Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Research lines

Proinflammatory cytokines TNF and IL-6 in cellular senescence. A HUVEC aging model.

Cells that are chronically exposed to inflammatory signals are more prone to aging than those which are not exposed to such signals. Human vascular endothelial cell (HUVEC) primary cultures activated with TNF-alpha probably increase the expression of ICAM and VCAM, synthesize ROS, and express senescence markers. It is not known what the principal intracellular pathway is (although it is thought that STAT may play a role) and it is unknown if one or more proinflammatory cytokines are needed to activate NF-KB. We are trying to find out the role that IFN-alpha and/or IL-6 and IL-1B may have on the aging inflammatory phenomena and we aim at detecting the intracellular signal pathways (STAT). We are also working on the characterization of the genes involved in these abnormal biologic responses.

IP: Jaume Alijotas Reig

Protein expression of small collagenase 3 and leucine-rich proteoglycans in cutaneous tissue of patients with diffuse scleroderma.

This study, carried out along with researchers from the Hospital del Mar and from the "Institut Municipal d'Investigació Mèdica", aims at correlating the expression of SLRPs and MMP-13 with the severity of cutaneous involvement, hand dysfunctional capacity, capillaroscopy patterns, and cutaneous ultrasonography of patients affected with diffuse scleroderma in different evolutive stages of the disease.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

RECORD study (RECOmbinant allergens in diagnosis resolution).

This study aims at detecting the prevalence of specific IgE in polisensitized patients towards pollen in Barcelona by means of the "component resolved diagnosis" technique from ISAC® (IgE specific microarray).

IP: Victòria Cardona Dahl

Risk factors for ischemic events in biopsy-proven Giant Cell Arteritis (GCA).

The study aims to investigate the risk factors for ischemic complications in patients with GCA, and the role that some endothelial growth factors may play in its development. This study is coordinated by Dr. Gonzalez Gay from University Hospital of Valdecilla, Santander.

IP: Roser Solans Laque

Projects

Aquest any no hi ha projectes actius.

Publications

Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies.

PMID: 37130727
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2023
Reference: Ann Rheum Dis. 2023 May 2:ard-2023-223873. doi: 10.1136/ard-2023-223873.
Impact factor:
Publication type: Paper in international publication
Authors: Albayda, Jemima; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Dell'Orso, Stefania; Duque-Jaimez, Yaiza; Garcia-Garcia, Francesc J; Garrabou, Gloria; Grau-Junyent, Josep Maria; Guitart-Mampel, Mariona; Gutierrez-Cruz, Gustavo et al.
DOI: 10.1136/ard-2023-223873

Avapritinib versus Placebo in Indolent Systemic Mastocytosis.

PMID: 38320129
Journal:
Year: 2023
Reference: NEJM Evid. 2023 Jun;2(6):EVIDoa2200339. doi: 10.1056/EVIDoa2200339. Epub 2023 May 23.
Impact factor:
Publication type: Paper in international publication
Authors: Akin, Cem; Alvarez-Twose, Ivan; Arana Yi, Cecilia; Bandini, Perla; Barete, Stephane; Berrueco, Ruben; Bidollari, Ilda; Bonadonna, Patrizia; Borras, Nina; Bose, Prithviraj et al.
DOI: 10.1056/EVIDoa2200339

WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).

PMID: 36910595
Journal: World Allergy Organization Journal
Year: 2023
Reference: World Allergy Organ J. 2023 Mar 2;16(3):100753. doi: 10.1016/j.waojou.2023.100753. eCollection 2023 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Alvaro-Lozano, Montserrat; Ansotegui, Ignacio J; Arasi, Stefania; Asaria, Miqdad; Begin, Philippe; Boyle, Robert; Bozzola, Martin; Brough, Helen; Cardona, Victoria; Chinthrajah, R Sharon et al.
DOI: 10.1016/j.waojou.2023.100753

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection.

