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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Esteve Valverde, Enrique

Esteve Valverde, Enrique

Postdoctoral researcher
Systemic Diseases
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Júlia Vivancos Pons

Júlia Vivancos Pons

Systemic Diseases
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Laura Triginer Gil

Laura Triginer Gil

Research technician
Systemic Diseases
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Maria Roca Herrera

Maria Roca Herrera

Predoctoral researcher
Systemic Diseases
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Pereira González, Mario Javier

Pereira González, Mario Javier

Predoctoral researcher
Systemic Diseases
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Tatiana Murillo Fontana

Tatiana Murillo Fontana

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Esteve Valverde, Enrique

Esteve Valverde, Enrique

Postdoctoral researcher
Systemic Diseases
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Júlia Vivancos Pons

Júlia Vivancos Pons

Systemic Diseases
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Laura Triginer Gil

Laura Triginer Gil

Research technician
Systemic Diseases
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Maria Roca Herrera

Maria Roca Herrera

Predoctoral researcher
Systemic Diseases
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Pereira González, Mario Javier

Pereira González, Mario Javier

Predoctoral researcher
Systemic Diseases
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Tatiana Murillo Fontana

Tatiana Murillo Fontana

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Research lines

Detection of retrovirus XMRV in peripheral blood mononuclear cells of patients with Systemic Lupus Erythematosus.

The presence of the recently discovered retrovirus XMRV ("xenotropic murine leukaemia virus-related virus") is being currently studied in our lab in patients with SLE. This virus has been detected in blood samples of patients suffering from chronic fatigue syndrome (CFS). Interestingly, many patients with lupus also suffer from CFS. Based on these facts, with this project we establish as a hypothesis the possibility of finding XMRV DNA and RNA sequences in peripheral blood mononuclear cells from SLE patients, especially in those with CFS. We are nowadays setting up the already described XMRV-specific PCR and RT-PCR assays. We will also study the immunologic response of these patients against particular XMRV proteins.

IP: -

Development and validation of a consensus of a systemic disease activity index for primary Sjögren’s syndrome. EULAR Sjögren’s Task Force.

We are currently enrolled in this multicentre study supported by the “EULAR Sjögren’s Task  Force”  to elaborate and agree on a systemic disease activity index for patients with primary Sjögren’s syndrome, that will be useful in the management of the disease. This study is coordinated by Dr. Raphaele Seror from the “Service de Rheumatologie Hôpital Bicêtre”, France.

IP: Roser Solans Laque

Development of the European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS/EUROMAP).

The so-called obstetric antiphospholipid syndrome seems to have pathogenic, biologic, therapeutic, and evolution features somehow different from the ones observed in those patients who suffer from "classic" antiphospholipid syndrome. Although experience and scientific evidence seem to support this idea, there is a lack of information that allows us to suggest changes in the classification and/or therapeutic criteria. The European Forum on Antiphospholipid Antibody Syndrome has decided to carry on this project and it has chosen the Vall d'Hebron Hospital as the European Coordinating Centre. Many important Spanish and European hospitals will participate in this multicentric study.

IP: Jaume Alijotas Reig

DNA methylation study in Systemic Lupus Erythematosus (SLE) patients.

DNA is hypomethylated in T cells from SLE patients. It may lead to an increase in the expression of some genes that are usually silenced and, consequently, autoimmune phenomena may develop. On the other hand, this "unprotected" DNA could be the responsible for triggering anti-DNA antibodies. To find out the reason why this DNA hypomethylation is taking place, we have evaluated the expression level of different DNA methylases and demethylases. We have observed that two demethylases (MBD2 and MBD4) are overexpressed in T CD4+ lymphocytes of patients with SLE. We are now studying the effect the overexpression of these proteins may have in the expression regulation of different molecules involved in the immunologic response.

IP: -

Projects

Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudio de aplicabilidad traslacional.

IP: Ernesto Trallero Araguas
Collaborators: Albert Selva O'Callaghan, Raul Tortosa Mendez, Albert Gil Vila, Gloria Aparicio Español, Adria Aterido Ballonga, Hugo Fernando Avalos Bogado
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI22/00708
Duration: 01/01/2023 - 31/12/2025

Ayudas para facultativos investigadores

IP: Sara Marsal Barril
Collaborators: Alejandro Gòmez Gomez, Miriam Izquierdo Sans, Judit Álvarez González
Funding agency: Fundación Española de Reumatología
Funding: 135000
Reference: FER/RECERCA/2021/MARSAL
Duration: 14/02/2022 - 13/02/2025

DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES (DOCTIS)

IP: Sara Marsal Barril
Collaborators: Antonio Julia Cano, Javier Hoyo Pérez, Elena Granell Pallares, Adria Aterido Ballonga, Montse Sender Beleta, Nuria Palau Balaña, Edgar Nuñez Gallardo, Raul Tortosa Mendez, Maria Alba Erra Duran
Funding agency: EUROPEAN COMMISSION
Funding: 1079085
Reference: DOCTIS_H2020_SC1-BHC2019
Duration: 01/01/2020 - 31/12/2025

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Jordi Riera Heredia, The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies an, Daniela Samaniego Toro, Laura Castillo Ribelles, Daniela Samaniego Toro
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Publications

Systemic inflammation biomarkers during angioedema attacks in hereditary angioedema.

