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Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Team

Daniel Alejandro Pacha Vicente

Daniel Alejandro Pacha Vicente

Musculoskeletal Tissue Engineering
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Joan Albert Prat Matifoll

Joan Albert Prat Matifoll

Musculoskeletal Tissue Engineering
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Carmen Pastor Quiñones

Carmen Pastor Quiñones

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Margalida Hernandez Vicens

Margalida Hernandez Vicens

Main researcher
Musculoskeletal Tissue Engineering
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Anna Server Salvà

Anna Server Salvà

Main researcher
Musculoskeletal Tissue Engineering
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Joaquim Vives Armengol

Joaquim Vives Armengol

Main researcher
Musculoskeletal Tissue Engineering
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Daniel Alejandro Pacha Vicente

Daniel Alejandro Pacha Vicente

Musculoskeletal Tissue Engineering
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Joan Albert Prat Matifoll

Joan Albert Prat Matifoll

Musculoskeletal Tissue Engineering
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Carmen Pastor Quiñones

Carmen Pastor Quiñones

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Margalida Hernandez Vicens

Margalida Hernandez Vicens

Main researcher
Musculoskeletal Tissue Engineering
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Anna Server Salvà

Anna Server Salvà

Main researcher
Musculoskeletal Tissue Engineering
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Joaquim Vives Armengol

Joaquim Vives Armengol

Main researcher
Musculoskeletal Tissue Engineering
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Research lines

Bone Regeneration

This research line seeks to promote bone regeneration using advanced cell therapy. Our alliance between biologists, engineers and clinical researchers enables us to develop new tissue engineering products that after thorough evaluation in the scopes of basic research and preclinical testing can then be applied in the human clinical setting.


Current Studies:


1. Autologous cell therapy with adult stem cells for osteonecrosis of the femoral head.

Osteonecrosis Clinical phase I-II study: We are currently conducting a comparative study between a product developed by our research group of advanced cell therapy in the context of osteonecrosis of the femoral head precollapse stage. It is a pioneering study at a national and international level by assessing the bone regenerative capability of this product compared to the classical treatment of core decompression.


2. Treatment of femoral head osteonecrosis with advanced cell therapy and biomaterials in an experimental sheep model.

Osteonecrosis preclinical study: We are evaluating mesenchymal stem cells expanded ex-vivo associated with different scaffolds and BMP in osteonecrosis of the femoral head in an ovine model. We are evaluating the different  osteoconductive, osteoinductive and osteogenerative components to optimize the best biologic for the treatment of femoral head necrosis.


3. Experimental study of "in vivo" expanded adult stem cell therapy .

Critical size defect preclinical study:  We are evaluating mesenchymal stem cells expanded ex-vivo in a critical segmental defect in an ovine model.

IP: Màrius Aguirre Canyadell, Roberto Vélez Villa

Orthopaedic oncology - 3D planification / printing

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.

Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.

Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.

Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.


Current research:

1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).

A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.

Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.

3. 3D Planification / Printing

3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.

IP: Roberto Vélez Villa

Soft tissue Regeneration

Orthopaedic surgeons treat diseases of the "Soft Tissues" including muscles, tendons, ligaments, cartilage and peripheral nerves.
Certain degenerative diseases can affect tendons and cartilage, altering their healing capabilities. Traumatic injuries of ligaments, muscles or peripheral nerves may have difficulty healing. These processes lead to dysfunctions and pain. Our working group aims to study the healing process of soft tissues, and propose and evaluate methods to improve tissue reparative processes from the biological standpoint. The ultimate goal is to provide solutions to clinical practice from translational research.


Current studies:


1. In vivo study of the tensile strength of a suture to flexor tendons fluted point compared with conventional yarn Kessler.

This paper studies the flexor tendon healing in rabbits, with different surgical strategies and materials.


2. Clinical prospective randomized study comparing subacromial injection of platelet-rich plasma bupivacaine with betamethasone and rotator cuff tendinosis.


This clinical trial is studying the healing of the rotator cuff tendons with symptomatic degenerative phase that does not respond to treatment through rehabilitation and oral anti-inflammatory. Compare functional outcomes and quality of life with two different treatments. Inflammatory and other biological one.

IP: Daniel Alejandro Pacha Vicente

Projects

BIOBANCOS Y BIOMODELOS

IP: Isabel Novoa Garcia
Collaborators: Joaquim Vives Armengol, Anna Duarri Piqué, Eva Colas Ortega, Oriol Bestard Matamoros, Marta Rosal Fontana, Carmen Espejo Ruiz, Marielle Esteves Coelho, Juan Jose Gonzalez Lopez, Sheyla Pascual Martín, Alejandro Tomasello Weitz, Shirley Guzmán Avilés
Funding agency: Instituto de Salud Carlos III
Funding: 137460
Reference: PT23/00040
Duration: 01/01/2024 - 31/12/2026

Pot un tercer clau intramedul·lar flexible ser una opció de tractament en fractures diafisàries de fèmur inestables? Anàlisi biomecànica

IP: Daniel Alejandro Pacha Vicente
Collaborators: Margalida Hernandez Vicens
Funding agency: Acadèmia Ciències Mèdiques Catalunya i Balears
Funding: 8000
Reference: TRUETA/PACHA/23
Duration: 01/09/2023 - 31/08/2025

Traslación de un producto alogénico de ingeniería tisular para el tratamiento de lesiones focales del cartílago articular

IP: Roberto Vélez Villa
Collaborators: Nayana Joshi Jubert, Anna Server Salvà, Daniel Alejandro Pacha Vicente, Joan Albert Prat Matifoll, Raquel Cabrera Perez
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 00877
Duration: 01/01/2022 - 30/06/2025

Traslación de un producto alogénico de ingeniería tisular para el tratamiento de lesiones focales del cartílago articular.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Anna Server Salvà, Juan Minguell Moñart, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 105270
Reference: PI22/01906
Duration: 01/01/2023 - 31/12/2025

Publications

Acromial physeal fracture in an adolescent: a case report and literature review.

