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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Maria Urquizu Padilla

Maria Urquizu Padilla

Senior researcher
Systemic Diseases
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Moisés Labrador Horrillo

Moisés Labrador Horrillo

Main researcher
Systemic Diseases
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Vicenç Fonollosa Pla

Vicenç Fonollosa Pla

Systemic Diseases
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Victòria Cardona Dahl

Victòria Cardona Dahl

Main researcher
Systemic Diseases
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Francesc Miro Mur

Francesc Miro Mur

Main researcher
Systemic Diseases
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Galvan Blasco, Paula

Galvan Blasco, Paula

Main researcher
Systemic Diseases
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Maria Urquizu Padilla

Maria Urquizu Padilla

Senior researcher
Systemic Diseases
Read more
Moisés Labrador Horrillo

Moisés Labrador Horrillo

Main researcher
Systemic Diseases
Read more
Vicenç Fonollosa Pla

Vicenç Fonollosa Pla

Systemic Diseases
Read more
Victòria Cardona Dahl

Victòria Cardona Dahl

Main researcher
Systemic Diseases
Read more
Francesc Miro Mur

Francesc Miro Mur

Main researcher
Systemic Diseases
Read more
Galvan Blasco, Paula

Galvan Blasco, Paula

Main researcher
Systemic Diseases
Read more

Research lines

Cardiac involvement in Churg-Strauss Granulomatosis (EGPE).

Cardiac involvement is one of the most important causes of dead in EGPE. The aim of this study is to investigate the prevalence of silent cardiac involvement in patients with EGPE, and if some chemotaxins (eotaxins 1, 2 and 3) may play a key role in its development, in order to establish an early tretament.

IP: Roser Solans Laque

Cellular microparticles study in women with and without antiphospholipid antibodies with recurrent pregnancy loses and preeclampsia.

Cellular microparticles (CMP) are released depending on the activation and/or the presence of cell apoptosis. They are capable of activating both inflammatory and coagulation pathways. It seems that levels of CMP are higher in healthy pregnant women. A working hypothesis establishes that an increase of CMP levels may be found in recurrent pregnancy loses and preeclampsia. It is thought that their thrombophilic capacity may be higher in those patients with anti-phospholipid antibodies, especially among those with lupus anticoagulant. We want to determine MPC levels in non-pregnant healthy women, pregnant women without previous abnormal obstetric events, women with recurrent pregnancy loses, and women with severe preeclampsia. We are also evaluating whether there are differences related to the presence or absence of antiphospholipid antibodies. Finally, we will also characterize the exact type of CMP (endothelial, platelet-like, leuco-monocyte, and throphoblastic).

IP: Jaume Alijotas Reig

Characterization of inhibitors in patients with acquired haemophilia

Spanish multicenter clinical assay in collaboration with Vall d´Hebrón Hospital Haemophilia Unit and Spanish Society of Thrombosis and Haemostasis. The objective is to characterize the FVIII domains that act as epitopes for autoantibodies in acquired haemophilia, and its relationship with clinical manifestations and treatment of disease.

IP: José Pardos Gea

Construcción de un Predictor Diagnóstico para las enfermedades Inflamatorias mediadas por mecanismos inmunes (predictor-IMID)

Subprograma de apoyo a proyectos singulares y estratégicos 2008-2009

IP: Sara Marsal Barril

Thesis

Malaltia Relacionada amb la IgG4

PhD student: Andreu Fernández Codina, Andreu Fernández Codina, Andreu Fernández Codina, Andreu Fernández Codina
Director/s: Inés de Torres Ramirez, Fernando Martínez Valle, Roser Solans Laque
University: Universidad Autònoma de Barcelona
Year: 2019

Evaluación inmunogénica de los tumores de mama triple negativos en relación a la presencia o no de linfocitos intratumorales

PhD student:
Director/s: Javier Cortés Castan, Eva Muñoz Couselo, Vicente Peg Camara
University: Universitat Autònoma de Barcelona
Year: 2019

Factors pronòstics en la pèrdua visual en larteritis de cèl·lules gegants

PhD student: Jaume Mestre Torres
Director/s: Roser Solans Laque
University: Universidad Autònoma de Barcelona
Year: 2019

Relación entre constructos psicológicos y discapacidad funcional y diestrés en subgrupos de pacientes con fibromialgia

PhD student: Sara Nieves Maurel Ibáñez
Director/s: José Alegre Martin
University: Universidad Autònoma de Barcelona
Year: 2018

Blog

News

15 researchers from the Rheumatology, Systemic Diseases and the Physiology and Pathophysiology of the Digestive Tract groups gave around 25 presentations.

The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.