PMID: 37019909
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Apr 5;14(1):1887. doi: 10.1038/s41467-023-37559-w.
Impact factor:
Publication type: Paper in international publication
Authors: Buzon, Maria J; Esperalba, Juliana; Falco, Vicenc; Genesca, Meritxell; Kuguel, Sebastian G; Kuguel, Sebastian G; Mancebo, Cristina; Mancebo, Cristina; Pieren, Daan K J; Rey-Cano, Joan et al.
DOI: 10.1038/s41467-023-37559-w

Gastrointestinal Involvement in Dermatomyositis.

PMID: 35626355
Journal: Diagnostics
Year: 2022
Reference: Diagnostics (Basel). 2022 May 11;12(5). pii: diagnostics12051200. doi: 10.3390/diagnostics12051200.
Impact factor:
Publication type: Review in international publication
Authors: Cuatrecasas, Miriam; Espinosa, Gerard; Grau, Josep Maria; Matas-Garcia, Ana; Milisenda, Jose C; Prieto-Gonzalez, Sergio; Selva-O'Callaghan, Albert et al.
DOI: 10.3390/diagnostics12051200

Inflammatory immune-mediated adverse reactions induced by COVID-19 vaccines in previously injected patients with soft tissue fillers: a case-series of 20 patients.

PMID: 35621234
Journal: Journal of Cosmetic Dermatology
Year: 2022
Reference: J Cosmet Dermatol. 2022 Aug;21(8):3181-3187. doi: 10.1111/jocd.15117. Epub 2022 Jun 10.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Decates, Tom S; Garcia-GImenez, Victor; Niessen, Frank B; Velthuis, Peter J et al.
DOI: 10.1111/jocd.15117

Radiography-based triage for COVID-19 in the Emergency Department in a Spanish cohort of patients.

PMID: 34256936
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcli.2021.05.013. Epub 2021 Jun 16.
Impact factor:
Publication type: Paper in national publication
Authors: Arranz-Betegon, Maria; Canas-Ruano, Esperanza; Domingo-Baldrich, Eva; Fernandez-Codina, Andreu; Garcia-Vives, Eloi; Gil-Vila, Albert; Llaneras-Artigues, Jordi; Meza, Beatriz; Michelena, Xabier; Orozco-Galvez, Olimpia et al.
DOI: 10.1016/j.medcli.2021.05.013

Comparison of rhinitis treatments using MASK-air(R) data and considering the Minimal Important Difference.

PMID: 35567393
Journal: ALLERGY
Year: 2022
Reference: Allergy. 2022 Oct;77(10):3002-3014. doi: 10.1111/all.15371. Epub 2022 Jun 13.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, Ioana; Amaral, Rita; Ansotegui, Ignacio J; Anto, Josep M; Bedbrook, Anna; Bergmann, Karl C; Bosnic-Anticevich, Sinthia; Bousquet, Jean; Brozek, Jan; Brussino, Luisa et al.
DOI: 10.1111/all.15371

Naive hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study.

PMID: 34497439
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Aug 14;27(30):5112-5125. doi: 10.3748/wjg.v27.i30.5112.
Impact factor:
Publication type: Paper in international publication
Authors: Bronte, Fabrizio; Buti, Maria; Craxi, Antonio; Esteban, Rafael; Marcos-Fosch, Cristina; Martinez-Valle, Fernando; Orozco, Olimpia; Petta, Salvatore; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.3748/wjg.v27.i30.5112

Differential diagnosis of necrotizing myopathy.

PMID: 34482348
Journal: CURRENT OPINION IN RHEUMATOLOGY
Year: 2021
Reference: Curr Opin Rheumatol. 2021 Nov 1;33(6):544-553. doi: 10.1097/BOR.0000000000000836.
Impact factor:
Publication type: Review in international publication
Authors: Grau-Junyent, Josep M; Milisenda, Jose C; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1097/BOR.0000000000000836

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

PMID: 34444817
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082658. doi: 10.3390/nu13082658.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Martin, Jose; Castro-Marrero, Jesus; Lacasa, Marcos; Martinez-Martinez, Alba; Segundo, Maria Jose; Sentanes, Ramon Sanmartin et al.
DOI: 10.3390/nu13082658

Bleeding and antithrombotic therapy during pregnancy in women with poor aPL-related obstetric outcomes: A survey of 1075 cases from EUROAPS registry *.