PMID: 38312296
Journal:
Year: 2024
Reference: JSES Int. 2023 Nov 7;8(1):6-10. doi: 10.1016/j.jseint.2023.10.002. eCollection 2024 Jan.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Carbonell Rosell, Carla; Gonzalez-Morgado, Diego; Pacha-Vicente, Daniel; Sevil Mayayo, Raquel; Soza Leiva, Diego; Vargas Meouchi, Enrique Alberto et al.
DOI: 10.1016/j.jseint.2023.10.002

Identification of critical process parameters for expansion of clinical grade human Wharton's jelly-derived mesenchymal stromal cells in stirred-tank bioreactors.

PMID: 38403461
Journal: Biotechnology Journal
Year: 2024
Reference: Biotechnol J. 2024 Feb;19(2):e2300381. doi: 10.1002/biot.202300381.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Gragera, Victor; Lecina, Marti; Lopez-Fernandez, Alba; Vives, Joaquim et al.
DOI: 10.1002/biot.202300381

Current challenges in cell and gene therapy: a joint view from the European Committee of the International Society for Cell & Gene Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT).

PMID: 38416085
Journal: CYTOTHERAPY
Year: 2024
Reference: Cytotherapy. 2024 Feb 17:S1465-3249(24)00054-9. doi: 10.1016/j.jcyt.2024.02.007.
Impact factor:
Publication type: Paper in international publication
Authors: Chabannon, Christian; Corbacioglu, Selim; Dolstra, Harry; Farge, Dominique; Gagelmann, Nico; Gnecchi, Massimiliano; Horgan, Claire; Kuball, Jurgen; Neven, Benedicte; Rintala, Tuula et al.
DOI: 10.1016/j.jcyt.2024.02.007

Implantation of a double allogeneic human engineered tissue graft on damaged heart: insights from the PERISCOPE phase I clinical trial.

PMID: 38490102
Journal: EBioMedicine
Year: 2024
Reference: EBioMedicine. 2024 Mar 14;102:105060. doi: 10.1016/j.ebiom.2024.105060.
Impact factor:
Publication type: Paper in international publication
Authors: Bayes-Genis, Antoni; Bisbal, Felipe; Camara, Maria Luisa; Cediel, German; Ferrer-Curriu, Gemma; Galvez-Monton, Carolina; Gastelurrutia, Paloma; Monguio-Tortajada, Marta; Munoz-Guijosa, Christian; Prat-Vidal, Cristina et al.
DOI: 10.1016/j.ebiom.2024.105060

First surgical experience treating scoliosis using HGT and ECMO: a case report.

PMID: 36121561
Journal: Spine Deformity
Year: 2023
Reference: Spine Deform. 2023 Mar;11(2):507-511. doi: 10.1007/s43390-022-00588-4. Epub 2022 Sep 19.
Impact factor:
Publication type: Letter or abstract
Authors: Balcells, Joan; Moreira, Felipe; Moreno, Antonio; Nuno, Rosario; Pellise, Ferran; Pujol, Oriol et al.
DOI: 10.1007/s43390-022-00588-4

Allografts and lateral extra-articular tenodesis for revision anterior cruciate ligament reconstruction: enhanced rotational stability and improved functional outcomes.

PMID: 36708388
Journal: European Journal of Orthopaedic Surgery and Traumatology
Year: 2023
Reference: Eur J Orthop Surg Traumatol. 2023 Aug;33(6):2579-2586. doi: 10.1007/s00590-023-03475-4. Epub 2023 Jan 28.
Impact factor:
Publication type: Paper in international publication
Authors: Castellet Feliu, Enric; Joshi Jubert, Nayana; Minguell Monyart, Joan; Minguell Monyart, Joan; Moreira Borim, Felipe; Pijoan Bueno, Joan; Pijoan Bueno, Joan; Portas-Torres, Irene; Reverte Vinaixa, Maria Mercedes et al.
DOI: 10.1007/s00590-023-03475-4

Atraumatic Fracture of the Femoral Component of a Cemented Total Knee Arthroplasty: A Case Report.

PMID: 36812361
Journal: JBJS case connector
Year: 2023
Reference: JBJS Case Connect. 2023 Feb 22;13(1). doi: 10.2106/JBJS.CC.22.00641. eCollection 2023 Jan 1.
Impact factor:
Publication type: Letter or abstract
Authors: Castellet, Enric; Joshi-Jubert, Nayana; Minguell, Joan; Pijoan, Joan; Pujol, Oriol; Reverte, Merce; Reverte, Merce et al.
DOI: 10.2106/JBJS.CC.22.00641

Preliminary Outcomes of a Staged Percutaneous Retrograde Prefabricated Gentamicin-coated Intramedullary Nail to Manage Complications after Ankle Fusion through Tibial Bone Transport.

