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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

False Lumen Flow Assessment by Magnetic Resonance Imaging and Long-Term Outcomes in Uncomplicated Aortic Dissection.

PMID: 35710193
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 Jun 21;79(24):2415-2427. doi: 10.1016/j.jacc.2022.04.017.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Rodriguez-Palomares, Jose, Ferreira, Ignacio, Bellmunt, Sergi, Rodriguez-Lecoq, Rafael, Teixido-Tura, Gisela, Ruiz, Aroa, Sao-Aviles, Augusto, Rudenick, Paula, Cuellar, Hig, Bijnens, Bart et al.
DOI: 10.1016/j.jacc.2022.04.017

Interregional variability in the use of cardiovascular technologies (2011-2019). Correlation with economic indicators, admissions, and in-hospital mortality.

PMID: 35688688
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2022
Reference: Rev Esp Cardiol (Engl Ed). 2022 Jun 7. pii: S1885-5857(22)00117-7. doi: 10.1016/j.rec.2022.02.016.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Jimenez Quevedo, Pilar, Serrador, Ana, Garcia Del Blanco, Bruno, Diaz, Jose F, Moreno, Raul, Cruz-Gonzalez, Ignacio, Perez de Prado, Armando, Fernandez Lozano, Ignacio, Cano Perez, Oscar, Cantarero Prieto, David et al.
DOI: 10.1016/j.rec.2022.02.016

Fully Three-Dimensional Hemodynamic Characterization of Altered Blood Flow in Bicuspid Aortic Valve Patients With Respect to Aortic Dilatation: A Finite Element Approach.

PMID: 35665243
Journal: Frontiers in Cardiovascular Medicine
Year: 2022
Reference: Front Cardiovasc Med. 2022 May 18;9:885338. doi: 10.3389/fcvm.2022.885338. eCollection 2022.
Impact factor: 6.05
Publication type: Paper in international publication
Authors: Sotelo, Julio, Franco, Pamela, Guala, Andrea, Dux-Santoy, Lydia, Ruiz-Munoz, Aroa, Evangelista, Arturo, Mella, Hernan, Mura, Joaquin, Hurtado, Daniel E, Rodriguez-Palomares, Jose F et al.
DOI: 10.3389/fcvm.2022.885338

Transcatheter aortic valve replacement in obese patients: procedural vascular complications with the trans-femoral and trans-carotid access routes.

PMID: 34942005
Journal: Interactive Cardiovascular and Thoracic Surgery
Year: 2022
Reference: Interact Cardiovasc Thorac Surg. 2022 Jun 1;34(6):982-989. doi: 10.1093/icvts/ivab354.
Impact factor: 1.905
Publication type: Paper in international publication
Authors: Nombela-Franco, Luis, Rodes-Cabau, Josep, Mohammadi, Siamak, Compagnone, Miriam, Arif, Mobeena, Alperi, Alberto, McInerney, Angela, Modine, Thomas, Chamandi, Chekrallah, Tafur-Soto, Jose D et al.
DOI: 10.1093/icvts/ivab354

Predictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve.

PMID: 34830546
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Nov 12;10(22). pii: jcm10225264. doi: 10.3390/jcm10225264.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Rodriguez-Palomares, Jose, Evangelista, Arturo, Teixido-Tura, Gisela, Gutierrez, Laura, Moral, Sergio, Lopez, Angela, Dentamaro, Ilaria, Galian, Laura, Calvo, Francisco, Alegret, Josep M et al.
DOI: 10.3390/jcm10225264

Predictive Value of Cardiac Magnetic Resonance Feature Tracking after Acute Myocardial Infarction: A Comparison with Dobutamine Stress Echocardiography.

PMID: 34830543
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Nov 12;10(22). pii: jcm10225261. doi: 10.3390/jcm10225261.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Valente, Filipa X, Gavara, Jose, Gutierrez, Laura, Rios-Navarro, Cesar, Rello, Pau, Maymi, Manel, Fernandez-Galera, Ruben, Monmeneu, Jose V, Sao-Aviles, Augusto, Lopez-Lereu, Maria P et al.
DOI: 10.3390/jcm10225261

Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis.

PMID: 34833453
Journal: Medicina-Lithuania
Year: 2021
Reference: Medicina (Kaunas). 2021 Nov 12;57(11). pii: medicina57111235. doi: 10.3390/medicina57111235.
Impact factor: 2.43
Publication type: Paper in international publication
Authors: Shen, Win-Kuang, Sun, Benjamin C, Thiruganasambandamoorthy, Venkatesh, Ungar, Andrea, Costantino, Giorgio, Solbiati, Monica, Sheldon, Robert S, Reed, Matthew J, Quinn, James V, Perez-Rodon, Jordi et al.
DOI: 10.3390/medicina57111235

Quality of life after transcatheter or surgical aortic valve replacement using the Toronto Aortic Stenosis Quality of Life Questionnaire.