PMID: 34397526
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2021
Reference: Eur J Anaesthesiol. 2021 Sep 1;38(9):916-922. doi: 10.1097/EJA.0000000000001484.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Arnau, Anna; Belizna, Cristina; Canti, Valentina; Chighizola, Cecilia; De Carolis, Sara; Espinosa, Gerard; Esteve-Valverde, Enrique; Ferrer-Oliveras, Raquel; Latino, Omar et al.
DOI: 10.1097/EJA.0000000000001484

Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 32740086
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: Am J Gastroenterol. 2020 Dec;115(12):2047-2059. doi: 10.14309/ajg.0000000000000789.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Antolin, Maria; Azpiroz, Fernando; de Torres, Ines; Fortea, Marina; Gonzalez-Castro, Ana; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pardo-Camacho, Cristina et al.
DOI: 10.14309/ajg.0000000000000789

Antihistamine-resistant chronic spontaneous urticaria remains undertreated: 2-year data from the AWARE study.

PMID: 32735720
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2020
Reference: Clin Exp Allergy. 2020 Oct;50(10):1166-1175. doi: 10.1111/cea.13716. Epub 2020 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Chapman-Rothe, N; Costa, C; Gimenez Arnau, A; Guillet, G; Labrador-Horrillo, M; Lapeere, H; Maurer, M; Meshkova, R; Savic, S et al.
DOI: 10.1111/cea.13716

Analysis of the correlation between disease activity score 28 and its ultrasonographic equivalent in rheumatoid arthritis patients.

PMID: 32716834
Journal: European journal of rheumatology
Year: 2020
Reference: Eur J Rheumatol. 2020 Jul 21. pii: eurjrheum.2020.20038. doi: 10.5152/eurjrheum.2020.20038.
Impact factor:
Publication type: Paper in international publication
Authors: Badia, Salvador Campos; Bru, Mireia Barcelo; Coras, Roxana; de Agustin de Oro, Juan Jose; Diez, Basilio Rodriguez; Farietta, Sandra; Fernandez, Agusti Sellas; Sturchio, Gustavo Anez et al.
DOI: 10.5152/eurjrheum.2020.20038

Efficacy of Thalidomide in Discoid Lupus Erythematosus: Insights into the Molecular Mechanisms.

PMID: 32659758
Journal: DERMATOLOGY
Year: 2020
Reference: Dermatology. 2020;236(5):467-476. doi: 10.1159/000508672. Epub 2020 Jul 13.
Impact factor:
Publication type: Review in international publication
Authors: Cortes-Hernandez, Josefina; Domingo, Sandra; Ferrer, Berta; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina et al.
DOI: 10.1159/000508672

Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients.

PMID: 31464664
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2019
Reference: Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):97-106. Epub 2019 Aug 28.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Armagan, Berkan; Atzeni, Fabiola; Baldini, Chiara; Bartoloni, Elena; Bombardieri, Stefano; Brito-Zeron, Pilar; Consani-Fernandez, Sandra; Danda, Debashish; Devauchelle-Pensec, Valerie et al.
DOI:

[Clinical Practice Guide for Anaphylaxis in Latin America (Galaxia-Latam)].

PMID: 31443138
Journal: Revista Alergia Mexico
Year: 2019
Reference: Rev Alerg Mex. 2019;66 Suppl 2:1-39. doi: 10.29262/ram.v66i6.588.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Perea, Alberto; Ansotegui-Zubeldia, Ignacio Javier; Arias-Cruz, Alfredo; Cabanes-Higuero, Nieves; Cardona, Victoria; Chivato, Tomas; De la Hoz, Belen; Fernandez-Rivas, Montserrat; Gangoiti, Iker; Gonzalez-Diaz, Sandra Nora et al.
DOI: 10.29262/ram.v66i6.588

Identification of distinctive interferon gene signatures in different types of myositis.

PMID: 31434690
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Sep 17;93(12):e1193-e1204. doi: 10.1212/WNL.0000000000008128. Epub 2019 Aug 21.
Impact factor:
Publication type: Paper in international publication
Authors: Albayda, Jemima; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Corse, Andrea M; Derfoul, Assia; Grau-Junyent, Josep M; Lloyd, Thomas E; Mammen, Andrew L; Milisenda, Jose C; Miller, Frederick W et al.
DOI: 10.1212/WNL.0000000000008128

Mobile technology in allergic rhinitis: evolution in management or revolution in health and care?

