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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

Gender Differences in Takotsubo Syndrome.

PMID: 35618345
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 May 31;79(21):2085-2093. doi: 10.1016/j.jacc.2022.03.366.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Arcari, Luca, Nunez Gil, Ivan J, Stiermaier, Thomas, El-Battrawy, Ibrahim, Guerra, Federico, Novo, Giuseppina, Musumeci, Beatrice, Cacciotti, Luca, Mariano, Enrica, Caldarola, Pasquale et al.
DOI: 10.1016/j.jacc.2022.03.366

Genetically Triggered Aortic Disease Outcomes: On the Long Road to Personalized Medicine.

PMID: 35618344
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 May 31;79(21):2082-2084. doi: 10.1016/j.jacc.2022.03.368.
Impact factor: 24.093
Publication type: Editorail in international publication
Authors: Evangelista, Arturo, Teixido-Tura, Gisela et al.
DOI: 10.1016/j.jacc.2022.03.368

Balloon- Versus Self-Expanding Valve Systems for Treating Small Failed Surgical Aortic Bioprostheses: The LYTEN Trial.

PMID: 35597385
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 May 13. pii: S0735-1097(22)04978-6. doi: 10.1016/j.jacc.2022.05.005.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Pibarot, Philippe, Pelletier-Beaumont, Emilie, Panagides, Vassili, Mohammadi, Siamak, Rodes-Cabau, Josep, Abbas, Amr, Vilalta, Victoria, Nombela-Franco, Luis, Regueiro, Ander, Al-Azizi, Karim M et al.
DOI: 10.1016/j.jacc.2022.05.005

A systematic study and literature review of parental somatic mosaicism of FBN1 pathogenic variants in Marfan syndrome.

PMID: 33910934
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2022
Reference: J Med Genet. 2022 Jun;59(6):605-612. doi: 10.1136/jmedgenet-2020-107604. Epub 2021 Apr 28.
Impact factor: 6.318
Publication type: Paper in international publication
Authors: Fernandez-Alvarez, Paula, Codina-Sola, Marta, Valenzuela, Irene, Teixido-Tura, Gisela, Cueto-Gonzalez, Anna, Paramonov, Ida, Antolin, Maria, Lopez-Grondona, Fermina, Vendrell, Teresa, Evangelista, Artur et al.
DOI: 10.1136/jmedgenet-2020-107604

Left Atrium Assessment by Speckle Tracking Echocardiography in Cryptogenic Stroke: Seeking Silent Atrial Fibrillation.

PMID: 34441797
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Aug 9;10(16). pii: jcm10163501. doi: 10.3390/jcm10163501.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Ble, Mireia, Benito, Begona, Cuadrado-Godia, Elisa, Perez-Fernandez, Silvia, Gomez, Miquel, Mas-Stachurska, Aleksandra, Tizon-Marcos, Helena, Molina, Lluis, Marti-Almor, Julio, Cladellas, Merce et al.
DOI: 10.3390/jcm10163501

Differential Effects of Western and Mediterranean-Type Diets on Gut Microbiota: A Metagenomics and Metabolomics Approach.

PMID: 34444797
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082638. doi: 10.3390/nu13082638.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Barber, Claudia, Mego, Marianela, Sabater, Carlos, Vallejo, Fernando, Bendezu, Rogger Alvaro, Masihy, Marcela, Guarner, Francisco, Espin, Juan Carlos, Margolles, Abelardo, Azpiroz, Fernando et al.
DOI: 10.3390/nu13082638

Recurrent superinfection in a patient with transjugular intrahepatic portosystemic shunt (endotipsitis), findings on (18)F-FDG PET/CT.