PMID: 34810276
Journal: Open heart
Year: 2021
Reference: Open Heart. 2021 Nov;8(2). pii: openhrt-2021-001821. doi: 10.1136/openhrt-2021-001821.
Impact factor: 0
Publication type: Paper in international publication
Authors: Lefevre, Thierry, Di Mario, Carlo, Stefano, Pierluigi, Ribichini, Flavio Luciano, Himbert, Dominique, Urena-Alcazar, Marina, Salgado-Fernandez, Jorge, Cuenca Castillo, Jose Joaquin, Garcia, Bruno, Deutsch, Cornelia et al.
DOI: 10.1136/openhrt-2021-001821

Mapping Potentials Adjacent to the Cavo-tricuspid Isthmus Ablation Line during Incremental Pacing: A Feasible and Highly Accurate Maneuver to Confirm Complete CTI Conduction Block.

PMID: 32400073
Journal: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Year: 2020
Reference: J Cardiovasc Electrophysiol. 2020 Jul;31(7):1649-1657. doi: 10.1111/jce.14542. Epub 2020 May 23.
Impact factor: 2.424
Publication type: Paper in international publication
Authors: Bas, D, Benito, B, Alcalde, O, Cabrera, S, Altaba, C, Bazan, V, Gonzalez-Matos, C, Marti-Almor, J, Valles, E, Jimenez-Lopez, J et al.
DOI: 10.1111/jce.14542

Prior adherence to recommended lipid control targets in patients admitted for acute coronary syndrome.

PMID: 31706709
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2020
Reference: Rev Esp Cardiol. 2020 May;73(5):376-382. doi: 10.1016/j.rec.2019.06.014. Epub 2019 Nov 6.
Impact factor: 4.642
Publication type: Paper in national publication
Authors: Mila, Laia, Barrabes, Jose A, Lidon, Rosa-Maria, Sambola, Antonia, Baneras, Jordi, Oristrell, Gerard, Rafecas, Agnes, Garcia-Dorado, David et al.
DOI: 10.1016/j.recesp.2019.06.012

Cardiomyocyte ageing and cardioprotection: Consensus Document from the ESC Working Groups Cell Biology of the Heart and Myocardial Function.

PMID: 32384145
Journal: CARDIOVASCULAR RESEARCH
Year: 2020
Reference: Cardiovasc Res. 2020 Sep 1;116(11):1835-1849. doi: 10.1093/cvr/cvaa132.
Impact factor: 8.168
Publication type: Review in international publication
Authors: Bou-Teen, Diana, Ferdinandy, Peter, Gyongyosi, Mariann, Pesce, Maurizio, Perrino, Cinzia, Schulz, Rainer, Sluijter, Joost, Tocchetti, Carlo G, Thum, Thomas, Madonna, Rosalinda et al.
DOI: 10.1093/cvr/cvaa132

Cardiac metabolism as a driver and therapeutic target of myocardial infarction.

PMID: 32384583
Journal: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Year: 2020
Reference: J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8.
Impact factor: 4.486
Publication type: Review in international publication
Authors: Liepinsh, Edgars, Brookes, Paul S, Krieg, Thomas, Kaambre, Tuuli, Montessuit, Christophe, Dambrova, Maija, Eric Botker, Hans, Zuurbier, Coert J, Bertrand, Luc, Beauloye, Christoph R et al.
DOI: 10.1111/jcmm.15180

Estimated Percentage of Patients With Stable Coronary Heart Disease Candidates for PCSK9 Inhibitors.

PMID: 30981589
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Jun;72(6):518-519. doi: 10.1016/j.rec.2018.11.018. Epub 2019 Apr 10.
Impact factor: 5.078
Publication type: Letter or abstract
Authors: Facila, Lorenzo, Galve, Enrique, Gonzalez Juanatey, Jose Ramon, Cordero, Alberto et al.
DOI: 10.1016/j.rec.2018.11.018

Proximal aorta longitudinal strain predicts aortic root dilation rate and aortic events in Marfan syndrome.

PMID: 30977783
Journal: EUROPEAN HEART JOURNAL
Year: 2019
Reference: Eur Heart J. 2019 Jul 1;40(25):2047-2055. doi: 10.1093/eurheartj/ehz191.
Impact factor: 23.239
Publication type: Paper in international publication
Authors: Guala, Andrea, Teixido-Tura, Gisela, Rodriguez-Palomares, Jose, Ruiz-Munoz, Aroa, Dux-Santoy, Lydia, Villalva, Nicolas, Granato, Chiara, Galian, Laura, Gutierrez, Laura, Gonzalez-Alujas, Teresa et al.
DOI: 10.1093/eurheartj/ehz191

Sudden Cardiovascular Death in Young Patients With Aortic Dissection. What Lessons Should We Learn?

