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Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Team

Daniel Alejandro Pacha Vicente

Daniel Alejandro Pacha Vicente

Musculoskeletal Tissue Engineering
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Joan Albert Prat Matifoll

Joan Albert Prat Matifoll

Musculoskeletal Tissue Engineering
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Ángela Roig Molina

Ángela Roig Molina

Research technician
Musculoskeletal Tissue Engineering
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Anna Server Salvà

Anna Server Salvà

Musculoskeletal Tissue Engineering
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Felipe Moreira Borim

Felipe Moreira Borim

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Joaquim Vives Armengol

Joaquim Vives Armengol

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Daniel Alejandro Pacha Vicente

Daniel Alejandro Pacha Vicente

Musculoskeletal Tissue Engineering
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Joan Albert Prat Matifoll

Joan Albert Prat Matifoll

Musculoskeletal Tissue Engineering
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Ángela Roig Molina

Ángela Roig Molina

Research technician
Musculoskeletal Tissue Engineering
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Anna Server Salvà

Anna Server Salvà

Musculoskeletal Tissue Engineering
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Felipe Moreira Borim

Felipe Moreira Borim

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Joaquim Vives Armengol

Joaquim Vives Armengol

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Research lines

Bone Regeneration

This research line seeks to promote bone regeneration using advanced cell therapy. Our alliance between biologists, engineers and clinical researchers enables us to develop new tissue engineering products that after thorough evaluation in the scopes of basic research and preclinical testing can then be applied in the human clinical setting. Current Studies: 1. Autologous cell therapy with adult stem cells for osteonecrosis of the femoral head. Osteonecrosis Clinical phase I-II study: We are currently conducting a comparative study between a product developed by our research group of advanced cell therapy in the context of osteonecrosis of the femoral head precollapse stage. It is a pioneering study at a national and international level by assessing the bone regenerative capability of this product compared to the classical treatment of core decompression. 2. Treatment of femoral head osteonecrosis with advanced cell therapy and biomaterials in an experimental sheep model. Osteonecrosis preclinical study: We are evaluating mesenchymal stem cells expanded ex-vivo associated with different scaffolds and BMP in osteonecrosis of the femoral head in an ovine model. We are evaluating the different  osteoconductive, osteoinductive and osteogenerative components to optimize the best biologic for the treatment of femoral head necrosis. 3. Experimental study of "in vivo" expanded adult stem cell therapy . Critical size defect preclinical study:  We are evaluating mesenchymal stem cells expanded ex-vivo in a critical segmental defect in an ovine model.

IP: Màrius Aguirre Canyadell, Roberto Vélez Villa

Orthopaedic oncology - 3D planification / printing

This research line seeks the development of new treatments and new surgical techniques of limb salvage in orthopaedic oncology. Surgical treatments of patients with bone tumours use free bone grafts, vascularized bone grafts or from donors in order to solve massive bone loss. Long surgeries, radiotherapy or chemotherapy could be factors that negatively affect the bone integration of these bone grafts, increasing complications rates such as non-unions, infections or graft fractures. Research in this field search solutions to decrease graft consolidation time, increase their revitalization and decrease infection rates, and develop new treatment alternatives for limb salvage affected with bone tumours. Development of new 3D printing techniques applied to orthopaedic oncology can allow development of new prostheses with biocompatible materials, surgical guides and customized 3D models depending on each tumour lesion. Current research: 1. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY). A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotics Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements 2. Preclinical study on the revitalization of bone allografts with vascularized periosteal grafts in a rat animal model. Preclinical study to verify the osteoproductive, revitalizing and osteointegrative capacity of a vascularized periosteal graft associated with a structural bone allograft. 3. 3D Planification / Printing 3D planification precision and personalised osteotomy guides in pelvic tumour surgery. Pilot study.

IP: Roberto Vélez Villa

Soft tissue Regeneration

Orthopaedic surgeons treat diseases of the "Soft Tissues" including muscles, tendons, ligaments, cartilage and peripheral nerves. Certain degenerative diseases can affect tendons and cartilage, altering their healing capabilities. Traumatic injuries of ligaments, muscles or peripheral nerves may have difficulty healing. These processes lead to dysfunctions and pain. Our working group aims to study the healing process of soft tissues, and propose and evaluate methods to improve tissue reparative processes from the biological standpoint. The ultimate goal is to provide solutions to clinical practice from translational research. Current studies: 1. In vivo study of the tensile strength of a suture to flexor tendons fluted point compared with conventional yarn Kessler. This paper studies the flexor tendon healing in rabbits, with different surgical strategies and materials. 2. Clinical prospective randomized study comparing subacromial injection of platelet-rich plasma bupivacaine with betamethasone and rotator cuff tendinosis. This clinical trial is studying the healing of the rotator cuff tendons with symptomatic degenerative phase that does not respond to treatment through rehabilitation and oral anti-inflammatory. Compare functional outcomes and quality of life with two different treatments. Inflammatory and other biological one.

