.
To identify which of the endogenous substrates of ALDH and corresponding reaction products are specifically involved in cell death resistance.
To evaluate the therapeutic efficacy of specific inhibitors of ALDHs
Environmental insults are directly involved in cancer development. In particular, Ultraviolet (UV) radiation has been associated to the acquisition of different types of skin cancer and premature skin aging. UV radiation causes modifications in the genetic material of cells (DNA) that if not repaired properly will lead to a mutated DNA (mutated genes) which might trigger the development of cancer. Understanding the molecular basis of the UV-induced DNA damage response is important to elucidate the mechanisms of skin tumorigenesis.
In the study, published in Plos Genetics, the authors used a UV-induced skin cancer mouse model (Hepatocyte growth factor (HGF) transgenic mice), where one of the two Lkb1 gene alleles was deleted (haploinsufficiency), and consequently the amounts of LKB1 protein was half of the normal levels. A single dose of UVB radiation in Lkb1 haploinsufficient neonates mice expressing HGF was enough to induced the quickly development of squamous cell carcinomas, and this, was associated to a deficient response in DNA damage repair. Moreover, cells harboring the damaged DNA were resistant to cell death (apoptosis). Thus, lack of LKB1 promotes a double effect: cells not only fail to repair the damage in their DNA, but they do not die, leading to the accumulation of mutated cells and the development of tumors. The research team has obtained similar results (to be published soon) in two additional mouse models of melanoma, a much more lethal type of UV-induced skin cancer.
One of the beauties of this model is that reflects the real scenario for cancer adquisition where initially just one of gene copies is damaged. It also reproduces a tumor related to chronic DNA damage using a single dose of UV radiation, underlining the importance of this protein’s function.
LKB1 mutations have been found epithelial human cancers associated to environmental insults. “However, this is the first study that links LKB1 to the UV-induced DNA repair responses” explains Dr. Recio, “and provides an important insight into how cells can defend themselves from external genotoxic damage”.
Importantly, these results can be extrapolated to human cancer. In fact, when examining the expression of LKB1 protein in samples from patients with skin tumors, the authors found that roughly half of these samples showed low or no expression of LKB1. Furthermore, absence of the protein was detected in all stages of the disease, particularly in UV-exposed skin areas, suggesting that the loss of expression of LKB1 is an early event and very likely contributes to UV-induced skin cancer development.
In the near future, we will be evaluating LKB1 as a prognostic risk factor for UV–induced skin cancer. They also are investigating the different factors that may alter LKB1 expression, with a particular emphasis in families with skin cancer predisposition or skin cancer history.
IP: Juan Angel Recio Conde Collaborators: Paula Granado Martinez, Kimberley Anne McGrail Fernández, Vicente García-Patos Briones, Berta Ferrer Fábrega, Eva Muñoz Couselo, Yuxin Ding, Roberto Orsenigo Funding agency: Instituto de Salud Carlos III Funding: 321250 Reference: PI23/00428 Duration: 01/01/2024 - 31/12/2026
IP: Juan Angel Recio Conde Collaborators: - Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 233708 Reference: CPP2022-009781 Duration: 01/11/2023 - 31/10/2026
