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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Antonio González Fernández

Antonio González Fernández

Senior researcher
Systemic Diseases
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Ariadna Anunciacion Llunell

Ariadna Anunciacion Llunell

Predoctoral researcher
Systemic Diseases
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Basilio Rodriguez  Diez

Basilio Rodriguez Diez

Senior researcher
Systemic Diseases
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Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
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David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
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Antonio González Fernández

Antonio González Fernández

Senior researcher
Systemic Diseases
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Ariadna Anunciacion Llunell

Ariadna Anunciacion Llunell

Predoctoral researcher
Systemic Diseases
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Basilio Rodriguez  Diez

Basilio Rodriguez Diez

Senior researcher
Systemic Diseases
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Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
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David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
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Research lines

Evaluation and characterization of cardiac involvement in patients with Systemic Sclerosis.

Cardiac involvement is one of the most serious internal organ involvements and the leading cause of death in SSc patients. The prevalence is 14% by clinical observation and even higher by autopsy Many SSc patients with cardiac involvement are asymptomatic or underdiagnosed. The condition may progress silently to overt clinical manifestations, including systolic and/or diastolic dysfunction, myocardial ischaemia, myocardial hypertrophy, heart failure, pericardial effusion and arrhythmias. Early detection of cardiac abnormalities is therefore very important. We evaluate cardiac involvement by echocardiography, MR, SPECT, and coronary CT.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

Genetic bases of Behçet disease.

We are currently enrolled in this multicentre study to investigate the possible influence of the genetic background in the disease pathogenesis, and to try to establish links between genetic variations and different clinical and biological patterns. The research is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute by sending samples from our cohort of patients along with the clinical data, and reviewing the results. It is supported by a SAS grant.

IP: Roser Solans Laque

Genetic bases of giant cell arteritis (GCA).

With this study we aim to investigate the genetic background of the disease, to deepen in its pathogenesis and to be able to establish links between genetic variations and different clinic and biologic patterns. This research is based on a multicentric study and it is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute by sending samples from our cohort of patients along with the clinical data, and reviewing the results.

IP: Roser Solans Laque

Genetic basis of scleroderma.

With this study we aim at studying the genetic background of the disease to deepen in its pathogenesis to be able to establish links between genetic variations and different clinic-biologic patterns. This research is based on a multicentric study and it is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute to it by sending samples from our cohort of patients along with the clinical data.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

Projects

Identificación de biomarcadores celulares y moleculares en angioedema idiopático y hereditario para su diferenciación en fenotipos y endotipos

IP: Mar Guilarte Clavero
Collaborators: Manuel Hernández González, Moisés Labrador Horrillo, Anna Sala Cunill, Olga Luengo Sanchez, Paula Galvan Blasco, Ingrid Johana Gil Serrano
Funding agency: Instituto de Salud Carlos III
Funding: 84700
Reference: PI20/01061
Duration: 01/01/2021 - 30/06/2025

Publications

CORRESPONDENCE/COMMENTS ON ACR/EULAR ANTIPHOSPHOLIPID SYNDROME CLASSIFICATION CRITERIA.

PMID: 38200647
Journal: Arthritis & Rheumatology
Year: 2024
Reference: Arthritis Rheumatol. 2024 Jan 10. doi: 10.1002/art.42792.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Belizna, Cristina; Canti, Valentina; de Carolis, Sara; Esteve-Valverde, Enrique; Ferrer-Oliveras, Raquel; Hoxha, Ariella; Jaume Alijotas-Reig, J; Latino, Omar; Lefkou, Eleftheria; Llurba, Elisa et al.
DOI: 10.1002/art.42792

Clinico-pathological phenotypes of Systemic Sclerosis associated myopathy: analysis of a multicenter large cohort.

PMID: 35713496
Journal: RHEUMATOLOGY
Year: 2023
Reference: Rheumatology (Oxford). 2023 Feb 6;62(SI):SI82-SI90. doi: 10.1093/rheumatology/keac361.
Impact factor:
Publication type: Paper in international publication
Authors: Espinosa, Gerard; Garrabou, Gloria; Grau-Junyent, Josep Maria; Guillen-Del-Castillo, Alfredo; Kisluk, Boris; Lozano, Pedro Moreno; Matas-Garcia, Ana; Milisenda, Jose C; Prieto-Gonzalez, Sergio; Selva-O'Callaghan, Albert et al.
DOI: 10.1093/rheumatology/keac361

What drives the decision to optimise biological treatment in children and youngsters with juvenile idiopathic arthritis? A discrete-choice experiment.

