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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Antonio González Fernández

Antonio González Fernández

Senior researcher
Systemic Diseases
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Ariadna Anunciacion Llunell

Ariadna Anunciacion Llunell

Predoctoral researcher
Systemic Diseases
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Basilio Rodriguez  Diez

Basilio Rodriguez Diez

Senior researcher
Systemic Diseases
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Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
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David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
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Antonio González Fernández

Antonio González Fernández

Senior researcher
Systemic Diseases
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Ariadna Anunciacion Llunell

Ariadna Anunciacion Llunell

Predoctoral researcher
Systemic Diseases
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Basilio Rodriguez  Diez

Basilio Rodriguez Diez

Senior researcher
Systemic Diseases
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Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
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David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
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Research lines

Evaluation and characterization of cardiac involvement in patients with Systemic Sclerosis.

Cardiac involvement is one of the most serious internal organ involvements and the leading cause of death in SSc patients. The prevalence is 14% by clinical observation and even higher by autopsy Many SSc patients with cardiac involvement are asymptomatic or underdiagnosed. The condition may progress silently to overt clinical manifestations, including systolic and/or diastolic dysfunction, myocardial ischaemia, myocardial hypertrophy, heart failure, pericardial effusion and arrhythmias. Early detection of cardiac abnormalities is therefore very important. We evaluate cardiac involvement by echocardiography, MR, SPECT, and coronary CT.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

Genetic bases of Behçet disease.

We are currently enrolled in this multicentre study to investigate the possible influence of the genetic background in the disease pathogenesis, and to try to establish links between genetic variations and different clinical and biological patterns. The research is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute by sending samples from our cohort of patients along with the clinical data, and reviewing the results. It is supported by a SAS grant.

IP: Roser Solans Laque

Genetic bases of giant cell arteritis (GCA).

With this study we aim to investigate the genetic background of the disease, to deepen in its pathogenesis and to be able to establish links between genetic variations and different clinic and biologic patterns. This research is based on a multicentric study and it is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute by sending samples from our cohort of patients along with the clinical data, and reviewing the results.

IP: Roser Solans Laque

Genetic basis of scleroderma.

With this study we aim at studying the genetic background of the disease to deepen in its pathogenesis to be able to establish links between genetic variations and different clinic-biologic patterns. This research is based on a multicentric study and it is led by Prof. Javier Martín from the "Instituto López-Neyra" of Parasitology, CSIC (Granada). We contribute to it by sending samples from our cohort of patients along with the clinical data.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

Projects

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Jordi Riera Heredia, Marta Montpeyó Garcia-Moreno, Daniela Samaniego Toro, Laura Castillo Ribelles
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Identificación de biomarcadores celulares y moleculares en angioedema idiopático y hereditario para su diferenciación en fenotipos y endotipos

IP: Mar Guilarte Clavero
Collaborators: Manuel Hernández González, Moisés Labrador Horrillo, Anna Sala Cunill, Olga Luengo Sanchez, Paula Galvan Blasco, Ingrid Johana Gil Serrano
Funding agency: Instituto de Salud Carlos III
Funding: 84700
Reference: PI20/01061
Duration: 01/01/2021 - 30/06/2025

Design of an integrative patients stratification approach for the systemic sclerosis management

IP: Carmen Pilar Simeón i Aznar
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 72250
Reference: 202022-30-31-32-33
Duration: 10/05/2021 - 09/05/2024

Publications

In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case-control study.

PMID: 37666644
Journal: RMD Open
Year: 2023
Reference: RMD Open. 2023 Sep;9(3):e003081. doi: 10.1136/rmdopen-2023-003081.
Impact factor:
Publication type: Paper in international publication
Authors: Arnaud, Laurent; Barsotti, Simone; Bellando-Randone, Silvia; Bernardi, Livio; Bini, Paola; Blagojevic, Jelena; Bouchard-Marmen, Maude; Cavagna, Lorenzo; Codullo, Veronica; Couderc, Marion et al.
DOI: 10.1136/rmdopen-2023-003081

Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism.

PMID: 37666646
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2023
Reference: Ann Rheum Dis. 2023 Sep 4:ard-2023-224460. doi: 10.1136/ard-2023-224460.
Impact factor:
Publication type: Paper in international publication
Authors: Alamo-Moreno, Jose R; Alvarez-Abella, Alba; Andres, Mariano; Andres, Mariano; Arostegui, Juan I; Bonet, Nuria; Bujan, Segundo; Bujan, Segundo; Caminal-Montero, Luis; Casals, Ferran et al.
DOI: 10.1136/ard-2023-224460

Does the impact of COVID-19 on patients with systemic sclerosis change over time?

