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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Publications

Phase II trial of afatinib in patients with advanced urothelial carcinoma with genetic alterations in ERBB1-3 (LUX-Bladder 1).

PMID: 38102226
Journal: BRITISH JOURNAL OF CANCER
Year: 2023
Reference: Br J Cancer. 2023 Dec 15. doi: 10.1038/s41416-023-02513-6.
Impact factor:
Publication type: Paper in international publication
Authors: Aldecoa, Iban; Araujo, Silvia G; Buti, Maria; Castellano, Daniel; Climent, Miguel A; Fernandez, Emma; Fernandez, Pedro L; Font, Albert; Forns, Xavier; Gibson, Neil et al.
DOI: 10.1038/s41416-023-02513-6

Assessing the rate of non-linkage to care and identifying barriers in individuals living with hepatitis B. Results of the LINK-B study.

PMID: 38111084
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Dec 18. doi: 10.1111/liv.15814.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Feliu-Prius, Anna; Palom, Adriana; Rando, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruiz-Cobo, Juan C; Vargas-Accarino, Elena et al.
DOI: 10.1111/liv.15814

Highlights from the 24th European Congress on Gynaecological Oncology in Istanbul: an ENYGO-IJGC Fellows compilation.

PMID: 38114163
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Year: 2023
Reference: Int J Gynecol Cancer. 2023 Dec 18:ijgc-2023-005109. doi: 10.1136/ijgc-2023-005109.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Nuria; Angeles, Martina Aida; Barreira-Diaz, Ana; Bilir, Esra; Bizzarri, Nicolo; Bonaldo, Giulio; Buti, Maria; Cucinella, Giuseppe; De Vitis, Luigi Antonio; du Bois, Andreas et al.
DOI: 10.1136/ijgc-2023-005109

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral Treatments.

PMID: 38139013
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Dec 6;24(24):17185. doi: 10.3390/ijms242417185.
Impact factor:
Publication type: Paper in international publication
Authors: Adombi, Caroline Melanie; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Ibanez-Lligona, Marta; Quer, Josep et al.
DOI: 10.3390/ijms242417185

What is the optimal antimicrobial prophylaxis to prevent postoperative infectious complications after liver transplantation? - A systematic review of the literature and expert panel recommendations.

PMID: 35257411
Journal: CLINICAL TRANSPLANTATION
Year: 2022
Reference: Clin Transplant. 2022 Oct;36(10):e14631. doi: 10.1111/ctr.14631.
Impact factor:
Publication type: Review in international publication
Authors: Blumberg, Emily A; Campos-Varela, Isabel; Giorgio, Patricia; Kotton, Camille N; Raptis, Dimitri Aristotle; Saliba, Fauzi; Spiro, Michael; Villamil, Federico; Wey, Emmanuel Q et al.
DOI: 10.1111/ctr.14631

Sinusoidal Obstruction Syndrome after Liver Transplantation: A Multicenter Observational Study.

PMID: 35255179
Journal: LIVER TRANSPLANTATION
Year: 2022
Reference: Liver Transpl. 2022 Jul;28(7):1257-1261. doi: 10.1002/lt.26452. Epub 2022 Apr 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Victoria; Baliellas, Carme; Banares, Rafael; Caballero-Marcos, Aranzazu; Campos-Varela, Isabel; Castells, Lluis; Colmenero, Jordi; Diaz, Alba; Gomez-Bravo, Miguel Angel; Gonzalez-Dieguez, Luisa et al.
DOI: 10.1002/lt.26452

Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).

PMID: 35220659
Journal: LIVER INTERNATIONAL
Year: 2022
Reference: Liver Int. 2022 May;42(5):1109-1120. doi: 10.1111/liv.15207. Epub 2022 Mar 7.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Altamirano, Jose; Bataller, Ramon; Bosques-Padilla, Francisco; Brown, Robert S Jr; Caballeria, Juan; Calafat, Margalida; Canete, Nuria; Cirera, Isabel; Garcia-Retortillo, Montserrat et al.
DOI: 10.1111/liv.15207

Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1: Conservation and Variability.