PMID: 38404568
Journal:
Year: 2023
Reference: Strategies Trauma Limb Reconstr. 2023 Sep-Dec;18(3):155-162. doi: 10.5005/jp-journals-10080-1595.
Impact factor:
Publication type: Paper in international publication
Authors: Castellanos, Sara; Corona, Pablo; Joshi-Jubert, Nayana; Pujol, Oriol; Vicente, Matias et al.
DOI: 10.5005/jp-journals-10080-1595

Feasibility of a brief mindfulness-based program for burnout in pain healthcare professionals.

PMID: 36420394
Journal: Frontiers in Psychology
Year: 2022
Reference: Front Psychol. 2022 Nov 7;13:1009266. doi: 10.3389/fpsyg.2022.1009266. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Ayora, Alfonso; Gracia, Rosa Maria; Medel, Javier; Mesas, Angela; Perez-Carrasco, Marcos; Server, Anna; Suso-Ribera, Carlos et al.
DOI: 10.3389/fpsyg.2022.1009266

Preoperative mechanical axis has no influence on reoperation rate in primary rotating-hinge knee arthroplasty.

PMID: 36238960
Journal: Journal of orthopaedics
Year: 2022
Reference: J Orthop. 2022 Oct 7;34:364-367. doi: 10.1016/j.jor.2022.09.020. eCollection 2022 Nov-Dec.
Impact factor:
Publication type: Paper in international publication
Authors: Altayo, Marta; Castellet, Enric; Joshi-Jubert, Nayana; Lara, Yuri; Minguell, Joan; Pijoan, Joan; Pujol, Oriol; Reverte-Vinaixa, Merce et al.
DOI: 10.1016/j.jor.2022.09.020

Tourniquet use in patients undergoing tumour resection and endoprosthetic reconstruction of the knee.

PMID: 36177639
Journal: Bone & Joint Journal
Year: 2022
Reference: Bone Joint J. 2022 Oct;104-B(10):1168-1173. doi: 10.1302/0301-620X.104B10.BJJ-2022-0286.R1.
Impact factor:
Publication type: Paper in international publication
Authors: Gazendam, Aaron M; Ghert, Michelle; Schneider, Patricia; Velez, Roberto et al.
DOI: 10.1302/0301-620X.104B10.BJJ-2022-0286.R1

Optimisation of processing methods to improve success in the derivation of human multipotent mesenchymal stromal cells from cryopreserved umbilical cord tissue fragments.

PMID: 36041506
Journal: CRYOBIOLOGY
Year: 2022
Reference: Cryobiology. 2022 Oct;108:34-41. doi: 10.1016/j.cryobiol.2022.08.002. Epub 2022 Aug 28.
Impact factor:
Publication type: Paper in international publication
Authors: Carreras-Sanchez, Irene; Lopez-Fernandez, Alba; Munoz-Dominguez, Noelia; Vives, Joaquim et al.
DOI: 10.1016/j.cryobiol.2022.08.002

Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY): a multi-center randomized controlled study comparing alternative antibiotic regimens in patients undergoing tumor resections with endoprosthetic replacements-a statistical analysis plan.

PMID: 33752752
Journal: Trials
Year: 2021
Reference: Trials. 2021 Mar 22;22(1):223. doi: 10.1186/s13063-021-05147-2.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelbary, Hesham; Abidin, Suraya Zainul; Aboulafia, Albert; Abraham, John; Anderson, Megan; Arteau, Annie; Avedian, Raffi; Balach, Tessa; Baptista, Andre Mathias; Becker, Ricardo et al.
DOI: 10.1186/s13063-021-05147-2

Trigger Digit Incidence After Carpal Tunnel Release: Reconstruction in Elongated Position Versus Traditional Carpal Tunnel Release.

PMID: 31847590
Journal: Hand (New York, N.Y.)
Year: 2021
Reference: Hand (N Y). 2021 Nov;16(6):741-745. doi: 10.1177/1558944719893055. Epub 2019 Dec 17.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Esteban-Feliu, Ignacio; Gallardo-Calero, Irene; Lluch-Bergada, Alex; Nunez-Camarena, Jorge; Vidal-Tarrason, Nuria et al.
DOI: 10.1177/1558944719893055

Wharton's Jelly Mesenchymal Stromal Cells and Derived Extracellular Vesicles as Post-Myocardial Infarction Therapeutic Toolkit: An Experienced View.

PMID: 34575412
Journal: Pharmaceutics
Year: 2021
Reference: Pharmaceutics. 2021 Aug 26;13(9). pii: pharmaceutics13091336. doi: 10.3390/pharmaceutics13091336.
Impact factor:
Publication type: Review in international publication
Authors: Munoz-Dominguez, Noelia; Prat-Vidal, Cristina; Roura, Santiago; Vives, Joaquim et al.
DOI: 10.3390/pharmaceutics13091336

Pulmonary Embolism after Core Decompression of the Femoral Head Using Injectable Bone Graft Substitute: A Case Report.

PMID: 34552895
Journal: Hip & pelvis
Year: 2021
Reference: Hip Pelvis. 2021 Sep;33(3):167-172. doi: 10.5371/hp.2021.33.3.167. Epub 2021 Sep 6.
Impact factor:
Publication type: Letter or abstract
Authors: Aguirre, Marius; Gargallo, Alberto; Pacha, Daniel; Pujol, Oriol; Riera, Luis; Uria, Maria-Luz et al.
DOI: 10.5371/hp.2021.33.3.167

Factors Associated With Mortality After Surgical Management of Femoral Neck Fractures.

