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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Research lines

Sumoylation in TTR Amyloidosis. Effect of Tafamidis in patients affected with TTR-Amyloidosis

Protein misfolding and aggregation are common features in many degenerative amyloid disorders. In each case, a specific amyloidogenic protein misfolds and follows a toxic aggregation pathway leading to a defined clinical outcome. Many factors that may trigger protein misfolding and aggregation have been implied in the development of these pathologies, such as abnormal proteolysis, point mutations and post-translational modifications. So far, though, no one has studied the SUMOylation status of TTR. In this project we are evaluating the role that SUMOylation plays in TTR amyloidosis in the different subtypes of patients with this disease. Furthermore, we are also studying the effect that the drug of choice, tafamidis, might have on the sumoylation process.

IP: -

Systemic Autoimmune diseases

SLE, Systemic sclerosis, vasculitis, dermatomyositis, Sjogren Syndrome, antiphospholipid síndrome and autoinflammatory síndromes.


1.-Epigenetic and Genetic studies in Autoimmune systemic diseases 

2.-Development of new diagnostic criteria for the autoimmune systemic diseases.

3.-Identification of new diagnostic diseases biomarkers and for assessing disease activity.

4- Evaluation of new immunosuppressive drugs, biological therapies and antifibrotic agents in these conditons.

5.-Epidemiologic and Morbi-mortality studies

IP: -

Urinary biomarkers detection in lupus nephritis.

Our main goal in this project is to try to avoid the repeated renal biopsies needed for establishing both the diagnosis and the following up of patients who suffer with lupus nephritis. By using just urine from the patients, we want to find out whether there is one/some biomarker/s (MCP-1, TWEAK, NGAL, APRIL, RANTES,...) that allow us to establish particular diagnosis and prognosis criteria  equally effective or even more accurate than those obtained with the renal biopsy.

IP: José Ordi Ros

Publications

Recommendations by the Spanish Society of Rheumatology on Fibromyalgia. Part 1: Diagnosis and treatment.

PMID: 34649820
Journal: Reumatologia clinica
Year: 2022
Reference: Reumatol Clin. 2022 Mar;18(3):131-140. doi: 10.1016/j.reumae.2021.02.002. Epub 2021 Oct 11.
Impact factor: 0
Publication type: Paper in international publication
Authors: Rivera Redondo, Javier, Diaz Del Campo Fontecha, Petra, Alegre de Miquel, Cayetano, Almirall Bernabe, Miriam, Casanueva Fernandez, Benigno, Castillo Ojeda, Cristina, Collado Cruz, Antonio, Monteso-Curto, Pilar, Palao Tarrero, Angela, Trillo Calvo, Eva et al.
DOI: 10.1016/j.reuma.2021.02.004

Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air((R)) real-world data.

PMID: 35258105
Journal: ALLERGY
Year: 2022
Reference: Allergy. 2022 Mar 8. doi: 10.1111/all.15275.
Impact factor: 13.146
Publication type: Paper in international publication
Authors: Vieira, Rafael Jose, Sousa-Pinto, Bernardo, Sa-Sousa, Ana, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Desiree E et al.
DOI: 10.1111/all.15275

Daily Clinical Practice in the Management of Chronic Urticaria in Spain: Results of the UCREX Study.

PMID: 35249717
Journal: Actas dermo-sifiliograficas
Year: 2022
Reference: Actas Dermosifiliogr. 2022 Jan;113(1):T4-T14. doi: 10.1016/j.ad.2021.06.007. Epub 2021 Jul 20.
Impact factor: 0
Publication type: Paper in national publication
Authors: Terradas-Montana, P, Vidal-Jorge, M, Jauregui Presa, I, Valero Santiago, A, Sastre Dominguez, J, Ortiz de Frutos, F J, Miquel-Miquel, J, Ferrer Puga, M, Silvestre Salvador, J F, Bartra Tomas, J et al.
DOI: 10.1016/j.ad.2021.06.007

Daily Clinical Practice in the Management of Chronic Urticaria in Spain: Results of the UCREX Study.