IP: Juan Angel Recio Conde Collaborators: Beca VHIR PhD, Laia Perez Lasarte, Yuxin Ding Funding agency: Fundació Institut de Recerca HUVH Funding: 69188.74 Reference: VPHD/YUXUNG_D Duration: 01/09/2023 - 31/08/2026
IP: Juan Angel Recio Conde Collaborators: Roberto Orsenigo Funding agency: Fundació "La Caixa" Funding: 115092 Reference: CAIXA/INPHINIT/2022/ORSENIGO Duration: 01/11/2022 - 31/10/2025
PMID: 40081473 Journal: Actas Dermo-Sifiliograficas Year: 2025 Reference: Actas Dermosifiliogr. 2025 Mar 11:S0001-7310(25)00139-5. doi: 10.1016/j.ad.2025.03.008. Impact factor: Publication type: Paper in international publication Authors: Abadias-Granado, I; Almagro, M; Almenara-Blasco, M; Arias-Santiago, S; Banuls, J; Buendia-Eisman, A; Colmenero, M; De-la-Fuente-Meira, S; Diago, A; Florez, A et al. DOI: 10.1016/j.ad.2025.03.008
PMID: 39756676 Journal: Actas Dermo-Sifiliograficas Year: 2025 Reference: Actas Dermosifiliogr. 2025 Jan 3:S0001-7310(24)01056-1. doi: 10.1016/j.ad.2024.09.022. Impact factor: Publication type: Paper in international publication Authors: Abadias-Granado, I; Almagro, M; Almenara-Blasco, M; Arias-Santiago, S; Banuls, J; Buendia-Eisman, A; Colmenero, M; Diago, A; Florez, A; Fuente-Meira, S De-la et al. DOI: 10.1016/j.ad.2024.09.022
PMID: 40057604 Journal: ONCOGENE Year: 2025 Reference: Oncogene. 2025 Mar 8. doi: 10.1038/s41388-025-03339-7. Impact factor: Publication type: Paper in international publication Authors: Caratu, Ginevra; Ferrer, Berta; Garcia-Patos, Vicenc; Granado-Martinez, Paula; Hernandez-Losa, Javier; Heyn, Holger; McGrail, Kimberley; Munoz-Couselo, Eva; Nieto, Paula; Orsenigo, Roberto et al. DOI: 10.1038/s41388-025-03339-7
PMID: 40075744 Journal: Cancers Year: 2025 Reference: Cancers (Basel). 2025 Mar 5;17(5):897. doi: 10.3390/cancers17050897. Impact factor: Publication type: Paper in international publication Authors: Ferrandiz-Pulido, Carla; Jaka, Ane; Marti-Marti, Ignasi; Sandoval-Clavijo, Alejandra; Toll, Agusti; Verdaguer-Faja, Julia et al. DOI: 10.3390/cancers17050897
PMID: 38301923 Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Year: 2024 Reference: J Am Acad Dermatol. 2024 Jan 30:S0190-9622(24)00157-9. doi: 10.1016/j.jaad.2024.01.040. Impact factor: Publication type: Paper in international publication Authors: Anene, Chinedu Anthony; Angeliki-Gkini, Maria; Borges-Costa, Joao; Borik-Heil, Liliane; Bouwes Bavinck, Jan Nico; Cetkovska, Petra; de Jong, Estella; Debska-Slizien, Alicja; Ducroux, Emilie; Euvrard, Sylvie et al. DOI: 10.1016/j.jaad.2024.01.040
PMID: 38339415 Journal: Cancers Year: 2024 Reference: Cancers (Basel). 2024 Feb 4;16(3):664. doi: 10.3390/cancers16030664. Impact factor: Publication type: Paper in international publication Authors: Boada, Aram; Ferrandiz-Pulido, Carla; Guerra-Amor, Alvaro; Jaka, Ane; Toll, Agusti; Verdaguer-Faja, Julia et al. DOI: 10.3390/cancers16030664
PMID: 38531692 Journal: CLINICAL AND EXPERIMENTAL DERMATOLOGY Year: 2024 Reference: Clin Exp Dermatol. 2024 Mar 26:llae092. doi: 10.1093/ced/llae092. Impact factor: Publication type: Paper in international publication Authors: Aguayo-Ortiz, Rafael S; Alcaraz, Inmaculada; Arandes-Marcocci, Jorge; Barchino-Ortiz, Lucia; Bea-Ardebol, Sonia; Delgado, Yolanda; Deza, Gustavo; Escola, Helena; Escola-Rodriguez, Alba; Ferrandiz-Pulido, Carla et al. DOI: 10.1093/ced/llae092
