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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

David Moreno Martinez

David Moreno Martinez

Systemic Diseases
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Fernando Martínez Valle

Fernando Martínez Valle

Systemic Diseases
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Jaume Alijotas Reig

Jaume Alijotas Reig

Head of group
Systemic Diseases
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Jaume Mestre Torres

Jaume Mestre Torres

Main researcher
Systemic Diseases
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Joan Lima Ruiz

Joan Lima Ruiz

Systemic Diseases
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Joan Rey Cano

Joan Rey Cano

Research technician
Systemic Diseases
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David Moreno Martinez

David Moreno Martinez

Systemic Diseases
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Fernando Martínez Valle

Fernando Martínez Valle

Systemic Diseases
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Jaume Alijotas Reig

Jaume Alijotas Reig

Head of group
Systemic Diseases
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Jaume Mestre Torres

Jaume Mestre Torres

Main researcher
Systemic Diseases
Read more
Joan Lima Ruiz

Joan Lima Ruiz

Systemic Diseases
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Joan Rey Cano

Joan Rey Cano

Research technician
Systemic Diseases
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Research lines

IgG4 Related Disease: Clinical and Immunological studies

IgG4 Related Disease (IgG4RD) is a new fibroinflammatory disorder, described in 2009, and characterized by the presence of a lymphoplasmacytic infiltrate, storiform fibrosis and pylephlebitis. A Spanish Register of that disease is currently being established, the coordinator member of our institution being one of our researchers. This collaborative study encompasses 16 centers around Spain and has allowed us to describe one of the most important series of patients in the world. A program of a PhD fellowship is currently active, along with a clinical trial due to start very soon. On the other hand, studies on the immunologic mechanism of the disease and a radiologic evaluation with PET-SCAN is also expected to be carried out in the near future.

IP: -

Immunobiology and immunopathology of recurrent pregnancy loses and spontaneous loses.

Around 2-3% of reproductive-age couples suffer recurrent pregnancy loses. Almost 18% of couples that wish to have children suffer infertility problems. Simultaneously, 2-3% of all pregnant women are diagnosed with spontaneous loses. The expression of HLA molecules, specially type G, the degree of trophoblastic apoptosis, the outsourcing of new neoantigens such as phospholipids, the balance between Th1/Th2/Th3 cytokines, the type and quantity of CD4+CD25+Foxp3+ lymphocytes, the kind and the activity of uterine NK cells (uNK) cells, the presence or absence of blocking antibodies, and other mechanisms play different roles in the achievement of the so-called "tolerant microenvironment" needed to develop a normal pregnancy. Therefore, both autoimmune and alloimmune mechanisms are important. We aim at studying which isolated, and specially associated, anomalies can be identified as risk markers to be able to evaluate possible treatments.

IP: Jaume Alijotas Reig

Immunologic lesional mechanisms in late adverse reactions against bioimplants.

The late clinical manifestations that arise when bioimplants are applied seem to have an immunologic basis. We are studying both the histological characteristics and the lesional mechanisms of the most frequently used implants. We try to analyze the role that bacteria may have in the induction and/or maintenance of these reactions and the possible correlation between particular HLA haplotypes and the adverse effects.

IP: Jaume Alijotas Reig

Immunological basis and new therapeutic options in severe preeclampsia.

Three to five percent of pregnancies are complicated by preeclampsia (PE). PE is a multisystemic-related endothelial dysfunction disorder characterized by hypertension, proteinuria and renal injury. Despite considerable research, its etiology and pathophysiology still remains unclear. Different theories involving many pathways including thrombophilia, immunologic changes, circulating angiogenic /antiangiogenic factors and increased oxidative stress have been related to its pathogenesis. The role played by antiphospholipid antibodies (aPL) is a matter of discussion in PE.  Biological evidence of endothelial dysfunction related to PE/FGR has been shown by modified plasma markers including fibronectin, von Willebrand factor and ICAM-1 in a similar manner to that which occurs in aPL-related obstetric complications. We are searching now the role played by different aPL and cofactor antibodies, as well as its relationship with angiogenic /antiangiogenic factors and microparticle number in severe PE.

IP: Jaume Alijotas Reig, Elisa Llurba Olivé, Anna Suy Franch

Publications

Post-COVID-19 Symptoms and Heart Disease: Incidence, Prognostic Factors, Outcomes and Vaccination: Results from a Multi-Center International Prospective Registry (HOPE 2).

PMID: 36675633
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Jan 16;12(2):706. doi: 10.3390/jcm12020706.
Impact factor:
Publication type: Paper in international publication
Authors: Alfonso-Rodriguez, Emilio; Becerra-Munoz, Victor; Castro-Mejia, Alex F; Cerrato, Enrico; El-Battrawy, Ibrahim; Espejo-Paeres, Carolina; Feltes, Gisela; Fernandez-Ortiz, Antonio; Gonzalez, Adelina; Lopez Masjuan, Alvaro et al.
DOI: 10.3390/jcm12020706

Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air((R)) approach.