PMID: 31445223
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2019
Reference: J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2511-2523. doi: 10.1016/j.jaip.2019.07.044. Epub 2019 Aug 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ansotegui, Ignacio J; Anto, Josep M; Arnavielhe, Sylvie; Bachert, Claus; Basagana, Xavier; Bedard, Annabelle; Bedbrook, Anna; Bonini, Matteo; Bosnic-Anticevich, Sinthia; Bousquet, Jean et al.
DOI: 10.1016/j.jaip.2019.07.044

The diagnostic work-up of cancer-associated myositis.

PMID: 29965856
Journal: CURRENT OPINION IN RHEUMATOLOGY
Year: 2018
Reference: Curr Opin Rheumatol. 2018 Nov;30(6):630-636. doi: 10.1097/BOR.0000000000000535.
Impact factor:
Publication type: Paper in international publication
Authors: Martinez-Gomez, Xavier; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1097/BOR.0000000000000535

Update in ethiopathogeny, diagnosis and treatment of the IgG4 related disease.

PMID: 29241876
Journal: MEDICINA CLINICA
Year: 2018
Reference: Med Clin (Barc). 2018 Jul 13;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034. Epub 2017 Dec 11.
Impact factor:
Publication type: Review in national publication
Authors: Fernandez-Codina, Andreu; Martinez-Valle, Fernando; Orozco-Galvez, Olimpia et al.
DOI: 10.1016/j.medcli.2017.10.034

Correction to: First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study.

PMID: 29931516
Journal: CLINICAL RHEUMATOLOGY
Year: 2018
Reference: Clin Rheumatol. 2018 Aug;37(8):2303-2304. doi: 10.1007/s10067-018-4179-y.
Impact factor:
Publication type: Letter or abstract
Authors: Callejas Moraga, E; Calvo, E; Carbonell, C; Castillo, Alfredo Guillen-Del; Castillo, M J; Castillo-Palma, Maria Jesus; Chamorro, A J; Colunga, D; Colunga-Arguelles, Dolores; Corbella, X et al.
DOI: 10.1007/s10067-018-4179-y

Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities?

PMID: 29885541
Journal: AUTOIMMUNITY REVIEWS
Year: 2018
Reference: Autoimmun Rev. 2018 Aug;17(8):739-745. doi: 10.1016/j.autrev.2018.01.027. Epub 2018 Jun 6.
Impact factor:
Publication type: Review in international publication
Authors: Arnaud, Laurent; Belizna, Cristina; Chretien, Jean Marie; Damian, Laura; Devreese, Katrien; Fassot, Celine; Godon, Alban; Hasan, Milena; Henrion, Daniel; Loufrani, Laurent et al.
DOI: 10.1016/j.autrev.2018.01.027

Applying prevention concepts to anaphylaxis: A call for worldwide availability of adrenaline auto-injectors.

PMID: 28856836
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2017
Reference: Clin Exp Allergy. 2017 Sep;47(9):1108-1114. doi: 10.1111/cea.12973.
Impact factor:
Publication type: Editorail in international publication
Authors: Calderon, M A; Cardona, V; Casale, T; Demoly, P; Moon, H-B; Muraro, A; Sanchez-Borges, M; Simons, F E R; Sisul, J C; Tanno, L K et al.
DOI: 10.1111/cea.12973

Mutational profile of rare variants in inflammasome-related genes in Behcet disease: A Next Generation Sequencing approach.

PMID: 28814775
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Aug 16;7(1):8453. doi: 10.1038/s41598-017-09164-7.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Sancho, Juan-Jose; Barnosi-Marin, Ana-Celia; Blanco, Ricardo; Burillo-Sanz, Sergio; Camps, Teresa; Castaneda, Santos; Espinosa, Gerard; Fanlo, Patricia; Garcia-Hernandez, Francisco-Jose; Garcia-Lozano, Jose-Raul et al.
DOI: 10.1038/s41598-017-09164-7

The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis.

