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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

Survival analyses in cardiovascular research, part II: statistical methods in challenging situations.

PMID: 34326022
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2022
Reference: Rev Esp Cardiol. 2022 Jan;75(1):77-85. doi: 10.1016/j.rec.2021.07.001. Epub 2021 Jul 27.
Impact factor: 4.753
Publication type: Review in national publication
Authors: Rossello, Xavier; Gonzalez-Del-Hoyo, Maribel et al.
DOI: 10.1016/j.rec.2021.07.001

Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d'Hebron University Hospital.

PMID: 34872890
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2022
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Feb;40(2):71-77. doi: 10.1016/j.eimce.2021.11.003. Epub 2021 Nov 26.
Impact factor: 1.731
Publication type: Paper in international publication
Authors: Ferrer, Ricard; Baguena, Marcelino; Balcells, Joan; Baneras, Jordi; Biarnes, Alfons; de Nadal, Miriam; Gracia, Rosa Maria; Martinez, Jesus; Nuvials, Xavier; Riera, Jordi et al.
DOI: 10.1016/j.eimce.2021.11.003

Parvovirus B19 myocarditis in children: a diagnostic and therapeutic approach.

PMID: 35138467
Journal: EUROPEAN JOURNAL OF PEDIATRICS
Year: 2022
Reference: Eur J Pediatr. 2022 May;181(5):2045-2053. doi: 10.1007/s00431-022-04406-x. Epub 2022 Feb 9.
Impact factor: 3.183
Publication type: Paper in international publication
Authors: Esmel-Vilomara, Roger; Dolader, Paola; Izquierdo-Blasco, Jaume; Balcells, Joan; Sorli, Moises; Escudero, Fuensanta; Vera, Elena; Gran, Ferran et al.
DOI: 10.1007/s00431-022-04406-x

Neurotoxicity-associated sinus bradycardia after chimeric antigen receptor T-cell therapy.

PMID: 35139240
Journal: HEMATOLOGICAL ONCOLOGY
Year: 2022
Reference: Hematol Oncol. 2022 Feb 9. doi: 10.1002/hon.2976.
Impact factor: 5.271
Publication type: Letter or abstract
Authors: Barba, Pere; Tintore, Mar; Bosch, Francesc; Cabirta, Alba; Catala, Eva; Iacoboni, Gloria; Vidal-Jordana, Angela; Oristrell, Gerard; Carpio, Cecilia; Vilaseca, Andreu et al.
DOI: 10.1002/hon.2976

Secular trends in the epidemiology and clinical characteristics of Enterococcus faecalis infective endocarditis at a referral center (2007-2018).

PMID: 33404892
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2021
Reference: Eur J Clin Microbiol Infect Dis. 2021 Jun;40(6):1137-1148. doi: 10.1007/s10096-020-04117-x. Epub 2021 Jan 6.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Escola-Verge, Laura; Fernandez-Galera, Ruben; Fernandez-Hidalgo, Nuria; Larrosa, Maria Nieves et al.
DOI: 10.1007/s10096-020-04117-x

Pregnancy Outcomes in Women After Arterial Switch Operation for Transposition of the Great Arteries: Results From ROPAC (Registry of Pregnancy and Cardiac Disease) of the European Society of Cardiology EURObservational Research Programme.

PMID: 33350866
Journal: Journal of the American Heart Association
Year: 2021
Reference: J Am Heart Assoc. 2021 Jan 5;10(1):e018176. doi: 10.1161/JAHA.120.018176. Epub 2020 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel Meguid Mahdy, M; Abdilaahi, A A; Abilova, S; Abo Elenin, H; Adamson, D; Ahamed, N; Ahanya, S N; Ahmed, C M; Ain, Al; Ait Ali, L et al.
DOI: 10.1161/JAHA.120.018176

Persistent Pulmonary Hypertension in Corrected Valvular Heart Disease: Hemodynamic Insights and Long-Term Survival.

PMID: 33399006
Journal: Journal of the American Heart Association
Year: 2021
Reference: J Am Heart Assoc. 2021 Jan 19;10(2):e019949. doi: 10.1161/JAHA.120.019949. Epub 2021 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alberto San Roman, J; Alonso-Gomez, Angel; Bayes-Genis, Antoni; Bermejo, Javier; Borras, Xavier; Botas, Javier; Castano, Mario; Crespo-Leiro, Maria G; Elizaga, Jaime; Escribano-Subias, Pilar et al.
DOI: 10.1161/JAHA.120.019949

Clinical cases referring to current options and recommendations for the use of thoracic endovascular aortic repair in acute and chronic thoracic aortic disease: an expert consensus document of the European Society for Cardiology (ESC) Working Group of Cardiovascular Surgery, the ESC Working Group on Aorta and Peripheral Vascular Diseases, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the European Association for Cardio-Thoracic Surgery (EACTS).