PMID: 38577496 Journal: Year: 2024 Reference: JAAD Case Rep. 2024 Mar 1;46:67-69. doi: 10.1016/j.jdcr.2024.02.011. eCollection 2024 Apr. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Ferrandiz-Pulido, Carla; Ferrer, Berta; Garcia-Patos, Vicente; Gonzalez-Cruz, Carlos; Munoz-Couselo, Eva; Ortiz-Velez, Carolina et al. DOI: 10.1016/j.jdcr.2024.02.011
PMID: 36521505 Journal: LANCET INFECTIOUS DISEASES Year: 2023 Reference: Lancet Infect Dis. 2023 Apr;23(4):445-453. doi: 10.1016/S1473-3099(22)00794-0. Epub 2022 Dec 12. Impact factor: Publication type: Paper in international publication Authors: 2022/12/16 06:00; Acosta, Marlon; Agud-Dios, Manuel; Alemany, Andrea; Alvarez, Patricia; Angeles Melendez, Maria; Arando, Maider; Arroyo Andres, Jorge; Bailon, Lucia; Benet, Susana et al. DOI: 10.1016/S1473-3099(22)00794-0
PMID: 36416811 Journal: JAMA Dermatology Year: 2023 Reference: JAMA Dermatol. 2023 Jan 1;159(1):29-36. doi: 10.1001/jamadermatol.2022.4820. Impact factor: Publication type: Paper in international publication Authors: Arron, Sarah; Bouwes Bavinck, Jan Nico; de Jong, Estella; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Genders, Roel; Gomez-Tomas, Alvaro; Gonzalez-Cruz, Carlos et al. DOI: 10.1001/jamadermatol.2022.4820
PMID: 36049539 Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY Year: 2023 Reference: J Invest Dermatol. 2023 Feb;143(2):209-219.e13. doi: 10.1016/j.jid.2022.08.036. Epub 2022 Aug 30. Impact factor: Publication type: Paper in international publication Authors: Aparicio, Gloria; Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Penzo, Eleonora; Porres, Laura; Sole, Cristina et al. DOI: 10.1016/j.jid.2022.08.036
PMID: 35781803 Journal: INTERNATIONAL JOURNAL OF DERMATOLOGY Year: 2023 Reference: Int J Dermatol. 2023 Mar;62(3):e130-e132. doi: 10.1111/ijd.16345. Epub 2022 Jul 3. Impact factor: Publication type: Letter or abstract Authors: Barrabes-Torrella, Cristina; Fernandez-Figueras, Maria-Teresa; Garcia-Patos Briones, Vicente; Gonzalez-Cruz, Carlos; Perez-Munoz, Noelia; Quintana-Codina, Monica; Salleras-Redonnet, Montse et al. DOI: 10.1111/ijd.16345
PMID: 34980445 Journal: Revista espanola de patologia Year: 2022 Reference: Rev Esp Patol. 2022 Jan-Mar;55(1):68-72. doi: 10.1016/j.patol.2019.01.006. Epub 2019 Mar 16. Impact factor: Publication type: Letter or abstract Authors: Elizalde, Javier; Ferre, Berta; Gomez-Benlloch, Alba; Lopez, Rocio; Martinez-Lanao, Maria Angeles; Tresserra, Francisco et al. DOI: 10.1016/j.patol.2019.01.006
PMID: 36402789 Journal: Nature Communications Year: 2022 Reference: Nat Commun. 2022 Nov 19;13(1):7113. doi: 10.1038/s41467-022-34907-0. Impact factor: Publication type: Paper in international publication Authors: Bartrons, Ramon; Canals, Francesc; Ding, Yuxin; Esteve-Puig, Rosaura; Ferrer, Berta; Garcia-Ortega, Sara; Garcia-Patos, Vicenc; Granado-Martinez, Paula; Hernandez-Losa, Javier; Manzano, Anna et al. DOI: 10.1038/s41467-022-34907-0
PMID: 35982955 Journal: Frontiers in Oncology Year: 2022 Reference: Front Oncol. 2022 Aug 2;12:943483. doi: 10.3389/fonc.2022.943483. eCollection 2022. Impact factor: Publication type: Paper in international publication Authors: Carron, Juliana; Coser, Lilian Oliveira; Fernandez, Kimberly Anne McGrail; Gomez, Gabriela Vilas Boas; Lima, Carmen Silvia Passos; Lourenco, Gustavo Jacob; Monteiro, Lummy Maria Oliveira; Moraes, Aparecida Machado; Oliveira, Alexandre Leite Rodrigues; Recio, Juan Angel et al. DOI: 10.3389/fonc.2022.943483
PMID: 35607918 Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY Year: 2022 Reference: J Eur Acad Dermatol Venereol. 2022 Nov;36(11):1991-2001. doi: 10.1111/jdv.18256. Epub 2022 Jun 14. Impact factor: Publication type: Paper in international publication Authors: Baykal, C; Bouwes-Bavinck, J N; Cetkovska, P; de Oliveira, W Roncalli; Del Marmol, V; Ducroux, E; Ferrandiz-Pulido, C; Geusau, A; Gkini, M A; Gomez-Tomas, A et al. DOI: 10.1111/jdv.18256