PMID: 35244542
Journal: Actas dermo-sifiliograficas
Year: 2022
Reference: Actas Dermosifiliogr. 2022 Jan;113(1):4-14. doi: 10.1016/j.ad.2021.06.014. Epub 2022 Feb 3.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vidal-Jorge, M, Jauregui Presa, I, Terradas-Montana, P, Valero Santiago, A, Sastre Dominguez, J, Ortiz de Frutos, F J, Ferrer Puga, M, Silvestre Salvador, J F, Bartra Tomas, J, Gimenez-Arnau, A et al.
DOI: 10.1016/j.ad.2021.06.014

Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

PMID: 34201806
Journal: Antioxidants
Year: 2021
Reference: Antioxidants (Basel). 2021 Jun 23;10(7). pii: antiox10071010. doi: 10.3390/antiox10071010.
Impact factor: 6.313
Publication type: Paper in international publication
Authors: Castro-Marrero, Jesus, Zaragoza, Maria-Cleofe, Lopez-Vilchez, Irene, Galmes, Jose Luis, Maurel, Sara, Domingo, Joan Carles, Alegre-Martin, Jose, Cordobilla, Begona et al.
DOI: 10.3390/antiox10071010

Tocilizumab in refractory Caucasian Takayasu's arteritis: a multicenter study of 54 patients and literature review.

PMID: 34211589
Journal: Therapeutic Advances in Musculoskeletal Disease
Year: 2021
Reference: Ther Adv Musculoskelet Dis. 2021 Jun 18;13:1759720X211020917. doi: 10.1177/1759720X211020917. eCollection 2021.
Impact factor: 5.346
Publication type: Paper in international publication
Authors: Bravo, Beatriz, Romero-Yuste, Susana, Salvatierra, Juan, Hidalgo, Cristina, Manrique, Sara, Romero-Gomez, Carlos, Moya, Patricia, Alvarez-Rivas, Noelia, Mendizabal, Javier, Ortiz-Sanjuan, Francisco et al.
DOI: 10.1177/1759720X211020917

One-dilution rapid desensitization protocol to chemotherapeutic and biological agents: a five-year experience.

PMID: 34214705
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2021
Reference: J Allergy Clin Immunol Pract. 2021 Nov;9(11):4045-4054. doi: 10.1016/j.jaip.2021.06.024. Epub 2021 Jun 30.
Impact factor: 8.861
Publication type: Paper in international publication
Authors: Cardona, Victoria, Sala-Cunill, Anna, Molina-Molina, Gustavo-Jorge, Verdesoto, Jenny-Tatiana, Labrador-Horrillo, Moises, Luengo, Olga, Galvan-Blasco, Paula, Guilarte, Mar et al.
DOI: 10.1016/j.jaip.2021.06.024

Association between psychological constructs and physical and emotional distress in individuals with fibromyalgia.

PMID: 32167877
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):13-19. Epub 2020 Mar 13.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Maurel, Sara, Calvo, Natalia, Saez-Francas, Naia, Alegre, Jose, Castro-Marrero, Jesus et al.
DOI:

Sampling time-dependent artifacts in single-cell genomics studies.

PMID: 32393363
Journal: GENOME BIOLOGY
Year: 2020
Reference: Genome Biol. 2020 May 11;21(1):112. doi: 10.1186/s13059-020-02032-0.
Impact factor: 10.806
Publication type: Paper in international publication
Authors: Moutinho, Catia, Kulis, Marta, Palau, Nuria, Marchese, Domenica, Rodriguez-Ubreva, Javier, Ballestar, Esteban, Rodriguez-Esteban, Gustavo, Marsal, Sara, Aymerich, Marta, Colomer, Dolors et al.
DOI: 10.1186/s13059-020-02032-0

Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review.

PMID: 32376394
Journal: AUTOIMMUNITY REVIEWS
Year: 2020
Reference: Autoimmun Rev. 2020 Jul;19(7):102569. doi: 10.1016/j.autrev.2020.102569. Epub 2020 May 3.
Impact factor: 7.767
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Belizna, Cristina, Selva-O'Callaghan, Albert, Pardos-Gea, Josep, Quintana, Angela, Mekinian, Arsene, Anunciacion-Lunell, Ariadna, Miro-Mur, Francesc et al.
DOI: 10.1016/j.autrev.2020.102569

Fatal anaphylactic shock induced by intravenous gelatin colloid: An allergological postmortem work-up.