PMID: 30956035
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Jul;72(7):528-530. doi: 10.1016/j.rec.2019.01.010. Epub 2019 Apr 5.
Impact factor: 5.078
Publication type: Paper in national publication
Authors: Evangelista, Arturo, Teixido-Tura, Gisela et al.
DOI: 10.1016/j.rec.2019.01.010

Worse 12-month prognosis in women with non-valvular atrial fibrillation undergoing percutaneous coronary intervention.

PMID: 30953959
Journal: THROMBOSIS RESEARCH
Year: 2019
Reference: Thromb Res. 2019 Jun;178:20-25. doi: 10.1016/j.thromres.2019.03.017. Epub 2019 Mar 28.
Impact factor: 3.266
Publication type: Paper in international publication
Authors: Sambola, Antonia, Bueno, Hector, Gordon, Blanca, Mutuberria, Maria, Barrabes, Jose A, Del Blanco, Bruno Garcia, Gonzalez-Fernandez, Victor, Casamira, Nuria, Garcia-Dorado, David et al.
DOI: 10.1016/j.thromres.2019.03.017

Sex Differences in Timeliness of Reperfusion in Young Patients With ST-Segment-Elevation Myocardial Infarction by Initial Electrocardiographic Characteristics.

PMID: 29514807
Journal: Journal of the American Heart Association
Year: 2018
Reference: J Am Heart Assoc. 2018 Mar 7;7(6). pii: JAHA.117.007021. doi: 10.1161/JAHA.117.007021.
Impact factor: 4.45
Publication type: Paper in international publication
Authors: Gupta, Aakriti, Barrabes, Jose A, Strait, Kelly, Bueno, Hector, Porta-Sanchez, Andreu, Acosta-Velez, J Gabriel, Lidon, Rosa-Maria, Spatz, Erica, Geda, Mary, Dreyer, Rachel P et al.
DOI: 10.1161/JAHA.117.007021

Comments on the 2017 ESC Focused Update on Dual Antiplatelet Therapy in Coronary Artery Disease.

PMID: 29277237
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2018
Reference: Rev Esp Cardiol (Engl Ed). 2018 Jan;71(1):6-12. doi: 10.1016/j.rec.2017.11.019.
Impact factor: 5.166
Publication type: Letter or abstract
Authors: Valencia, Felix, Ballesteros, Sara, Ruiz-Nodar, Juan Miguel, Ferreiro, Jose Luis, Tello Montoliu, Antonio, Marin, Francisco, Perez de Prado, Armando, Romero Moreno, Miguel, Bravo, M Sol, Ruiz Ortiz, Martin et al.
DOI: 10.1016/j.rec.2017.11.019

E/e' ratio and left atrial area are predictors of atrial fibrillation in patients with hypertrophic cardiomyopathy.

PMID: 29505666
Journal: ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
Year: 2018
Reference: Echocardiography. 2018 Jul;35(7):935-940. doi: 10.1111/echo.13857. Epub 2018 Mar 5.
Impact factor: 1.197
Publication type: Paper in international publication
Authors: Galve, Enrique, Costabel, Juan Pablo, Ronderos, Ricardo, Baranchuk, Adrian, Evangelista, Arturo, Avegliano, Gustavo, Ametrano, Clara, Terricabras, Maria et al.
DOI: 10.1111/echo.13857

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.

PMID: 29502044
Journal: Redox Biology
Year: 2018
Reference: Redox Biol. 2018 Jun;16:146-156. doi: 10.1016/j.redox.2018.02.021. Epub 2018 Mar 1.
Impact factor: 7.126
Publication type: Paper in international publication
Authors: Sanchis, Daniel, Marti, Ramon, Blasco, Natividad, Camara, Yolanda, Nunez, Estefania, Bea, Aida, Bares, Gisel, Forne, Carles, Ruiz-Meana, Marisol, Giron, Cristina et al.
DOI: 10.1016/j.redox.2018.02.021

Ten-year longitudinal change in aortic stiffness assessed by cardiac MRI in the second half of the human lifespan: the multi-ethnic study of atherosclerosis.

PMID: 26758407
Journal: EUROPEAN JOURNAL OF CELL BIOLOGY
Year: 2016
Reference: Eur Heart J Cardiovasc Imaging. 2016 Sep;17(9):1044-53. doi: 10.1093/ehjci/jev332. Epub 2016 Jan 12.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Ohyama, Yoshiaki, Teixido-Tura, Gisela, Ambale-Venkatesh, Bharath, Noda, Chikara, Chugh, Atul R, Liu, Chia-Ying, Stacey, R Brandon, Dietz, Harry, Gomes, Antoinette S, Prince, Martin R et al.
DOI: 10.1093/ehjci/jev332

Medical treatment for chronic aortic regurgitation: beta-blockers horizontal line maybe not bad, but good?