PMID: 37667424
Journal: ARTHRITIS CARE & RESEARCH
Year: 2023
Reference: Arthritis Care Res (Hoboken). 2023 Sep 4. doi: 10.1002/acr.25226.
Impact factor:
Publication type: Paper in international publication
Authors: Airo, Paolo; Alegre-Sancho, Juan J; Allanore, Yannick; Atzeni, Fabiola; Balbir-Gurman, Alexandra; Becvar, Radim; Belloli, Laura; Bernardino, Vera; Brito de Araujo, Daniel; Brunborg, Cathrine et al.
DOI: 10.1002/acr.25226

Identification of Unique microRNA Profiles in Different Types of Idiopathic Inflammatory Myopathy.

PMID: 37681930
Journal: Cells
Year: 2023
Reference: Cells. 2023 Sep 2;12(17):2198. doi: 10.3390/cells12172198.
Impact factor:
Publication type: Paper in international publication
Authors: Albayda, Jemima; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Corse, Andrea M; Dell'Orso, Stefania; Gadina, Massimo; Grau-Junyent, Josep Maria; Grau-Junyent, Josep Maria; Gutierrez-Cruz, Gustavo; Lloyd, Thomas E et al.
DOI: 10.3390/cells12172198

Tacrolimus CYP3A Single-Nucleotide Polymorphisms and Preformed T- and B-Cell Alloimmune Memory Improve Current Pretransplant Rejection-Risk Stratification in Kidney Transplantation.

PMID: 35833145
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Jun 27;13:869554. doi: 10.3389/fimmu.2022.869554. eCollection 2022.
Impact factor: 7.561
Publication type: Paper in international publication
Authors: Crespo, Elena, Vidal-Alabro, Anna, Jouve, Thomas, Fontova, Pere, Stein, Maik, Mocka, Sonila, Meneghini, Maria, Sefrin, Anett, Hruba, Petra, Goma, Montserrat et al.
DOI: 10.3389/fimmu.2022.869554

COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study.

PMID: 35713499
Journal: RHEUMATOLOGY
Year: 2022
Reference: Rheumatology (Oxford). 2022 Jun 17. pii: 6609762. doi: 10.1093/rheumatology/keac305.
Impact factor: 7.58
Publication type: Paper in international publication
Authors: Parodis, Ioannis, O'Callaghan, Albert Selva, Nikiphorou, Elena, Chatterjee, Tulika, Tan, Ai Lyn, Cavagna, Lorenzo, Saavedra, Miguel A, Shinjo, Samuel Katsuyuki, Ziade, Nelly, Knitza, Johannes et al.
DOI: 10.1093/rheumatology/keac305

Clinico-pathological phenotypes of Systemic Sclerosis associated myopathy: analysis of a multicenter large cohort.

PMID: 35713496
Journal: RHEUMATOLOGY
Year: 2022
Reference: Rheumatology (Oxford). 2022 Jun 17. pii: 6609769. doi: 10.1093/rheumatology/keac361.
Impact factor: 7.58
Publication type: Paper in international publication
Authors: Prieto-Gonzalez, Sergio, Matas-Garcia, Ana, Guillen-Del-Castillo, Alfredo, Kisluk, Boris, Selva-O'Callaghan, Albert, Espinosa, Gerard, Milisenda, Jose C, Simeon-Aznar, Carmen Pilar, Grau-Junyent, Josep Maria, Garrabou, Gloria et al.
DOI: 10.1093/rheumatology/keac361

Left ventricular diastolic dysfunction in systemic sclerosis: Clinical, immunological and survival differences in the Spanish RESCLE registry.

PMID: 35691226
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2022
Reference: Semin Arthritis Rheum. 2022 Aug;55:152033. doi: 10.1016/j.semarthrit.2022.152033. Epub 2022 May 28.
Impact factor: 5.532
Publication type: Paper in international publication
Authors: Freire, Mayka, Chamorro, Antonio-J, Perales Fraile, Isabel, Madronero Vuelta, Ana Belen, Sanchez Trigo, Sabela, Tolosa Vilella, Carles, Fonollosa Pla, Vicent, Simeon Aznar, Carmen Pilar, Herranz Marin, Maria Teresa, Trapiella Martinez, Luis et al.
DOI: 10.1016/j.semarthrit.2022.152033

Development and validation of combined symptom-medication scores for allergic rhinitis.

PMID: 34932829
Journal: ALLERGY
Year: 2021
Reference: Allergy. 2021 Dec 21. doi: 10.1111/all.15199.
Impact factor: 13.146
Publication type: Paper in international publication
Authors: Agache, Ioana, Sousa-Pinto, Bernardo, Filipe Azevedo, Luis, Jutel, Marek, Gemicioglu, Bilun, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan Carlos, Kvedariene, Violeta, Kuna, Piotr et al.
DOI: 10.1111/all.15199

Influence of the age at diagnosis in the disease expression of primary Sjogren syndrome. Analysis of 12,753 patients from the Sjogren Big Data Consortium.

