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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Research lines

Serological markers study in anaphylaxis.

We are performing a follow up study of different serological markers in patients who have suffered some anaphylactic episodes. The main goal consists on detecting anaphylaxis patients at the intensive care unit and to determine different serological and plasma markers, mainly tryptase and carboxypeptidase levels by means of a sandwich ELISA.

IP: Moisés Labrador Horrillo

Significance of Capillaroscopy in Raynaud's phenomenon and scleroderma.

We want to describe the capillaroscopy alterations observed in patients with Raynaud's phenomenon and scleroderma. Our main objective is to establish the different patterns that may be related to visceral involvement and to the prognosis in the early stages of the disease.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

Spanish Registry of patients with Behçet disease (REGEB).

This is a multicentre study supported by the Systemic Autoimmune Diseases Group from the Spanish Internal Medicine Society. The aim of the study is to describe the different clinical forms of disease presentation in our country and the response of the disease to conventional treatment.

IP: Roser Solans Laque

Spanish Registry of patients with primary Sjögren’s syndrome.

This is a multicentre study supported by the Systemic Autoimmune Diseases Group (GEAS) from the Spanish Internal Medicine Society (SEMI). Its main goal consist in investigate the factors involved in extraglandular development in our country. This study is coordinated by Dr. Manel Ramos  from the Clinic Hospital, Barcelona.

IP: Roser Solans Laque

Blog

News

The study describes the first documented case worldwide of hereditary angioedema transmission through assisted reproduction.

15 researchers from the Rheumatology, Systemic Diseases and the Physiology and Pathophysiology of the Digestive Tract groups gave around 25 presentations.

The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.