PMID: 36603964
Journal: Reumatologia clinica
Year: 2023
Reference: Reumatol Clin (Engl Ed). 2023 Jan;19(1):26-33. doi: 10.1016/j.reumae.2022.11.002.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Jordi; Boteanu, Alina; Bravo, Beatriz; Bustabad, Sagrario; Calvo, Inmaculada; Camacho, Marisol; Clemente, Daniel; de Inocencio, Jaime; Grana, Jenaro; Lacruz, Lucia et al.
DOI: 10.1016/j.reumae.2022.11.002

Development of an algorithm for IgG4-related disease management.

PMID: 36682575
Journal: AUTOIMMUNITY REVIEWS
Year: 2023
Reference: Autoimmun Rev. 2023 Mar;22(3):103273. doi: 10.1016/j.autrev.2023.103273. Epub 2023 Jan 20.
Impact factor:
Publication type: Review in international publication
Authors: Culver, Emma L; D'Cruz, David P; Ebbo, Mikael; Fernandez-Codina, Andreu; Lanzillotta, Marco; Martinez-Valle, Fernando; Orozco-Galvez, Olimpia; Rebours, Vinciane; Schleinitz, Nicolas; Torre, Emanuel Della et al.
DOI: 10.1016/j.autrev.2023.103273

Predictive Model for Preeclampsia Combining sFlt-1, PlGF, NT-proBNP, and Uric Acid as Biomarkers.

PMID: 36675361
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Jan 5;12(2):431. doi: 10.3390/jcm12020431.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Alvarez, Francisco V; Carretero, Francisco; Cruz-Lemini, Monica; Fernandez-Oliva, Antonio; Garcia-Osuna, Alvaro; Garrido-Gimenez, Carmen; Llurba, Elisa; Mora, Josefina; Nan, Madalina Nicoleta et al.
DOI: 10.3390/jcm12020431

Angioedema severity and impact on quality of life: chronic histaminergic angioedema versus chronic spontaneous urticaria.

PMID: 35934307
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2022
Reference: J Allergy Clin Immunol Pract. 2022 Nov;10(11):3039-3043.e3. doi: 10.1016/j.jaip.2022.07.011. Epub 2022 Aug 4.
Impact factor:
Publication type: Paper in international publication
Authors: Azofra, Julian; Baeza, Maria Luisa; Donado, Camen Diaz; Ferrer, Marta; Gaig, Pere; Gil, Maria Pilar; Guilarte, Mar; Herrera-Lasso, Valeria; Labrador-Horrillo, Moises; Rodriguez-Garijo, Nuria et al.
DOI: 10.1016/j.jaip.2022.07.011

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE).

PMID: 35931315
Journal: AUTOIMMUNITY REVIEWS
Year: 2022
Reference: Autoimmun Rev. 2022 Oct;21(10):103167. doi: 10.1016/j.autrev.2022.103167. Epub 2022 Aug 2.
Impact factor:
Publication type: Review in international publication
Authors: Argibay, Ana; Balda-Masmiquel, Maria; Callejas-Moraga, Eduardo; Carbonell, Cristina; Castro-Salomo, Antoni; Chamorro, Antonio-Javier; Colunga, Dolores; de-la-Red-Bellvis, Gloria; Fernandez-Luque, Alejandra; Fonollosa-Pla, Vicent et al.
DOI: 10.1016/j.autrev.2022.103167

Author Correction: Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension.

PMID: 35902683
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Jul 28;12(1):12947. doi: 10.1038/s41598-022-17525-0.
Impact factor:
Publication type: Letter or abstract
Authors: Argibay, Ana; Argibay, Ana; Arjona, Josefa Jimenez; Baldomero, Idaira Famara Hernandez; Ballve, Adela Marin; Barbera, Joan Albert; Barbera, Joan Albert; Blanco, Isabel; Blanco, Isabel; Candelera, Remedios Otero et al.
DOI: 10.1038/s41598-022-17525-0

Safety of Drugs Used during the First Wave of COVID-19: A Hospital-Registry-Based Study.

PMID: 35885517
Journal: Diagnostics
Year: 2022
Reference: Diagnostics (Basel). 2022 Jul 1;12(7). pii: diagnostics12071612. doi: 10.3390/diagnostics12071612.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cristina; Agusti, Antonia; Bosch, Montserrat; Campos-Varela, Isabel; Cereza, Gloria; Danes, Immaculada; Guillen, Elena; Mestre-Torres, Jaume; Miarons, Marta; Sanchez-Montalva, Adrian et al.
DOI: 10.3390/diagnostics12071612

Role of MUC1 rs4072037 polymorphism and serum KL-6 levels in patients with antisynthetase syndrome.