IP: Daniel Alejandro Pacha Vicente

Projects

Cirugía de revisión de reconstrucción del ligamento cruzado anterior (RLCA) mediante el uso de autoinjerto de tipo hueso-tendón-hueso (HTH) y plastia de refuerzo extrarticular: estudio prospectivo

IP: Nayana Joshi Jubert
Collaborators: Felipe Moreira Borim, Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 35000
Reference: HUVH/BPFSE_CM/2022/MOREIRA
Duration: 27/06/2022 - 26/06/2023

TRASLACIÓN DE UN PRODUCTO DE INGENIERÍA TISULAR ALOGÉNICO CON MSC DE GELATINA DE WHARTON PARA EL TRATAMIENTO DE LA OSTEONECROSIS EN PACIENTES ONCOLÓGICOS PEDIÁTRICOS.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Lluis Martorell Cedres, Maria Cristina Díaz de Heredia Rubio, Màrius Aguirre Canyadell, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI19/01788
Duration: 01/01/2020 - 31/12/2022

Estudio pre-clínico de un producto de ingeniería tisular con Células Madre Mesequimales de la gelatina de Wharton del cordón umbilical para el tratamiento de las lesiones focales del cartílago articular de la rodilla.

IP: Nayana Joshi Jubert
Collaborators: -
Funding agency: SOCIEDAD ESPAÑOLA DE LA RODILLA
Funding: 10000
Reference: SEROD/PROJ/2021/JOSHI
Duration: 26/09/2021 - 25/09/2023

TRASLACIÓN DE UN PRODUCTO DE INGENIERÍA TISULAR ALOGÉNICO CON MSC DE GELATINA DE WHARTON PARA EL TRATAMIENTO DE LA OSTEONECROSIS EN PACIENTES ONCOLÓGICOS PEDIÁTRICOS.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Lluis Martorell Cedres, Maria Cristina Díaz de Heredia Rubio, Màrius Aguirre Canyadell, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI19/01788
Duration: 01/01/2020 - 31/12/2022

Estudio pre-clínico de un producto de ingeniería tisular con Células Madre Mesequimales de la gelatina de Wharton del cordón umbilical para el tratamiento de las lesiones focales del cartílago articular de la rodilla.

IP: Nayana Joshi Jubert
Collaborators: -
Funding agency: SOCIEDAD ESPAÑOLA DE LA RODILLA
Funding: 10000
Reference: SEROD/PROJ/2021/JOSHI
Duration: 26/09/2021 - 25/09/2023

TRASLACIÓN DE UN PRODUCTO DE INGENIERÍA TISULAR ALOGÉNICO CON MSC DE GELATINA DE WHARTON PARA EL TRATAMIENTO DE LA OSTEONECROSIS EN PACIENTES ONCOLÓGICOS PEDIÁTRICOS.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Lluis Martorell Cedres, Maria Cristina Díaz de Heredia Rubio, Màrius Aguirre Canyadell, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI19/01788
Duration: 01/01/2020 - 31/12/2022

ADVANCECAT: Acceleradora pel desenvolupament de Teràpies Avançades a Catalunya..

IP: Jordi Barquinero Mañez
Collaborators: Màrius Aguirre Canyadell
Funding agency: Agència Competitivitat Empresa Catalana ACCIO
Funding: 47221.52
Reference: COMRDI15-1-0013-08
Duration: 01/02/2016 - 31/01/2019

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

ADVANCECAT: Acceleradora pel desenvolupament de Teràpies Avançades a Catalunya..

IP: Jordi Barquinero Mañez
Collaborators: Màrius Aguirre Canyadell
Funding agency: Agència Competitivitat Empresa Catalana ACCIO
Funding: 47221.52
Reference: COMRDI15-1-0013-08
Duration: 01/02/2016 - 31/01/2019

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

ADVANCECAT: Acceleradora pel desenvolupament de Teràpies Avançades a Catalunya..