PMID: 34919044
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):166-174. Epub 2021 Dec 16.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Sandhya, Pulukool, Retamozo, Soledad, Acar-Denizli, Nihan, Horvath, Ildiko Fanny, Ng, Wan-Fai, Rasmussen, Astrid, Dong, Xu, Li, Xiaomei, Baldini, Chiara, Olsson, Peter et al.
DOI:

Serum CXCL13, BAFF, IL-21 and IL-22 levels are related to disease activity and lymphocyte profile in primary Sjogren's syndrome.

PMID: 34919042
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):131-139. Epub 2021 Dec 15.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Loureiro-Amigo, Jose, Franco-Jarava, Clara, Perurena-Prieto, Janire, Palacio, Carlos, Martinez-Valle, Fernando, Solans-Laque, Roser et al.
DOI:

Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjogren's syndrome: an OMERACT reliability exercise.

PMID: 34849616
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Nov 25. pii: 6440080. doi: 10.1093/rheumatology/keab876.
Impact factor: 7.58
Publication type: Paper in international publication
Authors: Ohrndorf, Sarah, Perko, Nejc, Schmidt, Wolfgang A, Tamborrini, Giorgio, Tomsic, Matija, Chary-Valckenaere, Isabelle, Zabotti, Alen, Keen, Helen I, Pineda, Carlos, D'Agostino, Maria-Antonietta et al.
DOI: 10.1093/rheumatology/keab876

Systemic phenotype related to primary Sjogren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies.

PMID: 33095152
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2020
Reference: Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):85-94. Epub 2020 Oct 22.
Impact factor: 3.319
Publication type: Paper in international publication
Authors: Rischmueller, Maureen, Pasoto, Sandra G, Nordmark, Gunnel, Nakamura, Hideki, Fernandes Moca Trevisani, Virginia, Retamozo, Soledad, Carsons, Steven E, Maure-Noia, Brenda, Sanchez-Berna, Isabel, Lopez-Dupla, Miguel et al.
DOI:

Effectiveness of a Multicomponent Treatment for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): A Pragmatic Randomized Controlled Trial.

PMID: 33081069
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Oct 18;9(10). pii: jcm9103348. doi: 10.3390/jcm9103348.
Impact factor: 3.303
Publication type: Paper in international publication
Authors: Serrat, Mayte, Almirall, Miriam, Muste, Marta, Sanabria-Mazo, Juan P, Feliu-Soler, Albert, Mendez-Ulrich, Jorge L, Luciano, Juan V, Sanz, Antoni et al.
DOI: 10.3390/jcm9103348

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.

PMID: 32977850
Journal: Genome Medicine
Year: 2020
Reference: Genome Med. 2020 Sep 25;12(1):81. doi: 10.1186/s13073-020-00779-6.
Impact factor: 10.675
Publication type: Paper in international publication
Authors: Ortiz-Fernandez, Lourdes, Andres-Leon, Eduardo, Ciudad, Laura, Javierre, Biola M, Lopez-Isac, Elena, Guillen-Del-Castillo, Alfredo, Simeon-Aznar, Carmen Pilar, Ballestar, Esteban, Li, Tianlu, Martin, Javier et al.
DOI: 10.1186/s13073-020-00779-6

Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic.

PMID: 32947588
Journal: JOURNAL OF ORTHOPAEDIC TRAUMA
Year: 2020
Reference: J Orthop Trauma. 2020 Oct;34(10):e377-e381. doi: 10.1097/BOT.0000000000001903.
Impact factor: 1.897
Publication type: Paper in international publication
Authors: Teixidor-Serra, Jordi, Bhandari, Mohit, Tomas-Hernandez, Jordi, Porcel-Vazquez, Juan A, Andres-Peiro, Jose V, Garcia-Sanchez, Yaiza, Guerra-Farfan, Ernesto, Mestre-Torres, Jaume, Minguell-Monyart, Joan, Molero-Garcia, Vicente et al.
DOI: 10.1097/BOT.0000000000001903

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

PMID: 30573655
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2019
Reference: Ann Rheum Dis. 2019 Mar;78(3):311-319. doi: 10.1136/annrheumdis-2018-214127. Epub 2018 Dec 20.
Impact factor: 14.299
Publication type: Paper in international publication
Authors: Lamb, Janine A, Martin, Javier, Miller, Frederick W, Chen, Wei, O'Hanlon, Terrance P, Cooper, Robert G, Vencovsky, Jiri, Rider, Lisa G, Danko, Katalin, Wedderburn, Lucy R et al.
DOI: 10.1136/annrheumdis-2018-214127

ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy": AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Sante) POLLAR (Impact of Air POLLution on Asthma and Rhinitis) GARD Demonstration project.

PMID: 30565275
Journal: ALLERGY
Year: 2019
Reference: Allergy. 2019 Jul;74(7):1219-1236. doi: 10.1111/all.13701. Epub 2019 Apr 30.
Impact factor: 6.771
Publication type: Review in international publication
Authors: Bosnic-Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenco, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Correia de Sousa, Jaime, Cruz, Alvaro A, Czarlewski, Wienczyslawa et al.
DOI: 10.1111/all.13701

Objectives and methodology of BIOBADASER phase iii.

