Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Research lines

Sumoylation in TTR Amyloidosis. Effect of Tafamidis in patients affected with TTR-Amyloidosis

Protein misfolding and aggregation are common features in many degenerative amyloid disorders. In each case, a specific amyloidogenic protein misfolds and follows a toxic aggregation pathway leading to a defined clinical outcome. Many factors that may trigger protein misfolding and aggregation have been implied in the development of these pathologies, such as abnormal proteolysis, point mutations and post-translational modifications. So far, though, no one has studied the SUMOylation status of TTR. In this project we are evaluating the role that SUMOylation plays in TTR amyloidosis in the different subtypes of patients with this disease. Furthermore, we are also studying the effect that the drug of choice, tafamidis, might have on the sumoylation process.

IP: -

Systemic Autoimmune diseases

SLE, Systemic sclerosis, vasculitis, dermatomyositis, Sjogren Syndrome, antiphospholipid síndrome and autoinflammatory síndromes.

1.-Epigenetic and Genetic studies in Autoimmune systemic diseases

2.-Development of new diagnostic criteria for the autoimmune systemic diseases.

3.-Identification of new diagnostic diseases biomarkers and for assessing disease activity.

4- Evaluation of new immunosuppressive drugs, biological therapies and antifibrotic agents in these conditons.

5.-Epidemiologic and Morbi-mortality studies

IP: -

Urinary biomarkers detection in lupus nephritis.

Our main goal in this project is to try to avoid the repeated renal biopsies needed for establishing both the diagnosis and the following up of patients who suffer with lupus nephritis. By using just urine from the patients, we want to find out whether there is one/some biomarker/s (MCP-1, TWEAK, NGAL, APRIL, RANTES,...) that allow us to establish particular diagnosis and prognosis criteria equally effective or even more accurate than those obtained with the renal biopsy.

IP: José Ordi Ros

Projects

Aquest any no hi ha projectes actius.

Publications

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy.

PMID: 37427115
Journal: Frontiers in Oncology
Year: 2023
Reference: Front Oncol. 2023 Jun 22;13:1200646. doi: 10.3389/fonc.2023.1200646. eCollection 2023.
Impact factor:
Publication type: Review in international publication
Authors: Achyut, Bhagelu R; Czajka-Francuz, Paulina; Jensen, Taylor J; Mankan, Arun; Pabla, Sarabjot; Peiro, Sandra; Poelman, Martine; Prendes, Maria J; Quintana, Angela; Ramkissoon, Shakti et al.
DOI: 10.3389/fonc.2023.1200646

Efficacy and safety of on-demand versus daily rupatadine in chronic spontaneous urticaria: A randomized trial.

PMID: 37597162
Journal: ALLERGY
Year: 2023
Reference: Allergy. 2023 Aug 19. doi: 10.1111/all.15854.
Impact factor:
Publication type: Paper in international publication
Authors: Baron, Jens; Brehler, Randolf; Ferrer, Marta; Gimenez-Arnau, Ana Maria; Groffik, Adriane; Grundmann, Sonja; Jakob, Thilo; Labrador-Horrillo, Moises; Maurer, Marcus; Metz, Martin et al.
DOI: 10.1111/all.15854

Screening for late-onset Pompe disease in Internal Medicine departments in Spain.

PMID: 37653444
Journal: Orphanet Journal of Rare Diseases
Year: 2023
Reference: Orphanet J Rare Dis. 2023 Aug 31;18(1):256. doi: 10.1186/s13023-023-02887-z.
Impact factor:
Publication type: Paper in international publication
Authors: Barba-Romero, Miguel Angel; de la Pena, Jose Luis Patier; de Los Santos Moreno, Alberto; de Los Santos Moreno, Alberto; de Pedro, Ivan Perez; de Ureta, Pablo Tutor; Garate, Igor Gomez; Garcia, Andres Gonzalez; Gil, Roi Suarez; Gomez-Belda, Ana et al.
DOI: 10.1186/s13023-023-02887-z

In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case-control study.

PMID: 37666644
Journal: RMD Open
Year: 2023
Reference: RMD Open. 2023 Sep;9(3):e003081. doi: 10.1136/rmdopen-2023-003081.
Impact factor:
Publication type: Paper in international publication
Authors: Arnaud, Laurent; Barsotti, Simone; Bellando-Randone, Silvia; Bernardi, Livio; Bini, Paola; Blagojevic, Jelena; Bouchard-Marmen, Maude; Cavagna, Lorenzo; Codullo, Veronica; Couderc, Marion et al.
DOI: 10.1136/rmdopen-2023-003081

Impact of home CPAP treated obstructive sleep apnea on COVID-19 outcomes in hospitalized patients.