IP: Jordi Barquinero Mañez
Collaborators: Màrius Aguirre Canyadell
Funding agency: Agència Competitivitat Empresa Catalana ACCIO
Funding: 47221.52
Reference: COMRDI15-1-0013-08
Duration: 01/02/2016 - 31/01/2019

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Estudio experimental de terapia celular con células madre adultas expandida "in vivo"

IP: Màrius Aguirre Canyadell
Collaborators: Joaquim Piqueras Pardellans, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 79255
Reference: PI11/02231
Duration: 01/01/2012 - 30/06/2016

Femoral head osteonecrosis treatment with advanced cell therapy and biomaterials in an experimental sheep animal model.

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joaquim Vives Armengol, Anna Server Salvà
Funding agency: Fundació La Marató de TV3
Funding: 200000
Reference: 122030
Duration: 30/01/2013 - 31/12/2016

ADVANCECAT: Acceleradora pel desenvolupament de Teràpies Avançades a Catalunya..

IP: Jordi Barquinero Mañez
Collaborators: Màrius Aguirre Canyadell
Funding agency: Agència Competitivitat Empresa Catalana ACCIO
Funding: 47221.52
Reference: COMRDI15-1-0013-08
Duration: 01/02/2016 - 31/01/2019

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Estudio experimental de terapia celular con células madre adultas expandida "in vivo"

IP: Màrius Aguirre Canyadell
Collaborators: Joaquim Piqueras Pardellans, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 79255
Reference: PI11/02231
Duration: 01/01/2012 - 30/06/2016

Femoral head osteonecrosis treatment with advanced cell therapy and biomaterials in an experimental sheep animal model.

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joaquim Vives Armengol, Anna Server Salvà
Funding agency: Fundació La Marató de TV3
Funding: 200000
Reference: 122030
Duration: 30/01/2013 - 31/12/2016

Anàlisi de la revitalització en empelts estructurals d’os criopreservat associat a penjoll periòstic vascularitzat. Model animal a rata

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa
Funding agency: SOCIETAT CATALANA DE CIRURGIA
Funding: 12000
Reference: SCCOT-2014-01
Duration: 27/02/2014 - 26/02/2015

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Estudio experimental de terapia celular con células madre adultas expandida "in vivo"

IP: Màrius Aguirre Canyadell
Collaborators: Joaquim Piqueras Pardellans, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 79255
Reference: PI11/02231
Duration: 01/01/2012 - 30/06/2016

Femoral head osteonecrosis treatment with advanced cell therapy and biomaterials in an experimental sheep animal model.

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joaquim Vives Armengol, Anna Server Salvà
Funding agency: Fundació La Marató de TV3
Funding: 200000
Reference: 122030
Duration: 30/01/2013 - 31/12/2016

Estudio sobre la viabilidad de la anastomosis vascular microquirúrgica en población irradiada. Estudio en modelo animal en rata

IP: Roberto Vélez Villa
Collaborators: Manuel Llusà Pérez, Ramona Vergés Capdevila, David Barastegui Fernández
Funding agency: FUNDACIÓN SECOT
Funding: 12000
Reference: SECOT-2012-01
Duration: 07/07/2012 - 06/07/2014

Estudio clínico prospectivo y randomizado comparando la inyección subacromial de plasma rico en plaquetas, o de betametasona y bupivacaina en la tendinosis del manguito rotador del hombro

IP: Daniel Alejandro Pacha Vicente
Collaborators: Montserrat García Portabella, Manuel Llusà Pérez, Almudena Crespo Fresno
Funding agency: Instituto de Salud Carlos III
Funding: 36905
Reference: EC08/00284
Duration: 01/01/2009 - 31/07/2013

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Ensayo clínico aleatorizado, doble ciego, de grupos paralelos, de la inyección intra-articular de plasma rico en plaquetas frente a la inyección intra-articular de betametasona y bupivacaína en la artrosis degenerativa de rodilla

IP: Nayana Joshi Jubert
Collaborators: -
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 45966
Reference: EC10-310
Duration: 01/01/2011 - 31/12/2013

Estudio experimental de terapia celular con células madre adultas expandida "in vivo"

IP: Màrius Aguirre Canyadell
Collaborators: Joaquim Piqueras Pardellans, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 79255
Reference: PI11/02231
Duration: 01/01/2012 - 30/06/2016

Estudio clínico prospectivo y randomizado comparando la inyección subacromial de plasma rico en plaquetas, o de betametasona y bupivacaina en la tendinosis del manguito rotador del hombro

IP: Daniel Alejandro Pacha Vicente
Collaborators: Montserrat García Portabella, Manuel Llusà Pérez, Almudena Crespo Fresno
Funding agency: Instituto de Salud Carlos III
Funding: 36905
Reference: EC08/00284
Duration: 01/01/2009 - 31/07/2013