PMID: 28798744
Journal: Frontiers in Immunology
Year: 2017
Reference: Front Immunol. 2017 Jul 26;8:846. doi: 10.3389/fimmu.2017.00846. eCollection 2017.
Impact factor:
Publication type: Review in international publication
Authors: Cardona, Victoria; Guilarte, Mar; Labrador-Horrillo, Moises; Luengo, Olga; Sala-Cunill, Anna et al.
DOI: 10.3389/fimmu.2017.00846

Safety of Adrenaline Use in Anaphylaxis: A Multicentre Register.

PMID: 28793302
Journal: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Year: 2017
Reference: Int Arch Allergy Immunol. 2017;173(3):171-177. doi: 10.1159/000477566. Epub 2017 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alcoceba-Borras, Eva; Cardona, Victoria; Delavalle, Maria Belen; Ferre-Ybarz, Laia; Garriga-Baraut, Teresa; Gomez-Galan, Catalina; Guilarte, Mar; Moreno-Perez, Nuria et al.
DOI: 10.1159/000477566

Fast 1.5 T chest MRI for the assessment of interstitial lung disease extent secondary to systemic sclerosis.

PMID: 27107755
Journal: CLINICAL RHEUMATOLOGY
Year: 2016
Reference: Clin Rheumatol. 2016 Sep;35(9):2339-45. doi: 10.1007/s10067-016-3267-0. Epub 2016 Apr 23.
Impact factor:
Publication type: Paper in international publication
Authors: Fonollosa-Pla, Vicente; Pallisa-Nunez, Esther; Pinal-Fernandez, Iago; Pineda-Sanchez, Victor; Selva-O'Callaghan, Albert; Simeon-Aznar, Carmen Pilar; Vilardell-Tarres, Miquel et al.
DOI: 10.1007/s10067-016-3267-0

Cognitive and hedonic responses to meal ingestion correlate with changes in circulating metabolites.

PMID: 27271780
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2016
Reference: Neurogastroenterol Motil. 2016 Dec;28(12):1806-1814. doi: 10.1111/nmo.12879. Epub 2016 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, A; Alonso-Cotoner, C; Azpiroz, F; Barba, I; Campos, E; Gonzalez, A; Malagelada, C; Malagelada, J-R; Mendez, S; Molne, L et al.
DOI: 10.1111/nmo.12879

Defining disease activity states and clinically meaningful improvement in primary Sjogren's syndrome with EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI).

PMID: 25480887
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Feb;75(2):382-9. doi: 10.1136/annrheumdis-2014-206008. Epub 2014 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Baron, Gabriel; Bartoloni, Elena; Bartoloni, Elena; Bombardieri, Stefano; Bombardieri, Stefano; Bootsma, Hendrika; Bootsma, Hendrika; Bowman, Simon J; Bowman, Simon J; Brito-Zeron, Pilar et al.
DOI: 10.1136/annrheumdis-2014-206008

Polypharmacy in elderly people with diabetes admitted to hospital.

PMID: 26607825
Journal: ACTA DIABETOLOGICA
Year: 2016
Reference: Acta Diabetol. 2016 Oct;53(5):857-8. doi: 10.1007/s00592-015-0818-9. Epub 2015 Nov 25.
Impact factor:
Publication type: Letter or abstract
Authors: Agusti, Antonia; Formiga, Francesc; Jose, Antonio San et al.
DOI: 10.1007/s00592-015-0818-9

Central nervous system involvement of granulomatosis with polyangiitis: clinical-radiological presentation distinguishes different outcomes.

PMID: 25187644
Journal: RHEUMATOLOGY
Year: 2015
Reference: Rheumatology (Oxford). 2015 Mar;54(3):424-32. doi: 10.1093/rheumatology/keu336. Epub 2014 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Charles, Pierre; Cohen, Pascal; Costedoat-Chalumeau, Nathalie; De Luna, Gonzalo; Godmer, Pascal; Guillevin, Loic; Kaminsky, Pierre; Le Quellec, Alain; Maurier, Francois; Mouthon, Luc et al.
DOI: 10.1093/rheumatology/keu336

Delayed diagnosis of late-onset Pompe disease in patients with myopathies of unknown origin and/or hyperCKemia.

