About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.
This research line seeks to promote bone regeneration using advanced cell therapy. Our alliance between biologists, engineers and clinical researchers enables us to develop new tissue engineering products that after thorough evaluation in the scopes of basic research and preclinical testing can then be applied in the human clinical setting.
Current Studies:
1. Autologous cell therapy with adult stem cells for osteonecrosis of the femoral head.
Osteonecrosis Clinical phase I-II study: We are currently conducting a comparative study between a product developed by our research group of advanced cell therapy in the context of osteonecrosis of the femoral head precollapse stage. It is a pioneering study at a national and international level by assessing the bone regenerative capability of this product compared to the classical treatment of core decompression.
2. Treatment of femoral head osteonecrosis with advanced cell therapy and biomaterials in an experimental sheep model.
Osteonecrosis preclinical study: We are evaluating mesenchymal stem cells expanded ex-vivo associated with different scaffolds and BMP in osteonecrosis of the femoral head in an ovine model. We are evaluating the different osteoconductive, osteoinductive and osteogenerative components to optimize the best biologic for the treatment of femoral head necrosis.
3. Experimental study of "in vivo" expanded adult stem cell therapy .
Critical size defect preclinical study: We are evaluating mesenchymal stem cells expanded ex-vivo in a critical segmental defect in an ovine model.
IP: Màrius Aguirre Canyadell, Roberto Vélez Villa
This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology.
Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures.
Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours.
Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion.
Current research:
1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY).
A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements
2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model.
Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft.
3. 3D Planification / Printing
3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.
IP: Roberto Vélez Villa
Orthopaedic surgeons treat diseases of the "Soft Tissues" including muscles, tendons, ligaments, cartilage and peripheral nerves. Certain degenerative diseases can affect tendons and cartilage, altering their healing capabilities. Traumatic injuries of ligaments, muscles or peripheral nerves may have difficulty healing. These processes lead to dysfunctions and pain. Our working group aims to study the healing process of soft tissues, and propose and evaluate methods to improve tissue reparative processes from the biological standpoint. The ultimate goal is to provide solutions to clinical practice from translational research.
Current studies:
1. In vivo study of the tensile strength of a suture to flexor tendons fluted point compared with conventional yarn Kessler.
This paper studies the flexor tendon healing in rabbits, with different surgical strategies and materials.
2. Clinical prospective randomized study comparing subacromial injection of platelet-rich plasma bupivacaine with betamethasone and rotator cuff tendinosis.