PMID: 38953032
Journal: Frontiers in Immunology
Year: 2024
Reference: Front Immunol. 2024 Jun 17;15:1400526. doi: 10.3389/fimmu.2024.1400526. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Bigas, Patricia; Cardona, Victoria; Galvan-Blasco, Paula; Gil-Serrano, Johana; Guilarte, Mar; Labrador-Horrillo, Moises; Luengo, Olga; Pereira-Gonzalez, Javier; Sala-Cunill, Anna et al.
DOI: 10.3389/fimmu.2024.1400526

Retroperitoneal and lower extremities muscle bleeding in acquired haemophilia A (AHA): Risk factors and implications in disability and survival.

PMID: 39086272
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2024
Reference: Eur J Haematol. 2024 Jul 31. doi: 10.1111/ejh.14279.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez, Olga; Pardos-Gea, Jose et al.
DOI: 10.1111/ejh.14279

Long-term safety and efficacy of garadacimab for preventing hereditary angioedema attacks: Phase 3 open-label extension study.

PMID: 39370961
Journal: ALLERGY
Year: 2024
Reference: Allergy. 2024 Oct 7. doi: 10.1111/all.16351.
Impact factor:
Publication type: Paper in international publication
Authors: Bernstein, Jonathan A; Craig, Tim J; Guilarte, Mar; Hsu, Connie; Katelaris, Constance H; Keith, Paul K; Lawo, John-Philip; Li, Philip H; Magerl, Markus; Pollen, Maressa et al.
DOI: 10.1111/all.16351

Nailfold videocapillaroscopy abnormalities and vascular manifestations in Behcet's syndrome.

PMID: 39404484
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2024
Reference: Clin Exp Rheumatol. 2024 Oct;42(10):2065-2070. doi: 10.55563/clinexprheumatol/v5mz8d. Epub 2024 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Bujan, Segundo; Guillen-Del-Castillo, Alfredo; Mercade-Torras, Joan Maria; Solans-Laque, Roser et al.
DOI: 10.55563/clinexprheumatol/v5mz8d

Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1gamma autoantibodies.

PMID: 36008132
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2023
Reference: Ann Rheum Dis. 2023 Feb;82(2):246-252. doi: 10.1136/ard-2022-222441. Epub 2022 Aug 25.
Impact factor:
Publication type: Paper in international publication
Authors: Aggarwal, Rohit; Albayda, Jemima; Carmona-Rivera, Carmelo; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Danoff, Sonye; Grau-Junyent, Josep Maria; Hosono, Yuji; Kaplan, Mariana J; Larman, H Benjamin et al.
DOI: 10.1136/ard-2022-222441

Understanding Severe Asthma Through Small and Big Data in Spanish Hospitals: The PAGE Study.

PMID: 36000822
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2023
Reference: J Investig Allergol Clin Immunol. 2023 Oct 16;33(5):373-382. doi: 10.18176/jiaci.0848. Epub 2023 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Almonacid Sanchez, C; Alvarez Gutierrez, F J; Banas Conejero, D; Cardona, V; Danzi, Vinicio; De Cal, Massimo; De Rosa, Silvia; Ferrer, Ricard; Forfori, Francesco; Forin, Edoardo et al.
DOI: 10.18176/jiaci.0848

Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review.

PMID: 35929796
Journal: RHEUMATOLOGY
Year: 2023
Reference: Rheumatology (Oxford). 2023 Feb 1;62(2):497-511. doi: 10.1093/rheumatology/keac417.
Impact factor:
Publication type: Review in international publication
Authors: Ahmed, Kawser; Alijotas-Reig, Jaume; Giles, Ian; Goulden, Bethan; Munoz, Candido Munoz et al.
DOI: 10.1093/rheumatology/keac417

Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey.

PMID: 35920795
Journal: RHEUMATOLOGY
Year: 2023
Reference: Rheumatology (Oxford). 2023 Mar 1;62(3):1204-1215. doi: 10.1093/rheumatology/keac441.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Vikas; Agarwal, Vishwesh; Aggarwal, Rohit; Cavagna, Lorenzo; Chatterjee, Tulika; Chinoy, Hector; Day, Jessica; Distler, Oliver; Edgar Gracia-Ramos, Abraham; Gheita, Tamer et al.
DOI: 10.1093/rheumatology/keac441

Identification of Two Eosinophil Subsets in Induced Sputum from Patients with Allergic Asthma According to CD15 and CD66b Expression.

PMID: 36293979
Journal: International Journal of Environmental Research and Public Health
Year: 2022
Reference: Int J Environ Res Public Health. 2022 Oct 17;19(20). pii: ijerph192013400. doi: 10.3390/ijerph192013400.
Impact factor:
Publication type: Paper in international publication
Authors: Crespo-Lessmann, Astrid; Curto, Elena; Galvan-Blasco, Paula; Garcia-Moral, Alba; Mateus-Medina, Eder F; Osuna-Gomez, Ruben; Plaza, Vicente; Ramos-Barbon, David; Soto-Retes, Lorena; Ujaldon-Miro, Cristina et al.
DOI: 10.3390/ijerph192013400

Management of Cancer-Associated Myositis.