PMID: 33027161
Journal: JOURNAL OF ORTHOPAEDIC TRAUMA
Year: 2020
Reference: J Orthop Trauma. 2020 Nov;34 Suppl 3:S15-S21. doi: 10.1097/BOT.0000000000001937.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelbary, Hesham; Abdelgawad, Amr; Abelseth, Gregory; Adams, Benita; Adams, John D; Adamsahib, Fathima; Agel, Julie; Ahmad, Shanaz; Ahmed, Sarim S; Ahn, Henry et al.
DOI: 10.1097/BOT.0000000000001937

What Predicts Health-Related Quality of Life for Patients With Displaced Femoral Neck Fractures Managed With Arthroplasty? A Secondary Analysis of the HEALTH Trial.

PMID: 33027163
Journal: JOURNAL OF ORTHOPAEDIC TRAUMA
Year: 2020
Reference: J Orthop Trauma. 2020 Nov;34 Suppl 3:S29-S36. doi: 10.1097/BOT.0000000000001933.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelbary, Hesham; Abdelgawad, Amr; Abelseth, Gregory; Adams, Benita; Adamsahib, Fathima; Ahmad, Shanaz; Ahmed, Sarim S; Ahn, Henry; Ahn, Jaimo; Akbari, Aftab et al.
DOI: 10.1097/BOT.0000000000001933

Study Summaries.

PMID: 33027158
Journal: JOURNAL OF ORTHOPAEDIC TRAUMA
Year: 2020
Reference: J Orthop Trauma. 2020 Nov;34 Suppl 3:Sii-Siii. doi: 10.1097/BOT.0000000000001927.
Impact factor:
Publication type: Letter or abstract
Authors: Abdelbary, Hesham; Abdelgawad, Amr; Abelseth, Gregory; Adams, Benita; Adams, John D; Adamsahib, Fathima; Agel, Julie; Ahmad, Shanaz; Ahmed, Sarim S; Ahn, Henry et al.
DOI: 10.1097/BOT.0000000000001927

Strategies for large-scale expansion of clinical-grade human multipotent mesenchymal stromal cells

PMID: NOPMID0085
Journal: BIOCHEMICAL ENGINEERING JOURNAL
Year: 2020
Reference: Biochemical Engineering Journal. 2020 Jul;159:107601. doi: 10.1016/j.bej.2020.107601
Impact factor:
Publication type: Review in international publication
Authors: Borrós, Salvador; García-Fernández, Coral; Lecina, Martí; López-Fernández, Alba; Vives, Joaquim et al.
DOI: 10.1016/j.bej.2020.107601

Osteogenic commitment of Wharton's jelly mesenchymal stromal cells: mechanisms and implications for bioprocess development and clinical application.

PMID: 31779673
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Nov 28;10(1):356. doi: 10.1186/s13287-019-1450-3.
Impact factor:
Publication type: Paper in international publication
Authors: Borras, Francesc Enric; Cabrera-Perez, Raquel; Gamez-Valero, Ana; Monguio-Tortajada, Marta; Rojas-Marquez, Raquel; Roura, Santiago; Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1450-3

Cannabis for pain in orthopedics: a systematic review focusing on study methodology

PMID: 31782292
Journal: CANADIAN JOURNAL OF SURGERY
Year: 2019
Reference: Can J Surg. 2019 Dec 1;62(6):001018. doi: 10.1503/cjs.001018.
Impact factor:
Publication type: Review in international publication
Authors: Bhandari, Mohit; Borim, Felipe Moreira; George, Annie; Madden, Kim; Mammen, George; van der Hoek, Niek J. et al.
DOI: 10.1503/cjs.001018

Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study.

PMID: 31666550
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Oct 30;9(1):15686. doi: 10.1038/s41598-019-51936-w.
Impact factor:
Publication type: Paper in international publication
Authors: Bago, Joan; Catala, Jordi; de Albert, Matias; Ramirez, Manuel; Rodriguez-Baeza, Alfonso; Sallent, Andrea; Velez, Roberto et al.
DOI: 10.1038/s41598-019-51936-w

Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.

PMID: 31557429
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2019
Reference: N Engl J Med. 2019 Dec 5;381(23):2199-2208. doi: 10.1056/NEJMoa1906190. Epub 2019 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: ; Andres Peiro, José vicente; Barro Ojeda, Victor ; Bhandari, Mohit; Bzovsky, Sofia; Carbonell Rosell, Carla; Collado Gastalver, Diego; Devereaux, P J; Einhorn, Thomas A; Frihagen, Frede et al.
DOI: 10.1056/NEJMoa1906190

Triple elastofibromas located in the supra- and infrascapular regions-a case report.

PMID: 29170811
Journal: SKELETAL RADIOLOGY
Year: 2018
Reference: Skeletal Radiol. 2018 Apr;47(4):569-573. doi: 10.1007/s00256-017-2813-4. Epub 2017 Nov 23.
Impact factor:
Publication type: Paper in international publication
Authors: Ciriaco, Nikaoly; de Delas-Vigo, Matias de Albert; Olchowy, Cyprian; Oronoz, Rosa Dominguez; Perez, Manolo et al.
DOI: 10.1007/s00256-017-2813-4

TRest as a New Diagnostic Variable for Chronic Exertional Compartment Syndrome of the Forearm: A Prospective Cohort Analysis of 124 Athletes.