This clinical trial is studying the healing of the rotator cuff tendons with symptomatic degenerative phase that does not respond to treatment through rehabilitation and oral anti-inflammatory. Compare functional outcomes and quality of life with two different treatments. Inflammatory and other biological one.
IP: Daniel Alejandro Pacha Vicente
IP: - Collaborators: José Andrés Molino Gahete, Ana Lain Fernandez, María Díaz Hervás, José Luis Peiró Ibáñez, Laura Vidal Fornells, Carlos Giné Prades, Gloria Fatou Royo Gomes, Francisco Soldado Carrera, Ingrid Vila Fernández, Mario Marotta Baleriola, Felipe Moreira Borim, Sergio Lopez Fernandez, Romy Gander , Rodrigo Maluje Juri Funding agency: AGAUR no fer servir-correcte 4301-37 Funding: 0.01 Reference: 2021 SGR 01240 Duration: 01/01/2022 - 31/12/2024
IP: Roberto Vélez Villa Collaborators: Ángela Roig Molina, Nayana Joshi Jubert, Anna Server Salvà, Daniel Alejandro Pacha Vicente, Joan Albert Prat Matifoll, Raquel Cabrera Perez, Sara Morini Funding agency: AGAUR no fer servir-correcte 4301-37 Funding: 0.01 Reference: 2021 SGR 00877 Duration: 01/01/2022 - 31/12/2024
IP: Nayana Joshi Jubert Collaborators: Felipe Moreira Borim, Miriam Izquierdo Sans Funding agency: Fundació Institut de Recerca HUVH Funding: 35000 Reference: HUVH/BPFSE_CM/2022/MOREIRA Duration: 27/06/2022 - 26/06/2023
IP: Joaquim Vives Armengol Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Anna Server Salvà, Juan Minguell Moñart, Irene Portas Torres, Raquel Cabrera Perez Funding agency: Instituto de Salud Carlos III Funding: 105270 Reference: PI22/01906 Duration: 01/01/2023 - 31/12/2025
PMID: 34950754 Journal: Bone reports Year: 2022 Reference: Bone Rep. 2021 Dec 9;16:101157. doi: 10.1016/j.bonr.2021.101157. eCollection 2022 Jun. Impact factor: 0 Publication type: Paper in international publication Authors: Chaverri, Daniel; Vivas, Daniel; Gallardo-Villares, Santiago; Granell-Escobar, Fernando; Pinto, Javier A; Vives, Joaquim et al. DOI: 10.1016/j.bonr.2021.101157
PMID: 34989778 Journal: JAMA Oncology Year: 2022 Reference: JAMA Oncol. 2022 Mar 1;8(3):345-353. doi: 10.1001/jamaoncol.2021.6628. Impact factor: 31.777 Publication type: Paper in international publication Authors: Betournay, Marysa; Cheng, Edward Y; Doung, Yee-Cheen; Ferguson, Peter C; Giglio, Victoria; Hayden, James; Heels-Ansdell, Diane; Khan, Shah Alam; Sampath Kumar, Venkatesan; McKay, Paula et al. DOI: 10.1001/jamaoncol.2021.6628
PMID: 35739187 Journal: Communications Biology Year: 2022 Reference: Commun Biol. 2022 Jun 23;5(1):620. doi: 10.1038/s42003-022-03568-6. Impact factor: 6.268 Publication type: Paper in international publication Authors: Molina-Granada, David; Gonzalez-Vioque, Emiliano; Dibley, Marris G; Cabrera-Perez, Raquel; Vallbona-Garcia, Antoni; Torres-Torronteras, Javier; Sazanov, Leonid A; Ryan, Michael T; Camara, Yolanda; Marti, Ramon et al. DOI: 10.1038/s42003-022-03568-6
PMID: 35830540 Journal: Stem Cells Translational Medicine Year: 2022 Reference: Stem Cells Transl Med. 2022 Jul 13. pii: 6643345. doi: 10.1093/stcltm/szac046. Impact factor: 6.94 Publication type: Paper in international publication Authors: Vives, Joaquim, Sanchez-Pernaute, Rosario, Torrents, Silvia, Lopez-Navas, Luis et al. DOI: 10.1093/stcltm/szac046