PMID: 34799647
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Nov 19;11(1):22574. doi: 10.1038/s41598-021-01992-y.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Moralejo, Rodrigo; Atienza-Mateo, Belen; Balsa, Alejandro; Berastegui, Cristina; Bonilla, Gema; Calvo-Alen, Jaime; Castaneda, Santos; Cavagna, Lorenzo; Cifrian, Jose M; Diez, Elvira et al.
DOI: 10.1038/s41598-021-01992-y

Off-Label Use of Rituximab in Patients with Different Types of Nephropathies in a Tertiary Hospital: A Retrospective Study.

PMID: 34768461
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Oct 26;10(21). pii: jcm10214941. doi: 10.3390/jcm10214941.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Agusti, Antonia; Alerany, Carmen; Bosch, Josep Angel; Danes, Immaculada; Sans-Pola, Carla et al.
DOI: 10.3390/jcm10214941

[World Allergy Organization Anaphylaxis Guidance 2020].

PMID: 34759087
Journal: Japanese Journal of Allergology
Year: 2021
Reference: Arerugi. 2021;70(9):1211-1234. doi: 10.15036/arerugi.70.1211.
Impact factor:
Publication type: Paper in international publication
Authors: Ansotegui, Ignacio J; Borges, Mario Sanchez; Cardona, Victoria; Ebisawa, Motohiro; El-Gamal, Yehia; Fineman, Stanley; Geller, Mario; Gonzalez-Estrada, Alexei; Greenberger, Paul A; Rivas, Montserrat Fernandez et al.
DOI: 10.15036/arerugi.70.1211

Clinical features and health-related quality of life in adult patients with mucopolysaccharidosis IVA: the Spanish experience.

PMID: 34732228
Journal: Orphanet Journal of Rare Diseases
Year: 2021
Reference: Orphanet J Rare Dis. 2021 Nov 3;16(1):464. doi: 10.1186/s13023-021-02074-y.
Impact factor:
Publication type: Paper in international publication
Authors: Arranz Canales, Elena; Ballesta-Martinez, Maria Juliana; Blasco-Alonso, Javier; Cortes-Saladelafont, Elisenda; Couce, Maria Luz; Garcia Morillo, Salvador; Garcia-Silva, Maria Teresa; Gil Sanchez, Ricardo; Guillen-Navarro, Encarna; Lopez Rodriguez, Monica A et al.
DOI: 10.1186/s13023-021-02074-y

World allergy organization anaphylaxis guidance 2020.

PMID: 33204386
Journal: World Allergy Organization Journal
Year: 2020
Reference: World Allergy Organ J. 2020 Oct 30;13(10):100472. doi: 10.1016/j.waojou.2020.100472. eCollection 2020 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Ansotegui, Ignacio J; Cardona, Victoria; Ebisawa, Motohiro; El-Gamal, Yehia; Fernandez Rivas, Montserrat; Fineman, Stanley; Geller, Mario; Gonzalez-Estrada, Alexei; Greenberger, Paul A; Sanchez Borges, Mario et al.
DOI: 10.1016/j.waojou.2020.100472

In-vivo diagnostic test allergens in Europe: A call to action and proposal for recovery plan-An EAACI position paper.

PMID: 32306414
Journal: ALLERGY
Year: 2020
Reference: Allergy. 2020 Sep;75(9):2161-2169. doi: 10.1111/all.14329.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, Ioana; Bonertz, Andreas; Bonini, Matteo; Bonini, Sergio; Bousquet, Jean; Brough, Helen A; Cardona, Victoria; Demoly, Pascal; Dreborg, Sten; Hellings, Peter W et al.
DOI: 10.1111/all.14329

Determinants and Differences in Satisfaction with the Inhaler Among Patients with Asthma or COPD.

PMID: 31586668
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2020
Reference: J Allergy Clin Immunol Pract. 2020 Feb;8(2):645-653. doi: 10.1016/j.jaip.2019.09.020. Epub 2019 Oct 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Ortiz, M Belen; Arrondo, Antonio Parra; Balaguer, Enrique Mascaros; Batlles, Joan Serra; Bernal, Berta Roman; Castillo, Rafael; Cesar, Eva Cabrera; Cosio, Borja G; Cunill, Anna Sala; Curto, Elena et al.
DOI: 10.1016/j.jaip.2019.09.020

Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

PMID: 33110492
Journal: Clinical and Translational Allergy
Year: 2020
Reference: Clin Transl Allergy. 2020 Oct 26;10:44. doi: 10.1186/s13601-020-00351-w. eCollection 2020.
Impact factor:
Publication type: Letter or abstract
Authors: Abdul Latiff, Amir Hamzah; Abdullah, Baharudin; Aberer, Werner; Abusada, Nancy; Adcock, Ian; Afani, Alejandro; Agache, Ioana; Aggelidis, Xenofon; Agustin, Jenifer; Akdis, Cezmi et al.
DOI: 10.1186/s13601-020-00351-w

Time to revisit the definition and clinical criteria for anaphylaxis?