PMID: 28817409
Journal: CLINICAL JOURNAL OF SPORT MEDICINE
Year: 2018
Reference: Clin J Sport Med. 2018 Nov;28(6):516-523. doi: 10.1097/JSM.0000000000000482.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Campillo-Recio, David; Correa-Vazquez, Eva; Gallardo-Calero, Irene; Haddad, Sleiman; Haddad, Sleiman; Mir-Bullo, Xavier; Sallent, Andrea; Soldado, Francisco et al.
DOI: 10.1097/JSM.0000000000000482

Vascularized ulnar periosteal pedicled flap for forearm reconstruction: Anatomical study and a case report.

PMID: 28745437
Journal: MICROSURGERY
Year: 2018
Reference: Microsurgery. 2018 Jul;38(5):530-535. doi: 10.1002/micr.30208. Epub 2017 Jul 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alfonso, Rodriguez-Baeza; Francisco, Soldado; Jorge, Knorr; Josep Maria, De Bergua-Domingo; Roberto, Velez; Sergi, Barrera-Ochoa et al.
DOI: 10.1002/micr.30208

Clinical translation of a Mesenchymal Stromal Cell-based therapy developed in a large animal model and two case studies of the treatment of atrophic pseudoarthrosis.

PMID: 27684058
Journal: Journal of Tissue Engineering and Regenerative Medicine
Year: 2018
Reference: J Tissue Eng Regen Med. 2018 Jan;12(1):e532-e540. doi: 10.1002/term.2323. Epub 2017 Jun 1.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Blanco, Margarita; Caminal, Marta; Carreno, Ana; Chaverri, Daniel; Codinach, Margarita; Coll, Ruth; Gallardo-Villares, Santiago; Garcia-Lopez, Joan; Granell-Escobar, Fernando et al.
DOI: 10.1002/term.2323

Should lower limb fractures be treated surgically in patients with chronic spinal injuries? Experience in a reference centre.

PMID: 27908583
Journal: Revista espanola de cirugia ortopedica y traumatol
Year: 2017
Reference: Rev Esp Cir Ortop Traumatol. 2017 Jan - Feb;61(1):19-27. doi: 10.1016/j.recot.2016.07.007. Epub 2016 Nov 29.
Impact factor:
Publication type: Paper in national publication
Authors: Barrera-Ochoa, S; Haddad, S; Molero, V; Rodriguez-Alabau, S; Teixidor, J; Tomas, J et al.
DOI: 10.1016/j.recot.2016.07.007

New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research.

PMID: 27357187
Journal: LAB ANIMAL
Year: 2017
Reference: Lab Anim. 2017 Apr;51(2):124-137. doi: 10.1177/0023677216656221. Epub 2016 Jul 9.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Canyadell, Marius; Barrera-Ochoa, Sergi; Gallardo-Calero, Irene; Giralt, Jordi; Lopez-Fernandez, Alba; Sallent, Andrea; Velez, Roberto; Verges, Ramona et al.
DOI: 10.1177/0023677216656221

Free vascularized tibial periosteal graft with monitoring skin island for limb reconstruction: Anatomical study and case report.

PMID: 26621668
Journal: MICROSURGERY
Year: 2017
Reference: Microsurgery. 2017 Mar;37(3):248-251. doi: 10.1002/micr.30011. Epub 2015 Dec 1.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Corona, Pablo S; Diaz-Gallardo, Paula; Knorr, Jorge; Mascarenhas, Vasco V; Rodriguez-Baeza, Alfonso; Soldado, Francisco; Vega-Encina, I et al.
DOI: 10.1002/micr.30011

A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies.

PMID: 27860364
Journal: Journal of Tissue Engineering and Regenerative Medicine
Year: 2017
Reference: J Tissue Eng Regen Med. 2017 Dec;11(12):3408-3416. doi: 10.1002/term.2254. Epub 2016 Nov 18.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Barquinero, Jordi; Batlle-Morera, Laura; Caminal, Marta; Garcia, Joan; Rabanal, Rosa Maria; Velez, Roberto; Vivas, Daniel; Vives, Joaquim et al.
DOI: 10.1002/term.2254

Bernese Periacetabular Osteotomy in a Young Adult with an Ipsilateral Renal Transplant: A Case Report.

PMID: 29252567
Journal: JBJS case connector
Year: 2016
Reference: JBJS Case Connect. 2016 Jan 27;6(1):e51-e55. doi: 10.2106/JBJS.CC.O.00105.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Canyadell, Marius; Collado, Diego; Ganz, Reinhold; Sallent, Andrea; Seijas, Roberto et al.
DOI: 10.2106/JBJS.CC.O.00105

Femoral head bone viability after free vascularized fibular grafting for osteonecrosis: SPECT/CT study.