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Ensayo clínico aleatorizado, doble ciego, de grupos paralelos, de la inyección intra-articular de plasma rico en plaquetas frente a la inyección intra-articular de betametasona y bupivacaína en la artrosis degenerativa de rodilla

IP: Nayana Joshi Jubert
Collaborators: -
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 45966
Reference: EC10-310
Duration: 01/01/2011 - 31/12/2013

Estudio experimental de terapia celular con células madre adultas expandida "in vivo"

IP: Màrius Aguirre Canyadell
Collaborators: Joaquim Piqueras Pardellans, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 79255
Reference: PI11/02231
Duration: 01/01/2012 - 30/06/2016

Estudio clínico prospectivo y randomizado comparando la inyección subacromial de plasma rico en plaquetas, o de betametasona y bupivacaina en la tendinosis del manguito rotador del hombro

IP: Daniel Alejandro Pacha Vicente
Collaborators: Montserrat García Portabella, Manuel Llusà Pérez, Almudena Crespo Fresno
Funding agency: Instituto de Salud Carlos III
Funding: 36905
Reference: EC08/00284
Duration: 01/01/2009 - 31/07/2013

Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral

IP: Màrius Aguirre Canyadell
Collaborators: Roberto Vélez Villa, Joan García López, Joaquim Vives Armengol, Alejandro Hernández Martínez
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 250000
Reference: EC10-208
Duration: 01/01/2011 - 30/06/2018

Ensayo clínico aleatorizado, doble ciego, de grupos paralelos, de la inyección intra-articular de plasma rico en plaquetas frente a la inyección intra-articular de betametasona y bupivacaína en la artrosis degenerativa de rodilla

IP: Nayana Joshi Jubert
Collaborators: -
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 45966
Reference: EC10-310
Duration: 01/01/2011 - 31/12/2013

Estudio in vivo de la resistencia a la tensión de una sutura estriada para tendones flexores comparada con el punto de Kessler con hilo convencional

IP: Daniel Alejandro Pacha Vicente
Collaborators: Manuel Llusà Pérez
Funding agency: Instituto de Salud Carlos III
Funding: 20110.2
Reference: PI070093
Duration: 01/01/2008 - 30/12/2010

Efectos del plasma rico en factores de crecimiento en la consolidación del callo óseo de elongación

IP: Màrius Aguirre Canyadell
Collaborators: Ignacio Barber Martinez de la Torre, Francisco Soldado Carrera, Marta Rosal Fontana
Funding agency: Instituto de Salud Carlos III
Funding: 28314
Reference: PI070874
Duration: 01/01/2008 - 30/12/2010

Estudio clínico prospectivo y randomizado comparando la inyección subacromial de plasma rico en plaquetas, o de betametasona y bupivacaina en la tendinosis del manguito rotador del hombro

IP: Daniel Alejandro Pacha Vicente
Collaborators: Montserrat García Portabella, Manuel Llusà Pérez, Almudena Crespo Fresno
Funding agency: Instituto de Salud Carlos III
Funding: 36905
Reference: EC08/00284
Duration: 01/01/2009 - 31/07/2013

Estudio in vivo de la resistencia a la tensión de una sutura estriada para tendones flexores comparada con el punto de Kessler con hilo convencional

IP: Daniel Alejandro Pacha Vicente
Collaborators: Manuel Llusà Pérez
Funding agency: Instituto de Salud Carlos III
Funding: 20110.2
Reference: PI070093
Duration: 01/01/2008 - 30/12/2010

Efectos del plasma rico en factores de crecimiento en la consolidación del callo óseo de elongación

IP: Màrius Aguirre Canyadell
Collaborators: Ignacio Barber Martinez de la Torre, Francisco Soldado Carrera, Marta Rosal Fontana
Funding agency: Instituto de Salud Carlos III
Funding: 28314
Reference: PI070874
Duration: 01/01/2008 - 30/12/2010

Estudio clínico prospectivo y randomizado comparando la inyección subacromial de plasma rico en plaquetas, o de betametasona y bupivacaina en la tendinosis del manguito rotador del hombro

IP: Daniel Alejandro Pacha Vicente
Collaborators: Montserrat García Portabella, Manuel Llusà Pérez, Almudena Crespo Fresno
Funding agency: Instituto de Salud Carlos III
Funding: 36905
Reference: EC08/00284
Duration: 01/01/2009 - 31/07/2013

Estudio in vivo de la resistencia a la tensión de una sutura estriada para tendones flexores comparada con el punto de Kessler con hilo convencional

IP: Daniel Alejandro Pacha Vicente
Collaborators: Manuel Llusà Pérez
Funding agency: Instituto de Salud Carlos III
Funding: 20110.2
Reference: PI070093
Duration: 01/01/2008 - 30/12/2010