PMID: 31599728
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Investig Allergol Clin Immunol. 2020 Apr 24;30(2):143-145. doi: 10.18176/jiaci.0459. Epub 2019 Oct 10.
Impact factor: 3.488
Publication type: Paper in international publication
Authors: Labrador Horrillo, M, Cardona, V, Sala Cunill, A, Guilarte, M, Luengo, O, Molina Molina, G J, Carrasco Gonzalez, M D, Vinas Gimenez, L, Sanz Martinez, M, Galvan Blasco, P et al.
DOI: 10.18176/jiaci.0459

Secondary prevention measures in anaphylaxis patients: Data from the Anaphylaxis Registry.

PMID: 31584692
Journal: ALLERGY
Year: 2020
Reference: Allergy. 2020 Apr;75(4):901-910. doi: 10.1111/all.14069. Epub 2019 Oct 21.
Impact factor: 8.706
Publication type: Paper in international publication
Authors: Kraft, M, Knop, M, Renaudin, J M, Scherer Hofmeier, K, Pfohler, C, Bilo, M B, Lang, R, Treudler, R, Wagner, N, Spindler, T et al.
DOI: 10.1111/all.14069

Clinical and therapeutic management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: RADAR study.

PMID: 31396685
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2019
Reference: Rheumatol Int. 2019 Dec;39(12):2015-2024. doi: 10.1007/s00296-019-04378-6. Epub 2019 Aug 8.
Impact factor: 2.2
Publication type: Paper in international publication
Authors: Gomez-Centeno, Antonio, Rubio-Romero, Esteban, Ovalles, Juan Gabriel, Manrique-Arija, Sara, Marsal-Barril, Sara, Amarelo-Ramos, Juan, Del Pino-Montes, Javier, Munoz-Fernandez, Santiago, Bustabad, Sagrario, Barbazan-Alvarez, Ceferino et al.
DOI: 10.1007/s00296-019-04378-6

Measuring inflammation in rheumatoid arthritis with a new clinical and ultrasound index: development and initial validation.

PMID: 31396686
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2019
Reference: Rheumatol Int. 2019 Dec;39(12):2137-2145. doi: 10.1007/s00296-019-04383-9. Epub 2019 Aug 8.
Impact factor: 2.2
Publication type: Paper in international publication
Authors: de Agustin, Juan Jose, Erra, Alba, Ponce, Andres, Moragues, Carmen, Diaz-Torne, Cesar, Reina, Delia, Moreno, Estefania, Ramirez, Julio, Mateo, Lourdes, Pujol Busquets, Manel et al.
DOI: 10.1007/s00296-019-04383-9

[Very elderly institutionalised population of Barcelona: Evaluation of frailty according to the Frail-VIG index and analysis of therapeutic appropriateness according to the STOPP-frail criteria].

PMID: 31362844
Journal: Revista espanola de geriatria y gerontologia
Year: 2019
Reference: Rev Esp Geriatr Gerontol. 2019 Nov - Dec;54(6):334-338. doi: 10.1016/j.regg.2019.06.004. Epub 2019 Jul 28.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vivanco, Maria Victoria, Formiga, Francesc, Mundet Riera, Imma, San Jose Laporte, Antonio, Curto Prieto, David et al.
DOI: 10.1016/j.regg.2019.06.004

An Exosomal Urinary miRNA Signature for Early Diagnosis of Renal Fibrosis in Lupus Nephritis.

PMID: 31349698
Journal: Cells
Year: 2019
Reference: Cells. 2019 Jul 25;8(8). pii: cells8080773. doi: 10.3390/cells8080773.
Impact factor: 5.656
Publication type: Paper in international publication
Authors: Sole, Cristina, Moline, Teresa, Vidal, Marta, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al.
DOI: 10.3390/cells8080773

Diagnostic delay in acquired haemophilia: Analysis of causes and consequences in a 20-year Spanish cohort.