PMID: 33020812
Journal: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Year: 2021
Reference: Eur J Cardiothorac Surg. 2021 Jan 4;59(1):74-79. doi: 10.1093/ejcts/ezaa313.
Impact factor:
Publication type: Paper in international publication
Authors: Aboyans, Victor; Al-Attar, Nawwar; Czerny, Martin; de Paulis, Ruggero; Eggebrecht, Holger; Evangelista, Arturo; Grabenwoger, Martin; Kolowca, Maciej; Lescan, Mario; Micari, Antonio et al.
DOI: 10.1093/ejcts/ezaa313

Flecainide intoxication in pediatric patients with supraventricular tachycardia.

PMID: 32863668
Journal: Annals of pediatric cardiology
Year: 2020
Reference: Ann Pediatr Cardiol. 2020 Jul-Sep;13(3):264-266. doi: 10.4103/apc.APC_116_19. Epub 2020 Jun 29.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vaquer, Guiem, Marfil, Laura, Ortega, Josep, Sabate-Rotes, Anna, Gran-Ipina, Ferran, Roses-Noguer, Ferran et al.
DOI: 10.4103/apc.APC_116_19

Differential features in composition of coronary thrombus of women with ST-segment elevation myocardial infarction.

PMID: 31887625
Journal: THROMBOSIS RESEARCH
Year: 2020
Reference: Thromb Res. 2020 Feb;186:64-70. doi: 10.1016/j.thromres.2019.12.010. Epub 2019 Dec 17.
Impact factor: 2.869
Publication type: Paper in international publication
Authors: Rello, Pau, Garcia Del Blanco, Bruno, Ruiz-Meana, Marisol, Miro-Casas, Elisabet, Alfonso, Fernando, Garcia-Picart, Joan, Barrabes, Jose A, Borras, Guillermo, Martin, Pilar, Dorado, David Garcia et al.
DOI: 10.1016/j.thromres.2019.12.010

Right-sided endocarditis on Contegra tube in a complex cianotic congenital heart disease.

PMID: 30972721
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2020
Reference: J Nucl Cardiol. 2020 Aug;27(4):1402-1404. doi: 10.1007/s12350-019-01708-w. Epub 2019 Apr 10.
Impact factor: 3.366
Publication type: Paper in international publication
Authors: Olivella, Aleix, Pizzi, Maria Nazarena, Dos-Subira, Laura, Aguade-Bruix, Santiago, Fernandez-Hidalgo, Nuria, Cuellar-Calabria, Hug, Roque, Albert et al.
DOI: 10.1007/s12350-019-01708-w

Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction.

PMID: 32747454
Journal: Open heart
Year: 2020
Reference: Open Heart. 2020 Aug;7(2). pii: openhrt-2019-001169. doi: 10.1136/openhrt-2019-001169.
Impact factor: 0
Publication type: Paper in international publication
Authors: Fernandez-Berges, Daniel, Degano, Irene R, Gonzalez Fernandez, Reyes, Subirana, Isaac, Vila, Joan, Jimenez-Navarro, Manuel, Perez-Fernandez, Silvia, Roque, Merce, Bayes-Genis, Antoni, Fernandez-Aviles, Francisco et al.
DOI: 10.1136/openhrt-2019-001169

EuroCMR 2019 HIGHLIGHTS.

PMID: 31411719
Journal: EUROPEAN HEART JOURNAL
Year: 2019
Reference: Eur Heart J. 2019 Aug 14;40(31):2557-2559. doi: 10.1093/eurheartj/ehz557.
Impact factor: 23.239
Publication type: Editorail in international publication
Authors: Rodriguez Palomares, Jose F et al.
DOI: 10.1093/eurheartj/ehz557

Management of Aortic Stenosis: The Trees Should Not Stop Us From Seeing the Forest.

PMID: 31345431
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2019
Reference: J Am Coll Cardiol. 2019 Jul 30;74(4):564-566. doi: 10.1016/j.jacc.2019.06.002.
Impact factor: 18.639
Publication type: Editorail in international publication
Authors: Evangelista, Arturo, Galian, Laura et al.
DOI: 10.1016/j.jacc.2019.06.002

Safe and Efficacious Use of 1-Month Triple Therapy in Patients with Atrial Fibrillation and High Bleeding Risk Undergoing PCI.