PMID: 36313478
Journal: Current treatment options in rheumatology
Year: 2022
Reference: Curr Treatm Opt Rheumatol. 2022;8(4):91-104. doi: 10.1007/s40674-022-00197-2. Epub 2022 Oct 21.
Impact factor:
Publication type: Review in international publication
Authors: Agusti, Antonia; Alvarado-Cardenas, Marcelo; Gil-Vila, Albert; Lostes, Julia; Pinal-Fernandez, Iago; Riera-Arnau, Judit; Ros, Javier; Ros, Javier; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1007/s40674-022-00197-2

Personalized Surgery Service in a Tertiary Hospital: A Method to Increase Effectiveness, Precision, Safety and Quality in Maxillofacial Surgery Using Custom-Made 3D Prostheses and Implants.

PMID: 36013033
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Aug 16;11(16). pii: jcm11164791. doi: 10.3390/jcm11164791.
Impact factor:
Publication type: Paper in international publication
Authors: Bescos-Atin, Coro; de-Pablo-Garcia-Cuenca, Alba; Masnou-Pratdesaba, Joan; Pamias-Romero, Jorge; Pujol-Pina, Rosa; Saez-Barba, Manel; Sala-Cunill, Anna; Siurana-Montilva, Sahyly; Valls-Comamala, Victoria et al.
DOI: 10.3390/jcm11164791

COVAD survey 2 long-term outcomes: unmet need and protocol.

PMID: 35964271
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2022
Reference: Rheumatol Int. 2022 Dec;42(12):2151-2158. doi: 10.1007/s00296-022-05157-6. Epub 2022 Aug 14.
Impact factor:
Publication type: Paper in international publication
Authors: A, Becky; Agarwal, Vikas; Agarwal, Vishwesh; Aggarwal, Rohit; Aharonov, Or; Airenakho, Emorinken; Ajmani, Sajal; Akawatcharangura, P; Alonzo, Hugo; Aranega, Raquel et al.
DOI: 10.1007/s00296-022-05157-6

Influence of the age at diagnosis in the disease expression of primary Sjogren syndrome. Analysis of 12,753 patients from the Sjogren Big Data Consortium.

PMID: 34919044
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):166-174. Epub 2021 Dec 16.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Armagan, Berkan; Atzeni, Fabiola; Baldini, Chiara; Bartoloni, Elena; Bombardieri, Michele; Bombardieri, Stefano; Bootsma, Hendrika; Brito-Zeron, Pilar; Carsons, Steven E et al.
DOI:

Serum CXCL13, BAFF, IL-21 and IL-22 levels are related to disease activity and lymphocyte profile in primary Sjogren's syndrome.

PMID: 34919042
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):131-139. Epub 2021 Dec 15.
Impact factor:
Publication type: Paper in international publication
Authors: Franco-Jarava, Clara; Loureiro-Amigo, Jose; Martinez-Valle, Fernando; Palacio, Carlos; Perurena-Prieto, Janire; Solans-Laque, Roser et al.
DOI:

COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

PMID: 34830495
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Nov 9;10(22). pii: jcm10225213. doi: 10.3390/jcm10225213.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Anton, Andres; Aznar, Maria Luisa; Bosch-Nicolau, Pau; Campos-Varela, Isabel; Espinosa-Pereiro, Juan; Guillen-Del-Castillo, Alfredo; Leguizamo-Martinez, Lina Maria; Miarons, Marta; Monforte, Arnau et al.
DOI: 10.3390/jcm10225213

Evaluating the Effect of Pravastatin in Early-Onset Fetal Growth Restriction: A Nonrandomized and Historically Controlled Pilot Study.

PMID: 32615618
Journal: AMERICAN JOURNAL OF PERINATOLOGY
Year: 2021
Reference: Am J Perinatol. 2021 Dec;38(14):1472-1479. doi: 10.1055/s-0040-1713651. Epub 2020 Jul 2.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Bonacina, Erika; Carreras, Elena; Ferrer-Oliveras, Raquel; Garcia-Manau, Pablo; Mendoza, Manel; Rodo, Carlota et al.
DOI: 10.1055/s-0040-1713651

Nailfold capillaroscopy in the Spanish Group of Systemic Autoimmune Diseases (GEAS). Results of an electronic survey.

PMID: 31594659
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Dec 11;155(11):509-510. doi: 10.1016/j.medcli.2019.07.012. Epub 2019 Oct 5.
Impact factor:
Publication type: Letter whit IF
Authors: Antonio Todoli Parra, Jose; Espinosa-Garriga, Gerard; Fanlo-Mateo, Patricia; Fonollosa Pla, Vicens; Freire-Dapena, Mayka; Garcia-Hernandez, Francisco; Gracia-Tello, Borja; Guillen Del Castillo, Alfredo; Jose Rios Blanco, Juan; Mari Alfonso, Begona et al.
DOI: 10.1016/j.medcli.2019.07.012

Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis.