PMID: 29732654
Journal: HAEMOPHILIA
Year: 2018
Reference: Haemophilia. 2018 May;24(3):e163-e166. doi: 10.1111/hae.13499. Epub 2018 May 6.
Impact factor: 2.768
Publication type: Review in international publication
Authors: Pardos-Gea, J, Fernandez-Diaz, N, Parra, R, Cortina, V, Altisent, C et al.
DOI: 10.1111/hae.13499

Utility of the (18)F-Florbetapir positron emission tomography in systemic amyloidosis.

PMID: 29706127
Journal: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
Year: 2018
Reference: Amyloid. 2018 Jun;25(2):109-114. doi: 10.1080/13506129.2018.1467313. Epub 2018 Apr 28.
Impact factor: 4.048
Publication type: Paper in international publication
Authors: Lorenzo-Bosquet, Carles, Mestre-Torres, Jaume, Solans-Laque, Roser, Fernandez-Codina, Andreu, Bujan-Rivas, Segundo, Castell-Conesa, Joan, Martinez-Valle, Fernando, Gironella, Mercedes, Cuberas-Borros, Gemma et al.
DOI: 10.1080/13506129.2018.1467313

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

PMID: 29696075
Journal: Journal of Extracellular Vesicles
Year: 2018
Reference: J Extracell Vesicles. 2018 Mar 22;7(1):1453730. doi: 10.1080/20013078.2018.1453730. eCollection 2018.
Impact factor: 0
Publication type: Paper in international publication
Authors: Zaragoza, Maria Cleofe, Martinez-Martinez, Alba, Blanco-Lopez, Maria Del Carmen, Alegre, Jose, Oliveira-Rodriguez, Myriam, Serrano-Pertierra, Esther, Castro-Marrero, Jesus et al.
DOI: 10.1080/20013078.2018.1453730

Critical view of anaphylaxis epidemiology: open questions and new perspectives.

PMID: 29632547
Journal: Allergy Asthma and Clinical Immunology
Year: 2018
Reference: Allergy Asthma Clin Immunol. 2018 Apr 4;14:12. doi: 10.1186/s13223-018-0234-0. eCollection 2018.
Impact factor: 2.051
Publication type: Review in national publication
Authors: Tanno, Luciana Kase, Bierrenbach, Ana Luiza, Simons, F Estelle R, Cardona, Victoria, Thong, Bernard Yu-Hor, Molinari, Nicolas, Calderon, Moises A, Worm, Margitta, Papadopoulos, Nikolaos G, Casale, Thomas et al.
DOI: 10.1186/s13223-018-0234-0

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.

PMID: 28619073
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2017
Reference: Arthritis Res Ther. 2017 Jun 15;19(1):138. doi: 10.1186/s13075-017-1345-6.
Impact factor: 4.121
Publication type: Paper in international publication
Authors: Marsal, Sara, Blanco, Ricardo, Lopez-Longo, Jose Javier, Venegas, Jose Javier Perez, Olive, Alex, Andreu, Jose Luis, Aguirre-Zamorano, Maria Angeles, Vela, Paloma, Nolla, Joan M, Marenco-de la Fuente, Jose Luis et al.
DOI: 10.1186/s13075-017-1345-6

High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center.

PMID: 28615037
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2017
Reference: Arthritis Res Ther. 2017 Jun 14;19(1):135. doi: 10.1186/s13075-017-1327-8.
Impact factor: 4.121
Publication type: Paper in international publication
Authors: Guillen-Del Castillo, Alfredo, Callejas-Moraga, Eduardo L, Garcia, Gabriela, Rodriguez-Palomares, Jose F, Roman, Antonio, Berastegui, Cristina, Lopez-Meseguer, Manuel, Domingo, Enric, Fonollosa-Pla, Vicente, Simeon-Aznar, Carmen Pilar et al.
DOI: 10.1186/s13075-017-1327-8

Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease.

