About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 35574376 Journal: Frontiers in Oncology Year: 2022 Reference: Front Oncol. 2022 Apr 27;12:835642. doi: 10.3389/fonc.2022.835642. eCollection 2022. Impact factor: 6.244 Publication type: Paper in international publication Authors: Cassandri, Matteo, Perrone, Clara, Pomella, Silvia, Colletti, Marta, Cossetti, Cristina, Pericoli, Giulia, Di Giannatale, Angela, de Billy, Emmanuel, Vinci, Maria, Petrini, Stefania et al. DOI: 10.3389/fonc.2022.835642
PMID: 35523687 Journal: ANALES DE PEDIATRIA Year: 2022 Reference: An Pediatr (Engl Ed). 2022 Apr;96(4):309-318. doi: 10.1016/j.anpede.2021.02.016. Epub 2022 May 3. Impact factor: 1.5 Publication type: Paper in international publication Authors: de la Fuente Regano, Lydia, Rodriguez Villa, Antonia, Diaz de Heredia Rubio, Cristina, Gonzalez Vicent, Marta, Badell Serra, Isabel, Maria Fernandez, Jose, Isabel Pascual Martinez, Antonia, Maria Perez Hurtado, Jose, Lopez Duarte, Monica, Soledad Maldonado Regalado, M et al. DOI: 10.1016/j.anpede.2021.02.016
PMID: 34718043 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2022 Reference: J Allergy Clin Immunol. 2022 May;149(5):1744-1754.e8. doi: 10.1016/j.jaci.2021.10.017. Epub 2021 Oct 27. Impact factor: 10.793 Publication type: Paper in international publication Authors: Courteille, Virginie, Lankester, Arjan C, Neven, Benedicte, Mahlaoui, Nizar, von Asmuth, Erik Gj, Kansoy, Savas, Kupesiz, Alphan, Lanfranchi, Arnalda, Lindemans, Caroline A, Meisel, Roland et al. DOI: 10.1016/j.jaci.2021.10.017
PMID: 35466492 Journal: PEDIATRIC TRANSPLANTATION Year: 2022 Reference: Pediatr Transplant. 2022 Apr 24:e14292. doi: 10.1111/petr.14292. Impact factor: 1.502 Publication type: Paper in international publication Authors: Navarro Jimenez, Alexandra, Garrido Pontnou, Marta, Camacho Soriano, Jessica, Hidalgo Llompart, Ernest, Bilbao Aguirre, Itxarone, Charco Torra, Itzarone, Esperalba, Juliana, Melendo Perez, Susana, Sabado Alvarez, Constantino, Quintero Bernabeu, Jesus et al. DOI: 10.1111/petr.14292
PMID: 34451907 Journal: Pharmaceuticals Year: 2021 Reference: Pharmaceuticals (Basel). 2021 Aug 18;14(8). pii: ph14080810. doi: 10.3390/ph14080810. Impact factor: 5.863 Publication type: Review in international publication Authors: Giralt, Irina, Zarzosa, Patricia, Pons, Guillem, Magdaleno, Ainara, Segura, Miguel F, Sanchez de Toledo, Jose, Moreno, Lucas, Gallego, Soledad, Roma, Josep, Navarro, Natalia et al. DOI: 10.3390/ph14080810
PMID: 34413474 Journal: BONE MARROW TRANSPLANTATION Year: 2021 Reference: Bone Marrow Transplant. 2021 Oct;56(10):2615. doi: 10.1038/s41409-021-01424-5. Impact factor: 5.483 Publication type: Letter or abstract Authors: Sedlacek, Petr, Willasch, Andre Manfred, Peters, Christina, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kalman, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc et al. DOI: 10.1038/s41409-021-01424-5
PMID: 34416158 Journal: LANCET ONCOLOGY Year: 2021 Reference: Lancet Oncol. 2021 Sep;22(9):1312-1321. doi: 10.1016/S1470-2045(21)00387-9. Epub 2021 Aug 17. Impact factor: 41.316 Publication type: Paper in international publication Authors: Casanova, Michela, Gaspar, Nathalie, Venkatramani, Rajkumar, Hecker-Nolting, Stefanie, Melcon, Soledad Gallego, Locatelli, Franco, Bautista, Francisco, Longhi, Alessandra, Lervat, Cyril, Entz-Werle, Natacha et al. DOI: 10.1016/S1470-2045(21)00387-9
PMID: 34406671 Journal: AMERICAN JOURNAL OF HEMATOLOGY Year: 2021 Reference: Am J Hematol. 2021 Nov 1;96(11):E416-E420. doi: 10.1002/ajh.26323. Epub 2021 Aug 30. Impact factor: 10.047 Publication type: Letter or abstract Authors: Papasavva, Panayiota, Zulkipli, Ihsan Nazurah, Yusof, Hajah Noorainun Haji Mohd, Ghani, Muhammad Hazim Haji Abdul, Wong, Seow Chin, Lim, Mei Ann, Lettre, Guillaume, Kuo, Kevin, Justiniano, Anneliesse, Chin-Yee, Benjamin et al. DOI: 10.1002/ajh.26323
PMID: 31257135 Journal: ANALES DE PEDIATRIA Year: 2020 Reference: An Pediatr (Barc). 2020 Jul;93(1):16-23. doi: 10.1016/j.anpedi.2019.05.014. Epub 2019 Jun 27. Impact factor: 1.313 Publication type: Paper in national publication Authors: Garcia Iniguez, Juan Pablo, Samper Villagrasa, Maria Pilar, Calvo Escribano, Carlota, Murillo Sanjuan, Laura, Sanz de Miguel, Maria Pilar, Rodriguez-Vigil Iturrate, Carmen, Martinez Faci, Cristina et al. DOI: 10.1016/j.anpedi.2019.05.014
PMID: 32653773 Journal: EUROPEAN JOURNAL OF CANCER Year: 2020 Reference: Eur J Cancer. 2020 Sep;136:52-68. doi: 10.1016/j.ejca.2020.05.010. Epub 2020 Jul 9. Impact factor: 7.275 Publication type: Review in international publication Authors: Moreno, Lucas, Barone, Giuseppe, DuBois, Steven G, Molenaar, Jan, Fischer, Matthias, Poon, Evon, Shay, Jerry W, Tonelli, Roberto, Valteau-Couanet, Dominique, Vassal, Gilles et al. DOI: 10.1016/j.ejca.2020.05.010
PMID: 32638196 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2020 Reference: J Clin Immunol. 2020 Aug;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7. Impact factor: 6.78 Publication type: Paper in international publication Authors: Ehl, Stephan, Elmaksoud, Marwa Abd, Astigarraga, Itziar, Kurjane, Natalja, Bulina, Inita, Kenina, Viktorija, Bryceson, Yenan, Rascon, Jelena, Lortie, Anne, Goldstein, Gal et al. DOI: 10.1007/s10875-020-00814-6
PMID: 32595135 Journal: CANCER RESEARCH Year: 2020 Reference: Cancer Res. 2020 Aug 15;80(16):3424-3435. doi: 10.1158/0008-5472.CAN-20-0133. Epub 2020 Jun 28. Impact factor: 9.727 Publication type: Paper in international publication Authors: Carceller, Fernando, Koers, Alexander, Barone, Giuseppe, Pearson, Andrew D J, Moreno, Lucas, Anderson, John, Sebire, Neil, McHugh, Kieran, Koh, Dow-Mu, Chesler, Louis et al. DOI: 10.1158/0008-5472.CAN-20-0133
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