PMID: 34396424 Journal: ACTA DERMATO-VENEREOLOGICA Year: 2021 Reference: Acta Derm Venereol. 2021 Aug 25;101(8):adv00525. doi: 10.2340/00015555-3890. Impact factor: Publication type: Paper in international publication Authors: Almazan-Fernandez, Francisco M; Banuls, Jose; Bernal, Alvaro; Boada, Aram; Canueto, Javier; Del Carmen Gomez-Mateo, Maria; Dominguez-Mahamud, Carolina; Ferrandiz-Pulido, Carla; Garcia-Bracamonte, Beatriz; Garcia-Donoso, Carmen et al. DOI: 10.2340/00015555-3890
PMID: 34944673 Journal: Biomedicines Year: 2021 Reference: Biomedicines. 2021 Dec 7;9(12). pii: biomedicines9121857. doi: 10.3390/biomedicines9121857. Impact factor: Publication type: Paper in international publication Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Sole, Cristina et al. DOI: 10.3390/biomedicines9121857
PMID: 34758023 Journal: PLoS Neglected Tropical Diseases Year: 2021 Reference: PLoS Negl Trop Dis. 2021 Nov 10;15(11):e0009884. doi: 10.1371/journal.pntd.0009884. eCollection 2021 Nov. Impact factor: Publication type: Paper in international publication Authors: Aparicio, Gloria; Armas, Mayuli; Chicharro, Carmen; Ferrer, Berta; Garcia-Patos, Vicenc; Goterris, Lidia; Molina, Israel; Pumarola, Tomas; Sanchez-Montalva, Adrian; Serre-Delcor, Nuria et al. DOI: 10.1371/journal.pntd.0009884
PMID: 34684202 Journal: Pathogens Year: 2021 Reference: Pathogens. 2021 Sep 28;10(10). pii: pathogens10101253. doi: 10.3390/pathogens10101253. Impact factor: Publication type: Paper in international publication Authors: Aparicio-Espanol, Gloria; Bosch-Nicolau, Pau; Espiau, Maria; Ferrer, Berta; Garcia-Patos, Vicente; Molina, Israel; Pou, Diana; Salvador, Fernando; Sanchez-Montalva, Adrian; Silgado, Aroa et al. DOI: 10.3390/pathogens10101253
PMID: 33321931 Journal: Cells Year: 2020 Reference: Cells. 2020 Dec 10;9(12). pii: cells9122656. doi: 10.3390/cells9122656. Impact factor: Publication type: Review in international publication Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Sole, Cristina et al. DOI: 10.3390/cells9122656
PMID: 33122236 Journal: BMJ case reports Year: 2020 Reference: BMJ Case Rep. 2020 Oct 29;13(10). pii: 13/10/e238039. doi: 10.1136/bcr-2020-238039. Impact factor: Publication type: Paper in international publication Authors: Barbera, Maria Jesus; Camprodon Gomez, Maria; Ferrer, Berta; Gonzalez-Cruz, Carlos et al. DOI: 10.1136/bcr-2020-238039
PMID: 32910922 Journal: Actas dermo-sifiliograficas Year: 2020 Reference: Actas Dermosifiliogr. 2020 Dec;111(10):815-821. doi: 10.1016/j.ad.2020.08.008. Epub 2020 Sep 7. Impact factor: Publication type: Review in national publication Authors: Arimany-Manso, J; Garcia-Patos, V; Martin-Fumado, C; Pujol, R M; Saigi, U et al. DOI: 10.1016/j.ad.2020.08.008
PMID: 32422543 Journal: Translational Oncology Year: 2020 Reference: Transl Oncol. 2020 Jun;13(6):100750. doi: 10.1016/j.tranon.2020.100750. Epub 2020 May 15. Impact factor: Publication type: Paper in international publication Authors: Alos Hernandez, Lucia; Arance Fernandez, Ana; Cerezuela Fuentes, Pablo; Ferrer Fabrega, Berta; Hernandez-Losa, Javier; Lopez-Martin, Jose A; Marti, Rosa M; Ortega Izquierdo, Eugenia; Ortiz Reina, Sebastian; Rios-Martin, Juan Jose et al. DOI: 10.1016/j.tranon.2020.100750