PMID: 28935290
Journal: Reumatologia clinica
Year: 2019
Reference: Reumatol Clin. 2019 Jul - Aug;15(4):229-236. doi: 10.1016/j.reuma.2017.08.001. Epub 2017 Sep 19.
Impact factor: 0
Publication type: Paper in national publication
Authors: Del Pino-Montes, Javier, Sanchez-Piedra, Carlos, Hernandez Miguel, M Victoria, Manero, Javier, Rosello, Rosa, Sanchez-Costa, Jesus Tomas, Rodriguez-Lozano, Carlos, Campos, Cristina, Cuende, Eduardo, Fernandez-Lopez, Jesus Carlos et al.
DOI: 10.1016/j.reuma.2017.08.001

Time to revisit the definition and clinical criteria for anaphylaxis?

PMID: 31719946
Journal: World Allergy Organization Journal
Year: 2019
Reference: World Allergy Organ J. 2019 Oct 31;12(10):100066. doi: 10.1016/j.waojou.2019.100066. eCollection 2019 Oct.
Impact factor: 3.684
Publication type: Paper in international publication
Authors: Turner, Paul J, Worm, Margitta, Ansotegui, Ignacio J, El-Gamal, Yehia, Rivas, Montserrat Fernandez, Fineman, Stanley, Geller, Mario, Gonzalez-Estrada, Alexei, Greenberger, Paul A, Tanno, Luciana K et al.
DOI: 10.1016/j.waojou.2019.100066

Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

PMID: 30471769
Journal: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Year: 2018
Reference: Prostaglandins Leukot Essent Fatty Acids. 2018 Dec;139:20-24. doi: 10.1016/j.plefa.2018.11.006. Epub 2018 Nov 9.
Impact factor: 2.437
Publication type: Paper in international publication
Authors: Zaragoza, Maria Cleofe, Domingo, Joan Carles, Martinez-Martinez, Alba, Alegre, Jose, von Schacky, Clemens, Castro-Marrero, Jesus et al.
DOI: 10.1016/j.plefa.2018.11.006

Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study.

PMID: 30464782
Journal: World Allergy Organization Journal
Year: 2018
Reference: World Allergy Organ J. 2018 Nov 16;11(1):32. doi: 10.1186/s40413-018-0216-1. eCollection 2018.
Impact factor: 5.676
Publication type: Paper in international publication
Authors: Maurer, M, Houghton, K, Costa, C, Dabove, F, Ensina, L F, Gimenez-Arnau, A, Guillet, G, Konstantinou, G N, Labrador-Horrillo, M, Lapeere, H et al.
DOI: 10.1186/s40413-018-0216-1

Persistence and adverse events of biological treatment in adult patients with juvenile idiopathic arthritis: results from BIOBADASER.

PMID: 30305158
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2018
Reference: Arthritis Res Ther. 2018 Oct 10;20(1):227. doi: 10.1186/s13075-018-1728-3.
Impact factor: 4.269
Publication type: Paper in international publication
Authors: Bethencourt Baute, Juan Jose, Sanchez-Piedra, Carlos, Ruiz-Montesinos, Dolores, Medrano San Ildefonso, Marta, Rodriguez-Lozano, Carlos, Perez-Pampin, Eva, Ortiz, Ana, Manrique, Sara, Rosello, Rosa, Hernandez, Victoria et al.
DOI: 10.1186/s13075-018-1728-3

Food-induced fatal anaphylaxis: from epidemiological data to general prevention strategies.

PMID: 30288817
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2018
Reference: Clin Exp Allergy. 2018 Dec;48(12):1584-1593. doi: 10.1111/cea.13287. Epub 2018 Nov 26.
Impact factor: 5.158
Publication type: Paper in international publication
Authors: Pouessel, Guillaume, Turner, Paul J, Worm, Margitta, Cardona, Victoria, Deschildre, Antoine, Beaudouin, Etienne, Renaudin, Jean-Marie, Demoly, Pascal, Tanno, Luciana K et al.
DOI: 10.1111/cea.13287

DUSP23 is overexpressed and linked to the expression of DNMTs in CD4+ T cells from Systemic Lupus Erythematosus patients.

PMID: 27737517
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2017
Reference: Clin Exp Immunol. 2017 Feb;187(2):242-250. doi: 10.1111/cei.12883. Epub 2016 Nov 16.
Impact factor: 3.148
Publication type: Paper in international publication
Authors: Balada, E, Felip, L, Ordi-Ros, J, Vilardell-Tarres, M et al.
DOI: 10.1111/cei.12883

Preliminary definitions for the sonographic features of synovitis in children.