PMID: 31719946
Journal: World Allergy Organization Journal
Year: 2019
Reference: World Allergy Organ J. 2019 Oct 31;12(10):100066. doi: 10.1016/j.waojou.2019.100066. eCollection 2019 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Ansotegui, Ignacio J; Borges, Mario Sanchez; Cardona, Victoria; Ebisawa, Motohiro; El-Gamal, Yehia; Fineman, Stanley; Geller, Mario; Gonzalez-Estrada, Alexei; Greenberger, Paul A; Rivas, Montserrat Fernandez et al.
DOI: 10.1016/j.waojou.2019.100066

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study.

PMID: 30442823
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2019
Reference: J Rheumatol. 2019 Mar;46(3):279-284. doi: 10.3899/jrheum.180355. Epub 2018 Nov 15.
Impact factor:
Publication type: Paper in international publication
Authors: Araguas, Ernesto Trallero; Barsotti, Simone; Bauhammer, Jutta; Bergner, Raoul; Bertolazzi, Chiara; Bonella, Francesco; Bortoluzzi, Alessandra; Caproni, Marzia; Cassone, Giulia; Castaneda, Santos et al.
DOI: 10.3899/jrheum.180355

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

PMID: 30535994
Journal: CLINICAL RHEUMATOLOGY
Year: 2019
Reference: Clin Rheumatol. 2019 Apr;38(4):1117-1124. doi: 10.1007/s10067-018-4390-x. Epub 2018 Dec 7.
Impact factor:
Publication type: Paper in international publication
Authors: Argibay, A; Boldova, R; Callejas Moraga, E; Carbonell, C; Castillo, M J; Castillo-Palma, Maria J; Chamorro, A J; Chamorro, Antonio J; Colunga, D; Colunga-Arguelles, Dolores et al.
DOI: 10.1007/s10067-018-4390-x

Therapeutic strategy according to the differing patient response profiles to omalizumab in chronic spontaneous urticaria.

PMID: 30222111
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Investig Allergol Clin Immunol. 2019;29(5):338-348. doi: 10.18176/jiaci.0323. Epub 2018 Sep 17.
Impact factor:
Publication type: Review in international publication
Authors: Bartra Tomas, J; Ferrer Puga, M; Gimenez Arnau, A M; Jauregui Presa, I; Labrador-Horrillo, M; Miquel Miquel, F J; Ortiz de Frutos, J; Sastre, J; Silvestre Salvador, F J; Valero Santiago, A et al.
DOI: 10.18176/jiaci.0323

Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

PMID: 30471769
Journal: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Year: 2018
Reference: Prostaglandins Leukot Essent Fatty Acids. 2018 Dec;139:20-24. doi: 10.1016/j.plefa.2018.11.006. Epub 2018 Nov 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre, Jose; Castro-Marrero, Jesus; Domingo, Joan Carles; Martinez-Martinez, Alba; von Schacky, Clemens; Zaragoza, Maria Cleofe et al.
DOI: 10.1016/j.plefa.2018.11.006

Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study.

PMID: 30464782
Journal: World Allergy Organization Journal
Year: 2018
Reference: World Allergy Organ J. 2018 Nov 16;11(1):32. doi: 10.1186/s40413-018-0216-1. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Chapman-Rothe, N; Costa, C; Dabove, F; Ensina, L F; Gimenez-Arnau, A; Guillet, G; Houghton, K; Konstantinou, G N; Labrador-Horrillo, M; Lapeere, H et al.
DOI: 10.1186/s40413-018-0216-1

HIBISCUS: HYDROXYCHLOROQUINE FOR THE SECONDARY PREVENTION OF THROMBOTIC AND OBSTETRICAL EVENTS IN PRIMARY ANTIPHOSPHOLIPID SYNDROME.

PMID: 30316994
Journal: AUTOIMMUNITY REVIEWS
Year: 2018
Reference: Autoimmun Rev. 2018 Dec;17(12):1153-1168. doi: 10.1016/j.autrev.2018.05.012. Epub 2018 Oct 12.
Impact factor:
Publication type: Review in national publication
Authors: Abad, Sebastien; Alijotas-Reig, Jaume; Amital, Howard; Amoura, Zahir; Andreoli, Laura; Andres, Emmanuel; Aouba, Achile; Arnaud, Laurent; Belizna, Cristina; Bienvenu, Boris et al.
DOI: 10.1016/j.autrev.2018.05.012

Food-induced fatal anaphylaxis: from epidemiological data to general prevention strategies.