PMID: 34936017 Journal: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY Year: 2021 Reference: Arch Orthop Trauma Surg. 2021 Dec 22. pii: 10.1007/s00402-021-04299-9. doi: 10.1007/s00402-021-04299-9. Impact factor: 3.067 Publication type: Paper in international publication Authors: Corona, Pablo S, Carbonell-Rosell, Carla, Vicente, Matias, Serracanta, Jordi, Tetsworth, Kevin, Glatt, Vaida et al. DOI: 10.1007/s00402-021-04299-9
PMID: 31847590 Journal: Hand (New York, N.Y.) Year: 2021 Reference: Hand (N Y). 2021 Nov;16(6):741-745. doi: 10.1177/1558944719893055. Epub 2019 Dec 17. Impact factor: 0 Publication type: Paper in international publication Authors: Esteban-Feliu, Ignacio, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Nunez-Camarena, Jorge, Lluch-Bergada, Alex, Vidal-Tarrason, Nuria et al. DOI: 10.1177/1558944719893055
PMID: 34575412 Journal: Pharmaceutics Year: 2021 Reference: Pharmaceutics. 2021 Aug 26;13(9). pii: pharmaceutics13091336. doi: 10.3390/pharmaceutics13091336. Impact factor: 6.321 Publication type: Review in international publication Authors: Munoz-Dominguez, Noelia, Roura, Santiago, Prat-Vidal, Cristina, Vives, Joaquim et al. DOI: 10.3390/pharmaceutics13091336
PMID: 34402988 Journal: European journal of orthopaedic surgery & traumato Year: 2021 Reference: Eur J Orthop Surg Traumatol. 2021 Oct;31(7):1545. doi: 10.1007/s00590-021-03090-1. Impact factor: 0 Publication type: Letter or abstract Authors: Jurado Ruiz, Maria, Scott-Tennent, Ana, Fraile, Rosa, Carrera, Luis, Vicente, Matias, Corona, Pablo S et al. DOI: 10.1007/s00590-021-03090-1
PMID: NOPMID0085 Journal: BIOCHEMICAL ENGINEERING JOURNAL Year: 2020 Reference: Biochemical Engineering Journal. 2020 Jul;159:107601. doi: 10.1016/j.bej.2020.107601 Impact factor: 3.475 Publication type: Review in international publication Authors: García-Fernández, Coral, López-Fernández, Alba, Borrós, Salvador, Lecina, Martí, Vives, Joaquim et al. DOI: 10.1016/j.bej.2020.107601
PMID: 33074739 Journal: Hip International Year: 2020 Reference: Hip Int. 2020 Oct 19:1120700020964776. doi: 10.1177/1120700020964776. Impact factor: 1.349 Publication type: Paper in international publication Authors: Pujol, Oriol, Carrasco, Maria G, Vicente, Matias, Mimendia, Inaki, Garcia, Yaiza, Selga, Jordi, Barro, Victor et al. DOI: 10.1177/1120700020964776
PMID: 32730985 Journal: Spine Journal Year: 2020 Reference: Spine J. 2020 Jul 28. pii: S1529-9430(20)31003-2. doi: 10.1016/j.spinee.2020.07.014. Impact factor: 3.191 Publication type: Paper in international publication Authors: Garcia de Frutos, Ana, Gonzalez-Tartiere, Pilar, Coll Bonet, Ruth, Ubierna Garces, Maria Teresa, Del Arco Churruca, Alejandro, Rivas Garcia, Antoni, Matamalas Adrover, Antonia, Salo Bru, Guillem, Velazquez, Juan Jose, Vila-Canet, Gemma et al. DOI: 10.1016/j.spinee.2020.07.014
PMID: 32562174 Journal: MOLECULAR BIOLOGY REPORTS Year: 2020 Reference: Mol Biol Rep. 2020 Jul;47(7):5145-5154. doi: 10.1007/s11033-020-05588-z. Epub 2020 Jun 19. Impact factor: 1.402 Publication type: Paper in international publication Authors: Vivas, Daniel, Grau-Vorster, Marta, Oliver-Vila, Irene, Garcia-Lopez, Joan, Vives, Joaquim et al. DOI: 10.1007/s11033-020-05588-z
PMID: 31779673 Journal: Stem Cell Research & Therapy Year: 2019 Reference: Stem Cell Res Ther. 2019 Nov 28;10(1):356. doi: 10.1186/s13287-019-1450-3. Impact factor: 4.627 Publication type: Paper in international publication Authors: Cabrera-Perez, Raquel, Monguio-Tortajada, Marta, Gamez-Valero, Ana, Rojas-Marquez, Raquel, Borras, Francesc Enric, Roura, Santiago, Vives, Joaquim et al. DOI: 10.1186/s13287-019-1450-3