PMID: 27748074
Journal: ARTHRITIS CARE & RESEARCH
Year: 2017
Reference: Arthritis Care Res (Hoboken). 2017 Aug;69(8):1217-1223. doi: 10.1002/acr.23130.
Impact factor: 3.229
Publication type: Paper in international publication
Authors: Naredo, Esperanza, Herlin, Troels, Hernandez, Cristina, Iagnocco, Annamaria, Jousse-Joulin, Sandrine, Lanni, Stefano, Lilleby, Vibke, Malattia, Clara, Magni-Manzoni, Silvia, Modesto, Consuelo et al.
DOI: 10.1002/acr.23130

Anti-IL6-R Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to anti-TNF therapy. A multicenter study of 25 patients.

PMID: 27696756
Journal: Arthritis & Rheumatology
Year: 2017
Reference: Arthritis Rheumatol. 2017 Mar;69(3):668-675. doi: 10.1002/art.39940.
Impact factor: 6.009
Publication type: Paper in international publication
Authors: Calvo-Rio, Vanesa, Santos-Gomez, Montserrat, Calvo, Inmaculada, Gonzalez-Fernandez, Ma Isabel, Lopez Montesinos, Berta, Mesquida, Marina, Adan, Alfredo, Victoria Hernandez, Maria, Maiz, Olga, Atanes, Antonio et al.
DOI: 10.1002/art.39940

Lettuce allergy is a lipid transfer syndrome-related food allergy with high risk of severe reactions.

PMID: 27609533
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2017
Reference: J Investig Allergol Clin Immunol. 2017;27(2):98-103. doi: 10.18176/jiaci.0110. Epub 2016 Sep 9.
Impact factor: 2.131
Publication type: Paper in international publication
Authors: Cardona, V, Pastor-Vargas, C, Cuesta-Herranz, J, Moreno-Perez, N, Luengo-Sanchez, O, Munoz-Garcia, E et al.
DOI: 10.18176/jiaci.0110

Diagnostic and therapeutic delay of rheumatoid arthritis and its relationship with health care devices in Catalonia. The AUDIT study.

PMID: 26362843
Journal: Reumatologia clinica
Year: 2016
Reference: Reumatol Clin. 2016 May-Jun;12(3):146-50. doi: 10.1016/j.reuma.2015.08.002. Epub 2015 Sep 8.
Impact factor: 0
Publication type: Paper in national publication
Authors: Corominas, Hector, Narvaez, Javier, Diaz-Torne, Cesar, Salvador, Georgina, Gomez-Caballero, Maria Eugenia, de la Fuente, Diana, Campoy, Ester, Roig-Vilaseca, Daniel, Clavaguera, Teresa, Morla, Rosa et al.
DOI: 10.1016/j.reuma.2015.08.002

Burden and direct costs of non infectious uveitis in Spain.

PMID: 26490513
Journal: Reumatologia clinica
Year: 2016
Reference: Reumatol Clin. 2016 Jul-Aug;12(4):196-200. doi: 10.1016/j.reuma.2015.08.004. Epub 2015 Oct 17.
Impact factor: 0
Publication type: Paper in national publication
Authors: Adan-Civera, Alfredo Manuel, Benitez-Del-Castillo, Jose Manuel, Blanco-Alonso, Ricardo, Pato-Cour, Esperanza, Sellas-Fernandez, Agusti, Banares-Canizares, Antonio et al.
DOI: 10.1016/j.reuma.2015.08.004

Omalizumab: what benefits should we expect?

PMID: 27210073
Journal: EUROPEAN JOURNAL OF DERMATOLOGY
Year: 2016
Reference: Eur J Dermatol. 2016 Aug 1;26(4):340-4. doi: 10.1684/ejd.2016.2809.
Impact factor: 2.069
Publication type: Paper in international publication
Authors: Silvestre Salvador, Juan Francisco, Labrador-Horrillo, Moises, Armario Hita, Jose Carlos, Velasco, Manel, Gimenez-Arnau, Ana et al.
DOI: 10.1684/ejd.2016.2809

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.

PMID: 26362759
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Aug;75(8):1558-66. doi: 10.1136/annrheumdis-2015-208119. Epub 2015 Sep 11.
Impact factor: 12.384
Publication type: Paper in international publication
Authors: Mathiesen, Pernille, Rothwell, Simon, Cooper, Robert G, Lundberg, Ingrid E, Miller, Frederick W, Gregersen, Peter K, Bowes, John, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya et al.
DOI: 10.1136/annrheumdis-2015-208119

Consensus of the Spanish society of pediatric rheumatology for transition management from pediatric to adult care in rheumatic patients with childhood onset.