Efectos del plasma rico en factores de crecimiento en la consolidación del callo óseo de elongación

IP: Màrius Aguirre Canyadell
Collaborators: Ignacio Barber Martinez de la Torre, Francisco Soldado Carrera, Marta Rosal Fontana
Funding agency: Instituto de Salud Carlos III
Funding: 28314
Reference: PI070874
Duration: 01/01/2008 - 30/12/2010

Publications

A pilot study of circulating levels of TGF-beta1 and TGF-beta2 as biomarkers of bone healing in patients with non-hypertrophic pseudoarthrosis of long bones.

PMID: 34950754
Journal: Bone reports
Year: 2022
Reference: Bone Rep. 2021 Dec 9;16:101157. doi: 10.1016/j.bonr.2021.101157. eCollection 2022 Jun.
Impact factor: 0
Publication type: Paper in international publication
Authors: Chaverri, Daniel; Vivas, Daniel; Gallardo-Villares, Santiago; Granell-Escobar, Fernando; Pinto, Javier A; Vives, Joaquim et al.
DOI: 10.1016/j.bonr.2021.101157

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial.

PMID: 34989778
Journal: JAMA Oncology
Year: 2022
Reference: JAMA Oncol. 2022 Mar 1;8(3):345-353. doi: 10.1001/jamaoncol.2021.6628.
Impact factor: 31.777
Publication type: Paper in international publication
Authors: Betournay, Marysa; Cheng, Edward Y; Doung, Yee-Cheen; Ferguson, Peter C; Giglio, Victoria; Hayden, James; Heels-Ansdell, Diane; Khan, Shah Alam; Sampath Kumar, Venkatesan; McKay, Paula et al.
DOI: 10.1001/jamaoncol.2021.6628

Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.

PMID: 35739187
Journal: Communications Biology
Year: 2022
Reference: Commun Biol. 2022 Jun 23;5(1):620. doi: 10.1038/s42003-022-03568-6.
Impact factor: 6.268
Publication type: Paper in international publication
Authors: Molina-Granada, David; Gonzalez-Vioque, Emiliano; Dibley, Marris G; Cabrera-Perez, Raquel; Vallbona-Garcia, Antoni; Torres-Torronteras, Javier; Sazanov, Leonid A; Ryan, Michael T; Camara, Yolanda; Marti, Ramon et al.
DOI: 10.1038/s42003-022-03568-6

Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies.

PMID: 35830540
Journal: Stem Cells Translational Medicine
Year: 2022
Reference: Stem Cells Transl Med. 2022 Jul 13. pii: 6643345. doi: 10.1093/stcltm/szac046.
Impact factor: 6.94
Publication type: Paper in international publication
Authors: Vives, Joaquim, Sanchez-Pernaute, Rosario, Torrents, Silvia, Lopez-Navas, Luis et al.
DOI: 10.1093/stcltm/szac046

Three-stage limb salvage in tibial fracture related infection with composite bone and soft-tissue defect.

PMID: 34936017
Journal: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
Year: 2021
Reference: Arch Orthop Trauma Surg. 2021 Dec 22. pii: 10.1007/s00402-021-04299-9. doi: 10.1007/s00402-021-04299-9.
Impact factor: 3.067
Publication type: Paper in international publication
Authors: Corona, Pablo S, Carbonell-Rosell, Carla, Vicente, Matias, Serracanta, Jordi, Tetsworth, Kevin, Glatt, Vaida et al.
DOI: 10.1007/s00402-021-04299-9

Trigger Digit Incidence After Carpal Tunnel Release: Reconstruction in Elongated Position Versus Traditional Carpal Tunnel Release.

PMID: 31847590
Journal: Hand (New York, N.Y.)
Year: 2021
Reference: Hand (N Y). 2021 Nov;16(6):741-745. doi: 10.1177/1558944719893055. Epub 2019 Dec 17.
Impact factor: 0
Publication type: Paper in international publication
Authors: Esteban-Feliu, Ignacio, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Nunez-Camarena, Jorge, Lluch-Bergada, Alex, Vidal-Tarrason, Nuria et al.
DOI: 10.1177/1558944719893055

Wharton's Jelly Mesenchymal Stromal Cells and Derived Extracellular Vesicles as Post-Myocardial Infarction Therapeutic Toolkit: An Experienced View.