PMID: 34425974
Journal: Revista Espanola de Medicina Nuclear e Imagen Molecular
Year: 2021
Reference: Rev Esp Med Nucl Imagen Mol (Engl Ed). 2021 Sep-Oct;40(5):320-321. doi: 10.1016/j.remnie.2021.03.001. Epub 2021 Mar 11.
Impact factor: 1.359
Publication type: Letter or abstract
Authors: Villasboas-Rosciolesi, D, Simo-Perdigo, M, Castell-Conesa, J, Aguade-Bruix, S et al.
DOI: 10.1016/j.remnie.2021.03.001

Long-term intense FDG uptake in a non-infected prosthetic aortic heart valve implanted 18 years ago.

PMID: 34414551
Journal: JOURNAL OF NUCLEAR CARDIOLOGY
Year: 2021
Reference: J Nucl Cardiol. 2021 Aug 19. pii: 10.1007/s12350-021-02764-x. doi: 10.1007/s12350-021-02764-x.
Impact factor: 5.952
Publication type: Letter or abstract
Authors: Roque, Albert, Blanco, Emilia, Aguade-Bruix, Santiago, Fernandez-Hidalgo, Nuria, Cuellar-Calabria, Hug, Pizzi, Maria Nazarena et al.
DOI: 10.1007/s12350-021-02764-x

Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFbeta1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice.

PMID: 32340244
Journal: Biomolecules
Year: 2020
Reference: Biomolecules. 2020 Apr 23;10(4). pii: biom10040651. doi: 10.3390/biom10040651.
Impact factor: 4.082
Publication type: Paper in international publication
Authors: Ruiz-Meana, Marisol, Valls-Lacalle, Laura, Consegal, Marta, Barba, Ignasi, Ferreira-Gonzalez, Ignacio, Rodriguez-Sinovas, Antonio, Inserte, Javier, Benito, Begona et al.
DOI: 10.3390/biom10040651

Correction to: Pilot study of the multicentre DISCHARGE trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography.

PMID: 32333145
Journal: EUROPEAN RADIOLOGY
Year: 2020
Reference: Eur Radiol. 2020 Sep;30(9):5223-5225. doi: 10.1007/s00330-020-06820-x.
Impact factor: 4.101
Publication type: Letter or abstract
Authors: De Rubeis, Gianluca, Dodd, Jonathan Dermot, Hensey, Mark, Mancone, Massimo, Ceccacci, Andrea, Berzina, Marina, Zvaigzne, Ligita, Sakalyte, Gintare, Basevicius, Algidas, Ilnicka-Suckiel, Malgorzata et al.
DOI: 10.1007/s00330-020-06820-x

Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography.

PMID: 31844958
Journal: EUROPEAN RADIOLOGY
Year: 2020
Reference: Eur Radiol. 2020 Apr;30(4):1997-2009. doi: 10.1007/s00330-019-06522-z. Epub 2019 Dec 16.
Impact factor: 4.101
Publication type: Paper in international publication
Authors: Knuuti, Juhani, De Rubeis, Gianluca, Ball, Peter, Dodd, Jonathan, Hensey, Mark, Mancone, Massimo, Ceccacci, Andrea, Berzina, Marina, Zvaigzne, Ligita, Sakalyte, Gintare et al.
DOI: 10.1007/s00330-019-06522-z

Cardiovascular magnetic resonance to evaluate cardiopulmonary remodelling in endurance athletes: can we predict adaptation to exercise?

PMID: 31648541
Journal: European Journal of Preventive Cardiology
Year: 2020
Reference: Eur J Prev Cardiol. 2020 Apr;27(6):645-648. doi: 10.1177/2047487319882816. Epub 2019 Oct 24.
Impact factor: 5.864
Publication type: Editorail in international publication
Authors: Rodriguez-Palomares, Jose F et al.
DOI: 10.1177/2047487319882816

REDUCTION OF LEFT VENTRICULAR DILATATION BEYOND THE FIRST YEAR FOLLOWING ANTERIOR MYOCARDIAL INFARCTION.