PMID: 30288817
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2018
Reference: Clin Exp Allergy. 2018 Dec;48(12):1584-1593. doi: 10.1111/cea.13287. Epub 2018 Nov 26.
Impact factor:
Publication type: Paper in international publication
Authors: Beaudouin, Etienne; Cardona, Victoria; Demoly, Pascal; Deschildre, Antoine; Pouessel, Guillaume; Renaudin, Jean-Marie; Tanno, Luciana K; Turner, Paul J; Worm, Margitta et al.
DOI: 10.1111/cea.13287

Preliminary definitions for the sonographic features of synovitis in children.

PMID: 27748074
Journal: ARTHRITIS CARE & RESEARCH
Year: 2017
Reference: Arthritis Care Res (Hoboken). 2017 Aug;69(8):1217-1223. doi: 10.1002/acr.23130.
Impact factor:
Publication type: Paper in international publication
Authors: Backhaus, Marina; Balint, Peter; Bruns, Alessandra; Bruyn, George A; Collado, Paz; D'Agostino, Maria-Antonietta; De la Cruz, Lorenia; Guillaume-Czitrom, Severine; Herlin, Troels; Hernandez, Cristina et al.
DOI: 10.1002/acr.23130

Anti-IL6-R Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to anti-TNF therapy. A multicenter study of 25 patients.

PMID: 27696756
Journal: Arthritis & Rheumatology
Year: 2017
Reference: Arthritis Rheumatol. 2017 Mar;69(3):668-675. doi: 10.1002/art.39940.
Impact factor:
Publication type: Paper in international publication
Authors: Adan, Alfredo; Atanes, Antonio; Blanco, Ricardo; Bravo, Beatriz; Calvo, Inmaculada; Calvo-Rio, Vanesa; Demetrio-Pablo, Rosalia; Diaz-Cordoves, Gisela; Gonzalez-Fernandez, Ma Isabel; Gonzalez-Gay, Miguel A et al.
DOI: 10.1002/art.39940

Lettuce allergy is a lipid transfer syndrome-related food allergy with high risk of severe reactions.

PMID: 27609533
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2017
Reference: J Investig Allergol Clin Immunol. 2017;27(2):98-103. doi: 10.18176/jiaci.0110. Epub 2016 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, V; Cuesta-Herranz, J; Luengo-Sanchez, O; Moreno-Perez, N; Munoz-Garcia, E; Pastor-Vargas, C et al.
DOI: 10.18176/jiaci.0110

Immunotherapy in allergic rhinitis and lower airway outcomes.

PMID: 27439141
Journal: ALLERGY
Year: 2017
Reference: Allergy. 2017 Jan;72(1):35-42. doi: 10.1111/all.12989. Epub 2016 Aug 15.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, Victoria; Labrador, Moises; Luengo, Olga et al.
DOI: 10.1111/all.12989

Diagnostic and therapeutic delay of rheumatoid arthritis and its relationship with health care devices in Catalonia. The AUDIT study.

PMID: 26362843
Journal: Reumatologia clinica
Year: 2016
Reference: Reumatol Clin. 2016 May-Jun;12(3):146-50. doi: 10.1016/j.reuma.2015.08.002. Epub 2015 Sep 8.
Impact factor:
Publication type: Paper in national publication
Authors: Alegre, Cayetano; Arasa, Xavier; Campoy, Ester; Clavaguera, Teresa; Corominas, Hector; de la Fuente, Diana; Diaz-Torne, Cesar; Figuls, Ramon; Gomez-Caballero, Maria Eugenia; Gomez-Puerta, Jose Alfredo et al.
DOI: 10.1016/j.reuma.2015.08.002

HLA-B*57: 01 genotyping in the prevention of hypersensitivity to abacavir: 5 years of experience.

PMID: 27195528
Journal: Pharmacogenetics and Genomics
Year: 2016
Reference: Pharmacogenet Genomics. 2016 Aug;26(8):390-6. doi: 10.1097/FPC.0000000000000229.
Impact factor:
Publication type: Paper in international publication
Authors: Alia-Ramos, Pedro; Alonso-Pastor, Arnald; Candas-Estebanez, Beatriz; Padro-Miquel, Ariadna; Padulles-Zamora, Nuria; Podzamczer-Palter, Daniel; Ruiz-Iruela, Cristina et al.
DOI: 10.1097/FPC.0000000000000229

Omalizumab: what benefits should we expect?

PMID: 27210073
Journal: EUROPEAN JOURNAL OF DERMATOLOGY
Year: 2016
Reference: Eur J Dermatol. 2016 Aug 1;26(4):340-4. doi: 10.1684/ejd.2016.2809.
Impact factor:
Publication type: Paper in international publication
Authors: Armario Hita, Jose Carlos; Gimenez-Arnau, Ana; Labrador-Horrillo, Moises; Silvestre Salvador, Juan Francisco; Velasco, Manel et al.
DOI: 10.1684/ejd.2016.2809

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.