PMID: 34575412
Journal: Pharmaceutics
Year: 2021
Reference: Pharmaceutics. 2021 Aug 26;13(9). pii: pharmaceutics13091336. doi: 10.3390/pharmaceutics13091336.
Impact factor: 6.321
Publication type: Review in international publication
Authors: Munoz-Dominguez, Noelia, Roura, Santiago, Prat-Vidal, Cristina, Vives, Joaquim et al.
DOI: 10.3390/pharmaceutics13091336

Correction to: Uniplanar versus biplanar monolateral external fixator knee arthrodesis after end-stage failed infected total knee arthroplasty: a comparative study.

PMID: 34402988
Journal: European journal of orthopaedic surgery & traumato
Year: 2021
Reference: Eur J Orthop Surg Traumatol. 2021 Oct;31(7):1545. doi: 10.1007/s00590-021-03090-1.
Impact factor: 0
Publication type: Letter or abstract
Authors: Jurado Ruiz, Maria, Scott-Tennent, Ana, Fraile, Rosa, Carrera, Luis, Vicente, Matias, Corona, Pablo S et al.
DOI: 10.1007/s00590-021-03090-1

Strategies for large-scale expansion of clinical-grade human multipotent mesenchymal stromal cells

PMID: NOPMID0085
Journal: BIOCHEMICAL ENGINEERING JOURNAL
Year: 2020
Reference: Biochemical Engineering Journal. 2020 Jul;159:107601. doi: 10.1016/j.bej.2020.107601
Impact factor: 3.475
Publication type: Review in international publication
Authors: García-Fernández, Coral, López-Fernández, Alba, Borrós, Salvador, Lecina, Martí, Vives, Joaquim et al.
DOI: 10.1016/j.bej.2020.107601

Should we employ preoperative templating in hip hemiarthroplasty after femoral neck fracture? A nested case-control study.

PMID: 33074739
Journal: Hip International
Year: 2020
Reference: Hip Int. 2020 Oct 19:1120700020964776. doi: 10.1177/1120700020964776.
Impact factor: 1.349
Publication type: Paper in international publication
Authors: Pujol, Oriol, Carrasco, Maria G, Vicente, Matias, Mimendia, Inaki, Garcia, Yaiza, Selga, Jordi, Barro, Victor et al.
DOI: 10.1177/1120700020964776

Randomized clinical trial: expanded autologous bone marrow mesenchymal cells combined with allogeneic bone tissue, compared with autologous iliac crest graft in lumbar fusion surgery.

PMID: 32730985
Journal: Spine Journal
Year: 2020
Reference: Spine J. 2020 Jul 28. pii: S1529-9430(20)31003-2. doi: 10.1016/j.spinee.2020.07.014.
Impact factor: 3.191
Publication type: Paper in international publication
Authors: Garcia de Frutos, Ana, Gonzalez-Tartiere, Pilar, Coll Bonet, Ruth, Ubierna Garces, Maria Teresa, Del Arco Churruca, Alejandro, Rivas Garcia, Antoni, Matamalas Adrover, Antonia, Salo Bru, Guillem, Velazquez, Juan Jose, Vila-Canet, Gemma et al.
DOI: 10.1016/j.spinee.2020.07.014

Evaluation of a cell-based osteogenic formulation compliant with good manufacturing practice for use in tissue engineering.

PMID: 32562174
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2020
Reference: Mol Biol Rep. 2020 Jul;47(7):5145-5154. doi: 10.1007/s11033-020-05588-z. Epub 2020 Jun 19.
Impact factor: 1.402
Publication type: Paper in international publication
Authors: Vivas, Daniel, Grau-Vorster, Marta, Oliver-Vila, Irene, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.1007/s11033-020-05588-z

Osteogenic commitment of Wharton's jelly mesenchymal stromal cells: mechanisms and implications for bioprocess development and clinical application.

PMID: 31779673
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Nov 28;10(1):356. doi: 10.1186/s13287-019-1450-3.
Impact factor: 4.627
Publication type: Paper in international publication
Authors: Cabrera-Perez, Raquel, Monguio-Tortajada, Marta, Gamez-Valero, Ana, Rojas-Marquez, Raquel, Borras, Francesc Enric, Roura, Santiago, Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1450-3

HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study.

PMID: 31196185
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Jun 13;10(1):164. doi: 10.1186/s13287-019-1279-9.
Impact factor: 4.627
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Laitinen, Anita, Nystedt, Johanna, Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1279-9

Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton's Jelly.

PMID: 31117301
Journal: Cells
Year: 2019
Reference: Cells. 2019 May 21;8(5). pii: cells8050484. doi: 10.3390/cells8050484.
Impact factor: 5.656
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Rodriguez, Luciano, Del Mazo-Barbara, Anna, Mirabel, Clementine, Blanco, Margarita, Codinach, Margarita, Gomez, Susana G, Querol, Sergi, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.3390/cells8050484

Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application.