PMID: 26214835
Journal: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
Year: 2016
Reference: Microsurgery. 2016 Oct;36(7):573-577. doi: 10.1002/micr.22452. Epub 2015 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Barber, Ignasi; Barrera-Ochoa, Sergio; Collado, Diego; Fontecha, Cesar G; Mascarenhas, Vasco V; Menendez, Mariano E; Roca, Isabel; Soldado, Francisco et al.
DOI: 10.1002/micr.22452

Outcome after single-event multi-level surgery in patients with cerebral palsy / Resultados tras cirugía multinivel en pacientes afectados de parálisis cerebral

PMID: NOPMID026
Journal: Rehabilitación
Year: 2016
Reference: Rehabilitación. 2016;50(1):19-23. doi:10.1016/j.rh.2015.09.004
Impact factor:
Publication type: Paper in national publication
Authors: Aguirre Canyadell, Mario; Melendez Plumed, Mar; Pacha Vicente, Daniel Alejandro; Toro Tamargo, Esther et al.
DOI:

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

PMID: 26479291
Journal: CANCER
Year: 2016
Reference: Cancer. 2016 Jan 1;122(1):99-107. doi: 10.1002/cncr.29733. Epub 2015 Oct 19.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Dominguez, Rosa; Hernandez-Losa, Javier; Moline, Teresa; Perez, Manuel; Ramon Y Cajal, Santiago; Romagosa, Cleofe; Serrano, Cesar; Simonetti, Sara; Somoza, Rosa et al.
DOI: 10.1002/cncr.29733

Brucellosis as a Primary Cause of Flexor Tenosynovitis on the Hand: Case Report and Literature Review.

PMID: 26078527
Journal: Journal of hand and microsurgery
Year: 2015
Reference: J Hand Microsurg. 2015 Jun;7(1):140-2. doi: 10.1007/s12593-014-0122-x. Epub 2014 Feb 20.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Cortina, Josep; Lluch, Alex; Mir-Bullo, Xavier et al.
DOI: 10.1007/s12593-014-0122-x

Vascularized tibial periosteal graft in complex cases of bone nonunion in children.

PMID: 25328161
Journal: MICROSURGERY
Year: 2015
Reference: Microsurgery. 2015 Mar;35(3):239-43. doi: 10.1002/micr.22342. Epub 2014 Oct 18.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Collado, Diego; Corona, Pablo S; de Gauzy, Jerome Sales; Haddad, Sleiman; Knorr, Jorge; Mascarenhas, Vasco V; Soldado, Francisco et al.
DOI: 10.1002/micr.22342

Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study.

PMID: 25902753
Journal: EUR J PEDIATR
Year: 2015
Reference: Eur J Pediatr. 2015 Oct;174(10):1373-85. doi: 10.1007/s00431-015-2534-4. Epub 2015 Apr 23.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Mireia; Aguirre, Mireia; Alvarez, Victoria; Ariceta, Gema; Ariceta, Gema; Camacho, Juan Antonio; Castano, Luis; Castano, Luis; Chocron, Sara; Claverie, Felix et al.
DOI: 10.1007/s00431-015-2534-4

Bernese Periacetabular Osteotomy in a Hip Extra-Articular Resection Followed by Reconstruction Using an Extracorporeal Irradiated Acetabulum Autograft with Megaprosthesis, for Proximal Femur Osteosarcoma in a Pediatric Patient.

PMID: 26199628
Journal: Case reports in medicine
Year: 2015
Reference: Case Rep Med. 2015;2015:813683. doi: 10.1155/2015/813683. Epub 2015 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Barro, Victor; Giralt, Jordi; Pacha, Daniel; Roca, Isabel; Velez, Roberto et al.
DOI: 10.1155/2015/813683

Pyrocarbon interposition (PyroDisk) implant for trapeziometacarpal osteoarthritis: minimum 5-year follow-up.

PMID: 25218138
Journal: JOURNAL OF HAND SURGERY-AMERICAN VOLUME
Year: 2014
Reference: J Hand Surg Am. 2014 Nov;39(11):2150-60. doi: 10.1016/j.jhsa.2014.07.011. Epub 2014 Sep 11.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Correa-Vazquez, Eva; Font-Segura, Jordi; Mir-Bullo, Xavier; Reverte-Vinaixa, Maria Merce; Vidal-Tarrason, Nuria et al.
DOI: 10.1016/j.jhsa.2014.07.011

Periprosthetic proximal fracture in total wrist arthroplasty.

PMID: 24480695
Journal: JOURNAL OF HAND SURGERY-AMERICAN VOLUME
Year: 2014
Reference: J Hand Surg Am. 2014 Feb;39(2):399-400. doi: 10.1016/j.jhsa.2013.12.010.
Impact factor:
Publication type: Letter whit IF
Authors: Barrera-Ochoa, Sergi; Mir, Xavier; Muneton, David et al.
DOI: 10.1016/j.jhsa.2013.12.010

Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice.

PMID: 24127882
Journal: BJU INTERNATIONAL
Year: 2014
Reference: BJU Int. 2014 May;113(5b):E164-77. doi: 10.1111/bju.12503. Epub 2014 Feb 14.
Impact factor:
Publication type: Paper in international publication
Authors: Doll, Andreas; Garcia, Marta; Gomis, Roger R; Guiu, Marc; Majem, Blanca; Morote, Juan; Pedrola, Nuria; Reventos, Jaume; Rigau, Marina; Romagosa, Cleofe et al.
DOI: 10.1111/bju.12503

Gene Therapy Using a Liver-targeted AAV Vector Restores Nucleoside and Nucleotide Homeostasis in a Murine Model of MNGIE.