PMID: 31681265 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Oct 1;10:2325. doi: 10.3389/fimmu.2019.02325. eCollection 2019. Impact factor: Publication type: Paper in international publication Authors: Aguilo-Cucurull, Aina; Baz-Redon, Noelia; Carreras, Carmen; Colobran, Roger; Cusco, Ivon; Fernandez-Cancio, Monica; Franco-Jarava, Clara; Garcia-Patos, Vicenc; Garcia-Prat, Marina; Irastorza, Inaki et al. DOI: 10.3389/fimmu.2019.02325
PMID: 30176040 Journal: ACTA DERMATO-VENEREOLOGICA Year: 2019 Reference: Acta Derm Venereol. 2019 Jan 1;99(1):89-94. doi: 10.2340/00015555-3025. Impact factor: Publication type: Paper in international publication Authors: Andrades, Evelyn; Duran, Xavier; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Gimeno, Javier; Hernandez-Munoz, Inmaculada; Hernandez-Ruiz, Eugenia; Masferrer, Emili; Pujol, Ramon M; Toll, Agusti et al. DOI: 10.2340/00015555-3025
PMID: 31153547 Journal: Actas dermo-sifiliograficas Year: 2019 Reference: Actas Dermosifiliogr. 2019 Oct;110(8):659-665. doi: 10.1016/j.ad.2019.02.003. Epub 2019 May 29. Impact factor: Publication type: Paper in national publication Authors: Arias-Santiago, S; Buendia-Eisman, A; Descalzo, M A; Fernandez-Crehuet, P; Fernandez-Penas, P; Garcia-Doval, I; Garcia-Patos, V; Gilaberte, Y; Gonzalez-Cruz, C; Husein-ElAhmed, H et al. DOI: 10.1016/j.ad.2019.02.003
PMID: 31070730 Journal: CARCINOGENESIS Year: 2019 Reference: Carcinogenesis. 2019 Aug 22;40(8):1052. doi: 10.1093/carcin/bgz054. Impact factor: Publication type: Letter or abstract Authors: Andrades, Evelyn; Ferrandiz-Pulido, Carla; Garcia-Diez, Irene; Garcia-Patos, Vicenc; Gimeno, Javier; Gimeno, Ramon; Hernandez-Munoz, Inmaculada; Hernandez-Ruiz, Eugenia; Jaka, Ane; Masferrer, Emili et al. DOI: 10.1093/carcin/bgz054
PMID: 31360870 Journal: JNCI cancer spectrum Year: 2018 Reference: JNCI Cancer Spectr. 2019 Jan 7;2(4):pky045. doi: 10.1093/jncics/pky045. eCollection 2018 Oct. Impact factor: Publication type: Paper in international publication Authors: Alejo, Maria; Alemany, Laia; Bosch, Francesc Xavier; Clavero, Omar; de Sanjose, Silvia; Ferrandiz-Pulido, Carla; Halec, Gordana; Holzinger, Dana; Lloveras, Belen; Munoz, Nubia et al. DOI: 10.1093/jncics/pky045
PMID: 29572183 Journal: CLINICAL IMMUNOLOGY Year: 2018 Reference: Clin Immunol. 2018 Jun;191:44-51. doi: 10.1016/j.clim.2018.03.009. Epub 2018 Mar 20. Impact factor: Publication type: Paper in international publication Authors: Aksentijevich, Ivona; Alvarez, de la Sierra Daniel; Bodet, Domingo; Colobran, Roger; Franco-Jarava, Clara; Garcia-Latorre, Laura; Garcia-Patos, Vicenc; Garcia-Prat, Marina; Martin-Nalda, Andrea; Plaja, Alberto et al. DOI: 10.1016/j.clim.2018.03.009
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PMID: 30126736 Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Year: 2018 Reference: J Am Acad Dermatol. 2018 Nov;79(5):892-898. doi: 10.1016/j.jaad.2018.05.1243. Epub 2018 Aug 17. Impact factor: Publication type: Paper in international publication Authors: Bielsa, Isabel; Estrach, Teresa; Gallardo, Fernando; Garcia-Patos, Vicente; Lopez-Lerma, Ingrid; Marti, Rosa M; Mitxelena, Josune; Ortiz-Romero, Pablo L; Penate, Yeray; Pujol, Ramon M et al. DOI: 10.1016/j.jaad.2018.05.1243
PMID: 27168232 Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY Year: 2017 Reference: J Eur Acad Dermatol Venereol. 2017 Jan;31(1):e11-e13. doi: 10.1111/jdv.13584. Epub 2016 May 11. Impact factor: Publication type: Letter whit IF Authors: Bodet-Castillo, D; Bueno, E; Canueto, J; Garcia-Patos, V; Gonzalez-Sarmiento, R; Hernandez-Ruiz, M Eugenia; Vicente, M Asuncion et al. DOI: 10.1111/jdv.13584
