About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 35709412 Journal: JOURNAL OF CLINICAL ONCOLOGY Year: 2022 Reference: J Clin Oncol. 2022 Jun 16:JCO2102981. doi: 10.1200/JCO.21.02981. Impact factor: 44.544 Publication type: Paper in international publication Authors: Merks, Johannes H M, Schoot, Reineke A, Chisholm, Julia C, Casanova, Michela, Minard-Colin, Veronique, Geoerger, Birgit, Cameron, Alison L, Coppadoro, Beatrice, Zanetti, Ilaria, Orbach, Daniel et al. DOI: 10.1200/JCO.21.02981
PMID: 35686139 Journal: HemaSphere Year: 2022 Reference: Hemasphere. 2022 Jun 6;6(6):e739. doi: 10.1097/HS9.0000000000000739. eCollection 2022 Jun. Impact factor: 0 Publication type: Paper in international publication Authors: Roy, Noemi B A, Da Costa, Lydie, Russo, Roberta, Bianchi, Paola, Del Mar Manu-Pereira, Maria, Fermo, Elisa, Andolfo, Immacolata, Clark, Barnaby, Proven, Melanie, Sanchez, Mayka et al. DOI: 10.1097/HS9.0000000000000739
PMID: 35671096 Journal: JOURNAL OF CLINICAL INVESTIGATION Year: 2022 Reference: J Clin Invest. 2022 Jun 7. pii: 142842. doi: 10.1172/JCI142842. Impact factor: 14.808 Publication type: Paper in international publication Authors: Casado, Jose A, Valeri, Antonio, Sanchez-Dominguez, Rebeca, Vela, Paula, Lopez, Andrea, Navarro, Susana, Alberquilla, Omaira, Hanenberg, Helmut, Pujol, Roser, Segovia, Jose C et al. DOI: 10.1172/JCI142842
PMID: 35661144 Journal: BRITISH JOURNAL OF HAEMATOLOGY Year: 2022 Reference: Br J Haematol. 2022 Jun 6. doi: 10.1111/bjh.18191. Impact factor: 6.998 Publication type: Paper in international publication Authors: Russo, Roberta, Roy, Noemi B A, Da Costa, Lydie, Fermo, Elisa, Andolfo, Immacolata, Clark, Barnaby, Proven, Melanie, Sanchez, Mayka, van Wijk, Richard, van der Zwaag, Bert et al. DOI: 10.1111/bjh.18191
PMID: 34294484 Journal: Year: 2021 Reference: Nefrologia (Engl Ed). 2021 Jul 19:S0211-6995(21)00113-2. doi: 10.1016/j.nefro.2021.03.008. Impact factor: Publication type: Paper in international publication Authors: Aguera, Maria Luisa; Beneyto, Isabel; Bernal, Gabriel; Calderari, Elena; Crespo, Marta; de Gracia, Maria Carmen; de Santiago, Carlos; Diaz, Candido; Diaz-Corte, Carmen; Dominguez-Gil, Beatriz et al. DOI: 10.1016/j.nefro.2021.03.008
PMID: 33713387 Journal: EUROPEAN JOURNAL OF HAEMATOLOGY Year: 2021 Reference: Eur J Haematol. 2021 Jun;106(6):842-850. doi: 10.1111/ejh.13618. Epub 2021 Mar 30. Impact factor: 2.997 Publication type: Paper in international publication Authors: Gonzalez Vicent, Marta, Diaz de Heredia, Cristina, Gonzalez de Pablo, Jesus, Molina, Blanca, Regueiro, Alexandra, Perez Martinez, Antonio, Palomo, Pilar, Lopez Corral, Lucia, Garcia, Estefania, Fernandez, Jose Maria et al. DOI: 10.1111/ejh.13618
PMID: 35071133 Journal: Frontiers in Pediatrics Year: 2021 Reference: Front Pediatr. 2022 Jan 6;9:784377. doi: 10.3389/fped.2021.784377. eCollection 2021. Impact factor: 3.418 Publication type: Review in international publication Authors: Wolfl, Matthias, Qayed, Muna, Benitez Carabante, Maria Isabel, Sykora, Tomas, Bonig, Halvard, Lawitschka, Anita, Diaz-de-Heredia, Cristina et al. DOI: 10.3389/fped.2021.784377
PMID: 34884726 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2021 Reference: Int J Mol Sci. 2021 Nov 29;22(23). pii: ijms222312921. doi: 10.3390/ijms222312921. Impact factor: 5.924 Publication type: Paper in international publication Authors: Magdaleno, Ainara, Giralt, Irina, Gallo-Oller, Gabriel, Navarro, Natalia, Zarzosa, Patricia, Pons, Guillem, Hladun, Raquel, Arango, Diego, Sanchez de Toledo, Jose, Moreno, Lucas et al. DOI: 10.3390/ijms222312921
PMID: 33129040 Journal: EUROPEAN JOURNAL OF CANCER Year: 2020 Reference: Eur J Cancer. 2020 Dec;141:82-91. doi: 10.1016/j.ejca.2020.09.024. Epub 2020 Oct 9. Impact factor: 7.275 Publication type: Paper in international publication Authors: Rubio-San-Simon, Alba, Andre, Nicolas, Cefalo, Maria Giuseppina, Aerts, Isabelle, Castaneda, Alicia, Benezech, Sarah, Makin, Guy, van Eijkelenburg, Natasha, Nysom, Karsten, Marshall, Lynley et al. DOI: 10.1016/j.ejca.2020.09.024
PMID: 33110059 Journal: Nature Communications Year: 2020 Reference: Nat Commun. 2020 Oct 27;11(1):5376. doi: 10.1038/s41467-020-19175-0. Impact factor: 12.121 Publication type: Paper in international publication Authors: Gros, Luis, Ramon Y Cajal, Santiago, Poca, Maria A, Puente, Xose S, Sahuquillo, Juan, Gallego, Soledad, Seoane, Joan, Hladun, Raquel, Lesende-Rodriguez, Ivan, Vazquez-Mendez, Elida et al. DOI: 10.1038/s41467-020-19175-0
PMID: 33054048 Journal: HAEMATOLOGICA Year: 2020 Reference: Haematologica. 2020 Jun 5;105(9):2229-2239. doi: 10.3324/haematol.2019.240846. Impact factor: 7.116 Publication type: Paper in international publication Authors: Bianchi, Paola, Glenthoj, Andreas, Del Mar Manu Pereira, Maria, Van Wijk, Richard, Glader, Bertil, Grace, Rachael F, Barcellini, Wilma, Kuo, Kevin H M, Van Beers, Eduard J, Al-Samkari, Hanny et al. DOI: 10.3324/haematol.2019.240846
PMID: 32943619 Journal: Cell Death & Disease Year: 2020 Reference: Cell Death Dis. 2020 Sep 17;11(9):773. doi: 10.1038/s41419-020-02986-w. Impact factor: 6.304 Publication type: Paper in international publication Authors: Soriano, Aroa, Jimenez, Carlos, Erazo, Tatiana, Munoz-Guardiola, Pau, Masanas, Marc, Antonelli, Roberta, Boloix, Ariadna, Alfon, Jose, Perez-Montoyo, Hector, Yeste-Velasco, Marc et al. DOI: 10.1038/s41419-020-02986-w
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