PMID: 31332653
Journal: CARDIOVASCULAR DRUGS AND THERAPY
Year: 2019
Reference: Cardiovasc Drugs Ther. 2019 Aug;33(4):425-433. doi: 10.1007/s10557-019-06889-7.
Impact factor: 4.181
Publication type: Paper in international publication
Authors: Sambola, Antonia, Bueno, Hector, Miranda, Berta, Hernandez, Adrian V, Limeres, Javier, Del Blanco, Bruno Garcia, Garcia-Dorado, David et al.
DOI: 10.1007/s10557-019-06889-7

Persistence with dual antiplatelet therapy after percutaneous coronary intervention for ST-segment elevation acute coronary syndrome: a population-based cohort study in Catalonia (Spain).

PMID: 31340964
Journal: BMJ Open
Year: 2019
Reference: BMJ Open. 2019 Jul 23;9(7):e028114. doi: 10.1136/bmjopen-2018-028114.
Impact factor: 2.376
Publication type: Paper in international publication
Authors: Ribera, Aida, Ferreira-Gonzalez, Ignacio, Marsal, Josep Ramon, Oristrell, Gerard, Faixedas, Maria Teresa, Rosas, Alba, Tizon-Marcos, Helena, Rojas, Sergio, Labata, Carlos, Cardenas, Merida et al.
DOI: 10.1136/bmjopen-2018-028114

Comparison of Outcomes in DeBakey Type AI Versus AII Aortic Dissection.

PMID: 29970240
Journal: AMERICAN JOURNAL OF CARDIOLOGY
Year: 2018
Reference: Am J Cardiol. 2018 Aug 15;122(4):689-695. doi: 10.1016/j.amjcard.2018.04.042. Epub 2018 Jun 30.
Impact factor: 3.171
Publication type: Paper in international publication
Authors: Kohl, Louis P, Isselbacher, Eric M, Majahalme, Nilla, Evangelista, Arturo, Russo, Mark J, Hutchison, Stuart, Bossone, Eduardo, Suzuki, Toru, Pyeritz, Reed E, Gleason, Thomas G et al.
DOI: 10.1016/j.amjcard.2018.04.042

Marfan Syndrome and Loeys-Dietz Syndrome in Children: A Multidisciplinary Team Experience.

PMID: 28579256
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2018
Reference: Rev Esp Cardiol (Engl Ed). 2018 Jul;71(7):585-587. doi: 10.1016/j.rec.2017.03.031. Epub 2017 Jun 1.
Impact factor: 5.166
Publication type: Letter or abstract
Authors: Manchola-Linero, Alejandra, Gran Ipina, Ferran, Teixido-Tura, Gisela, Lopez Grondona, Fermina, Sabate-Rotes, Anna, Roses Noguer, Ferran et al.
DOI: 10.1016/j.rec.2017.03.031

Long-Term Follow-Up After Ablation of Intra-Atrial Re-Entrant Tachycardia in Patients With Congenital Heart Disease: Types and Predictors of Recurrence.

PMID: 29929671
Journal: JACC. Clinical electrophysiology
Year: 2018
Reference: JACC Clin Electrophysiol. 2018 Jun;4(6):771-780. doi: 10.1016/j.jacep.2018.04.011.
Impact factor: 0
Publication type: Paper in international publication
Authors: Dos Subira, Laura, Francisco Pascual, Jaume, Pijuan-Domenech, Antonia, Perez-Rodon, Jordi, Subirana-Domenech, M Teresa, Santos-Ortega, Alba, Roses-Noguer, Ferran, Miranda-Barrio, Berta, Ferreira-Gonzalez, Ignacio, Casaldaliga Ferrer, Jaume et al.
DOI: 10.1016/j.jacep.2018.04.011

Clinical Outcomes and Prognosis Markers of Patients With Liver Disease Undergoing Transcatheter Aortic Valve Replacement: A Propensity Score-Matched Analysis.

PMID: 29870383
Journal: Circulation-Cardiovascular Interventions
Year: 2018
Reference: Circ Cardiovasc Interv. 2018 Mar;11(3):e005727. doi: 10.1161/CIRCINTERVENTIONS.117.005727.
Impact factor: 6.504
Publication type: Paper in international publication
Authors: Nombela-Franco, Luis, Tamburino, Corrado, Rodes-Cabau, Josep, Rodriguez-Olivares, Ramon, Barbanti, Marco, Lhermusier, Thibault, Amat-Santos, Ignacio, Toggweiler, Stefan, Cheema, Asim N, Munoz-Garcia, Antonio J et al.
DOI: 10.1161/CIRCINTERVENTIONS.117.005727

Giant Right Atrial Myxoma and Refractory Hypoxia: An Unexpected Combination.