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PMID: 28038852 Journal: MEDICINA CLINICA Year: 2017 Reference: Med Clin (Barc). 2017 Nov 9;149(9):422. doi: 10.1016/j.medcli.2016.11.015. Epub 2016 Dec 27. Impact factor: Publication type: Paper in national publication Authors: Ferrandiz-Pulido, Carla; Figueras-Coll, Marc; Sabate-Rotes, Anna et al. DOI: 10.1016/j.medcli.2016.11.015
PMID: 29383126 Journal: Oncotarget Year: 2017 Reference: Oncotarget. 2017 Dec 12;8(70):114856-114876. doi: 10.18632/oncotarget.23145. eCollection 2017 Dec 29. Impact factor: Publication type: Paper in international publication Authors: Aasen, Trond; Bejar, Eva; Esteve-Codina, Anna; Fuentes, Pedro; McGrail, Kimberley; Ramon Y Cajal, Santiago; Sese, Marta; Thomas, George et al. DOI: 10.18632/oncotarget.23145
PMID: 26768316 Journal: Actas dermo-sifiliograficas Year: 2016 Reference: Actas Dermosifiliogr. 2016 Jul-Aug;107(6):524. doi: 10.1016/j.ad.2015.03.026. Epub 2016 Jan 5. Impact factor: Publication type: Paper in national publication Authors: Ferrandiz-Pulido, C; Juan, J; Pineda, V et al. DOI: 10.1016/j.ad.2015.03.026
PMID: 26701415 Journal: Pigment Cell & Melanoma Research Year: 2016 Reference: Pigment Cell Melanoma Res. 2016 Mar;29(2):247-53. doi: 10.1111/pcmr.12452. Impact factor: Publication type: Paper in international publication Authors: Bodet, Domingo; Caratu, Ginevra; Cortes, Javier; Ferrer, Berta; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Matito, Judit; Munoz, Eva; Perez-Alea, Mileidys; Recio, Juan A et al. DOI: 10.1111/pcmr.12452
PMID: 27894280 Journal: BMC Pulmonary Medicine Year: 2016 Reference: BMC Pulm Med. 2016 Nov 28;16(1):165. Impact factor: Publication type: Paper in international publication Authors: Aparicio, Gloria; Esteves, Tiago; Garcia-Patos, Vicente et al. DOI: 10.1186/s12890-016-0332-z
PMID: 26691244 Journal: Actas dermo-sifiliograficas Year: 2016 Reference: Actas Dermosifiliogr. 2016 Mar;107(2):125-32. doi: 10.1016/j.ad.2015.09.014. Epub 2015 Dec 13. Impact factor: Publication type: Paper in national publication Authors: Alegre, V; Alsina, M; Azon, T; Betlloch, I; Bielsa, I; Borrego, L; Bosch, R J; Casanova, J M; Diaz, R M; Estrach, T et al. DOI: 10.1016/j.ad.2015.09.014
PMID: 26094020 Journal: ARCH DERMATOL RES Year: 2015 Reference: Arch Dermatol Res. 2015 Oct;307(8):721-9. doi: 10.1007/s00403-015-1579-6. Epub 2015 Jun 21. Impact factor: Publication type: Paper in international publication Authors: Bigas, Anna; Espinosa, Lluis; Ferrandiz-Pulido, Carla; Gimeno, Javier; Margalef, Pol; Masferrer, Emili; Pujol, Ramon Maria; Toll, Agusti et al. DOI: 10.1007/s00403-015-1579-6
PMID: 26553412 Journal: EUR J DERMATOL Year: 2015 Reference: Eur J Dermatol. 2015 Nov-Dec;25(6):556-62. doi: 10.1684/ejd.2015.2666. Impact factor: Publication type: Paper in international publication Authors: Aparicio, Gloria; Esteves, Tiago C; Ferrer, Berta; Garcia-Patos, Vicente et al. DOI: 10.1684/ejd.2015.2666
PMID: 26265500 Journal: CLIN INFECT DIS Year: 2015 Reference: Clin Infect Dis. 2015 Dec 1;61(11):1688-94. doi: 10.1093/cid/civ690. Epub 2015 Aug 11. Impact factor: Publication type: Paper in international publication Authors: Aparicio, Gloria; Artaza, M Angeles; Ferrer, Berta; Garcia-Prat, Marina; Martinez-Gallo, Monica; Molina, Israel; Sala-Cunill, Anna; Salvador, Fernando; Sanchez-Montalva, Adrian; Sao Aviles, Augusto et al. DOI: 10.1093/cid/civ690