PMID: 35215809
Journal: Viruses-Basel
Year: 2022
Reference: Viruses. 2022 Jan 22;14(2). pii: v14020215. doi: 10.3390/v14020215.
Impact factor:
Publication type: Paper in international publication
Authors: Aldama, Unai; Buti, Maria; Casillas, Rosario; Cortese, Maria Francesca; Galan, Anna; Garcia-Garcia, Selene; Gonzalez-Aseguinolaza, Gloria; Gregori, Josep; Najarro, Adrian; Pacin-Ruiz, Beatriz et al.
DOI: 10.3390/v14020215

Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis (nash) in five european countries in 2018: A cost-of-illness analysis.

PMID: 33590598
Journal: LIVER INTERNATIONAL
Year: 2021
Reference: Liver Int. 2021 Jun;41(6):1227-1242. doi: 10.1111/liv.14825. Epub 2021 Mar 18.
Impact factor:
Publication type: Paper in international publication
Authors: Aghemo, Alessio; Atella, Vincenzo; Augustin, Salvador; Bantel, Heike; Boursier, Jerome; Bugianesi, Elisabetta; Castera, Laurent; Crespo, Javier; Cure, Sandrine; de Ledinghen, Victor et al.
DOI: 10.1111/liv.14825

A Prospective Cohort of SARS-CoV-2-Infected Health Care Workers: Clinical Characteristics, Outcomes, and Follow-up Strategy.

PMID: 33537362
Journal: Open Forum Infectious Diseases
Year: 2021
Reference: Open Forum Infect Dis. 2020 Dec 8;8(1):ofaa592. doi: 10.1093/ofid/ofaa592. eCollection 2021 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Alves, Eduarda; Alves, Eduarda; Alves, Elisenda; Anmella, Gerard; Anmella, Gerard; Aranda, Carmen; Arenas, Andrea; Arenas, Andrea; Asenjo, Maria; Avalos, Maribel et al.
DOI: 10.1093/ofid/ofaa592

Taking care of kidney transplant recipients during the COVID-19 pandemic: experience from a medicalized hotel.

PMID: 33103277
Journal: CLINICAL TRANSPLANTATION
Year: 2021
Reference: Clin Transplant. 2021 Jan;35(1):e14132. doi: 10.1111/ctr.14132. Epub 2020 Dec 16.
Impact factor:
Publication type: Letter or abstract
Authors: Bayes, Beatriu; Bodro, Marta; Cofan, Frederic; Coloma, Emmanuel; Creus, Paula; Cucchiari, David; Diekmann, Fritz; Esforzado, Nuria; Guillen, Elena; Hernandez, Carme et al.
DOI: 10.1111/ctr.14132

Reflex viral load testing in dried blood spots generated by plasma separation card allows the screening and diagnosis of chronic viral hepatitis.

PMID: 33338545
Journal: JOURNAL OF VIROLOGICAL METHODS
Year: 2021
Reference: J Virol Methods. 2021 Mar;289:114039. doi: 10.1016/j.jviromet.2020.114039. Epub 2020 Dec 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Barbosa, Gisela; Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Ferreira, Vicelma; Ferrer-Costa, Roser; Kuchta, Alison; Lopez, Eva; Martinez-Camprecios, Joan et al.
DOI: 10.1016/j.jviromet.2020.114039

Development and Validation of Hepamet Fibrosis Scoring System-a Simple, Non-invasive Test to Identify Patients With Nonalcoholic Fatty liver Disease With Advanced Fibrosis.

PMID: 31195161
Journal: Clinical Gastroenterology and Hepatology
Year: 2020
Reference: Clin Gastroenterol Hepatol. 2020 Jan;18(1):216-225.e5. doi: 10.1016/j.cgh.2019.05.051. Epub 2019 Jun 11.
Impact factor:
Publication type: Paper in international publication
Authors: Agustin, Salvador; Albillos, Agustin; Aller, Rocio; Ampuero, Javier; Andrade, Raul; Arias Loste, Maria Teresa; Aspichueta, Patricia; Banales, Jesus M; Benlloch, Salvador; Boursier, Jerome et al.
DOI: 10.1016/j.cgh.2019.05.051

Durability of Hepatitis B Surface Antigen Loss With Nucleotide Analogue and Peginterferon Therapy in Patients With Chronic Hepatitis B.