PMID: 28038794
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2017
Reference: Arch Bronconeumol. 2017 Mar;53(3):120-127. doi: 10.1016/j.arbres.2016.09.014. Epub 2016 Dec 27.
Impact factor: 2.979
Publication type: Paper in national publication
Authors: Guillen-Del Castillo, Alfredo, Sanchez-Vidaurre, Sara, Simeon-Aznar, Carmen P, Cruz, Maria J, Fonollosa-Pla, Vicente, Munoz, Xavier et al.
DOI: 10.1016/j.arbres.2016.09.014

Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study.

PMID: 28596045
Journal: PSYCHOSOMATICS
Year: 2017
Reference: Psychosomatics. 2017 Sep - Oct;58(5):533-543. doi: 10.1016/j.psym.2017.04.010. Epub 2017 Apr 21.
Impact factor: 1.436
Publication type: Paper in international publication
Authors: Castro-Marrero, Jesus, Faro, Monica, Aliste, Luisa, Saez-Francas, Naia, Calvo, Natalia, Martinez-Martinez, Alba, de Sevilla, Tomas Fernandez, Alegre, Jose et al.
DOI: 10.1016/j.psym.2017.04.010

Management of Pregnancy and Delivery in Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency.

PMID: 27326983
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2016
Reference: J Investig Allergol Clin Immunol. 2016 Jun;26(3):161-7. doi: 10.18176/jiaci.0037.
Impact factor: 2.131
Publication type: Paper in international publication
Authors: Pinero-Saavedra, M, Rubio, M, Caballero, T, Lopez-Serrano, M C, Cimbollek, S, Gonzalez-Quevedo, T, Guilarte, M, Marcos, C, Larco, J I, Baeza, M L et al.
DOI: 10.18176/jiaci.0037

[Descriptive Study of sickness absence in the health care sector of Catalonia (2009-2012)].

PMID: 27250623
Journal: Archivos de prevencion de riesgos laborales
Year: 2016
Reference: Arch Prev Riesgos Labor. 2016 Jan-Mar;19(1):15-21. doi: 10.12961/aprl.2016.19.1.03.
Impact factor: 0
Publication type: Paper in national publication
Authors: Carreras Valls, Rosa, Olive Cristany, Victoria, Bretau Vinas, Frederic, Subirats Cid, Pilar, Sanchez Flores, Eugenia, Villegas Rodriguez, Sonia, Guixeras Campos, Assumpcio, Torrecillas Mota, Susana, Barroso Reinon, Sonia, Serra Pujadas, Consol et al.
DOI: 10.12961/aprl.2016.19.01.3

The phenotype and genotype of mevalonate kinase deficiency: A series of 114 cases from the Eurofever Registry.

PMID: 27213830
Journal: Arthritis & Rheumatology
Year: 2016
Reference: Arthritis Rheumatol. 2016 Nov;68(11):2795-2805. doi: 10.1002/art.39763.
Impact factor: 6.009
Publication type: Paper in international publication
Authors: Rigante, Donato, Russo, Ricardo, Pachlopnik Schmid, Jana, Lane, Thirusha, Martini, Alberto, Ruperto, Nicolino, Frenkel, Joost, Gattorno, Marco, Consolini, Rita, Boros, Christina et al.
DOI: 10.1002/art.39763

Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus.

PMID: 27111665
Journal: Arthritis & Rheumatology
Year: 2016
Reference: Arthritis Rheumatol. 2016 Sep;68(9):2338-44. doi: 10.1002/art.39730.
Impact factor: 6.009
Publication type: Paper in national publication
Authors: Santaniello, Alessandro, Lopez-Isac, Elena, Martin, Jose-Ezequiel, Assassi, Shervin, Simeon, Carmen P, Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltran, Emma, Narvaez, Javier et al.
DOI: 10.1002/art.39730

Applying the ACR/EULAR Systemic Sclerosis Classification Criteria to the Spanish Scleroderma Registry Cohort.