PMID: 30910449
Journal: JOURNAL OF CARDIAC FAILURE
Year: 2019
Reference: J Card Fail. 2019 Aug;25(8):645-653. doi: 10.1016/j.cardfail.2019.03.012. Epub 2019 Mar 22.
Impact factor: 3.857
Publication type: Paper in international publication
Authors: Figueras, Jaume, Baneras, Jordi, Aguade, Santiago, Sambola, Antonia, Barrabes, Jose A, Candell-Riera, Jaume, Porta-Sanchez, Andreu, Garcia-Dorado, David et al.
DOI: 10.1016/j.cardfail.2019.03.012

Trends and Bibliometric Impact of Research Grants of the Spanish Society of Cardiology/Spanish Heart Foundation (2007-2012).

PMID: 30905664
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Dec;72(12):1012-1019. doi: 10.1016/j.rec.2018.08.029. Epub 2019 Mar 22.
Impact factor: 5.078
Publication type: Paper in national publication
Authors: Rodriguez-Padial, Luis, Fernandez Lozano, Ignacio, Hidalgo Urbano, Rafael, Silva Melchor, Lorenzo, Evangelista Massip, Arturo, Anguita Sanchez, Manuel, Iniguez Romo, Andres et al.
DOI: 10.1016/j.rec.2018.08.029

Pre-procedural imaging to guide transcoronary ethanol ablation for refractory septal ventricular tachycardia.

PMID: 30556327
Journal: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Year: 2019
Reference: J Cardiovasc Electrophysiol. 2019 Mar;30(3):448-456. doi: 10.1111/jce.13816. Epub 2019 Jan 5.
Impact factor: 2.91
Publication type: Paper in international publication
Authors: Roca-Luque, Ivo, Rivas-Gandara, Nuria, Francisco-Pascual, Jaume, Rodriguez-Sanchez, Jose, Cuellar-Calabria, Hug, Rodriguez-Palomares, Jose, Garcia-Del Blanco, Bruno, Perez-Rodon, Jordi, Santos-Ortega, Alba, Roses-Noguer, Ferran et al.
DOI: 10.1111/jce.13816

Improvement in the Assessment of Aortic Valve and Aortic Aneurysm Repair by 3-Dimensional Echocardiography.

PMID: 30878428
Journal: JACC-Cardiovascular Imaging
Year: 2019
Reference: JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 1):2225-2244. doi: 10.1016/j.jcmg.2018.06.032. Epub 2019 Mar 13.
Impact factor: 10.975
Publication type: Review in international publication
Authors: Hagendorff, Andreas, Evangelista, Arturo, Fehske, Wolfgang, Schafers, Hans-Joachim et al.
DOI: 10.1016/j.jcmg.2018.06.032

Impact of anticoagulation therapy on valve haemodynamic deterioration following transcatheter aortic valve replacement.

PMID: 29440192
Journal: HEART
Year: 2018
Reference: Heart. 2018 May;104(10):814-820. doi: 10.1136/heartjnl-2017-312514. Epub 2018 Feb 13.
Impact factor: 5.42
Publication type: Paper in international publication
Authors: Dager, Antonio, Del Trigo, Maria, Munoz-Garcia, Antonio J, Latib, Azeem, Auffret, Vincent, Wijeysundera, Harindra C, Nombela-Franco, Luis, Gutierrez, Enrique, Cheema, Asim N, Serra, Vicenc et al.
DOI: 10.1136/heartjnl-2017-312514

Impact of renin-angiotensin system inhibitors on clinical outcomes and ventricular remodelling after transcatheter aortic valve implantation: rationale and design of the RASTAVI randomised multicentre study.

PMID: 29440218
Journal: BMJ Open
Year: 2018
Reference: BMJ Open. 2018 Feb 13;8(2):e020255. doi: 10.1136/bmjopen-2017-020255.
Impact factor: 2.413
Publication type: Paper in international publication
Authors: Sevilla, Teresa, Arnold, Roman, Revilla, Ana, San Roman, J Alberto, Varela-Falcon, Luis H, Lopez, Javier, Garcia Del Blanco, Bruno, Jimenez-Diaz, Victor A, Amat-Santos, Ignacio J, Catala, Pablo et al.
DOI: 10.1136/bmjopen-2017-020255

Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve.