PMID: 33370397
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Dec 28;15(12):e0244627. doi: 10.1371/journal.pone.0244627. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Camps-Relats, Laura; Gonzalez, Antonio; Gonzalez-Sans, Didac; Hernandez, Manuel; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Martinez-Valle, Fernando; Nunez-Conde, Andrea; Pujol-Borrell, Ricardo et al.
DOI: 10.1371/journal.pone.0244627

Effect of bosentan in pulmonary hypertension development in systemic sclerosis patients with digital ulcers.

PMID: 33301540
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Dec 10;15(12):e0243651. doi: 10.1371/journal.pone.0243651. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Casademont, Jordi; Castellvi, Ivan; Corominas, Hector; Fonollosa, Vicenc; Sarmiento, Monica; Simeon, Carmen Pilar et al.
DOI: 10.1371/journal.pone.0243651

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study.

PMID: 33298191
Journal: Clinical and Translational Allergy
Year: 2020
Reference: Clin Transl Allergy. 2020 Dec 9;10(1):62. doi: 10.1186/s13601-020-00342-x.
Impact factor:
Publication type: Review in international publication
Authors: Agache, I; Almeida, R; Annesi-Maesano, I; Ansotegui, I J; Anto, J M; Arnavielhe, S; Bachert, C; Basagana, X; Bedard, A; Bedbrook, A et al.
DOI: 10.1186/s13601-020-00342-x

Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study.

PMID: 30951790
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Allergy Clin Immunol. 2019 Jul;144(1):135-143.e6. doi: 10.1016/j.jaci.2019.01.053. Epub 2019 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, Ioana; Almeida, Rute; Annesi-Maesano, Isabelle; Ansotegui, Ignacio J; Anto, Josep M; Arnavielhe, Sylvie; Bachert, Claus; Basagana, Xavier; Bedard, Annabelle; Bedbrook, Anna et al.
DOI: 10.1016/j.jaci.2019.01.053

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

PMID: 30573655
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2019
Reference: Ann Rheum Dis. 2019 Mar;78(3):311-319. doi: 10.1136/annrheumdis-2018-214127. Epub 2018 Dec 20.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Agarwal, Sandeep K; Airo, Paolo; Alarcon-Riquelme, Marta Eugenia; Alizadeh, Behrooz Z; Amos, Christopher I; Arnett, Frank C; Assassi, Shervin; Beretta, Lorenzo; Broen, Jasper C et al.
DOI: 10.1136/annrheumdis-2018-214127

ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy": AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Sante) POLLAR (Impact of Air POLLution on Asthma and Rhinitis) GARD Demonstration project.

PMID: 30565275
Journal: ALLERGY
Year: 2019
Reference: Allergy. 2019 Jul;74(7):1219-1236. doi: 10.1111/all.13701. Epub 2019 Apr 30.
Impact factor:
Publication type: Review in international publication
Authors: Agache, Ioana; Ansotegui, Ignacio J; Anto, Josep M; Bachert, Claus; Bedbrook, Anna; Bewick, Mike; Bialek, Slawomir; Bindslev-Jensen, Carsten; Bosnic-Anticevich, Sinthia; Bousquet, Jean et al.
DOI: 10.1111/all.13701

Objectives and methodology of BIOBADASER phase iii.

PMID: 28935290
Journal: Reumatologia clinica
Year: 2019
Reference: Reumatol Clin. 2019 Jul - Aug;15(4):229-236. doi: 10.1016/j.reuma.2017.08.001. Epub 2017 Sep 19.
Impact factor:
Publication type: Paper in national publication
Authors: Barcelo Bru, Mireia; Bustabad, Sagrario; Campos, Cristina; Cuende, Eduardo; Del Pino-Montes, Javier; Diaz-Gonzalez, Federico; Farietta Varela, Sandra Myriam; Fernandez-Lopez, Jesus Carlos; Gomez-Reino, Juan Jesus; Grp Trabajo BIOBADASER Fase III et al.
DOI: 10.1016/j.reuma.2017.08.001

Effect of Additional Treatments Combined with Conventional Therapies in Pregnant Patients with High-Risk Antiphospholipid Syndrome: A Multicentre Study.

PMID: 29490410
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2018
Reference: Thromb Haemost. 2018 Apr;118(4):639-646. doi: 10.1055/s-0038-1632388. Epub 2018 Feb 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Andreoli, Laura; Bertero, Maria T; Costedoat-Chalumeau, Nathalie; Cuadrado, Maria J; De Carolis, Sara; Gerosa, Maria; Grandone, Elvira; Haladyj, Ewa; Hoxha, Ariela et al.
DOI: 10.1055/s-0038-1632388

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.

PMID: 30586461
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Dec 26;13(12):e0209343. doi: 10.1371/journal.pone.0209343. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Beretta, Lorenzo; Boiardi, Luigi; Carmona, Elio G; Castaneda, Santos; Cid, Maria C; Cimmino, Marco A; Denton, Christopher P; Emmi, Giacomo; Fonseca, Carmen; Gonzalez-Gay, Miguel A et al.
DOI: 10.1371/journal.pone.0209343

Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis.