PMID: 25752415
Journal: MOL GENET METAB
Year: 2015
Reference: Mol Genet Metab. 2015 Apr;114(4):580-3. doi: 10.1016/j.ymgme.2015.02.004. Epub 2015 Feb 21.
Impact factor:
Publication type: Paper in international publication
Authors: Coll, M Josep; Gallego-Galindo, Luis; Garcia-Morillo, Salvador; Grau-Junyent, Josep M; Perez-Lopez, Jordi; Selva-O'Callaghan, Albert; Torralba-Cabeza, Miguel A; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.ymgme.2015.02.004

IgG4-Related Disease: Results From a Multicenter Spanish Registry.

PMID: 26266361
Journal: MEDICINE
Year: 2015
Reference: Medicine (Baltimore). 2015 Aug;94(32):e1275. doi: 10.1097/MD.0000000000001275.
Impact factor:
Publication type: Paper in international publication
Authors: Barragan-Gonzalez, Maria Jesus; Brito-Zeron, Pilar; Casanovas-Martinez, Arnau; Cid, Maria Cinta; Cruces-Moreno, Maria Teresa; DeTorres, Ines; Fernandez-Codina, Andreu; Fonseca-Aizpuru, Eva; Fraile-Rodriguez, Guadalupe; Gil, Judith et al.
DOI: 10.1097/MD.0000000000001275

Evaluation of Cytokine Profile and HLA Association in Benznidazole Related Cutaneous Reactions in Patients With Chagas Disease.

PMID: 26265500
Journal: CLIN INFECT DIS
Year: 2015
Reference: Clin Infect Dis. 2015 Dec 1;61(11):1688-94. doi: 10.1093/cid/civ690. Epub 2015 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Aparicio, Gloria; Artaza, M Angeles; Ferrer, Berta; Garcia-Prat, Marina; Martinez-Gallo, Monica; Molina, Israel; Sala-Cunill, Anna; Salvador, Fernando; Sanchez-Montalva, Adrian; Sao Aviles, Augusto et al.
DOI: 10.1093/cid/civ690

Correlation of ultrasound B-lines with high-resolution computed tomography in antisynthetase syndrome.

PMID: 24773767
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2014
Reference: Clin Exp Rheumatol. 2014 May-Jun;32(3):404-7. Epub 2014 Apr 28.
Impact factor:
Publication type: Clinical Trials
Authors: Castella-Fierro, E; Martinez-Gomez, X; Pallisa Nunez, E; Pinal Fernandez, I; Selva-O'Callaghan, A; Vilardell-Tarres, Miquel et al.
DOI:

Identification of a novel myositis-associated antibody directed against cortactin.

PMID: 25182205
Journal: AUTOIMMUNITY REVIEWS
Year: 2014
Reference: Autoimmun Rev. 2014 Oct;13(10):1008-12. doi: 10.1016/j.autrev.2014.08.038. Epub 2014 Aug 27.
Impact factor:
Publication type: Paper in international publication
Authors: Grau-Junyent, Josep M; Juarez, Candido; Labrador-Horrillo, Moises; Martinez, Maria Angeles; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.autrev.2014.08.038

Increased myo-inositol in parietal white and gray matter as a biomarker of poor prognosis in neuropsychiatric lupus: a case report.

PMID: 25118052
Journal: LUPUS
Year: 2014
Reference: Lupus. 2014 Sep;23(10):1073-8. doi: 10.1177/0961203314534303. Epub 2014 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, J; Alonso-Vila, S; Garrido-Castro, A C; Guillen-Del Castillo, A; Martinez-Valle, F; Ordi-Ros, J; Rovira, A; Vilardell-Tarres, M et al.
DOI: 10.1177/0961203314534303

Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy.