PMID: 25917856
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2015
Reference: Rheumatol Int. 2015 Oct;35(10):1615-24. doi: 10.1007/s00296-015-3273-6. Epub 2015 Apr 28.
Impact factor: 1.516
Publication type: Paper in international publication
Authors: Calvo, Inmaculada, Anton, Jordi, Bustabad, Sagrario, Camacho, Marisol, de Inocencio, Jaime, Gamir, M Luz, Grana, Jenaro, La Cruz, Lucia, Robledillo, Juan Carlos Lopez, Medrano, Marta et al.
DOI: 10.1007/s00296-015-3273-6

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

PMID: 26291516
Journal: GENES AND IMMUNITY
Year: 2015
Reference: Genes Immun. 2015 Oct;16(7):470-80. doi: 10.1038/gene.2015.28. Epub 2015 Aug 20.
Impact factor: 2.913
Publication type: Paper in international publication
Authors: Miller, F W, Kiely, Patrick, Plotz, Paul H, Gourley, Mark, Varsani, Hemlata, Hilton-Jones, David, Denton, Christopher, Amos, C I, Gregersen, P K, Chen, W et al.
DOI: 10.1038/gene.2015.28

Antisynthetase antibodies in World Trade Center rescue and recovery workers with inflammatory myositis: comment on the article by Webber et al.

PMID: 26139542
Journal: Arthritis & Rheumatology
Year: 2015
Reference: Arthritis Rheumatol. 2015 Oct;67(10):2791. doi: 10.1002/art.39260.
Impact factor: 0
Publication type: Letter or abstract
Authors: Pinal-Fernandez, Iago, Selva-O'Callaghan, Albert, Labirua-Iturburu, Ane et al.
DOI: 10.1002/art.39260

Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European Perspective.

PMID: 26105127
Journal: ALLERGY
Year: 2015
Reference: Allergy. 2015 Oct;70(10):1329-31. doi: 10.1111/all.12676. Epub 2015 Aug 19.
Impact factor: 6.028
Publication type: Paper in international publication
Authors: Klimek, L, Hoffmann, H J, Renz, H, Demoly, P, Werfel, T, Matricardi, P M, Muraro, A, Schmid-Grendelmeier, P, Cardona, V, Papadopoulos, N G et al.
DOI: 10.1111/all.12676

Eosinophilic myositis: an updated review.

PMID: 24424174
Journal: AUTOIMMUN REV
Year: 2014
Reference: Autoimmun Rev. 2014 Apr-May;13(4-5):375-8. doi: 10.1016/j.autrev.2014.01.018. Epub 2014 Jan 11.
Impact factor: 7.095
Publication type: Review in international publication
Authors: Selva-O'Callaghan, A, Trallero-Araguas, E, Grau, J M et al.
DOI: 10.1016/j.autrev.2014.01.018

Mortality and survival in systemic sclerosis: systematic review and meta-analysis.

PMID: 24931517
Journal: SEMIN ARTHRITIS RHEU
Year: 2014
Reference: Semin Arthritis Rheum. 2014 Oct;44(2):208-19. doi: 10.1016/j.semarthrit.2014.05.010. Epub 2014 May 14.
Impact factor: 3.629
Publication type: Review in international publication
Authors: Rubio-Rivas, Manuel, Royo, Cristina, Simeon, Carmen Pilar, Corbella, Xavier, Fonollosa, Vicent et al.
DOI: 10.1016/j.semarthrit.2014.05.010

Novel insights into the regulatory architecture of CD4+ T cells in rheumatoid arthritis.

PMID: 24959711
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jun 24;9(6):e100690. doi: 10.1371/journal.pone.0100690. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Aterido, Adria, Palacio, Carlos, Marsal, Sara, Avila, Gabriela, Julia, Antonio et al.
DOI: 10.1371/journal.pone.0100690

Atypical scleromyxedema with prominent nodular lesions associated with immune thrombocytopenia: an unusual presentation.

PMID: 25219747
Journal: J AM ACAD DERMATOL
Year: 2014
Reference: J Am Acad Dermatol. 2014 Oct;71(4):e158-9. doi: 10.1016/j.jaad.2014.07.004.
Impact factor: 5.004
Publication type: Letter or abstract
Authors: Lopez-Lerma, Ingrid, Fernandez-Codina, Andreu, Hilari, Helena, Ferrer, Berta, Selva-O'Callaghan, Albert, Garcia-Patos, Vicente et al.
DOI: 10.1016/j.jaad.2014.07.004

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

PMID: 23983088
Journal: ARTHRITIS AND RHEUMATISM
Year: 2013
Reference: Arthritis Rheum. 2013 Dec;65(12):3239-47. doi: 10.1002/art.38137.
Impact factor: 7.477
Publication type: Paper in international publication
Authors: Over, Katherine, Ytterberg, Steven R, Padyukov, Leonid, Selva-O'Callaghan, Albert, Radstake, Timothy R D J, Isenberg, David A, Chinoy, Hector, Ollier, William E R, O'Hanlon, Terrance P, Peng, Bo et al.
DOI: 10.1002/art.38137

Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.