PMID: 31909352
Journal: Hepatology communications
Year: 2020
Reference: Hepatol Commun. 2019 Oct 10;4(1):8-20. doi: 10.1002/hep4.1436. eCollection 2020 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Chan, Henry L Y; Dusheiko, Geoffrey; Flaherty, John F; Gaggar, Anuj; Ghany, Marc G; Locarnini, Stephen; Lok, Anna S; Marcellin, Patrick; Subramanian, G Mani et al.
DOI: 10.1002/hep4.1436

Editorial: rapid disease progression in hepatitis delta-can we turn the tide? Authors' reply.

PMID: 31850577
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2020
Reference: Aliment Pharmacol Ther. 2020 Jan;51(1):174-175. doi: 10.1111/apt.15558.
Impact factor:
Publication type: Editorail in international publication
Authors: Buti, Maria; Palom, Adriana; Riveiro-Barciela, Mar et al.
DOI: 10.1111/apt.15558

Long-term clinical outcomes in patients with chronic hepatitis delta: the role of persistent viraemia.

PMID: 31721254
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2020
Reference: Aliment Pharmacol Ther. 2020 Jan;51(1):158-166. doi: 10.1111/apt.15521. Epub 2019 Nov 13.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Rafael; Garcia-Samaniego, Javier; Lens, Sabela; Navascues, Carmen A; Palom, Adriana; Riveiro-Barciela, Mar; Rodriguez, Manuel; Rodriguez-Tajes, Sergio et al.
DOI: 10.1111/apt.15521

A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-beta induction.

PMID: 28527664
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Oct;67(4):669-679. doi: 10.1016/j.jhep.2017.05.010. Epub 2017 May 18.
Impact factor: 12.486
Publication type: Paper in international publication
Authors: Ni, Yi, Hommel, Mirja, Palomo, Laura, Segura, Victor, Olague, Cristina, Vales, Africa, Ruiz-Ripa, Alicia, Buti, Maria, Salido, Eduardo, Prieto, Jesus et al.
DOI: 10.1016/j.jhep.2017.05.010

Selection of the highly replicative and partially multidrug resistant rtS78T polymerase mutation in two patients with chronic hepatitis B virus infection during tenofovir-entecavir combination therapy.

PMID: 28392234
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Aug;67(2):246-254. doi: 10.1016/j.jhep.2017.03.027. Epub 2017 Apr 7.
Impact factor: 12.486
Publication type: Paper in international publication
Authors: Shirvani-Dastgerdi, Elham, Winer, Benjamin Y, Celia-Terrassa, Antoni, Kang, Yibin, Tabernero, David, Yagmur, Eray, Rodriguez-Frias, Francisco, Gregori, Josep, Luedde, Tom, Ploss, Alexander et al.
DOI: 10.1016/j.jhep.2017.03.027

Effectiveness, safety and clinical outcomes of direct-acting antiviral therapy in HCV genotype 1 infection: Results from a Spanish real-world cohort.

PMID: 28189751
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Jun;66(6):1138-1148. doi: 10.1016/j.jhep.2017.01.028. Epub 2017 Feb 9.
Impact factor: 12.486
Publication type: Paper in international publication
Authors: Llerena, Susana, Pascasio, Juan Manuel, Turnes, Juan, Torras, Xavier, Morillas, Rosa Maria, Llaneras, Jordi, Serra, Miguel A, Diago, Moises, Rodriguez, Conrado Fernandez, Ampuero, Javier et al.
DOI: 10.1016/j.jhep.2017.01.028

Serum Hepatitis B core-related antigen is more accurate than HBsAg to identify inactive carriers, regardless of HBV genotype.

PMID: 28288829
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2017
Reference: Clin Microbiol Infect. 2017 Nov;23(11):860-867. doi: 10.1016/j.cmi.2017.03.003. Epub 2017 Mar 11.
Impact factor: 5.292
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Bes, Marta, Rodriguez-Frias, Francisco, Tabernero, David, Ruiz, Alicia, Casillas, Rosario, Vidal, Judith, Homs, Maria, Nieto, Leonardo, Sauleda, Silvia et al.
DOI: 10.1016/j.cmi.2017.03.003

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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