PMID: 24448160
Journal: MOLECULAR THERAPY
Year: 2014
Reference: Mol Ther. 2014 May;22(5):901-7. doi: 10.1038/mt.2014.6. Epub 2014 Jan 22.
Impact factor:
Publication type: Paper in international publication
Authors: Auricchio, Alberto; Barquinero, Jordi; Cabrera-Perez, Raquel; Camara, Yolanda; Di Meo, Ivano; Hirano, Michio; Marti, Ramon; Pizzorno, Giuseppe; Torres-Torronteras, Javier; Viscomi, Carlo et al.
DOI: 10.1038/mt.2014.6

Medium-term outcome of mosaicplasty for grade III-IV cartilage defects of the knee.

PMID: 23629978
Journal: Journal of orthopaedic surgery (Hong Kong)
Year: 2013
Reference: J Orthop Surg (Hong Kong). 2013 Apr;21(1):4-9.
Impact factor:
Publication type: Paper in international publication
Authors: Diaz-Ferreiro, Eugenio Wenceslao; Dominguez-Oronoz, Rosa; Joshi, Nayana; Reverte-Vinaixa, Maria Mercedes; Teixidor-Serra, Jordi et al.
DOI: 10.1177/230949901302100104

Reduction in neural injury with earlier delivery in a mouse model of congenital myelomeningocele.

PMID: 23931768
Journal: Journal of Neurosurgery-Pediatrics
Year: 2013
Reference: J Neurosurg Pediatr. 2013 Oct;12(4):390-4. doi: 10.3171/2013.7.PEDS1351. Epub 2013 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Shanafey, Saud N; Canyadell, Marius Aguirre; Conesa, Xavier J; Fontecha, Cesar G; Ibanez, Vicenc M; Peiro, Jose L; Rojo, Alejandro A; Soldado, Francisco C; Toran, Nuria T et al.
DOI: 10.3171/2013.7.PEDS1351

Effect of administration of platelet-rich plasma in early phases of distraction osteogenesis: An experimental study in an ovine femur model.

PMID: 23141203
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2013
Reference: Injury. 2013 Jul;44(7):901-7. doi: 10.1016/j.injury.2012.10.018. Epub 2012 Nov 8.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Aguirre-Canyadell, Marius; Barber, Ignasi; Hernandez-Fernandez, Alberto; Saenz-Rios, Juan Carlos; Soldado, Francisco; Velez, Roberto; Velez, Roberto et al.
DOI: 10.1016/j.injury.2012.10.018

False Aneurysm of the Brachial Artery Secondary to K-Wire Fixation of a Supracondylar Fracture of the Humerus.

PMID: 22773356
Journal: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
Year: 2013
Reference: Eur J Pediatr Surg. 2013 Jun;23(3):251-3. doi: 10.1055/s-0032-1315806. Epub 2012 Jul 7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1055/s-0032-1315806

Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of the Hand: A Report of Two Atypical Cases.

PMID: 23326274
Journal: Case Report Med.
Year: 2012
Reference: Case Rep Med. 2012;2012:453560. doi: 10.1155/2012/453560. Epub 2012 Dec 25.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Gargallo-Margarit, Albert; Lluch, Alex; Perez, Manuel; Velez, Roberto; Velez, Roberto et al.
DOI: 10.1155/2012/453560

Treatment of femoral head osteonecrosis with advanced cell therapy in sheep.

PMID: 22821379
Journal: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
Year: 2012
Reference: Arch Orthop Trauma Surg. 2012 Nov;132(11):1611-8. doi: 10.1007/s00402-012-1584-6. Epub 2012 Jul 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; Aguirre, Marius; Caminal, Marta; Fernandez, Alejandro; Hernandez-Fernandez, Alberto; Pla, Arnau; Soldado, Francisco; Velez, Roberto; Vives, Joaquim et al.
DOI: 10.1007/s00402-012-1584-6

External validity of the Tokuhashi score in patients with vertebral metastasis.

PMID: 22526160
Journal: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Year: 2012
Reference: J Cancer Res Clin Oncol. 2012 Sep;138(9):1493-500. doi: 10.1007/s00432-012-1222-2. Epub 2012 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1007/s00432-012-1222-2

Vascularized fibular periosteal graft: a new technique to enhance bone union in children.

PMID: 22411339
Journal: JOURNAL OF PEDIATRIC ORTHOPAEDICS
Year: 2012
Reference: J Pediatr Orthop. 2012 Apr;32(3):308-13.
Impact factor:
Publication type: Paper in international publication
Authors: Barber, Ignasi; Collado, Diego; Fontecha, Cesar G; Llusa, Manel; Martinez-Ibanez, Vicens; Rodriguez-Baeza, Alfonso; Soldado, Francisco; Velez, Roberto et al.
DOI: 10.1097/BPO.0b013e31824b2843

Low Back Pain in Adolescents. Is Quality of Life Poorer in Those Seeking Medical Attention?

PMID: 21343861
Journal: Spine Journal
Year: 2011
Reference: Spine (Phila Pa 1976). 2011 Aug 1;36(17):E1154-61.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/BRS.0b013e318203ed5b

Fetoscopic coverage of experimental myelomeningocele in sheep using a patch with surgical sealant.

PMID: 21353374
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2011
Reference: Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):171-6. Epub 2011 Feb 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.ejogrb.2010.12.046

A new preclinical femoral head osteonecrosis model in sheep.

PMID: 20217102
Journal: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
Year: 2011
Reference: Arch Orthop Trauma Surg. 2011 Jan;131(1):5-9. Epub 2010 Mar 9.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1007/s00402-010-1084-5

Solitary osteochondroma: spontaneous regression.