PMID: 30567570
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2018
Reference: Arthritis Res Ther. 2018 Dec 19;20(1):281. doi: 10.1186/s13075-018-1775-9.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Vila, Serafin; Callejas-Moraga, Eduardo L; Fonollosa-Pla, Vicente; Guillen-Del-Castillo, Alfredo; Selva-O'Callaghan, Albert; Simeon-Aznar, Carmen Pilar; Tolosa-Vilella, Carles et al.
DOI: 10.1186/s13075-018-1775-9

Brain angiogenic gene-expression in congenital heart disease.

PMID: 29205570
Journal: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
Year: 2018
Reference: Ultrasound Obstet Gynecol. 2018 Dec;52(6):734-738. doi: 10.1002/uog.18977. Epub 2018 Nov 2.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas, Jaume; Arevalo, Silvia; Cabero, Lluis; Carreras, Elena; Dominguez, Carmen; Ferrer, Queralt; Llurba, Elisa; Ribera, Irene; Rodriguez-Sureda, Victor; Ruiz-Romero, Aina et al.
DOI: 10.1002/uog.18977

Pregnancy and autoimmune diseases.

PMID: 28038858
Journal: MEDICINA CLINICA
Year: 2017
Reference: Med Clin (Barc). 2017 Feb 23;148(4):161-163. doi: 10.1016/j.medcli.2016.11.008. Epub 2016 Dec 27.
Impact factor:
Publication type: Paper in national publication
Authors: Alijotas-Reig, Jaume; Esteve-Valverde, Enrique et al.
DOI: 10.1016/j.medcli.2016.11.008

High resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset.

PMID: 27935079
Journal: MUSCLE & NERVE
Year: 2017
Reference: Muscle Nerve. 2017 Sep;56(3):386-392. doi: 10.1002/mus.25507. Epub 2017 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Casal-Dominguez, Maria; Jubany, Lluis; Mego, Marianela; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert et al.
DOI: 10.1002/mus.25507

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium.

PMID: 27899373
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2017
Reference: Ann Rheum Dis. 2017 Jun;76(6):1042-1050. doi: 10.1136/annrheumdis-2016-209952. Epub 2016 Nov 29.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Akasbi, M; Astorri, E; Atzeni, F; Atzeni, Fabiola; Baldini, Chiara; Bartoloni, E; Benessiano, J; Bombardieri, Michele; Bootsma, Hendrika et al.
DOI: 10.1136/annrheumdis-2016-209952

DUSP23 is overexpressed and linked to the expression of DNMTs in CD4+ T cells from Systemic Lupus Erythematosus patients.

PMID: 27737517
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2017
Reference: Clin Exp Immunol. 2017 Feb;187(2):242-250. doi: 10.1111/cei.12883. Epub 2016 Nov 16.
Impact factor:
Publication type: Paper in international publication
Authors: Balada, E; Felip, L; Ordi-Ros, J; Vilardell-Tarres, M et al.
DOI: 10.1111/cei.12883

BACE-1, PS-1 and sAPPbeta Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies.

PMID: 26552061
Journal: MOLECULAR MEDICINE
Year: 2016
Reference: Mol Med. 2016 Mar;21(1):817-823. doi: 10.2119/molmed.2015.00168. Epub 2015 Nov 3.
Impact factor:
Publication type: Paper in international publication
Authors: Cardellach, Francesc; Catalan-Garcia, Marc; Gallego-Escuredo, Jose Miquel; Garrabou, Gloria; Gonzalez-Casacuberta, Ingrid; Grau, Josep Maria; Guitart-Mampel, Mariona; Hernando, Adriana; Montero, Raquel; Moren, Constanza et al.
DOI: 10.2119/molmed.2015.00168

Improvement of the nailfold capillaroscopy after immunosuppressive treatment in polymyositis.

PMID: 26454514
Journal: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
Year: 2016
Reference: QJM. 2016 Mar;109(3):205-6. doi: 10.1093/qjmed/hcv196. Epub 2015 Oct 10.
Impact factor:
Publication type: Letter or abstract
Authors: Fonollosa-Pla, V; Pinal-Fernandez, I; Selva-O'Callaghan, A et al.
DOI: 10.1093/qjmed/hcv196

A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis.

PMID: 25896534
Journal: PHARMACOGENOMICS JOURNAL
Year: 2016
Reference: Pharmacogenomics J. 2016 Apr;16(2):147-50. doi: 10.1038/tpj.2015.31. Epub 2015 Apr 21.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Colman, I; Alonso, A; Alperi-Lopez, M; Blanco, F; Canete, J D; Corominas, H; Erra, A; Fernandez-Gutierrez, B; Fernandez-Nebro, A; Julia, A et al.
DOI: 10.1038/tpj.2015.31

Obstetric antiphospholipid syndrome.