PMID: 35404224
Journal: Journal of Clinical Sleep Medicine
Year: 2022
Reference: J Clin Sleep Med. 2022 Jul 1;18(7):1857-1864. doi: 10.5664/jcsm.10016.
Impact factor:
Publication type: Paper in international publication
Authors: ; Barrecheguren, Miriam; Ferrer, Jaume; Guillen Del Castillo, Alfredo; Marti, Sergi; Miarons Font , Marta; Pallero, Mercedes; Saez, Maria; Sampol, Gabriel; Sampol, Julia et al.
DOI: 10.5664/jcsm.10016

Angioedema Due to Acquired Deficiency of C1-Inhibitor: a Cohort Study in Spain and a Comparison With Other series.

PMID: 34844023
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2022
Reference: J Allergy Clin Immunol Pract. 2022 Apr;10(4):1020-1028. doi: 10.1016/j.jaip.2021.11.018. Epub 2021 Nov 26.
Impact factor:
Publication type: Paper in international publication
Authors: Baeza, M L; Caballero, T; Castro, M; Diaz, C; Escudero, E; Garcia, M G; Gonzalez-Quevedo, T; Guilarte, M; Laffond, E; Lleonart, R et al.
DOI: 10.1016/j.jaip.2021.11.018

Characterization and outcomes of 414 patients with primary SS who developed hematological malignancies.

PMID: 35385104
Journal: RHEUMATOLOGY
Year: 2022
Reference: Rheumatology (Oxford). 2022 Dec 23;62(1):243-255. doi: 10.1093/rheumatology/keac205.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, N; Alberto Rojas, R; Andrea Consani, S; Armagan, B; Armagan, Berkan; Astorri, E; Atzeni, F; Atzeni, Fabiola; Baldini, C; Baldini, Chiara et al.
DOI: 10.1093/rheumatology/keac205

Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients.

PMID: 35351135
Journal: BMC Medicine
Year: 2022
Reference: BMC Med. 2022 Mar 29;20(1):129. doi: 10.1186/s12916-022-02345-w.
Impact factor:
Publication type: Paper in international publication
Authors: Arrese-Munoz, Iria; Borrell, Ricardo Pujol; Diaz-Troyano, Noelia; Ferrer, Roser; Gabriel-Medina, Pablo; Gallo, Monica Martinez; Gine, Anna; Hernandez-Gonzalez, Manuel; Labrador-Horrillo, Moises; Martinez-Valle, Fernando et al.
DOI: 10.1186/s12916-022-02345-w

Anaphylaxis viewed by experts: unmet needs.

PMID: 34269744
Journal: Current opinion in allergy and clinical immunology
Year: 2021
Reference: Curr Opin Allergy Clin Immunol. 2021 Oct 1;21(5):435-441. doi: 10.1097/ACI.0000000000000771.
Impact factor:
Publication type: Review in international publication
Authors: Cardona, Victoria; Sala-Cunill, Anna et al.
DOI: 10.1097/ACI.0000000000000771

Erratum to "IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper" [World Allergy Organ J 13/2 (2020) 100080].

PMID: 34221218
Journal: World Allergy Organization Journal
Year: 2021
Reference: World Allergy Organ J. 2021 Jun 17;14(7):100557. doi: 10.1016/j.waojou.2021.100557. eCollection 2021 Jul.
Impact factor:
Publication type: Letter or abstract
Authors: Ansotegui, Ignacio J; Antila, Martti; Bousquet, Jean J; Canonica, Giorgio Walter; Caraballo, Luis; Cardona, Victoria; Chiang, Wen Chin; Demoly, Pascal M; DuBuske, Lawrence M; Ebisawa, Motohiro et al.
DOI: 10.1016/j.waojou.2021.100557

Real-World Safety and Effectiveness Evidence of a Microcrystalline Tyrosine-Associated Mite Allergoid in Children and Adolescents with Allergic Rhinitis.

PMID: 34224224
Journal: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
Year: 2021
Reference: Allergol Immunopathol (Madr). 2021 Jul 1;49(4):98-108. doi: 10.15586/aei.v49i4.195. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Almeida-Sanchez, Zulay M; Boronat, Anna; Garcia-Nunez, Ignacio; Justicia, Jose L; Lain, Sofia; Martinez-Tadeo, Juan A; Martos, Maria D; Nunez, Ramon; Ramirez, Mercedes; Sala-Cunill, Anna et al.
DOI: 10.15586/aei.v49i4.195

Tocilizumab in refractory Caucasian Takayasu's arteritis: a multicenter study of 54 patients and literature review.