PMID: 26362759
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Aug;75(8):1558-66. doi: 10.1136/annrheumdis-2015-208119. Epub 2015 Sep 11.
Impact factor:
Publication type: Paper in international publication
Authors: Amos, Christopher I; Benveniste, Olivier; Bowes, John; Chinoy, Hector; Cobb, Joanna; Cooper, Robert G; Danko, Katalin; De Bleecker, Jan; De Paepe, Boel; Denton, Christopher et al.
DOI: 10.1136/annrheumdis-2015-208119

Consensus of the Spanish society of pediatric rheumatology for transition management from pediatric to adult care in rheumatic patients with childhood onset.

PMID: 25917856
Journal: RHEUMATOL INT
Year: 2015
Reference: Rheumatol Int. 2015 Oct;35(10):1615-24. doi: 10.1007/s00296-015-3273-6. Epub 2015 Apr 28.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Jordi; Bustabad, Sagrario; Calvo, Inmaculada; Camacho, Marisol; Carmona, Loreto; de Inocencio, Jaime; Gamir, M Luz; Grana, Jenaro; La Cruz, Lucia; Loza, Estibaliz et al.
DOI: 10.1007/s00296-015-3273-6

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

PMID: 26291516
Journal: GENES IMMUN
Year: 2015
Reference: Genes Immun. 2015 Oct;16(7):470-80. doi: 10.1038/gene.2015.28. Epub 2015 Aug 20.
Impact factor:
Publication type: Paper in international publication
Authors: Amos, C I; Byun, J; Chen, W; Chinoy, H; Cooper, R G; Danko, K; Denton, Christopher; Gourley, Mark; Gregersen, P K; Hilton-Jones, David et al.
DOI: 10.1038/gene.2015.28

Antisynthetase antibodies in World Trade Center rescue and recovery workers with inflammatory myositis: comment on the article by Webber et al.

PMID: 26139542
Journal: Arthritis & rheumatology (Hoboken, N.J.)
Year: 2015
Reference: Arthritis Rheumatol. 2015 Oct;67(10):2791. doi: 10.1002/art.39260.
Impact factor:
Publication type: Letter or abstract
Authors: Labirua-Iturburu, Ane; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert et al.
DOI: 10.1002/art.39260

Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European Perspective.

PMID: 26105127
Journal: ALLERGY
Year: 2015
Reference: Allergy. 2015 Oct;70(10):1329-31. doi: 10.1111/all.12676. Epub 2015 Aug 19.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, V; Demoly, P; Hoffmann, H J; Klimek, L; Matricardi, P M; Muraro, A; Papadopoulos, N G; Renz, H; Schmid-Grendelmeier, P; Werfel, T et al.
DOI: 10.1111/all.12676

Management of angioedema without urticaria in the emergency department.

PMID: 25580506
Journal: ANNALS OF MEDICINE
Year: 2014
Reference: Ann Med. 2014 Dec;46(8):607-18. doi: 10.3109/07853890.2014.949300.
Impact factor:
Publication type: Review in international publication
Authors: Baeza, M L; Barcelo, J M; Caballero, T; Cabanas, R; Campos, A; Cimbollek, S; Daschner, A; Echechipia, M; Ferrer, M; Garces, M et al.
DOI:

First European data from the network of severe allergic reactions (NORA).

PMID: 24989080
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Oct;69(10):1397-404. doi: 10.1111/all.12475. Epub 2014 Aug 16.
Impact factor:
Publication type: Paper in international publication
Authors: Beyer, K; Bilo, M B; Cardona, V; Christoff, G; Fernandez-Rivas, M; Grabenhenrich, L B; Hourihane, J O B; Jutel, M; Kowalski, M L; Lang, R et al.
DOI: 10.1111/all.12475

International consensus on (ICON) anaphylaxis.

PMID: 24920969
Journal: World Allergy Organization Journal
Year: 2014
Reference: World Allergy Organ J. 2014 May 30;7(1):9. doi: 10.1186/1939-4551-7-9. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Ardusso, Ledit Rf; Bilo, M Beatrice; Cardona, Victoria; Ebisawa, Motohiro; El-Gamal, Yehia M; Lieberman, Phil; Lockey, Richard F; Muraro, Antonella; Roberts, Graham; Sanchez-Borges, Mario et al.
DOI: 10.1186/1939-4551-7-9

Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology.