PMID: 24894104
Journal: CLINICAL RHEUMATOLOGY
Year: 2014
Reference: Clin Rheumatol. 2014 Aug;33(8):1119-25. doi: 10.1007/s10067-014-2685-0. Epub 2014 Jun 4.
Impact factor:
Publication type: Paper in international publication
Authors: Armadans-Tremolosa, Imma; Guilera, Georgina; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert; Vilardell-Tarres, Miquel; Visauta-Vinacua, Bienvenido et al.
DOI: 10.1007/s10067-014-2685-0

Erdheim-Chester disease.

PMID: 23505236
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 Jun;72(6):e10. doi: 10.1136/annrheumdis-2013-203519. Epub 2013 Mar 16.
Impact factor:
Publication type: Letter whit IF
Authors: Juanos-Iborra, Montserrat; Selva-O'Callaghan, Albert; Solanich-Moreno, Javier et al.
DOI: 10.1136/annrheumdis-2013-203519

Calcineurin inhibitors in a cohort of patients with antisynthetase-associated interstitial lung disease.

PMID: 23465087
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2013
Reference: Clin Exp Rheumatol. 2013 May-Jun;31(3):436-9. Epub 2013 Mar 7.
Impact factor:
Publication type: Paper in international publication
Authors: Labirua-Iturburu, Ane; Labrador-Horrillo, Moises; Martinez-Gomez, Xavier; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI:

New insight on the Xq28 association with systemic sclerosis.

PMID: 23444193
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 Dec 1;72(12):2032-8. doi: 10.1136/annrheumdis-2012-202742. Epub 2013 Feb 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arnett, Frank C; Assassi, Shervin; Broen, Jasper C A; Callejas-Rubio, Jose-Luis; Carmona, F David; Carreira, Patricia E; Cenit, M Carmen; Denton, Christopher P; Diaz-Gallo, Lina-Marcela; Distler, Jorg H W et al.
DOI: 10.1136/annrheumdis-2012-202742

Social costs of icatibant self-administration vs. health professional-administration in the treatment of hereditary angioedema in Spain.

PMID: 23398817
Journal: Health economics review
Year: 2013
Reference: Health Econ Rev. 2013 Feb 12;3(1):2. doi: 10.1186/2191-1991-3-2.
Impact factor:
Publication type: Letter or abstract
Authors: Blasco, Antonio J; Caballero, Teresa; Guilarte, Mar; Lazaro, Pablo et al.
DOI: 10.1186/2191-1991-3-2

No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis.

PMID: 22742541
Journal: TISSUE ANTIGENS
Year: 2012
Reference: Tissue Antigens. 2012 Sep;80(3):254-8. doi: 10.1111/j.1399-0039.2012.01915.x. Epub 2012 Jun 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1399-0039.2012.01915.x

Anti-PL-7 (Anti-Threonyl-tRNA Synthetase) Antisynthetase Syndrome: Clinical Manifestations in a Series of Patients From a European Multicenter Study (EUMYONET) and Review of the Literature.

PMID: 22732951
Journal: MEDICINE
Year: 2012
Reference: Medicine (Baltimore). 2012 Jul;91(4):206-11.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1097/MD.0b013e318260977c

One hundred years of allergen immunotherapy European Academy of Allergy and Clinical Immunology celebration: review of unanswered questions.

PMID: 22309435
Journal: ALLERGY
Year: 2012
Reference: Allergy. 2012 Apr;67(4):462-76. doi: 10.1111/j.1398-9995.2012.02785.x. Epub 2012 Feb 6.
Impact factor:
Publication type: Review in international publication
Authors: Calderon, M; Cardona, V; Demoly, P et al.
DOI: 10.1111/j.1398-9995.2012.02785.x

Analysis of mite allergic patients in a diverse territory by improved diagnostic tools.

PMID: 22702511
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2012
Reference: Clin Exp Allergy. 2012 Jul;42(7):1129-38. doi: 10.1111/j.1365-2222.2012.03993.x.
Impact factor:
Publication type: Paper in international publication
Authors: Arias, J; Barber, D; Boquete, M; C Garcia-Robaina, J; Cardona, V; Carrillo, T; de la Torre, F; Gala, G; Gamboa, P; Hernandez, D et al.
DOI: 10.1111/j.1365-2222.2012.03993.x

Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis.