PMID: 34211589
Journal: Therapeutic Advances in Musculoskeletal Disease
Year: 2021
Reference: Ther Adv Musculoskelet Dis. 2021 Jun 18;13:1759720X211020917. doi: 10.1177/1759720X211020917. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Valdivielso, Jose L; Alvarez-Rivas, Noelia; Atienza-Mateo, Belen; Bernabeu, Pilar; Blanco, Ricardo; Bravo, Beatriz; Callejas Rubio, Jose L; Castaneda, Santos; de Miguel, Eugenio; Delgado Sanchez, Monica et al.
DOI: 10.1177/1759720X211020917

Statin use and myopathy. Not always guilty.

PMID: 32500148
Journal: RHEUMATOLOGY
Year: 2020
Reference: Rheumatology (Oxford). 2020 Dec 1;59(12):3853-3857. doi: 10.1093/rheumatology/keaa180.
Impact factor:
Publication type: Paper in international publication
Authors: Antoniol, Maria N; Grau, Josep M; Milisenda, Jose C; Moreno, Pedro J; Padrosa, Joan; Selva O'Callaghan, Albert et al.
DOI: 10.1093/rheumatology/keaa180

Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry.

PMID: 31580459
Journal: RHEUMATOLOGY
Year: 2020
Reference: Rheumatology (Oxford). 2020 Jun 1;59(6):1306-1314. doi: 10.1093/rheumatology/kez419.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Arnau, Anna; Belizna, Cristina; Canti, Valentina; Carolis, Sara De; Cervera, Ricard; Chighizola, Cecilia Beatrice; Espinosa, Gerard; Esteve-Valverde, Enrique; Farran-Codina, Inmaculada et al.
DOI: 10.1093/rheumatology/kez419

Critical clinical situations in adult patients with Mucopolysaccharidoses (MPS).

PMID: 32410642
Journal: Orphanet Journal of Rare Diseases
Year: 2020
Reference: Orphanet J Rare Dis. 2020 May 14;15(1):114. doi: 10.1186/s13023-020-01382-z.
Impact factor:
Publication type: Paper in international publication
Authors: Del Toro Riera, Mireia; Gevorkyan, Anait K; Hendriksz, Christian J; Lampe, Christina; Lobzhanidze, Tinatin V; Perez-Lopez, Jordi; Stepien, Karolina M; Tol, Govind; Vashakmadze, Nato D et al.
DOI: 10.1186/s13023-020-01382-z

Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review.

PMID: 32376394
Journal: AUTOIMMUNITY REVIEWS
Year: 2020
Reference: Autoimmun Rev. 2020 Jul;19(7):102569. doi: 10.1016/j.autrev.2020.102569. Epub 2020 May 3.
Impact factor:
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume; Anunciacion-Lunell, Ariadna; Belizna, Cristina; Esteve-Valverde, Enrique; Mekinian, Arsene; Miro-Mur, Francesc; Pardos-Gea, Josep; Quintana, Angela; Selva-O'Callaghan, Albert et al.
DOI: 10.1016/j.autrev.2020.102569

Recommendations for the detection, diagnosis and follow-up of patients with non-alcoholic fatty liver disease in primary and hospital care.

PMID: 31178295
Journal: MEDICINA CLINICA
Year: 2019
Reference: Med Clin (Barc). 2019 Aug 16;153(4):169-177. doi: 10.1016/j.medcli.2019.01.030. Epub 2019 Jun 6.
Impact factor:
Publication type: Paper in national publication
Authors: Augustin, Salvador; Broquetas, Teresa; Caballeria, Llorenc; Carrion, Jose Antonio; Fernandez-Real, Jose Manuel; Gines, Pere; Goday, Antonio; Graupera, Isabel; Hernandez, Maria Rosa; Morillas, Rosa Maria et al.
DOI: 10.1016/j.medcli.2019.01.030

Biologics and anaphylaxis.

PMID: 31169597
Journal: Current Opinion in Allergy and Clinical Immunology
Year: 2019
Reference: Curr Opin Allergy Clin Immunol. 2019 Oct;19(5):439-446. doi: 10.1097/ACI.0000000000000550.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, Victoria; Luengo, Olga; Sala-Cunill, Anna et al.
DOI: 10.1097/ACI.0000000000000550

Acquired von Willebrand syndrome in a patient with small lymphocytic lymphoma and Sjogren's syndrome: which associated condition should be prioritized?