PMID: 26603476
Journal: REVISTA CLINICA ESPANOLA
Year: 2016
Reference: Rev Clin Esp. 2016 Apr;216(3):135-45. doi: 10.1016/j.rce.2015.09.003. Epub 2015 Oct 23.
Impact factor:
Publication type: Review in national publication
Authors: Alijotas-Reig, J; Esteve-Valverde, E; Ferrer-Oliveras, R et al.
DOI: 10.1016/j.rce.2015.09.003

Prognostic value of glomerular filtration rate estimation equations in acute heart failure with preserved versus reduced ejection fraction.

PMID: 25651522
Journal: INT J CLIN PRACT
Year: 2015
Reference: Int J Clin Pract. 2015 Aug;69(8):829-39. doi: 10.1111/ijcp.12616. Epub 2015 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Anarte, L; Aramburu Bodas, O; Aramburu, O; Arevalo-Lorido, J C; Bas, F; Carrasco Sanchez, F J; Carrasco, F J; Carrera, M; Casado Cerrada, J; Casado, J et al.
DOI: 10.1111/ijcp.12616

Biomarkers of anaphylaxis, beyond tryptase.

PMID: 26110683
Journal: CURR OPIN ALLERGY CL
Year: 2015
Reference: Curr Opin Allergy Clin Immunol. 2015 Aug;15(4):329-36. doi: 10.1097/ACI.0000000000000184.
Impact factor:
Publication type: Review in international publication
Authors: Cardona, Victoria; Sala-Cunill, Anna et al.
DOI: 10.1097/ACI.0000000000000184

Profile of omalizumab in the treatment of chronic spontaneous urticaria.

PMID: 26346472
Journal: DRUG DES DEV THER
Year: 2015
Reference: Drug Des Devel Ther. 2015 Aug 25;9:4909-15. doi: 10.2147/DDDT.S56004. eCollection 2015.
Impact factor:
Publication type: Review in international publication
Authors: Ferrer, Marta; Labrador-Horrillo, Moises et al.
DOI: 10.2147/DDDT.S56004

Are all new allergens in TRUE Test(R) essential for a baseline set?

PMID: 25943823
Journal: CONTACT DERMATITIS
Year: 2015
Reference: Contact Dermatitis. 2015 Sep;73(3):186-7. doi: 10.1111/cod.12408. Epub 2015 May 5.
Impact factor:
Publication type: Letter whit IF
Authors: Daschner, Alvaro; Echechipia, Susana; Ferrer, Marta; Garces, Mar; Iriarte, Pilar; Jauregui, Ignacio; Quinones, Maria D; Sala-Cunill, Anna; Veleiro, Beatriz; Villarreal, Olga et al.
DOI: 10.1111/cod.12408

Influence of the IL17A locus in giant cell arteritis susceptibility.

PMID: 24919468
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2014
Reference: Ann Rheum Dis. 2014 Sep;73(9):1742-5. doi: 10.1136/annrheumdis-2014-205261. Epub 2014 Jun 11.
Impact factor:
Publication type: Paper in international publication
Authors: Beretta, L; Blanco, R; Boiardi, L; Braun, N; Caminal-Montero, L; Castaneda, S; Cid, M C; de Miguel, E; Fernandez-Contreras, M E; Garcia-Villanueva, M J et al.
DOI: 10.1136/annrheumdis-2014-205261

Management of angioedema without urticaria in the emergency department.

PMID: 25580506
Journal: ANNALS OF MEDICINE
Year: 2014
Reference: Ann Med. 2014 Dec;46(8):607-18. doi: 10.3109/07853890.2014.949300.
Impact factor:
Publication type: Review in international publication
Authors: Baeza, M L; Barcelo, J M; Caballero, T; Cabanas, R; Campos, A; Cimbollek, S; Daschner, A; Echechipia, M; Ferrer, M; Garces, M et al.
DOI:

Management of anaphylaxis: a systematic review.

PMID: 24251536
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Feb;69(2):168-75. doi: 10.1111/all.12318. Epub 2013 Nov 20.
Impact factor:
Publication type: Review in international publication
Authors: Akdis, C A; Bellou, A; Bilo, M B; Bindslev-Jensen, C; Brockow, K; Cardona, V; Clark, A; Demoly, P; Dhami, S; Dubois, A E J et al.
DOI: 10.1111/all.12318

Acute and long-term management of food allergy: systematic review.

PMID: 24215577
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Feb;69(2):159-67. doi: 10.1111/all.12314. Epub 2013 Nov 12.
Impact factor:
Publication type: Review in national publication
Authors: Agache, I; Akdis, C A; Alvarez, R; Beyer, K; Bindslev-Jensen, C; Cardona, V; de Silva, D; Demoly, P; Dubois, A E J; Eigenmann, P et al.
DOI: 10.1111/all.12314

Knowledge of anaphylaxis among ibero-American physicians: results of the Ibero-American Online Survey for Physicians on the management and treatment of anaphylaxis (IOSPTA) -Latin American society of Allergy, Asthma & Immunology (LASAAI).