PMID: 25471402 Journal: JAMA DERMATOL Year: 2015 Reference: JAMA Dermatol. 2015 Apr;151(4):458-9. doi: 10.1001/jamadermatol.2014.4382. Impact factor: Publication type: Paper in international publication Authors: Garcia-Patos, Vicente; Lopez-Lerma, Ingrid; Mollet, Jordi et al. DOI: 10.1001/jamadermatol.2014.4382
PMID: 24173126 Journal: ARCHIVES OF DERMATOLOGICAL RESEARCH Year: 2014 Reference: Arch Dermatol Res. 2014 Jan;306(1):93-5. doi: 10.1007/s00403-013-1424-8. Epub 2013 Oct 31. Impact factor: Publication type: Paper in international publication Authors: Ferrandiz-Pulido, C; Garcia-Patos, V; Gheit, T; Lloveras, B; Masferrer, E; Pujol, R M; Toll, A; Tommasino, M et al. DOI: 10.1007/s00403-013-1424-8
PMID: 25128142 Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Year: 2014 Reference: J Am Acad Dermatol. 2014 Sep;71(3):e90-2. doi: 10.1016/j.jaad.2014.03.008. Impact factor: Publication type: Letter or abstract Authors: Bodet, Domingo; Garcia-Patos, Vicente; Gemigniani, Franco; Gonzalez-Llavona, Beatriz et al. DOI: 10.1016/j.jaad.2014.03.008
PMID: 23668622 Journal: Actas dermo-sifiliograficas Year: 2014 Reference: Actas Dermosifiliogr. 2014 Jan-Feb;105(1):89-92. doi: 10.1016/j.ad.2012.12.016. Epub 2013 May 10. Impact factor: Publication type: Letter whit IF Authors: Ferrer, B; Garcia-Patos, V; Hilari, H; Kennedy, F E et al. DOI: 10.1016/j.ad.2012.12.016
PMID: 23773109 Journal: CLINICAL AND EXPERIMENTAL DERMATOLOGY Year: 2014 Reference: Clin Exp Dermatol. 2014 Jan;39(1):102-4. doi: 10.1111/ced.12181. Epub 2013 Jun 18. Impact factor: Publication type: Letter or abstract Authors: Combalia, A; Fernandez-Figueras, M T; Ferrandiz, C; Ferrandiz-Pulido, C; Marco, V et al. DOI: 10.1111/ced.12181
PMID: 23873883 Journal: ARCHIVES OF DISEASE IN CHILDHOOD Year: 2013 Reference: Arch Dis Child. 2013 Dec;98(12):998-1003. doi: 10.1136/archdischild-2013-303718. Epub 2013 Jul 19. Impact factor: Publication type: Review in international publication Authors: Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente et al. DOI: 10.1136/archdischild-2013-303718
PMID: 24382288 Journal: International Journal of Rheumatic Diseases Year: 2013 Reference: Int J Rheum Dis. 2013 Dec;16(6):777-9. doi: 10.1111/1756-185X.12103. Epub 2013 Jun 3. Impact factor: Publication type: Letter or abstract Authors: Ferrer Fabrega, Berta; Pinal-Fernandez, Iago; Ramentol Sintas, Marc; Solans Laque, Roser et al. DOI: 10.1111/1756-185X.12103
PMID: 23764082 Journal: JOURNAL OF UROLOGY Year: 2013 Reference: J Urol. 2013 Dec;190(6):2288-95. doi: 10.1016/j.juro.2013.06.015. Epub 2013 Jun 11. Impact factor: Publication type: Paper in international publication Authors: de Torres, Ines; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Hernandez-Losa, Javier; Masferrer, Emili; Mojal, Sergio; Pujol, Ramon M; Ramon Y Cajal, Santiago; Toll, Agustin et al. DOI: 10.1016/j.juro.2013.06.015
PMID: 24018211 Journal: Actas dermo-sifiliograficas Year: 2013 Reference: Actas Dermosifiliogr. 2013 Oct;104(8):694-709. doi: 10.1016/j.adengl.2013.04.013. Epub 2013 Sep 7. Impact factor: Publication type: Letter or abstract Authors: Alsina, M; Belinchon, I; Carrascosa, J M; Carretero, G; de la Cueva, P; Ferrandiz, C; Fonseca, E; Garcia-Bustinduy, M; Garcia-Patos, V; Herrera, E et al. DOI: 10.1016/j.adengl.2013.04.013
PMID: 23108309 Journal: DIGESTIVE DISEASES Year: 2012 Reference: Dig Dis. 2012;30(5):524-31. doi: 10.1159/000341705. Epub 2012 Oct 24. Impact factor: Publication type: Paper in international publication Authors: Avila, Matias A; Berasain, Carmen; Corrales, Fernando J; Elizalde, Maria; Garcia-Irigoyen, Oihane; Latasa, M Ujue; Nicou, Alexandra; Perugorria, Maria J; Prieto, Jesus; Recio, Juan A et al. DOI: 10.1159/000341705