PMID: 31157683
Journal: BLOOD COAGULATION & FIBRINOLYSIS
Year: 2019
Reference: Blood Coagul Fibrinolysis. 2019 Jul;30(5):239-242. doi: 10.1097/MBC.0000000000000814.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Bosch, Francesc; Martinez, Fernanda; Pardos-Gea, Jose; Santamaria, Amparo et al.
DOI: 10.1097/MBC.0000000000000814

Adherence to reporting guidelines increases the number of citations: the argument for including a methodologist in the editorial process and peer-review.

PMID: 31151417
Journal: BMC Medical Research Methodology
Year: 2019
Reference: BMC Med Res Methodol. 2019 May 31;19(1):112. doi: 10.1186/s12874-019-0746-4.
Impact factor:
Publication type: Paper in international publication
Authors: Altman, Douglas; Basagana, Xavier; Cardellach, Francesc; Cobo, Erik; Cortes, Jordi; Elmore, Matthew; Gonzalez, Jose-Antonio; Ribera, Josep-Maria; Selva-O'Callaghan, Albert; Urrutia, Agustin et al.
DOI: 10.1186/s12874-019-0746-4

A risk score to predict the absence of left ventricular reverse remodeling: Implications for the timing of ICD implantation in primary prevention.

PMID: 29183646
Journal: Journal of Cardiology
Year: 2018
Reference: J Cardiol. 2018 May;71(5):505-512. doi: 10.1016/j.jjcc.2017.10.019. Epub 2017 Nov 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alzola-Guevara, Mila; Cruz-Carlos, Luz Maria; Domingo-Baldrich, Eva; Evangelista-Masip, Artur; Ferreira-Gonzalez, Ignacio; Francisco-Pascual, Jaume; Galve, Enrique; Garcia-Dorado, David; Gutierrez Garcia-Moreno, Laura; Marsal, Josep Ramon et al.
DOI: 10.1016/j.jjcc.2017.10.019

Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes.

PMID: 29572561
Journal: ANNALS OF HEMATOLOGY
Year: 2018
Reference: Ann Hematol. 2018 Aug;97(8):1349-1356. doi: 10.1007/s00277-018-3302-0. Epub 2018 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bobillo, Sabela; Bosch, Francesc; Castellvi, Josep; Gallur, Laura; Martinez-Valle, Ferran; Merchan, Brayan; Molero, Antonieta; Montoro, Julia; Navarrete, Mayda; Navarrete, Mayda et al.
DOI: 10.1007/s00277-018-3302-0

Blau Syndrome - Associated Uveitis: Preliminary Results from an International Prospective Interventional Case Series.

PMID: 28887115
Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY
Year: 2018
Reference: Am J Ophthalmol. 2018 Mar;187:158-166. doi: 10.1016/j.ajo.2017.08.017. Epub 2017 Sep 6.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Jordi; Arostegui, Juan I; Bader-Meunier, Brigitte; Bertin, John; Brissaud, Philippe; Casteels, Ingele; Chedeville, Gaelle; Cimaz, Rolando; Dick, Andrew D; Espada, Graciella et al.
DOI: 10.1016/j.ajo.2017.08.017

Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations.

PMID: 29473763
Journal: Expert Review of Clinical Immunology
Year: 2018
Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado-Cardenas, Marcelo; Grau-Junyent, Josep Maria; Juarez, Candido; Labrador-Horrillo, Moises; Marin, Ana; Martinez, Maria Angeles; Milisenda, Jose Cesar; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1080/1744666X.2018.1440206

Component-Resolved Diagnosis of Dog Allergy.

PMID: 28570224
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2017
Reference: J Investig Allergol Clin Immunol. 2017 Jun;27(3):185-187. doi: 10.18176/jiaci.0150.
Impact factor:
Publication type: Paper in international publication
Authors: Basagana, M; Cardona, V; Garriga, T; Labrador, M; Lidholm, J; Luengo, O; Mattsson, L et al.
DOI: 10.18176/jiaci.0150

Very Early and Early Systemic Sclerosis in the Spanish Scleroderma Registry (RESCLE) Cohort.