PMID: 24459824
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2013
Reference: J Investig Allergol Clin Immunol. 2013;23(6):441-3.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, V; Ivancevich, J C; Sole, D et al.
DOI:

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

PMID: 23983088
Journal: ARTHRITIS AND RHEUMATISM
Year: 2013
Reference: Arthritis Rheum. 2013 Dec;65(12):3239-47. doi: 10.1002/art.38137.
Impact factor:
Publication type: Paper in international publication
Authors: Adams, Barbara S; Ahmed, Yasmeen; Amos, Christopher I; Armstrong, Raymond; Baildam, Eileen; Beard, Laura; Bernstein, Robert; Bingham, Catherine A; Black, Carol; Bowman, Simon et al.
DOI: 10.1002/art.38137

Phase II open-label study to assess efficacy and safety of lenalidomide in combination with cetuximab in KRAS-mutant metastatic colorectal cancer.

PMID: 24244261
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Nov 11;8(11):e62264. doi: 10.1371/journal.pone.0062264. eCollection 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Beck, Robert; Bencardino, Katia; Elez, Maria Elena; Gandhi, Anita; Jungnelius, Ulf; Li, Mingyu; Prenen, Hans; Romano, Alfredo; Sanchis, Mireia; Sartore-Bianchi, Andrea et al.
DOI: 10.1371/journal.pone.0062264

Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs.

PMID: 23763970
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2013
Reference: J Allergy Clin Immunol. 2013 Oct;132(4):989-91. doi: 10.1016/j.jaci.2013.04.045. Epub 2013 Jun 12.
Impact factor:
Publication type: Letter whit IF
Authors: Armisen, Margarita; Audicana, Maria Teresa; Cabanes, Rosario; Cardona, Victoria; Carracedo, Angel; Castillo, Luisa F; Colas, Carlos; Corominas, Merce; Cruz, Raquel; Hernandez, Dolores et al.
DOI: 10.1016/j.jaci.2013.04.045

alpha1-Antitrypsin in Fibromyalgia: Results of a Randomized, Placebo-Controlled, Double-Blind and Crossover Pilot Trial.

PMID: 22190533
Journal: Musculoskeletal care
Year: 2012
Reference: Musculoskeletal Care. 2012 Sep;10(3):178-83. doi: 10.1002/msc.1000. Epub 2011 Dec 22.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.1002/msc.1000

Nephrotic syndrome and lambda light-chain monoclonal gammopathy suggestive of primary amyloidosis with positive staining for AA amyloid.

PMID: 23057449
Journal: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Year: 2012
Reference: J Am Geriatr Soc. 2012 Oct;60(10):1974-5. doi: 10.1111/j.1532-5415.2012.04160.x.
Impact factor:
Publication type: Letter whit IF
Authors: Martinez-Valle, Fernando; Riveiro-Barciela, Mar; Vilardell-Tarres, Miquel et al.
DOI: 10.1111/j.1532-5415.2012.04160.x

Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

PMID: 23049788
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(9):e45356. doi: 10.1371/journal.pone.0045356. Epub 2012 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Perez, Elisa; Balada, Eva; Barizzone, Nadia; Bijl, Marc; Blanco, Francisco J; Calaza, Manuel; Carreira, Patricia; Endreffy, Emoke; Gomez-Reino, Juan J; Gonzalez, Antonio et al.
DOI: 10.1371/journal.pone.0045356

Associations between the expression of epigenetically regulated genes and the expression of DNMTs and MBDs in systemic lupus erythematosus.

PMID: 23029299
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(9):e45897. doi: 10.1371/journal.pone.0045897. Epub 2012 Sep 21.
Impact factor:
Publication type: Paper in international publication
Authors: Balada, Eva; Castro-Marrero, Jesus; Felip, Lledo; Ordi-Ros, Josep; Vilardell-Tarres, Miquel et al.
DOI: 10.1371/journal.pone.0045897

Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.

PMID: 21875883
Journal: RHEUMATOLOGY
Year: 2011
Reference: Rheumatology (Oxford). 2011 Nov;50(11):1976-81. Epub 2011 Aug 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Angeles; Airo, Paolo; Andreu, Jose Luis; Beretta, Lorenzo; Bossini-Castillo, Lara; Callejas-Rubio, Jose Luis; Camps, Maria T; Carreira, Patricia; Castellvi, Ivan; Castillo, Jesus et al.
DOI: 10.1093/rheumatology/ker259

Effect of using reporting guidelines during peer review on quality of final manuscripts submitted to a biomedical journal: masked randomised trial.

PMID: 22108262
Journal: BRITISH MEDICAL JOURNAL
Year: 2011
Reference: BMJ. 2011 Nov 22;343:d6783. doi: 10.1136/bmj.d6783.
Impact factor:
Publication type: Paper in international publication
Authors: Altman, D G; Cardellach, F; Cirugeda, L; Cobo, E; Cortes, J; Fonollosa, V; Garcia, L; Gonzalez, J A; Kostov, B; Miras, F et al.
DOI: 10.1136/bmj.d6783

Fighting allergies beyond symptoms: the European Declaration on Immunotherapy.