PMID: 27639409
Journal: Revista espanola de cardiologia (English ed.)
Year: 2016
Reference: Rev Esp Cardiol (Engl Ed). 2016 Dec;69(12):1219-1220. doi: 10.1016/j.rec.2016.05.023. Epub 2016 Sep 14.
Impact factor: 4.596
Publication type: Letter whit IF
Authors: Santos-Ortega, Alba, Sambola, Antonia, Marti, Gerard, Barrabes, Jose A, Rodriguez, Rafael, Garcia-Dorado, David et al.
DOI: 10.1016/j.rec.2016.05.023

Aortic dissection.

PMID: 27560366
Journal: Nature Reviews Disease Primers
Year: 2016
Reference: Nat Rev Dis Primers. 2016 Aug 25;2:16071. doi: 10.1038/nrdp.2016.71.
Impact factor: 0
Publication type: Paper in international publication
Authors: Nienaber, Christoph A, Clough, Rachel E, Sakalihasan, Natzi, Suzuki, Toru, Gibbs, Richard, Mussa, Firas, Jenkins, Michael P, Thompson, Matt M, Evangelista, Arturo, Yeh, James S M et al.
DOI: 10.1038/nrdp.2016.71

Aortic Calcium Score and Vascular Atherosclerosis in Asymptomatic Individuals: Beyond the Coronary Arteries.

PMID: 27422447
Journal: Revista espanola de cardiologia (English ed.)
Year: 2016
Reference: Rev Esp Cardiol (Engl Ed). 2016 Sep;69(9):813-6. doi: 10.1016/j.rec.2016.05.006. Epub 2016 Jul 13.
Impact factor: 4.596
Publication type: Paper in national publication
Authors: Evangelista Masip, Artur, Rodriguez-Palomares, Jose F et al.
DOI: 10.1016/j.rec.2016.05.006

Aortic dissection.

PMID: 27440162
Journal: Nature Reviews Disease Primers
Year: 2016
Reference: Nat Rev Dis Primers. 2016 Jul 21;2:16053. doi: 10.1038/nrdp.2016.53.
Impact factor: 0
Publication type: Review in international publication
Authors: Nienaber, Christoph A, Clough, Rachel E, Sakalihasan, Natzi, Suzuki, Toru, Gibbs, Richard, Mussa, Firas, Jenkins, Michael T, Thompson, Matt M, Evangelista, Arturo, Yeh, James S M et al.
DOI: 10.1038/nrdp.2016.53

Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.

PMID: 25965707
Journal: AMERICAN HEART JOURNAL
Year: 2015
Reference: Am Heart J. 2015 May;169(5):605-12. doi: 10.1016/j.ahj.2015.01.011. Epub 2015 Feb 12.
Impact factor: 4.463
Publication type: Paper in international publication
Authors: Pitcher, Alex, Emberson, Jonathan, Lacro, Ronald V, Sleeper, Lynn A, Stylianou, Mario, Mahony, Lynn, Pearson, Gail D, Groenink, Maarten, Mulder, Barbara J, Zwinderman, Aeilko H et al.
DOI: 10.1016/j.ahj.2015.01.011

Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization.

PMID: 25959001
Journal: BMC Cardiovascular Disorders
Year: 2015
Reference: BMC Cardiovasc Disord. 2015 May 12;15:37. doi: 10.1186/s12872-015-0027-z.
Impact factor: 1.878
Publication type: Paper in international publication
Authors: del Blanco, Bruno Garcia, Garcia-Dorado, David, Reig, Josep, Cordero, Alex, de Anta, Josep Maria, Otaegui, Imanol, Abdul-Jawad, Omar, Petit, Marius, Pelegrina, Eva Martin, Duran, Joan et al.
DOI: 10.1186/s12872-015-0027-z

Therapy for Syncope.

PMID: 26115833
Journal: CARDIOLOGY CLINICS
Year: 2015
Reference: Cardiol Clin. 2015 Aug;33(3):473-81. doi: 10.1016/j.ccl.2015.04.015.
Impact factor: 1.031
Publication type: Review in international publication
Authors: Moya, Angel et al.
DOI: 10.1016/j.ccl.2015.04.015

Syncope Unit: rationale and requirement - the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society.

PMID: 26108809
Journal: EUROPACE
Year: 2015
Reference: Europace. 2015 Sep;17(9):1325-40. doi: 10.1093/europace/euv115. Epub 2015 Jun 24.
Impact factor: 3.67
Publication type: Paper in international publication
Authors: Benditt, David, Krahn, Andrew, Morillo, Carlos Arturo, Olshansky, Brian, Raj, Satish, Sheldon, Robert, Shen, Win Kuang, Sun, Benjamin, Hachul, Denise, Abe, Haruhiko et al.
DOI: 10.1093/europace/euv115

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The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.