PMID: 28564618
Journal: AUTOIMMUNITY REVIEWS
Year: 2017
Reference: Autoimmun Rev. 2017 Aug;16(8):796-802. doi: 10.1016/j.autrev.2017.05.013. Epub 2017 May 28.
Impact factor:
Publication type: Review in national publication
Authors: Arandia, Nerea Iniesta; Arberas, Maria Victoria Egurbide; Arguelles, Dolores Colunga; Aznar, Carmen Pilar Simeon; Ballve, Adela Marin; Blanco, Juan Jose Rios; Carballeira, Monica Rodriguez; Comet, Luis Saez; Del Castillo, Alfredo Guillen; Fernandez, Antonio Javier Chamorro et al.
DOI: 10.1016/j.autrev.2017.05.013

In-flight allergic emergencies.

PMID: 28496564
Journal: The World Allergy Organization journal
Year: 2017
Reference: World Allergy Organ J. 2017 May 4;10(1):15. doi: 10.1186/s40413-017-0148-1. eCollection 2017.
Impact factor:
Publication type: Review in national publication
Authors: Ansotegui, Ignacio J; Cardona, Victoria; Ebisawa, Motohiro; El-Gamal, Yehia; Fineman, Stanley; Geller, Mario; Gonzalez-Estrada, Alexei; Greenberger, Paul A; Lockey, Richard F; Sanchez-Borges, Mario et al.
DOI: 10.1186/s40413-017-0148-1

Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project.

PMID: 28476652
Journal: Journal of Clinical Lipidology
Year: 2017
Reference: J Clin Lipidol. 2017 May - Jun;11(3):749-756.e3. doi: 10.1016/j.jacl.2017.02.018. Epub 2017 Mar 16.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Lydia; Alen, Jaime Calvo; Almagro, Raul Menor; Alonso, Elena Riera; Alvarez, Beatriz Gonzalez; Alvarez, Juana Sampedro; Amirall, Miriam; Aramburu, Jose M; Arias, Miriam Garcia; Audera, Chesus Beltran et al.
DOI: 10.1016/j.jacl.2017.02.018

Genetic Analysis with the Immunochip Platform in Behcet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.

PMID: 27548383
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Aug 22;11(8):e0161305. doi: 10.1371/journal.pone.0161305. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Sancho, Juan-Jose; Barnosi-Marin, Ana-Celia; Blanco, Ricardo; Camps, Teresa; Carmona, Francisco-David; Castaneda, Santos; Castillo, Maria Jesus; Conde-Jaldon, Marta; Espinosa, Gerard; Fanlo, Patricia et al.
DOI: 10.1371/journal.pone.0161305

Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort.

PMID: 27401589
Journal: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Year: 2016
Reference: Am J Reprod Immunol. 2016 Aug;76(2):164-71. doi: 10.1111/aji.12534.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Bertero, Maria Tiziana; Bremme, Katharina; Canti, Valentina; Cervera, Ricard; Coloma, Emmanuel; de Carolis, Sara; Del Ross, Teresa; Espinosa, Gerard; Esteve-Valverde, Enrique et al.
DOI: 10.1111/aji.12534

Angiogenic Gene Expression in Down Syndrome Fetal Hearts.

PMID: 26513650
Journal: FETAL DIAGNOSIS AND THERAPY
Year: 2016
Reference: Fetal Diagn Ther. 2016;40(1):21-7. doi: 10.1159/000441356. Epub 2015 Oct 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas, Jaume; Cabero, Lluis; Carreras, Elena; Dominguez, Carmen; Llurba, Elisa; Ribera, Irene; Ruiz, Aina; Sanchez, Olga et al.
DOI: 10.1159/000441356

Management of Pregnancy and Delivery in Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency.

PMID: 27326983
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2016
Reference: J Investig Allergol Clin Immunol. 2016 Jun;26(3):161-7. doi: 10.18176/jiaci.0037.
Impact factor:
Publication type: Paper in international publication
Authors: Baeza, M L; Caballero, T; Cimbollek, S; Gonzalez-Quevedo, T; Guilarte, M; Larco, J I; Lopez-Serrano, M C; Marcos, C; Pinero-Saavedra, M; Rubio, M et al.
DOI: 10.18176/jiaci.0037

Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.

PMID: 25240785
Journal: J ALLERGY CLIN IMMUN
Year: 2015
Reference: J Allergy Clin Immunol. 2015 Apr;135(4):1031-43.e6. doi: 10.1016/j.jaci.2014.07.057. Epub 2014 Sep 18.
Impact factor:
Publication type: Paper in international publication
Authors: Bjorkqvist, Jenny; Butler, Lynn; Cardona, Victoria; Cumin, Frederic; Di Gennaro, Antonio; Flohr, Stefanie; Fuchs, Tobias; Guilarte, Mar; Hassiepen, Ulrich; Jamsa, Anne et al.
DOI: 10.1016/j.jaci.2014.07.057

The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: Data from a European multicenter retrospective study.