PMID: 26472418
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2015
Reference: J Rheumatol. 2015 Dec;42(12):2327-31. doi: 10.3899/jrheum.150144. Epub 2015 Oct 15.
Impact factor: 3.187
Publication type: Paper in international publication
Authors: Perez-Conesa, Mercedes, Saez-Comet, Luis, Simeon-Aznar, Carmen Pilar, Iniesta-Arandia, Nerea, Colunga-Arguelles, Dolores, Egurbide-Arberas, Maria Victoria, Ortego-Centeno, Norberto, Vargas-Hitos, Jose Antonio, Freire-Dapena, Mayka, Rubio-Rivas, Manuel et al.
DOI: 10.3899/jrheum.150144

Association of haplotypes of the TLR8 locus with susceptibility to Crohn's and Behcet's diseases.

PMID: 26486764
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2015
Reference: Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S117-22. Epub 2015 Oct 19.
Impact factor: 2.724
Publication type: Paper in international publication
Authors: Sanchez-Burson, Juan, Julia, Maria-Rosa, Blanco, Ricardo, Barnosi-Marin, Ana-Celia, Solans, Roser, Fanlo, Patricia, Rodriguez-Carballeira, Monica, Camps, Teresa, Castaneda, Santos, Martin, Javier et al.
DOI:

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.

PMID: 26336855
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2015
Reference: Arthritis Res Ther. 2015 Sep 4;17:242. doi: 10.1186/s13075-015-0737-8.
Impact factor: 3.753
Publication type: Paper in international publication
Authors: Alperi-Lopez, Mercedes, Olive, Alex, Corominas, Hector, Tornero, Jesus, Erra, Alba, Almirall, Miriam, Palau, Nuria, Ortiz, Ana, Avila, Gabriela, Rodriguez-Rodriguez, Luis et al.
DOI: 10.1186/s13075-015-0737-8

Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology.

PMID: 26343462
Journal: COMPREHENSIVE PSYCHIATRY
Year: 2015
Reference: Compr Psychiatry. 2015 Oct;62:13-9. doi: 10.1016/j.comppsych.2015.06.010. Epub 2015 Jun 17.
Impact factor: 2.252
Publication type: Paper in international publication
Authors: Saez-Francas, Naia, Calvo, Natalia, Alegre, Jose, Castro-Marrero, Jesus, Ramirez, Nicolas, Hernandez-Vara, Jorge, Casas, Miguel et al.
DOI: 10.1016/j.comppsych.2015.06.010

Component resolved diagnosis: when should it be used?

PMID: 25250172
Journal: Clinical and Translational Allergy
Year: 2014
Reference: Clin Transl Allergy. 2014 Sep 8;4:28. doi: 10.1186/2045-7022-4-28. eCollection 2014.
Impact factor: 0
Publication type: Letter or abstract
Authors: Luengo, Olga, Cardona, Victoria et al.
DOI: 10.1186/2045-7022-4-28

First European data from the network of severe allergic reactions (NORA).

PMID: 24989080
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Oct;69(10):1397-404. doi: 10.1111/all.12475. Epub 2014 Aug 16.
Impact factor: 5.995
Publication type: Paper in international publication
Authors: Papadopoulos, N G, Worm, M, Moneret-Vautrin, A, Scherer, K, Lang, R, Fernandez-Rivas, M, Cardona, V, Kowalski, M L, Jutel, M, Poziomkowska-Gesicka, I et al.
DOI: 10.1111/all.12475

Anti-SSA/Ro52 autoantibodies in scleroderma: results of an observational, cross-sectional study.

PMID: 25372801
Journal: CLIN EXP RHEUMATOL
Year: 2014
Reference: Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-177-82. Epub 2014 Nov 5.
Impact factor: 2.973
Publication type: Paper in international publication
Authors: Sanchez-Montalva, A, Fernandez-Luque, A, Simeon, C P, Fonollosa-Pla, V, Marin, A, Guillen, A, Vilardell, M et al.
DOI:

A novel splice site mutation in the SERPING1 gene leads to haploinsufficiency by complete degradation of the mutant allele mRNA in a case of familial hereditary angioedema.

PMID: 24760113
Journal: J CLIN IMMUNOL
Year: 2014
Reference: J Clin Immunol. 2014 Jul;34(5):521-3. doi: 10.1007/s10875-014-0042-3. Epub 2014 Apr 24.
Impact factor: 2.654
Publication type: Paper in international publication
Authors: Guilarte, Mar, Hernandez-Gonzalez, Manuel, Colobran, Roger, Pujol-Borrell, Ricardo et al.
DOI: 10.1007/s10875-014-0042-3

[Absence of xenotropic murine leukaemia virus-related virus sequences in healthy blood donors and chronic fatigue syndrome patients in Catalonia, Spain.]