PMID: 24909803
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Aug;69(8):1026-45. doi: 10.1111/all.12437. Epub 2014 Jun 9.
Impact factor:
Publication type: Clinical guide
Authors: Akdis, C A; Bellou, A; Beyer, K; Bilo, M B; Bindslev-Jensen, C; Brockow, K; Cardona, V; Clark, A T; Demoly, P; Dhami, S et al.
DOI: 10.1111/all.12437

Pseudocystic Encapsulation: A Late Noninflammatory Complication of Hyaluronic Acid Filler Injections.

PMID: 24112418
Journal: DERMATOLOGIC SURGERY
Year: 2013
Reference: Dermatol Surg. 2013 Nov;39(11):1726-8. doi: 10.1111/dsu.12316. Epub 2013 Oct 1.
Impact factor:
Publication type: Letter whit IF
Authors: Alijotas-Reig, Jaume; Fernandez-Figueras, Maria Teresa; Puig, Lluis et al.
DOI: 10.1111/dsu.12316

Allergology in Europe, the blueprint.

PMID: 24053537
Journal: ALLERGY
Year: 2013
Reference: Allergy. 2013 Oct;68(10):1211-8. doi: 10.1111/all.12225. Epub 2013 Sep 21.
Impact factor:
Publication type: Paper in international publication
Authors: Akdis, C A; Cardona, V; de Monchy, J G; Demoly, P; Gayraud, J; Papadopoulos, N G; Schmid-Grendelmeier, P et al.
DOI: 10.1111/all.12225

Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review.

PMID: 22753383
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 May;72(5):678-85. doi: 10.1136/annrheumdis-2011-201268. Epub 2012 Jun 29.
Impact factor:
Publication type: Review in international publication
Authors: Aksu, Guzide; Al-Abrawi, Safi ya; Al-Mayouf, Sulaiman; Alessio, Maria; Amaryan, Gayane; Anton, Jordi; Avcin, Tadej; Berendes, Rainer; Boros, Christina; Borzutzky, Arturo et al.
DOI: 10.1136/annrheumdis-2011-201268

GStream: improving SNP and CNV coverage on genome-wide association studies.

PMID: 23844243
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Jul 3;8(7):e68822. doi: 10.1371/journal.pone.0068822. Print 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Arnald; Canela-Xandri, Oriol; Julia, Antonio; Marsal, Sara; Tortosa, Raul et al.
DOI: 10.1371/journal.pone.0068822

Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis.

PMID: 23027890
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2012
Reference: J Rheumatol. 2012 Dec;39(12):2294-2302. Epub 2012 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, M Angeles; Andreu, Jose Luis; Beltran, Emma; Blanco, Francisco J; Callejas-Rubio, Jose L; Camps, Maria Teresa; Carballeira, Monica Rodriguez; Carreira, Patricia; Castellvi, Ivan; Castillo, M Jesus et al.
DOI: 10.3899/jrheum.120506

Evaluation of a shared autoimmune disease-associated polymorphism of TRAF6 in systemic sclerosis and giant cell arteritis.

PMID: 22589256
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2012
Reference: J Rheumatol. 2012 Jun;39(6):1275-9. doi: 10.3899/jrheum.120038. Epub 2012 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, M Angeles; Andreu, Jose Luis; Beltran, Emma; Blanco, Ricardo; Callejas, Jose Luis; Camps, Maria Teresa; Carballeira, Monica Rodriguez; Carmona, F David; Carreira, Patricia; Castaneda, Santos et al.
DOI: 10.3899/jrheum.120038

Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations.

PMID: 22323340
Journal: LUPUS
Year: 2012
Reference: Lupus. 2012 May;21(6):611-5. Epub 2012 Feb 9.
Impact factor:
Publication type: Paper in international publication
Authors: Gallardo, E; Labrador-Horrillo, M; Martinez-Valle, F; Ordi-Ros, J; Rojas-Garcia, R; Vilardell, M et al.
DOI: 10.1177/0961203312436856

Angiogenic and anti-angiogenic factors before and after resolution of maternal mirror syndrome.

PMID: 22081513
Journal: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
Year: 2012
Reference: Ultrasound Obstet Gynecol. 2012 Sep;40(3):367-9. doi: 10.1002/uog.10136. Epub 2012 Jul 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1002/uog.10136

Prognostic evaluation of patients with acute variceal bleeding.

PMID: 22045401
Journal: DISEASE MARKERS
Year: 2011
Reference: Dis Markers. 2011 Jan 1;31(3):155-164.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.3233/DMA-2011-0838

Foreign-body granuloma after injection of calcium hydroxylapatite for treating urinary incontinence.