PMID: 25617818
Journal: AUTOIMMUN REV
Year: 2015
Reference: Autoimmun Rev. 2015 Jun;14(6):498-502. doi: 10.1016/j.autrev.2015.01.012. Epub 2015 Jan 21.
Impact factor:
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume; Andreoli, Laura; Benbara, Amelie; Bertero, Tiziana; Bezanahary, Holy; Bremme, Katarina; Canti, Valentina; Carbillon, Lionel; Dhote, Robin; Fain, Olivier et al.
DOI: 10.1016/j.autrev.2015.01.012

The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases.

PMID: 25555817
Journal: AUTOIMMUN REV
Year: 2015
Reference: Autoimmun Rev. 2015 May;14(5):387-95. doi: 10.1016/j.autrev.2014.12.010. Epub 2014 Dec 31.
Impact factor:
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume; Bertero, Ma Tiziana; Canti, Valentina; Cervera, Ricard; Coloma-Bazan, Emmanuel; de Carolis, Sara; del Ross, Teresa; Espinosa, Gerard; Farran-Codina, Inmaculada; Ferrer-Oliveras, Raquel et al.
DOI: 10.1016/j.autrev.2014.12.010

Human adjuvant-related syndrome or autoimmune/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria.

PMID: 25813870
Journal: LUPUS
Year: 2015
Reference: Lupus. 2015 Sep;24(10):1012-8. doi: 10.1177/0961203315579092. Epub 2015 Mar 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, J et al.
DOI: 10.1177/0961203315579092

Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children.

PMID: 23463692
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2014
Reference: Ann Rheum Dis. 2014 Apr;73(4):662-7. doi: 10.1136/annrheumdis-2012-202708. Epub 2013 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Acikel, C; Al-Mayouf, Sulaiman M; Amaryan, Gayane; Cantarini, Luca; Demirkaya, Erkan; Fabio, Giovanna; Finetti, Martina; Frenkel, Joost; Gallizzi, Romina; Gattorno, Marco et al.
DOI: 10.1136/annrheumdis-2012-202708

Early- versus Late-Onset Systemic Sclerosis: Differences in Clinical Presentation and Outcome in 1037 Patients.

PMID: 24646463
Journal: MEDICINE
Year: 2014
Reference: Medicine (Baltimore). 2014 Mar;93(2):73-81. doi: 10.1097/MD.0000000000000018.
Impact factor:
Publication type: Paper in national publication
Authors: Alba, Marco A; Callejas, Jose Luis; Camps, Maria Teresa; Castillo, Maria Jesus; Egurbide, Maria Victoria; Espinosa, Gerard; Fonollosa, Vicent; Freire, Mayka; Rios, Juan Jose; Saez, Luis et al.
DOI: 10.1097/MD.0000000000000018

A MELD-based model to determine risk of mortality among patients with acute variceal bleeding.

PMID: 24148622
Journal: GASTROENTEROLOGY
Year: 2014
Reference: Gastroenterology. 2014 Feb;146(2):412-19.e3. doi: 10.1053/j.gastro.2013.10.018. Epub 2013 Oct 19.
Impact factor:
Publication type: Clinical Trials
Authors: Abraldes, Juan G; Augustin, Salvador; Bastiampillai, Ravin; Berzigotti, Annalisa; Bosch, Jaume; Casu, Stefania; Garcia-Pagan, Joan Carles; Genesca, Joan; Gonzalez, Antonio; Keough, Adam et al.
DOI: 10.1053/j.gastro.2013.10.018

[Anti-tumoral necrosis factor-alpha medications and pregnancy.]

PMID: 24529880
Journal: MEDICINA CLINICA
Year: 2014
Reference: Med Clin (Barc). 2014 Sep 9;143(5):236. doi: 10.1016/j.medcli.2013.10.028. Epub 2014 Feb 14.
Impact factor:
Publication type: Letter whit IF
Authors: Alegre, Cayetano; Juverdeanu, Roxana-Georgiana et al.
DOI: 10.1016/j.medcli.2013.10.028

Histiocytoid Sweet syndrome and cutaneous polyarteritis nodosa secondary to myelodysplastic syndrome.