PMID: 22999547 Journal: JOURNAL OF UROLOGY Year: 2012 Reference: J Urol. 2012 Nov;188(5):1965-71. doi: 10.1016/j.juro.2012.07.003. Epub 2012 Sep 20. Impact factor: Publication type: Paper in international publication Authors: Alemany, Laia; Espinet, Blanca; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicenc; Gelabert, Antoni; Lloveras, Belen; Masferrer, Emili; Masferrer-Niubo, Magali; Placer, Jose; Pujol, Ramon M et al. DOI: 10.1016/j.juro.2012.07.003
PMID: 22583725 Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Year: 2012 Reference: J Am Acad Dermatol. 2012 Jun;66(6):e238-40. Impact factor: Publication type: Letter whit IF Authors: Ferrandiz-Pulido, Carla; Ferrer, Berta; Garcia-Patos, Vicente; Lopez-Lerma, Ingrid; Pisa, Sandra; Sabado, Constantino et al. DOI: 10.1016/j.jaad.2011.07.016
PMID: 21839539 Journal: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Year: 2012 Reference: J Am Acad Dermatol. 2012 Apr;66(4):617-21. Epub 2011 Aug 12. Impact factor: Publication type: Paper in international publication Authors: Azorin, Daniel; Bodemer, Christine; Colmenero, Isabel; de Salamanca, Javier Enriquez; Ferreres, Joan C; Fraitag, Sylvie; Garcia-Patos, Vicente; Hadj-Rabia, Smail; Happle, Rudolf; Hernandez-Martin, Angela et al. DOI: 10.1016/j.jaad.2011.04.002
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PMID: 21414644 Journal: MEDICINA CLINICA Year: 2011 Reference: Med Clin (Barc). 2011 May 14;136(13):583-7. doi: 10.1016/j.medcli.2010.12.007. Epub 2011 Mar 16. Impact factor: Publication type: Review in national publication Authors: Ferrandiz-Pulido, Carla; Garcia-Fernandez, Daniel; Garcia-Patos, Vicente; Gomez-Morell, Pablo; Palao, Ricard et al. DOI: 10.1016/j.medcli.2010.12.007
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PMID: 21917714 Journal: Science Signaling Year: 2011 Reference: Sci Signal. 2011 Sep 13;4(190):ra58. Impact factor: Publication type: Paper in international publication Authors: Andreu-Perez, Pedro; Avila, Matias A; Bech-Serra, Joan Josep; Canals, Francesc; de Torre-Minguela, Carlos; Esteve-Puig, Rosaura; Garcia-Trevijano, Elena R; Lopez-Fauqued, Marta; Merlino, Glenn; Recio, Juan A et al. DOI: 10.1126/scisignal.2001936
PMID: 20487693 Journal: Actas dermo-sifiliograficas Year: 2010 Reference: Actas Dermosifiliogr. 2010 May;101(4):357-8. Impact factor: Publication type: Letter or abstract Authors: Ferrandiz-Pulido, C; Ferrer, B; Garcia-Patos, V et al. DOI: 10.1016/S1578-2190(10)70648-X
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PhD student: Kimberley Anne McGrail Fernández, Kimberley Anne McGrail Fernández Director/s: Juan Angel Recio Conde University: Universidad Autònoma de Barcelona Year: 2021
PhD student: Elena González Sánchez Director/s: Juan Angel Recio Conde University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Director/s: Juan Angel Recio Conde University: Universitat Autònoma de Barcelona Year: 2019
PhD student: Maria eugenia Hernandez Ruiz Director/s: Vicente García-Patos Briones University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Patricia Bassas Freixas Director/s: Vicente García-Patos Briones, Aleix Prat Aparicio University: Universidad Autònoma de Barcelona Year: 2018
The study reveals that if the exposure of newborns to solar radiation of sufficient intensity to provoke a skin reaction is simultaneous with the activation of the BRAFv600E gene, it can trigger an uncontrolled proliferation of cancer cells.
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.