PMID: 20714716
Journal: PEDIATRIC RADIOLOGY
Year: 2010
Reference: Pediatr Radiol. 2010 Oct;40(10):1699-701. Epub 2010 Aug 17.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Canyadell, Marius; Barber, Ignasi; Enriquez, Goya; Soldado, Francisco; Valdivielso-Ortiz, Alazne et al.
DOI: 10.1007/s00247-010-1783-7

Effects of birth advancement in Chiari malformation in a surgical myelomeningocele model in rabbits.

PMID: 20223326
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2010
Reference: J Pediatr Surg. 2010 Mar;45(3):594-599.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.jpedsurg.2009.08.003

Inert patch with bioadhesive for gentle foetal surgery of myelomeningocele in a sheep model.

PMID: 19615808
Journal: EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Year: 2009
Reference: Eur J Obstet Gynecol Reprod Biol. 2009 Oct;146(2):174-9.
Impact factor:
Publication type: Paper in international publication
Authors: ; Aguirre, Marius; Anor, Sonia; Fontecha, Cesar G; Fresno, Laura; García Fontecha, César Galo; Martinez-Ibanez, Vicente; Peiro, Jose L; Soldado, Francisco et al.
DOI: 10.1016/j.ejogrb.2009.06.022

Fetoscopic release of extremity amniotic bands with risk of amputation.

PMID: 19305282
Journal: JOURNAL OF PEDIATRIC ORTHOPAEDICS
Year: 2009
Reference: J Pediatr Orthop. 2009 Apr-May;29(3):290-3.
Impact factor:
Publication type: Paper in international publication
Authors: ; Aguirre, Marius; Arevalo, Silvia; Barber, Ignasi; Carreras, Elena; Fontecha, Cesar G; García Fontecha, César Galo; Martinez-Ibanez, Vicenc; Peiro, Jose L; Soldado, Francisco et al.
DOI: 10.1097/BPO.0b013e31819c405f

Fetal surgery of extremity amniotic bands: an experimental model of in utero limb salvage in fetal lamb.

PMID: 19098655
Journal: JOURNAL OF PEDIATRIC ORTHOPAEDICS
Year: 2009
Reference: J Pediatr Orthop. 2009 Jan-Feb;29(1):98-102.
Impact factor:
Publication type: Paper in international publication
Authors: ; Aguirre, Marius; Esteves, Marielle; Fontecha, Cesar G; García Fontecha, César Galo; Martinez-Ibanez, Vicenc; Peiro, Jose L; Soldado, Francisco; Velez, Roberto et al.
DOI: 10.1097/BPO.0b013e318192196e

Prevalence of low back pain and its effect on health-related quality of life in adolescents.

PMID: 19124706
Journal: ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
Year: 2009
Reference: Arch Pediatr Adolesc Med. 2009 Jan;163(1):65-71.
Impact factor:
Publication type: Paper in international publication
Authors: ; Aguirre, Mario; Balague, Federico; Cedraschi, Christine; Ferrer, Montse; Fontecha, Cesar G; García Fontecha, César Galo; Pasarin, Maribel; Pellise, Ferran; Rajmil, Luis et al.
DOI: 10.1001/archpediatrics.2008.512

Thesis

The role of lateral extra-articular tenodesis in revision anterior crucate ligament reconstruction

PhD student: Felipe Moreira Borim
Director/s: Juan Minguell Moñart, Nayana Joshi Jubert
University: Universitat Autònoma de Barcelona
Year: 2023

Estudio preclínico sobre la revitalización de aloinjertos óseos mediante el uso de un biovidrio nanoparticulado de fosfato cálcico embebido en fibra de ácido poliláctico. Modelo animal en rata

PhD student: Matias Vicente Goma-Camps
Director/s: Màrius Aguirre Canyadell
University: Universidad Autònoma de Barcelona
Year: 2020

Síndrome compartimental crónico del antebrazo

PhD student: Eva Alicia Correa Vázquez
Director/s: Sergi Barrera Ochoa
University: Universidad Autònoma de Barcelona
Year: 2020

Microanatomia comparada del nervi ciàtic i validació d'un nou biomarcador en injeccions intraneurals

PhD student: Anna Server Salvà
Director/s: Ángeles Mesas Idáñez, Cristina Aguilera Martin
University: Universidad Autònoma de Barcelona
Year: 2019

Tratamiento con células madre mesenquimales en un modelo experimental ovino de osteonecrosis de cabeza femoral

PhD student: Alba López Fernandez
Director/s: Màrius Aguirre Canyadell, Roberto Vélez Villa
University: Universidad Autònoma de Barcelona
Year: 2018

Estudio sobre la viabilidad de la anastomosis vascular microquirúrgica en población irradiada. EStudio en modelo animal en rata

PhD student: Sergi Barrera Ochoa
Director/s: Enric Cáceres Palou, Joan Nardi Vilardaga, Roberto Vélez Villa
University: Universidad Autònoma de Barcelona
Year: 2014

Estimulación de la regeneración ósea mediante células madre en un modelo preclínico de osteonecrosis de la cabeza femoral.

PhD student: Roberto Vélez Villa
Director/s: Màrius Aguirre Canyadell, Joan Nardi Vilardaga, Vicenç Martínez Ibáñez
University: Universidad Autònoma de Barcelona
Year: 2010

Blog

News

The creation of hybrid digital-human interaction spaces between avatars and people offers new opportunities for personalized medicine