PMID: 24382288
Journal: International Journal of Rheumatic Diseases
Year: 2013
Reference: Int J Rheum Dis. 2013 Dec;16(6):777-9. doi: 10.1111/1756-185X.12103. Epub 2013 Jun 3.
Impact factor: 1.65
Publication type: Letter or abstract
Authors: Pinal-Fernandez, Iago, Ferrer Fabrega, Berta, Ramentol Sintas, Marc, Solans Laque, Roser et al.
DOI: 10.1111/1756-185X.12103

Evidence of association of the NLRP1 gene with giant cell arteritis.

PMID: 23253924
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 Apr;72(4):628-30. doi: 10.1136/annrheumdis-2012-202609. Epub 2012 Dec 19.
Impact factor: 9.111
Publication type: Letter or abstract
Authors: Serrano, Aurora, Carmona, F David, Castaneda, Santos, Solans, Roser, Hernandez-Rodriguez, Jose, Cid, Maria C, Prieto-Gonzalez, Sergio, Miranda-Filloy, Jose A, Rodriguez-Rodriguez, Luis, Morado, Inmaculada C et al.
DOI: 10.1136/annrheumdis-2012-202609

Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis.

PMID: 23946333
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 Nov;72(11):1882-6. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.
Impact factor: 9.111
Publication type: Paper in international publication
Authors: Braun, N, Latus, J, Molberg, O, Lie, B A, Moosig, F, Witte, T, Morgan, A W, Gonzalez-Gay, M A, Martin, J, Raya, E et al.
DOI: 10.1136/annrheumdis-2013-203641

HLA and non-HLA genes in Behcet's disease: a multicentric study in the Spanish population.

PMID: 24286189
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2013
Reference: Arthritis Res Ther. 2013 Oct 4;15(5):R145. doi: 10.1186/ar4328.
Impact factor: 4.302
Publication type: Paper in international publication
Authors: Camps, Teresa, Montes-Cano, Marco Antonio, Conde-Jaldon, Marta, Garcia-Lozano, Jose Raul, Ortiz-Fernandez, Lourdes, Ortego-Centeno, Norberto, Castillo-Palma, Maria Jesus, Espinosa, Gerard, Grana-Gil, Genaro, Gonzalez-Gay, Miguel Angel et al.
DOI: 10.1186/ar4328

Bias in effect size of Systemic Lupus Erythematosus susceptibility loci across Europe: a case control study.

PMID: 22541939
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2012
Reference: Arthritis Res Ther. 2012 Apr 27;14(2):R94. doi: 10.1186/ar3818.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/ar3818

[Home intravenous antimicrobial therapy in multi-drug resistant microorganism infections.]

PMID: 21621228
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 May 12;138(13):557-61. Epub 2011 May 28.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.medcli.2011.03.028

[Tracheal stenosis in Wegener's granulomatosis.]

PMID: 21349559
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 May 12;138(13):596. Epub 2011 Feb 23.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; et al.
DOI: 10.1016/j.medcli.2010.09.047

Current Considerations for the Treatment of Severe Chronic Pain: The Potential for Tapentadol.

PMID: 21797962
Journal: Pain Practice
Year: 2012
Reference: Pain Pract. 2012 Apr;12(4):290-306. doi: 10.1111/j.1533-2500.2011.00487.x. Epub 2011 Jul 29.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1533-2500.2011.00487.x

[Home intravenous antibiotic therapy of empyema and lung abscess: safety and efficacy.]

PMID: 21354662
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2011
Reference: Enferm Infecc Microbiol Clin. 2011 Mar;29(3):237-9. Epub 2011 Feb 26.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; José Pardos-Gea; Úrsula Maza et al.
DOI: 10.1016/j.eimc.2010.09.011

Circulating Cell-Derived Microparticles in Women with Pregnancy Loss.

PMID: 21276118
Journal: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Year: 2011
Reference: Am J Reprod Immunol. 2011 Sep;66(3):199-208. doi: 10.1111/j.1600-0897.2010.00972.x. Epub 2011 Jan 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1111/j.1600-0897.2010.00972.x

[Syndrome CINCA/NOMID].

PMID: 21596181
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Jan;136 Suppl 1:10-5. doi: 10.1016/S0025-7753(11)70003-3.
Impact factor: 1.413
Publication type: Paper in national publication
Authors: Modesto, Consuelo et al.
DOI: 10.1016/S0025-7753(11)70003-3

[A 47-year-old woman with progressive dyspnea, cutaneous oedema and muscular weakness].