PMID: 23332972
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2013
Reference: Enferm Infecc Microbiol Clin. 2013 Aug-Sep;31(7):491-2. doi: 10.1016/j.eimc.2012.11.016. Epub 2013 Jan 17.
Impact factor: 1.478
Publication type: Letter whit IF
Authors: Piron, Maria, Alegre, Jose, Ribera, Esteban, Sauleda, Silvia et al.
DOI: 10.1016/j.eimc.2012.11.016

Three-dimensional Volumetric Ultrasound: A Valid Method for Blinded Assessment of Response to Therapy in Rheumatoid Arthritis.

PMID: 23322469
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2013
Reference: J Rheumatol. 2013 Mar;40(3):253-60. doi: 10.3899/jrheum.121103. Epub 2013 Jan 15.
Impact factor: 3.258
Publication type: Paper in international publication
Authors: Naredo, Esperanza, Acebes, Carlos, Brito, Elia, de Agustin, Juan Jose, de Miguel, Eugenio, Mayordomo, Lucia, Moller, Ingrid, Moragues, Carmen, Rejon, Eduardo, Rodriguez, Ana et al.
DOI: 10.3899/jrheum.121103

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.

PMID: 22936669
Journal: GUT
Year: 2013
Reference: Gut. 2013 Oct;62(10):1440-5. doi: 10.1136/gutjnl-2012-302865. Epub 2012 Aug 30.
Impact factor: 10.732
Publication type: Paper in international publication
Authors: Absher, Devin, Panes, Julian, Marsal, Sara, Bertanpetit, Jaume, Garcia-Montero, Andres C, Codo, Laia, Julia, Antonio, Domenech, Eugeni, Ricart, Elena, Tortosa, Raul et al.
DOI: 10.1136/gutjnl-2012-302865

The Association of Apathy With Central Fatigue Perception in Patients With Parkinson's Disease.

PMID: 23339489
Journal: BEHAVIORAL NEUROSCIENCE
Year: 2013
Reference: Behav Neurosci. 2013 Apr;127(2):237-44. doi: 10.1037/a0031531. Epub 2013 Jan 21.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Saez-Francas, Naia, Hernandez-Vara, Jorge, Corominas Roso, Margarita, Martin, Jose Alegre, Brugue, Miguel Casas et al.
DOI: 10.1037/a0031531

Cortisol responses in children and adults with attention deficit hyperactivity disorder (ADHD): a possible marker of inhibition deficits.

PMID: 22576746
Journal: Attention deficit and hyperactivity disorders
Year: 2012
Reference: Atten Defic Hyperact Disord. 2012 Jun;4(2):63-75. doi: 10.1007/s12402-012-0075-5. Epub 2012 May 12.
Impact factor:
Publication type: Letter or abstract
Authors: , , , , , , et al.
DOI: 10.1007/s12402-012-0075-5

Bias in effect size of Systemic Lupus Erythematosus susceptibility loci across Europe: a case control study.

PMID: 22541939
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2012
Reference: Arthritis Res Ther. 2012 Apr 27;14(2):R94. doi: 10.1186/ar3818.
Impact factor: 4.445
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1186/ar3818

[Tracheal stenosis in Wegener's granulomatosis.]

PMID: 21349559
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 May 12;138(13):596. Epub 2011 Feb 23.
Impact factor: 1.385
Publication type: Paper in national publication
Authors: , , , et al.
DOI: 10.1016/j.medcli.2010.09.047

[Home intravenous antimicrobial therapy in multi-drug resistant microorganism infections.]

PMID: 21621228
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 May 12;138(13):557-61. Epub 2011 May 28.
Impact factor: 1.385
Publication type: Paper in national publication
Authors: , , , , , et al.
DOI: 10.1016/j.medcli.2011.03.028

[Home intravenous antibiotic therapy of empyema and lung abscess: safety and efficacy.]