PMID: 24267790
Journal: BMC GENOMICS
Year: 2013
Reference: BMC Genomics. 2013 Nov 23;14:825. doi: 10.1186/1471-2164-14-825.
Impact factor: 4.397
Publication type: Paper in international publication
Authors: Fonseca, Eduardo, Fernandez, Emilia, Lopez-Lasanta, Maria, Tortosa, Raul, Marsal, Sara, Puig, Lluis, Ferrandiz, Carlos, Julia, Antonio, Palau, Nuria et al.
DOI: 10.1186/1471-2164-14-825

GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis.

PMID: 23651021
Journal: PHARMACOGENOMICS
Year: 2013
Reference: Pharmacogenomics. 2013 May;14(7):727-34. doi: 10.2217/pgs.13.60.
Impact factor: 3.857
Publication type: Paper in international publication
Authors: Tortosa, Raul, Acosta-Colman, Isabel, Palau, Nuria, Tornero, Jesus, Fernandez-Nebro, Antonio, Blanco, Francisco, Gonzalez-Alvaro, Isidoro, Canete, Juan D, Maymo, Joan, Ballina, Javier et al.
DOI: 10.2217/pgs.13.60

The genetic architecture of rheumatoid arthritis: from susceptibility to clinical subphenotype associations.

PMID: 23574521
Journal: CURRENT TOPICS IN MEDICINAL CHEMISTRY
Year: 2013
Reference: Curr Top Med Chem. 2013;13(6):720-31.
Impact factor: 3.702
Publication type: Paper in international publication
Authors: Julia, Antonio, Marsal, Sara et al.
DOI:

Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis.

PMID: 23027890
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2012
Reference: J Rheumatol. 2012 Dec;39(12):2294-2302. Epub 2012 Oct 1.
Impact factor: 3.695
Publication type: Paper in international publication
Authors: Blanco, Francisco J, Cenit, Maria Carmen, Simeon, Carmen P, Vonk, Madelon C, Callejas-Rubio, Jose L, Espinosa, Gerard, Carreira, Patricia, Worthington, Jane, Koeleman, Bobby P, Radstake, Timothy R D J et al.
DOI: 10.3899/jrheum.120506

Evaluation of a shared autoimmune disease-associated polymorphism of TRAF6 in systemic sclerosis and giant cell arteritis.

PMID: 22589256
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2012
Reference: J Rheumatol. 2012 Jun;39(6):1275-9. doi: 10.3899/jrheum.120038. Epub 2012 May 15.
Impact factor: 3.695
Publication type: Paper in international publication
Authors: Gallego, Maria, Sanchez-Roman, Julio, Garcia-Hernandez, Francisco Jose, Castillo, M Jesus, Aguirre, M Angeles, Gomez-Gracia, Inmaculada, Fernandez-Gutierrez, Benjamin, Vicente, Esther, Andreu, Jose Luis, de Castro, Monica Fernandez et al.
DOI: 10.3899/jrheum.120038

Criterion and concurrent validity of Conners Adult ADHD Diagnostic Interview for DSM-IV (CAADID) Spanish version.

PMID: 23021295
Journal: Revista de psiquiatria y salud mental
Year: 2012
Reference: Rev Psiquiatr Salud Ment. 2012 Oct-Dec;5(4):229-35. doi: 10.1016/j.rpsm.2012.05.004. Epub 2012 Jul 4.
Impact factor: 0.308
Publication type: Paper in national publication
Authors: Vidal, Raquel, Chalita, Pablo J, Casas, Miguel, Real, Alberto, Corominas, Margarida, Corrales, Montse, Ramos-Quiroga, Josep Antoni, Bosch, Rosa, Richarte, Vanesa, Valero, Sergi et al.
DOI: 10.1016/j.rpsm.2012.05.004

Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations.

PMID: 22323340
Journal: LUPUS
Year: 2012
Reference: Lupus. 2012 May;21(6):611-5. Epub 2012 Feb 9.
Impact factor: 2.337
Publication type: Paper in international publication
Authors: Labrador-Horrillo, M, Martinez-Valle, F, Gallardo, E, Rojas-Garcia, R, Ordi-Ros, J, Vilardell, M et al.
DOI: 10.1177/0961203312436856

[Guideline for the management of anaphylaxis].

PMID: 21168172
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Mar 26;136(8):349-55. Epub 2010 Dec 17.
Impact factor: 1.413
Publication type: Paper in national publication
Authors: Pascual Marcos, Cristina, Vega Castro, Arantza, Villarroel Gonzalez, Pedro, Chivato Perez, Tomas, Nevot Falco, Santiago, Lobera Labairu, Teofilo, de la Hoz Caballer, Belen, Guardia Martinez, Pedro, Cardona Dahl, V, Cardona Dahl, Victoria et al.
DOI: 10.1016/j.medcli.2010.10.003

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part II. Treatment, follow-up, and special situations.

PMID: 21995176
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2011
Reference: J Investig Allergol Clin Immunol. 2011;21(6):422-41; quiz 442-3.
Impact factor: 1.489
Publication type: Review in international publication
Authors: Caballero, T, Baeza, M L, Cabanas, R, Campos, A, Cimbollek, S, Gomez-Traseira, C, Gonzalez-Quevedo, T, Guilarte, M, Jurado-Palomo, J, Larco, J I et al.
DOI:

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis.