PMID: 21953637
Journal: EUROPEAN JOURNAL OF IMMUNOLOGY
Year: 2011
Reference: Eur J Immunol. 2011 Oct;41(10):2802-4. doi: 10.1002/eji.201190061.
Impact factor:
Publication type: Editorail in international publication
Authors: Akdis, Cezmi; Cardona, Victoria; Papadopoulos, Nikos et al.
DOI: 10.1002/eji.201190061

[Guideline for the management of anaphylaxis].

PMID: 21168172
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Mar 26;136(8):349-55. Epub 2010 Dec 17.
Impact factor:
Publication type: Paper in national publication
Authors: Cabanes Higuero, Nieves; Cardona Dahl, V; Cardona Dahl, Victoria; Chivato Perez, Tomas; de la Hoz Caballer, Belen; Freijo Martin, Concepcion; Guardia Martinez, Pedro; Lobera Labairu, Teofilo; Montserrat Fernandez Rivas, Maria; Nevot Falco, Santiago et al.
DOI: 10.1016/j.medcli.2010.10.003

Results of the oral egg-challenge test performed on two different groups of children. One group with a history, suggestive of allergic reaction with egg intake and the other group sensitised to hen's egg without previous egg intake.

PMID: 20619526
Journal: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
Year: 2010
Reference: Allergol Immunopathol (Madr). 2010 Sep-Oct;38(5):233-40. Epub 2010 Jul 8.
Impact factor:
Publication type: Paper in national publication
Authors: Asin, J L Eseverri; Baraut, T Garriga; Conde, S L Romero; Fadeeva, T; Hontoria, O Esteso; Horrillo, M Labrador; Molina, A M Marin; Valero, C Blasco; Vela, R F Ocana et al.
DOI: 10.1016/j.aller.2010.01.004

Nailfold capillary microscopy in adults with inflammatory myopathy.

PMID: 19022479
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2010
Reference: Semin Arthritis Rheum. 2010 Apr;39(5):398-404. Epub 2008 Nov 20.
Impact factor:
Publication type: Review in international publication
Authors: Fonollosa-Pla, Vicente; Labrador-Horrillo, Moises; Martinez-Gomez, Xavier; Selva-O'Callaghan, Albert; Simeon-Aznar, Carmen Pilar; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.semarthrit.2008.09.003

Are Bacterial Growth and/or Chemotaxis Increased by Filler Injections? Implications for the Pathogenesis and Treatment of Filler-Related Granulomas.

PMID: 21071919
Journal: DERMATOLOGY
Year: 2010
Reference: Dermatology. 2010;221(4):356-64. Epub 2010 Nov 15.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1159/000321329

CNstream: a method for the identification and genotyping of copy number polymorphisms using Illumina microarrays.

PMID: 20482829
Journal: BMC BIOINFORMATICS
Year: 2010
Reference: BMC Bioinformatics. 2010 May 19;11:264.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Arnald; Ballina, Javier; Balsa, Alejandro; Canaleta, Cristina; Canete, Juan D; Julia, Antonio; Marsal, Sara; Tornero, Jesus; Tortosa, Raul et al.
DOI: 10.1186/1471-2105-11-264

Anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with idiopathic inflammatory myopathy.

PMID: 19386818
Journal: RHEUMATOLOGY
Year: 2009
Reference: Rheumatology (Oxford). 2009 Jun;48(6):676-9.
Impact factor:
Publication type: Paper in international publication
Authors: Delgado, Juan Francisco; Labrador-Horrillo, Moises; Martinez, Ma Angeles; Martinez-Gomez, Xavier; Rodriguez-Sanchez, Jose Luis; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI: 10.1093/rheumatology/kep065

[Search for information on the Internet by patients with chronic autoimmune diseases in different Spanish populations]

PMID: 19376539
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Oct 3;133(12):467-71.
Impact factor:
Publication type: Review or editorial in national publication
Authors: Barnosi Marin, Ana Celia; Ortego Centeno, Norberto; Ortego Jurado, Miguel; Simeon Aznar, Carmen Pilar et al.
DOI: 10.1016/j.medcli.2008.12.028

Generalized muscle pseudo-hypertrophy and stiffness associated with the myotilin Ser55Phe mutation: a novel myotilinopathy phenotype?

PMID: 19027924
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2009
Reference: J Neurol Sci. 2009 Feb 15;277(1-2):167-71.
Impact factor:
Publication type: Paper in international publication
Authors: Armstrong, Judith; Dominguez-Oronoz, Rosa; Ferrer, Isidre; Gamez, Josep; Goldfarb, Lev; Olive, Montse; Ortega, Arantxa; Selva-O'Callaghan, Albert; Shatunov, Alexey et al.
DOI: 10.1016/j.jns.2008.10.019

Serum levels of soluble CD40 ligand at flare and at remission in patients with systemic lupus erythematosus.

PMID: 19332622
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 May;36(5):953-60.
Impact factor:
Publication type: Paper in international publication
Authors: Balada, Eva; Cortes, Fina; Ordi-Ros, Josep; Perez, Eduardo Hermosilla; Urquizu-Padilla, Maria; Vilardell-Tarres, Miquel et al.
DOI: 10.3899/jrheum.080978

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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.