PMID: 30965661
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Apr 8;8(4). pii: jcm8040476. doi: 10.3390/jcm8040476.
Impact factor: 5.688
Publication type: Review in international publication
Authors: Alvarez-Palomo, Belen, Vives, Joaquim, Casaroli-Marano, Ricardo P P, G Gomez, Susana G, Rodriguez Gomez, Luciano, Edel, Michael J, Querol Giner, Sergi et al.
DOI: 10.3390/jcm8040476

Triple elastofibromas located in the supra- and infrascapular regions-a case report.

PMID: 29170811
Journal: SKELETAL RADIOLOGY
Year: 2018
Reference: Skeletal Radiol. 2018 Apr;47(4):569-573. doi: 10.1007/s00256-017-2813-4. Epub 2017 Nov 23.
Impact factor: 1.737
Publication type: Paper in international publication
Authors: Olchowy, Cyprian, de Delas-Vigo, Matias de Albert, Perez, Manolo, Ciriaco, Nikaoly, Oronoz, Rosa Dominguez et al.
DOI: 10.1007/s00256-017-2813-4

TRest as a New Diagnostic Variable for Chronic Exertional Compartment Syndrome of the Forearm: A Prospective Cohort Analysis of 124 Athletes.

PMID: 28817409
Journal: CLINICAL JOURNAL OF SPORT MEDICINE
Year: 2018
Reference: Clin J Sport Med. 2018 Nov;28(6):516-523. doi: 10.1097/JSM.0000000000000482.
Impact factor: 2.189
Publication type: Paper in international publication
Authors: Campillo-Recio, David, Mir-Bullo, Xavier, Soldado, Francisco, Sallent, Andrea, Haddad, Sleiman, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Correa-Vazquez, Eva et al.
DOI: 10.1097/JSM.0000000000000482

Septic Nonunion Caused by Mycobacterium canariasense: A Case Report.

PMID: 30431479
Journal: JBJS case connector
Year: 2018
Reference: JBJS Case Connect. 2018 Oct-Dec;8(4):e90. doi: 10.2106/JBJS.CC.18.00033.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vicente, Matias, Lung, Mayli, Gulin, Carlos, Tortola, Maria Teresa, Corona, Pablo S et al.
DOI: 10.2106/JBJS.CC.18.00033

Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products.

PMID: 30355298
Journal: Journal of Translational Medicine
Year: 2018
Reference: J Transl Med. 2018 Oct 24;16(1):291. doi: 10.1186/s12967-018-1659-4.
Impact factor: 4.197
Publication type: Paper in international publication
Authors: Vives, Joaquim, Godia, Francesc, Morton, Philip, Reyes, Blanca, Del Mazo-Barbara, Anna, Mirabel, Clementine, Puente-Massaguer, Eduard et al.
DOI: 10.1186/s12967-018-1659-4

New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research.

PMID: 27357187
Journal: LAB ANIMAL
Year: 2017
Reference: Lab Anim. 2017 Apr;51(2):124-137. doi: 10.1177/0023677216656221. Epub 2016 Jul 9.
Impact factor: 0.681
Publication type: Paper in international publication
Authors: Verges, Ramona, Giralt, Jordi, Aguirre-Canyadell, Marius, Velez, Roberto, Lopez-Fernandez, Alba, Sallent, Andrea, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi et al.
DOI: 10.1177/0023677216656221

A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies.

PMID: 27860364
Journal: Journal of Tissue Engineering and Regenerative Medicine
Year: 2017
Reference: J Tissue Eng Regen Med. 2017 Dec;11(12):3408-3416. doi: 10.1002/term.2254. Epub 2016 Nov 18.
Impact factor: 4.71
Publication type: Paper in international publication
Authors: Caminal, Marta, Rabanal, Rosa Maria, Vivas, Daniel, Batlle-Morera, Laura, Aguirre, Marius, Barquinero, Jordi, Garcia, Joan, Vives, Joaquim, Velez, Roberto et al.
DOI: 10.1002/term.2254

Toward the clinical use of circulating biomarkers predictive of bone union.

PMID: 29182015
Journal: Biomarkers in Medicine
Year: 2017
Reference: Biomark Med. 2017 Dec;11(12):1125-1133. doi: 10.2217/bmm-2017-0180. Epub 2017 Nov 28.
Impact factor: 2.02
Publication type: Editorail in international publication
Authors: Chaverri, Daniel, Vives, Joaquim et al.
DOI: 10.2217/bmm-2017-0180

Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?