PMID: 21367434
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Apr 23;136(11):495-500. doi: 10.1016/j.medcli.2010.10.023. Epub 2011 Mar 1.
Impact factor: 1.413
Publication type: Letter or abstract
Authors: Bujan, Segundo, Arguis, Pedro, Grau, Josep Maria et al.
DOI: 10.1016/j.medcli.2010.10.023

Echocardiography at diagnosis of antiphospholipid syndrome provides prognostic information on valvular disease evolution and identifies two subtypes of patients.

PMID: 20068017
Journal: LUPUS
Year: 2010
Reference: Lupus. 2010;19(5):575-82. Epub 2010 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1177/0961203309353772

Cancer-associated myositis and anti-p155 autoantibody in a series of 85 patients with idiopathic inflammatory myopathy.

PMID: 20075704
Journal: MEDICINE
Year: 2010
Reference: Medicine (Baltimore). 2010 Jan;89(1):47-52.
Impact factor:
Publication type: Paper in international publication
Authors: Labrador-Horrillo, Moises; Martinez, Maria Angeles; Martinez-Gomez, Xavier; Palou, Eduard; Rodriguez-Sanchez, Jose Luis; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI: 10.1097/MD.0b013e3181ca14ff

[Internet-based Continuing Medical Education. Presentation of the first experience of the Spanish Society of Internal Medicine].

PMID: 20633875
Journal: REVISTA CLINICA ESPANOLA
Year: 2010
Reference: Rev Clin Esp. 2010 Dec;210(11):567-72. doi: 10.1016/j.rce.2010.04.012. Epub 2010 Jul 14.
Impact factor: 0.584
Publication type: Paper in national publication
Authors: San Jose, A, Formiga, F, Lopez Soto, A, Ortiz, J, Tiberio, G, Ollero, M, Valero, J, Ballarin, M et al.
DOI: 10.1016/j.rce.2010.04.012

[Chronic fatigue syndrome: more than fatigue].

PMID: 21322184
Journal: Rev Enferm
Year: 2010
Reference: Rev Enferm. 2010 Dec;33(12):16-9.
Impact factor: 0
Publication type: Paper in national publication
Authors: Royes, Badia, Alvarez, Carballo, Lalinde, Sevillano, Vidal, Llinas, Martin, Alegre et al.
DOI:

Ultrasound validity in the measurement of knee cartilage thickness.

PMID: 18684742
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2009
Reference: Ann Rheum Dis. 2009 Aug;68(8):1322-7. Epub 2008 Aug 6.
Impact factor: 7.188
Publication type: Paper in international publication
Authors: Tuneu, R, Uson, J, Naredo, E, Canillas, F, de Agustin, J J, de Miguel, E, Filippucci, E, Iagnocco, A, Moragues, C, Acebes, C et al.
DOI: 10.1136/ard.2008.090738

Pleural fluid mesothelin for the differential diagnosis of exudative pleural effusions.

PMID: 19783262
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Oct 3;133(12):449-53. Epub 2009 Sep 24.
Impact factor: 1.258
Publication type: Paper in national publication
Authors: Ma Segura, Rosa, Alegre, Jose, Esquerda, Aureli, Ruiz, Eva, Bielsa, Silvia, de Sevilla, Tomas Fernandez, Manuel Porcel, Jose, Aleman, Carmen et al.
DOI: 10.1016/j.medcli.2008.11.047

Guidelines on the clinical usefulness of determination of specific immunoglobulin E to foods.

PMID: 20128415
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2009
Reference: J Investig Allergol Clin Immunol. 2009;19(6):423-32.
Impact factor: 1.254
Publication type: Paper in international publication
Authors: Garcia, B E, Gamboa, P M, Asturias, J A, Lopez-Hoyos, M, Sanz, M L, Caballero, M T, Garcia, J M, Labrador, M, Longo Areso, N, Martinez Quesada, J et al.
DOI:

Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients.

PMID: 19132976
Journal: ALLERGY
Year: 2009
Reference: Allergy. 2009 Jan;64(1):158-65.
Impact factor: 6.204
Publication type: Paper in international publication
Authors: Wessel, F, Belder, T de, Sys, L, Schmelzer, A A, van Vliet, J, Van-nieuwenhuyse, P, D'Hont, G, Jorissen, M B M, Gevers, G, Mandazhieva-Pepelanova, M A et al.
DOI: 10.1111/j.1398-9995.2008.01813.x

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