PMID: 31196185 Journal: Stem Cell Research & Therapy Year: 2019 Reference: Stem Cell Res Ther. 2019 Jun 13;10(1):164. doi: 10.1186/s13287-019-1279-9. Impact factor: 4.627 Publication type: Paper in international publication Authors: Grau-Vorster, Marta, Laitinen, Anita, Nystedt, Johanna, Vives, Joaquim et al. DOI: 10.1186/s13287-019-1279-9
PMID: 31117301 Journal: Cells Year: 2019 Reference: Cells. 2019 May 21;8(5). pii: cells8050484. doi: 10.3390/cells8050484. Impact factor: 5.656 Publication type: Paper in international publication Authors: Grau-Vorster, Marta, Rodriguez, Luciano, Del Mazo-Barbara, Anna, Mirabel, Clementine, Blanco, Margarita, Codinach, Margarita, Gomez, Susana G, Querol, Sergi, Garcia-Lopez, Joan, Vives, Joaquim et al. DOI: 10.3390/cells8050484
PMID: 30965661 Journal: Journal of Clinical Medicine Year: 2019 Reference: J Clin Med. 2019 Apr 8;8(4). pii: jcm8040476. doi: 10.3390/jcm8040476. Impact factor: 5.688 Publication type: Review in international publication Authors: Alvarez-Palomo, Belen, Vives, Joaquim, Casaroli-Marano, Ricardo P P, G Gomez, Susana G, Rodriguez Gomez, Luciano, Edel, Michael J, Querol Giner, Sergi et al. DOI: 10.3390/jcm8040476
PMID: 29170811 Journal: SKELETAL RADIOLOGY Year: 2018 Reference: Skeletal Radiol. 2018 Apr;47(4):569-573. doi: 10.1007/s00256-017-2813-4. Epub 2017 Nov 23. Impact factor: 1.737 Publication type: Paper in international publication Authors: Olchowy, Cyprian, de Delas-Vigo, Matias de Albert, Perez, Manolo, Ciriaco, Nikaoly, Oronoz, Rosa Dominguez et al. DOI: 10.1007/s00256-017-2813-4
PMID: 28817409 Journal: CLINICAL JOURNAL OF SPORT MEDICINE Year: 2018 Reference: Clin J Sport Med. 2018 Nov;28(6):516-523. doi: 10.1097/JSM.0000000000000482. Impact factor: 2.189 Publication type: Paper in international publication Authors: Campillo-Recio, David, Mir-Bullo, Xavier, Soldado, Francisco, Sallent, Andrea, Haddad, Sleiman, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Correa-Vazquez, Eva et al. DOI: 10.1097/JSM.0000000000000482
PMID: 30431479 Journal: JBJS case connector Year: 2018 Reference: JBJS Case Connect. 2018 Oct-Dec;8(4):e90. doi: 10.2106/JBJS.CC.18.00033. Impact factor: 0 Publication type: Paper in international publication Authors: Vicente, Matias, Lung, Mayli, Gulin, Carlos, Tortola, Maria Teresa, Corona, Pablo S et al. DOI: 10.2106/JBJS.CC.18.00033
PMID: 30355298 Journal: Journal of Translational Medicine Year: 2018 Reference: J Transl Med. 2018 Oct 24;16(1):291. doi: 10.1186/s12967-018-1659-4. Impact factor: 4.197 Publication type: Paper in international publication Authors: Vives, Joaquim, Godia, Francesc, Morton, Philip, Reyes, Blanca, Del Mazo-Barbara, Anna, Mirabel, Clementine, Puente-Massaguer, Eduard et al. DOI: 10.1186/s12967-018-1659-4
PMID: 27357187 Journal: LAB ANIMAL Year: 2017 Reference: Lab Anim. 2017 Apr;51(2):124-137. doi: 10.1177/0023677216656221. Epub 2016 Jul 9. Impact factor: 0.681 Publication type: Paper in international publication Authors: Verges, Ramona, Giralt, Jordi, Aguirre-Canyadell, Marius, Velez, Roberto, Lopez-Fernandez, Alba, Sallent, Andrea, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi et al. DOI: 10.1177/0023677216656221