PMID: 26729694
Journal: HEART
Year: 2016
Reference: Heart. 2016 Feb 1;102(3):168-9. doi: 10.1136/heartjnl-2015-308955. Epub 2016 Jan 4.
Impact factor: 5.693
Publication type: Editorail in international publication
Authors: Evangelista, Arturo et al.
DOI: 10.1136/heartjnl-2015-308955

Effects of Triple Therapy in Patients With Non-Valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention Regarding Thromboembolic Risk Stratification.

PMID: 26725763
Journal: CIRCULATION JOURNAL
Year: 2016
Reference: Circ J. 2016 Jan 25;80(2):354-62. doi: 10.1253/circj.CJ-15-0923. Epub 2015 Dec 25.
Impact factor: 4.124
Publication type: Paper in international publication
Authors: Barrabes, Jose A, Alfonso, Fernando, Bueno, Hector, Cequier, Angel, Zueco, Javier, Rodriguez-Leor, Oriol, Bosch, Eduard, Tornos, Pilar, Garcia-Dorado, David, Alonso, Albert et al.
DOI: 10.1253/circj.CJ-15-0923

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition.

PMID: 26705364
Journal: CARDIOVASCULAR RESEARCH
Year: 2016
Reference: Cardiovasc Res. 2016 Mar 1;109(3):374-84. doi: 10.1093/cvr/cvv279. Epub 2015 Dec 23.
Impact factor: 5.465
Publication type: Paper in international publication
Authors: Valls-Lacalle, Laura, Barba, Ignasi, Miro-Casas, Elisabet, Alburquerque-Bejar, Juan Jose, Ruiz-Meana, Marisol, Fuertes-Agudo, Marina, Rodriguez-Sinovas, Antonio, Garcia-Dorado, David et al.
DOI: 10.1093/cvr/cvv279

Cut-off values of myocardial perfusion gated-SPECT phase analysis parameters of normal subjects, and conduction and mechanical cardiac diseases.

PMID: 26017712
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2015
Reference: J Nucl Cardiol. 2015 Dec;22(6):1247-58. doi: 10.1007/s12350-015-0143-2. Epub 2015 May 28.
Impact factor: 2.942
Publication type: Paper in international publication
Authors: Romero-Farina, Guillermo, Aguade-Bruix, Santiago, Candell-Riera, Jaume, Pizzi, Maria N, Garcia-Dorado, David et al.
DOI: 10.1007/s12350-015-0143-2

Combination therapy with remote ischemic conditioning and insulin or exenatide enhances infarct size limitation in pigs.

PMID: 26045476
Journal: CARDIOVASCULAR RESEARCH
Year: 2015
Reference: Cardiovasc Res. 2015 Jul 15;107(2):246-54. doi: 10.1093/cvr/cvv171. Epub 2015 Jun 4.
Impact factor: 5.94
Publication type: Paper in international publication
Authors: Valls-Lacalle, Laura, Rodriguez-Sinovas, Antonio, Garcia-Dorado, David, Vilardosa, Ursula, Poncelas, Marcos, Ruiz-Meana, Marisol, Miro-Casas, Elisabet, Alburquerque-Bejar, Juan Jose, Barba, Ignasi, Inserte, Javier et al.
DOI: 10.1093/cvr/cvv171

Implantable Cardioverter-defibrillator Therapy for Hypertrophic Cardiomyopathy: Usefulness in Primary and Secondary Prevention.

PMID: 25449813
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2015
Reference: Rev Esp Cardiol (Engl Ed). 2015 Jun;68(6):492-6. doi: 10.1016/j.rec.2014.06.025. Epub 2014 Nov 20.
Impact factor: 3.792
Publication type: Paper in national publication
Authors: Sarrias, Axel, Galve, Enrique, Sabate, Xavier, Moya, Angel, Anguera, Ignacio, Nunez, Elaine, Villuendas, Roger, Garcia-Dorado, David, Alcalde, Oscar et al.
DOI: 10.1016/j.rec.2014.06.025

Warranty periods for normal myocardial perfusion stress SPECT.

PMID: 25116906
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2015
Reference: J Nucl Cardiol. 2015 Feb;22(1):44-54. doi: 10.1007/s12350-014-9957-6. Epub 2014 Aug 13.
Impact factor: 2.942
Publication type: Paper in international publication
Authors: Romero-Farina, Guillermo, Candell-Riera, Jaume, Aguade-Bruix, Santiago, Ferreira-Gonzalez, Ignacio, Cuberas-Borros, Gemma, Pizzi, Nazarena, Garcia-Dorado, David et al.
DOI: 10.1007/s12350-014-9957-6

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The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.