PMID: 21571730
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2011
Reference: Ann Rheum Dis. 2011 Nov;70(11):2050-2. Epub 2011 May 13.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/ard.2010.148874

Adverse reactions caused by different filler injections in the same region.

PMID: 21564323
Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Year: 2011
Reference: J Eur Acad Dermatol Venereol. 2011 Jun;25(6):736-7. doi: 10.1111/j.1468-3083.2011.04050.x. Epub 2011 Mar 24.
Impact factor:
Publication type: Letter or abstract
Authors: Alijotas-Reig, J; Alijotas-Reig, J; Garcia-Gimenez, V et al.
DOI: 10.1111/j.1468-3083.2011.04050.x

Enhanced transcript levels of CD48 in CD4(+) T cells from systemic lupus erythematosus patients.

PMID: 21474199
Journal: IMMUNOBIOLOGY
Year: 2011
Reference: Immunobiology. 2011 Sep;216(9):1034-7. Epub 2011 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.imbio.2011.03.004

[Anti-synthetase syndrome.]

PMID: 21543090
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Jun 11;137(2):77-83. Epub 2011 May 4.
Impact factor:
Publication type: Editorial in national publication
Authors: ; ; et al.
DOI: 10.1016/j.medcli.2011.02.026

[Pulmonary embolism during pregnancy: CT or lung scan?]

PMID: 19555981
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Feb 13;134(4):184-5. Epub 2009 Jun 25.
Impact factor:
Publication type: Letter or abstract
Authors: Alijotas Reig, Jaume; Alijotas-Reig, Jaume; Casellas-Caro, Manel et al.
DOI: 10.1016/j.medcli.2009.04.042

Anti-annexin A5 antibodies in women with spontaneous pregnancy loss.

PMID: 20022614
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Apr 10;134(10):433-438. Epub 2009 Dec 22.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; Alijotas Reig, Jaume et al.
DOI: 10.1016/j.medcli.2009.09.040

[The complement system as a main actor in the pathogenesis of obstetric antiphospholipid syndrome]

PMID: 19656533
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Jan 23;134(1):30-4. Epub 2009 Aug 5.
Impact factor:
Publication type: Review in national publication
Authors: Alijotas Reig, Jaume; Alijotas-Reig, Jaume et al.
DOI: 10.1016/j.medcli.2009.05.027

[Stop in bone remodeling in imperfect osteogenesis.]

PMID: 19712946
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Apr 10;134(10):472.
Impact factor:
Publication type: Paper in national publication
Authors: ; et al.
DOI: 10.1016/j.medcli.2009.06.028

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.

PMID: 19286670
Journal: HUMAN MOLECULAR GENETICS
Year: 2009
Reference: Hum Mol Genet. 2009 Jun 1;18(11):2071-7.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Zamorano, M A; Airo, P; Beretta, L; Broen, J; Camps, M T; Coenen, M J H; Diaz, B; Fonollosa, V; Garcia-Portales, R; Gonzalez-Escribano, M F et al.
DOI: 10.1093/hmg/ddp119

A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype.

PMID: 19054816
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2009
Reference: Ann Rheum Dis. 2009 Oct;68(10):1618-20.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Zamorano, M A; Camps, M T; Coenen, M J; Fonollosa, V; Garcia-Portales, R; Gonzalez-Escribano, M F; Gonzalez-Gay, M A; Herrick, A; Hesselstrand, R; Lambert, N et al.
DOI: 10.1136/ard.2008.100180

Changes in lipid profile between flare and remission of patients with systemic lupus erythematosus: a prospective study.

PMID: 19531751
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 Aug;36(8):1639-45.
Impact factor:
Publication type: Paper in international publication
Authors: Balada, Eva; Chacon, Pilar; Ordi-Ros, Josep; Perez, Eduardo Hermosilla; Urquizu-Padilla, Maria; Vilardell-Tarres, Miquel et al.
DOI: 10.3899/jrheum.081097

Genetic risk factors of thrombosis in the antiphospholipid syndrome.

PMID: 19659549
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2009
Reference: Br J Haematol. 2009 Nov;147(3):289-96.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; et al.
DOI: 10.1111/j.1365-2141.2009.07831.x

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