PMID: 21905496
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2011
Reference: J Investig Allergol Clin Immunol. 2011;21(5):333-47; quiz follow 347.
Impact factor: 1.489
Publication type: Review in international publication
Authors: Lopez-Trascasa, M, Marcos, C, Munoz-Caro, J M, Pedrosa, M, Prior, N, Rubio, M, Sala-Cunill, A, Lopez-Serrano, M C, Larco, J I, Guilarte, M et al.
DOI:

Venous thromboembolism in patients with dermatomyositis and polymyositis.

PMID: 21962007
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2011
Reference: Clin Exp Rheumatol. 2011 Sep-Oct;29(5):846-9. Epub 2011 Oct 31.
Impact factor: 2.358
Publication type: Paper in international publication
Authors: , , , , et al.
DOI:

Are Bacterial Growth and/or Chemotaxis Increased by Filler Injections? Implications for the Pathogenesis and Treatment of Filler-Related Granulomas.

PMID: 21071919
Journal: DERMATOLOGY
Year: 2010
Reference: Dermatology. 2010;221(4):356-64. Epub 2010 Nov 15.
Impact factor: 2.741
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1159/000321329

[Sleep disorders and restless legs syndrome in an adult with Asperger's disorder, a case report].

PMID: 20738960
Journal: NEUROLOGIA
Year: 2010
Reference: Neurologia. 2010 Jul-Aug;25(6):393-4.
Impact factor: 0.596
Publication type: Letter or abstract
Authors: Lopez-Ortiz, C, Saez-Francas, N, Roncero, C et al.
DOI:

CNstream: a method for the identification and genotyping of copy number polymorphisms using Illumina microarrays.

PMID: 20482829
Journal: BMC BIOINFORMATICS
Year: 2010
Reference: BMC Bioinformatics. 2010 May 19;11:264.
Impact factor: 3.428
Publication type: Paper in international publication
Authors: Alonso, Arnald, Julia, Antonio, Tortosa, Raul, Canaleta, Cristina, Canete, Juan D, Ballina, Javier, Balsa, Alejandro, Tornero, Jesus, Marsal, Sara et al.
DOI: 10.1186/1471-2105-11-264

Implication of human endogenous retroviruses in the development of autoimmune diseases.

PMID: 20635879
Journal: INTERNATIONAL REVIEWS OF IMMUNOLOGY
Year: 2010
Reference: Int Rev Immunol. 2010 Aug;29(4):351-70.
Impact factor: 2.641
Publication type: Review in international publication
Authors: Balada, Eva, Vilardell-Tarres, Miquel, Ordi-Ros, Josep et al.
DOI: 10.3109/08830185.2010.485333

Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

PMID: 19442287
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2009
Reference: Arthritis Res Ther. 2009;11(3):R69.
Impact factor: 4.485
Publication type: Paper in international publication
Authors: Domenico Sebastiani, Gian, Ruzickova, Sarka, Jose Santos, Maria, Papasteriades, Chryssa, Marchini, Maurizio, Skopouli, Fotini N, Suarez, Ana, Blanco, Francisco J, D'Alfonso, Sandra, Bijl, Marc et al.
DOI: 10.1186/ar2698

Genetic structure of Europeans: a view from the North-East.

PMID: 19424496
Journal: PLoS One
Year: 2009
Reference: PLoS One. 2009;4(5):e5472.
Impact factor:
Publication type: Letter or abstract
Authors: Meitinger, Thomas, Nelis, Mari, Esko, Tonu, Magi, Reedik, Zimprich, Fritz, Zimprich, Alexander, Toncheva, Draga, Karachanak, Sena, Piskackova, Tereza, Balascak, Ivan et al.
DOI: 10.1371/journal.pone.0005472

Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor alpha therapy in rheumatoid arthritis.

PMID: 18495732
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2009
Reference: Ann Rheum Dis. 2009 May;68(5):751-6.
Impact factor: 7.188
Publication type: Paper in international publication
Authors: Pablos, J L, de la Cruz, J, Lora, D, Sanmarti, R, Canete, J D, Celis, R, Moll, C, Izquierdo, E, Marsal, S, Palacin, A et al.
DOI: 10.1136/ard.2008.089284

Randomized clinical trial of the effectiveness of a home-based intervention in patients with heart failure: the IC-DOM study.

PMID: 19401125
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2009
Reference: Rev Esp Cardiol. 2009 Apr;62(4):400-8.
Impact factor: 2.88
Publication type: Paper in national publication
Authors: Brotons, Carlos, Falces, Carles, Alegre, Jose, Ballarin, Elena, Casanovas, Jordi, Cata, Teresa, Martinez, Mireia, Moral, Irene, Ortiz, Jacint, Perez, Eulalia et al.
DOI:

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Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

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The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.

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