PMID: 21354662
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2011
Reference: Enferm Infecc Microbiol Clin. 2011 Mar;29(3):237-9. Epub 2011 Feb 26.
Impact factor: 1.656
Publication type: Letter or abstract
Authors: José Pardos-Gea, Úrsula Maza, , et al.
DOI: 10.1016/j.eimc.2010.09.011

Circulating Cell-Derived Microparticles in Women with Pregnancy Loss.

PMID: 21276118
Journal: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Year: 2011
Reference: Am J Reprod Immunol. 2011 Sep;66(3):199-208. doi: 10.1111/j.1600-0897.2010.00972.x. Epub 2011 Jan 31.
Impact factor: 2.451
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1111/j.1600-0897.2010.00972.x

Aortic involvement in giant cell arteritis.

PMID: 20149900
Journal: AUTOIMMUNITY REVIEWS
Year: 2010
Reference: Autoimmun Rev. 2010 May;9(7):521-4. Epub 2010 Feb 8.
Impact factor: 6.368
Publication type: Paper in international publication
Authors: , , , et al.
DOI: 10.1016/j.autrev.2010.02.014

[Immediate care consultation. An experience of three years.]

PMID: 20144804
Journal: REVISTA CLINICA ESPANOLA
Year: 2010
Reference: Rev Clin Esp. 2010 Jan;210(1):55-56. Epub 2010 Jan 9.
Impact factor: 0.584
Publication type: Letter or abstract
Authors: , , , et al.
DOI: 10.1016/j.rce.2009.02.001

Is obstetric antiphospholipid syndrome a primary nonthrombotic, proinflammatory, complement-mediated disorder related to antiphospholipid antibodies?

PMID: 20040128
Journal: OBSTETRICAL & GYNECOLOGICAL SURVEY
Year: 2010
Reference: Obstet Gynecol Surv. 2010 Jan;65(1):39-45.
Impact factor: 3.097
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume, Vilardell-Tarres, Miquel, Alijotas Reig, Jaume et al.
DOI: 10.1097/OGX.0b013e3181c97809

Echocardiography at diagnosis of antiphospholipid syndrome provides prognostic information on valvular disease evolution and identifies two subtypes of patients.

PMID: 20068017
Journal: LUPUS
Year: 2010
Reference: Lupus. 2010;19(5):575-82. Epub 2010 Jan 12.
Impact factor: 2.586
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1177/0961203309353772

Circulating microparticles, lupus anticoagulant and recurrent miscarriages.

PMID: 19410360
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2009
Reference: Eur J Obstet Gynecol Reprod Biol. 2009 Jul;145(1):22-6.
Impact factor: 1.565
Publication type: Review in national publication
Authors: Alijotas-Reig, Jaume, Palacio-Garcia, Carles, Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.ejogrb.2009.04.002

Late-Onset Immune-Mediated Adverse Effects after Poly-L-Lactic Acid Injection in Non-HIV Patients: Clinical Findings and Long-Term Follow-Up.

PMID: 19797889
Journal: DERMATOLOGY
Year: 2009
Reference: Dermatology. 2009;219(4):303-8.
Impact factor: 2.227
Publication type: Paper in international publication
Authors: , , et al.
DOI: 10.1159/000243804

Livedo racemosa as a marker of increased risk of recurrent thrombosis in patients with negative anti-phospholipid antibodies.

PMID: 19403146
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 May 30;132(20):767-71.
Impact factor: 1.258
Publication type: Paper in national publication
Authors: Martinez-Valle, Ferran, Balada, Eva, Solans-Laque, Roser, Vilardell-Tarres, Miquel, Selva-O'Callaghan, Albert, Ordi-Ros, Josep et al.
DOI: 10.1016/j.medcli.2008.09.044

[Neuropsyquiatric manifestations in systemic lupus erythematosus]

PMID: 19442996
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 May 30;132(20):797-801.
Impact factor: 1.258
Publication type: Paper in national publication
Authors: Martinez Valle, Fernando, Ordi-Ros, Josep, Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.medcli.2009.02.045

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Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.

The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.

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