PMID: 29426841
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Feb 9;8(1):2777. doi: 10.1038/s41598-018-20642-4.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Kostina, Alexandra S, Osterholm, Cecilia, Malashicheva, Anna, Kostareva, Anna, Evangelista, Arturo, Teixido-Tura, Gisela, Maleki, Shohreh, Franco-Cereceda, Anders, Eriksson, Per, Dietz, Harry C et al.
DOI: 10.1038/s41598-018-20642-4

Comments on the 2017 ESC/EACTS Guidelines for the Management of Valvular Heart Disease.

PMID: 29425609
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2018
Reference: Rev Esp Cardiol (Engl Ed). 2018 Feb;71(2):67-73. doi: 10.1016/j.rec.2017.11.027.
Impact factor: 5.166
Publication type: Editorial in national publication
Authors: Evangelista, A et al.
DOI: 10.1016/j.rec.2017.11.027

Impact of Triple Therapy in Elderly Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.

PMID: 26808678
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Jan 25;11(1):e0147245. doi: 10.1371/journal.pone.0147245. eCollection 2016.
Impact factor: 3.057
Publication type: Paper in international publication
Authors: Bueno, Hector, Alfonso, Fernando, Cequier, Angel, Zueco, Javier, Rodriguez-Leor, Oriol, Tornos, Pilar, Garcia-Dorado, David, Barrabes, Jose A, Alonso, Albert, Mutuberria, Maria et al.
DOI: 10.1371/journal.pone.0147245

Hand-held cardiac ultrasound screening performed by family doctors with remote expert support interpretation.

PMID: 26802099
Journal: PROGRESS IN COMPUTATIONAL FLUID DYNAMICS
Year: 2016
Reference: Heart. 2016 Mar 1;102(5):376-82. doi: 10.1136/heartjnl-2015-308421. Epub 2016 Jan 22.
Impact factor: 0.288
Publication type: Paper in international publication
Authors: Evangelista, Arturo, Galuppo, Valentina, Mendez, Judith, Evangelista, Lidia, Arpal, Lidia, Rubio, Carles, Vergara, Montserrat, Liceran, Manuela, Lopez, Francesc, Sales, Carlos et al.
DOI: 10.1136/heartjnl-2015-308421

Hospital and 4-Year Mortality Predictors in Patients With Acute Pulmonary Edema With and Without Coronary Artery Disease.

PMID: 26883921
Journal: Journal of the American Heart Association
Year: 2016
Reference: J Am Heart Assoc. 2016 Feb 16;5(2). pii: e002581. doi: 10.1161/JAHA.115.002581.
Impact factor: 5.117
Publication type: Paper in international publication
Authors: Figueras, Jaume, Baneras, Jordi, Pena-Gil, Carlos, Barrabes, Jose A, Rodriguez Palomares, Jose, Garcia Dorado, David et al.
DOI: 10.1161/JAHA.115.002581

[Infective endocarditis in adult patients with congenital heart disease. Experience from a reference centre].

PMID: 26860418
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2016
Reference: Enferm Infecc Microbiol Clin. 2016 Dec;34(10):626-632. doi: 10.1016/j.eimc.2016.01.004. Epub 2016 Feb 6.
Impact factor: 1.53
Publication type: Paper in international publication
Authors: Loureiro-Amigo, Jose, Fernandez-Hidalgo, Nuria, Pijuan-Domenech, Antonia, Dos-Subira, Laura, Subirana-Domenech, Teresa, Gonzalez-Alujas, Teresa, Gonzalez-Lopez, Juan Jose, Tornos-Mas, Pilar, Garcia-Dorado, David, Almirante, Benito et al.
DOI: 10.1016/j.eimc.2016.01.004

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The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.