PMID: 27860364 Journal: Journal of Tissue Engineering and Regenerative Medicine Year: 2017 Reference: J Tissue Eng Regen Med. 2017 Dec;11(12):3408-3416. doi: 10.1002/term.2254. Epub 2016 Nov 18. Impact factor: 4.71 Publication type: Paper in international publication Authors: Caminal, Marta, Rabanal, Rosa Maria, Vivas, Daniel, Batlle-Morera, Laura, Aguirre, Marius, Barquinero, Jordi, Garcia, Joan, Vives, Joaquim, Velez, Roberto et al. DOI: 10.1002/term.2254
PMID: 29182015 Journal: Biomarkers in Medicine Year: 2017 Reference: Biomark Med. 2017 Dec;11(12):1125-1133. doi: 10.2217/bmm-2017-0180. Epub 2017 Nov 28. Impact factor: 2.02 Publication type: Editorail in international publication Authors: Chaverri, Daniel, Vives, Joaquim et al. DOI: 10.2217/bmm-2017-0180
PMID: 29078809 Journal: Stem Cell Research & Therapy Year: 2017 Reference: Stem Cell Res Ther. 2017 Oct 27;8(1):238. doi: 10.1186/s13287-017-0695-y. Impact factor: 4.211 Publication type: Review in national publication Authors: Roura, Santiago, Galvez-Monton, Carolina, Mirabel, Clementine, Vives, Joaquim, Bayes-Genis, Antoni et al. DOI: 10.1186/s13287-017-0695-y
PMID: 26857632 Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED Year: 2016 Reference: Injury. 2016 Apr;47(4):872-6. doi: 10.1016/j.injury.2015.12.032. Epub 2016 Jan 7. Impact factor: 1.91 Publication type: Paper in international publication Authors: Gallardo-Calero, Irene, Larrainzar-Coghen, Thais, Rodriguez-Pardo, Dolors, Pigrau, Carles, Sanchez-Raya, Judith, Amat, Carles, Lung, Maily, Carrera, Luis, Corona, Pablo S et al. DOI: 10.1016/j.injury.2015.12.032
PMID: 27975009 Journal: Plastic and reconstructive surgery. Global open Year: 2016 Reference: Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. eCollection 2016 Nov. Impact factor: 0 Publication type: Paper in international publication Authors: Verges, Ramona, Barrera-Ochoa, Sergi, Gallardo-Calero, Irene, Lopez-Fernandez, Alba, Romagosa, Cleofe, Velez, Roberto, Soldado, Francisco, Aguirre-Canyadell, Marius et al. DOI: 10.1097/GOX.0000000000001073
PMID: 26266069 Journal: Case reports in orthopedics Year: 2015 Reference: Case Rep Orthop. 2015;2015:591509. doi: 10.1155/2015/591509. Epub 2015 Jul 22. Impact factor: 0 Publication type: Paper in international publication Authors: Hernandez, A, Gargallo-Margarit, A, Barro, V, Gallardo-Calero, I, Sallent, A et al. DOI: 10.1155/2015/591509
PhD student: Matias Vicente Goma-Camps Director/s: Màrius Aguirre Canyadell University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Eva Alicia Correa Vázquez Director/s: Sergi Barrera Ochoa University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Anna Server Salvà Director/s: Ángeles Mesas Idáñez, Cristina Aguilera Martin University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Alba López Fernandez Director/s: Màrius Aguirre Canyadell, Roberto Vélez Villa University: Universidad Autònoma de Barcelona Year: 2018
PhD student: Sergi Barrera Ochoa Director/s: Enric Cáceres Palou, Joan Nardi Vilardaga, Roberto Vélez Villa University: Universidad Autònoma de Barcelona Year: 2014
PhD student: Roberto Vélez Villa Director/s: Màrius Aguirre Canyadell, Joan Nardi Vilardaga, Vicenç Martínez Ibáñez University: Universidad Autònoma de Barcelona Year: 2010
The creation of hybrid digital-human interaction spaces between avatars and people offers new opportunities for personalized medicine