PMID: 29078809
Journal: Stem Cell Research & Therapy
Year: 2017
Reference: Stem Cell Res Ther. 2017 Oct 27;8(1):238. doi: 10.1186/s13287-017-0695-y.
Impact factor: 4.211
Publication type: Review in national publication
Authors: Roura, Santiago, Galvez-Monton, Carolina, Mirabel, Clementine, Vives, Joaquim, Bayes-Genis, Antoni et al.
DOI: 10.1186/s13287-017-0695-y

Increased infection risk after hip hemiarthroplasty in institutionalized patients with proximal femur fracture.

PMID: 26857632
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2016
Reference: Injury. 2016 Apr;47(4):872-6. doi: 10.1016/j.injury.2015.12.032. Epub 2016 Jan 7.
Impact factor: 1.91
Publication type: Paper in international publication
Authors: Gallardo-Calero, Irene, Larrainzar-Coghen, Thais, Rodriguez-Pardo, Dolors, Pigrau, Carles, Sanchez-Raya, Judith, Amat, Carles, Lung, Maily, Carrera, Luis, Corona, Pablo S et al.
DOI: 10.1016/j.injury.2015.12.032

Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats.

PMID: 27975009
Journal: Plastic and reconstructive surgery. Global open
Year: 2016
Reference: Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. eCollection 2016 Nov.
Impact factor: 0
Publication type: Paper in international publication
Authors: Verges, Ramona, Barrera-Ochoa, Sergi, Gallardo-Calero, Irene, Lopez-Fernandez, Alba, Romagosa, Cleofe, Velez, Roberto, Soldado, Francisco, Aguirre-Canyadell, Marius et al.
DOI: 10.1097/GOX.0000000000001073

Fracture of the Modular Neck in Total Hip Arthroplasty.

PMID: 26266069
Journal: Case reports in orthopedics
Year: 2015
Reference: Case Rep Orthop. 2015;2015:591509. doi: 10.1155/2015/591509. Epub 2015 Jul 22.
Impact factor: 0
Publication type: Paper in international publication
Authors: Hernandez, A, Gargallo-Margarit, A, Barro, V, Gallardo-Calero, I, Sallent, A et al.
DOI: 10.1155/2015/591509

Thesis

Estudio preclínico sobre la revitalización de aloinjertos óseos mediante el uso de un biovidrio nanoparticulado de fosfato cálcico embebido en fibra de ácido poliláctico. Modelo animal en rata

PhD student: Matias Vicente Goma-Camps
Director/s: Màrius Aguirre Canyadell
University: Universitat Autònoma de Barcelona
Year: 2020

Síndrome compartimental crónico del antebrazo

PhD student: Eva Alicia Correa Vázquez
Director/s: Sergi Barrera Ochoa
University: Universitat Autònoma de Barcelona
Year: 2020

Microanatomia comparada del nervi ciàtic i validació d'un nou biomarcador en injeccions intraneurals

PhD student: Anna Server Salvà
Director/s: Ángeles Mesas Idáñez, Cristina Aguilera Martin
University: Universitat Autònoma de Barcelona
Year: 2019

Tratamiento con células madre mesenquimales en un modelo experimental ovino de osteonecrosis de cabeza femoral

PhD student: Alba López Fernandez
Director/s: Màrius Aguirre Canyadell, Roberto Vélez Villa
University: Universitat Autònoma de Barcelona
Year: 2018

Estudio sobre la viabilidad de la anastomosis vascular microquirúrgica en población irradiada. EStudio en modelo animal en rata

PhD student: Sergi Barrera Ochoa
Director/s: Enric Cáceres Palou, Joan Nardi Vilardaga, Roberto Vélez Villa
University: Universitat Autònoma de Barcelona
Year: 2014

Estimulación de la regeneración ósea mediante células madre en un modelo preclínico de osteonecrosis de la cabeza femoral.

PhD student: Roberto Vélez Villa
Director/s: Màrius Aguirre Canyadell, Joan Nardi Vilardaga, Vicenç Martínez Ibáñez
University: Universitat Autònoma de Barcelona
Year: 2010

Job offers

Research Support Technician Enginyeria tissular musculoesquelètica
Start date:
18/01/2022
End date:
01/02/2022
Document: Download
Postdoctoral position-Musculoskeletal Tissue Engineering Group
Start date:
10/12/2021
End date:
24/12/2021
Document: Download
Research Support Technician - Musculoskeletal Tissue Engineering Research Group (ITM)
Start date:
28/10/2021
End date:
11/11/2021
Document: Download