PMID: 22015900
Journal: OBSTETRICS AND GYNECOLOGY
Year: 2011
Reference: Obstet Gynecol. 2011 Nov;118(5):1181-2.
Impact factor:
Publication type: Letter or abstract
Authors: Alijotas-Reig, Jaume; Alijotas-Reig, Jaume et al.
DOI: 10.1097/AOG.0b013e318235962d

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part II. Treatment, follow-up, and special situations.

PMID: 21995176
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2011
Reference: J Investig Allergol Clin Immunol. 2011;21(6):422-41; quiz 442-3.
Impact factor:
Publication type: Review in international publication
Authors: Baeza, M L; Caballero, T; Cabanas, R; Campos, A; Cimbollek, S; Gomez-Traseira, C; Gonzalez-Quevedo, T; Guilarte, M; Jurado-Palomo, J; Larco, J I et al.
DOI:

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis.

PMID: 21905496
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2011
Reference: J Investig Allergol Clin Immunol. 2011;21(5):333-47; quiz follow 347.
Impact factor:
Publication type: Review in international publication
Authors: Baeza, M L; Caballero, T; Cabanas, R; Campos, A; Cimbollek, S; Gomez-Traseira, C; Gonzalez-Quevedo, T; Guilarte, M; Jurado-Palomo, G J; Larco, J I et al.
DOI:

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress.

PMID: 20600818
Journal: BRAIN BEHAVIOR AND IMMUNITY
Year: 2010
Reference: Brain Behav Immun. 2010 Oct;24(7):1166-75. Epub 2010 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Azpiroz, Fernando; Gonzalez, Ana; Guila, Meritxell; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pigrau, Marc; Ramos, Laura; Santos, Javier et al.
DOI: 10.1016/j.bbi.2010.06.002

Implication of human endogenous retroviruses in the development of autoimmune diseases.

PMID: 20635879
Journal: INTERNATIONAL REVIEWS OF IMMUNOLOGY
Year: 2010
Reference: Int Rev Immunol. 2010 Aug;29(4):351-70.
Impact factor:
Publication type: Review in international publication
Authors: Balada, Eva; Ordi-Ros, Josep; Vilardell-Tarres, Miquel et al.
DOI: 10.3109/08830185.2010.485333

The patient has the diagnosis.

PMID: 20971367
Journal: LANCET
Year: 2010
Reference: Lancet. 2010 Oct 23;376(9750):1436.
Impact factor:
Publication type: Editorail in international publication
Authors: Grau-Junyent, Jm; Hernandez-Losa, J; Jubany, Li; Perez-Vega, C; Selva-O'Callaghan, A; Vilardell-Tarres, M et al.
DOI: 10.1016/S0140-6736(10)61049-5

[Alcoholic patient with abdominal pain and vomits]

PMID: 19576597
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Mar 6;134(6):285. Epub 2009 Jul 2.
Impact factor:
Publication type: Letter or abstract
Authors: Labirua Iturburu, Ane; Navarro i Mercade, Jordi; Solans Laque, Roser et al.
DOI: 10.1016/j.medcli.2009.04.037

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features.

PMID: 19318394
Journal: LUPUS
Year: 2009
Reference: Lupus. 2009 Apr;18(5):418-23.
Impact factor:
Publication type: Paper in international publication
Authors: Balada, E; Bujan-Rivas, S; Martinez-Valle, F; Ordi-Ros, J; Sellas-Fernandez, A; Vilardell-Tarres, M et al.
DOI: 10.1177/0961203308098189

Delayed immune-mediated adverse effects related to polyacrylamide dermal fillers: clinical findings, management, and follow-up.

PMID: 19207326
Journal: DERMATOLOGIC SURGERY
Year: 2009
Reference: Dermatol Surg. 2009 Feb;35 Suppl 1:360-6.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas Reig, Jaume; Alijotas-Reig, Jaume; Garcia-Gimenez, Victor; Miro-Mur, Francesc; Vilardell-Tarres, Miquel et al.
DOI: 10.1111/j.1524-4725.2008.01041.x

Recurrent urticarial vasculitis related to nonanimal hyaluronic acid skin filler injection.

PMID: 19207332
Journal: DERMATOLOGIC SURGERY
Year: 2009
Reference: Dermatol Surg. 2009 Feb;35 Suppl 1:395-7; discussion 397-8.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas Reig, Jaume; Alijotas-Reig, Jaume et al.
DOI: 10.1111/j.1524-4725.2008.01049.x

[Treatment of Raynaud's phenomenon]

PMID: 19268093
Journal: REVISTA CLINICA ESPANOLA
Year: 2009
Reference: Rev Clin Esp. 2009 Jan;209(1):21-4.
Impact factor:
Publication type: Paper in national publication
Authors: Fonollosa-Pla, V; Pilar Simeon-Aznar, C; Vilardell-Tarres, M et al.
DOI:

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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.