PMID: 36705508
Journal: Clinical and Translational Allergy
Year: 2023
Reference: Clin Transl Allergy. 2023 Jan;13(1):e12215. doi: 10.1002/clt2.12215.
Impact factor:
Publication type: Paper in international publication
Authors: Amaral, Rita; Ansotegui, Ignacio J; Anto, Josep M; Arnavielhe, Sylvie; Basagana, Xavier; Bedard, Annabelle; Bedbrook, Anna; Benveniste, Samuel; Bergmann, Karl C; Bewick, Michael et al.
DOI: 10.1002/clt2.12215

mTOR inhibitors a potential predisposing factor for chronic hepatitis E: Results from the prospective collaborative CHES Study (Chronic Hepatitis E Screening in patients with immune impairment and increased transaminases levels)

PMID: 36731726
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Dec;46(10):764-773. doi: 10.1016/j.gastrohep.2023.01.010. Epub 2023 Jan 31.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, Virginia Robles; Barciela, Mar Riveiro; Berastegui, Cristina; Bilbao, Itxarone; Buti, Maria; Camprecios, Joan Martinez; Castells, Lluis; Cots, Meritxell Ventura; Diez, Basilio Rodriguez; Eliz, Maria Garcia et al.
DOI: 10.1016/j.gastrohep.2023.01.010

Coordinated local RNA overexpression of complement induced by interferon gamma in myositis.

PMID: 36739295
Journal: Scientific Reports
Year: 2023
Reference: Sci Rep. 2023 Feb 4;13(1):2038. doi: 10.1038/s41598-023-28838-z.
Impact factor:
Publication type: Paper in international publication
Authors: Albayda, Jemima; Casal-Dominguez, Maria; Christopher-Stine, Lisa; Corse, Andrea; Dell Orso, Stefania; Duque-Jaimez, Yaiza; Garrabou, Gloria; Grau, Josep Maria; Gutierrez-Cruz, Gustavo; Lloyd, Thomas E et al.
DOI: 10.1038/s41598-023-28838-z

Commercialized kits to assess T-cell responses against SARS-CoV-2 S peptides. A pilot study in health care workers.

PMID: 34666900
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Aug 12;159(3):116-123. doi: 10.1016/j.medcli.2021.09.013. Epub 2021 Sep 25.
Impact factor:
Publication type: Paper in national publication
Authors: Anton, Andres; Arrese-Munoz, Iria; Cardona, Victoria; Esperalba, Juliana; Fernandez-Naval, Candela; Hernandez-Gonzalez, Manuel; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Pujol-Borrell, Ricardo; Pumarola, Tomas et al.
DOI: 10.1016/j.medcli.2021.09.013

COVID-19 Vaccination In Autoimmune Diseases (COVAD) Study: Vaccine Safety In Idiopathic Inflammatory Myopathies.

PMID: 35869701
Journal: MUSCLE & NERVE
Year: 2022
Reference: Muscle Nerve. 2022 Oct;66(4):426-437. doi: 10.1002/mus.27681. Epub 2022 Aug 8.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Vikas; Agarwal, Vishwesh; Aggarwal, Rohit; Aharonov, Or Mr; Ajmani, Sajal; Asranna, Ajay; Barman, Bhupen; Bocci, Elena Bartoloni; Bommakanti, Keerthi Talari; Campagne, Julien et al.
DOI: 10.1002/mus.27681

Onset of nut allergy in a pediatric cohort: clinical and molecular patterns. AFRUSEN study.

PMID: 33884956
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Investig Allergol Clin Immunol. 2022 Jul 22;32(4):270-281. doi: 10.18176/jiaci.0696. Epub 2021 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado, M I; Blasco, C; Carrillo, T; Escudero, C; Garcia, B E; Garriga-Baraut, T; Ibanez-Sandin, M D; Infante, S; Labrador-Horrillo, M; Lasa, E M et al.
DOI: 10.18176/jiaci.0696

Sequential rituximab and mepolizumab in eosinophilic granulomatosis with polyangiitis (EGPA): a European multicentre observational study.

PMID: 35850947
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2022
Reference: Ann Rheum Dis. 2022 Dec;81(12):1769-1772. doi: 10.1136/ard-2022-222776. Epub 2022 Jul 18.
Impact factor:
Publication type: Paper in international publication
Authors: Andre, Marc; Bargagli, Elena; Bello, Federica; Bettiol, Alessandra; Cameli, Paolo; Caminati, Marco; Conti, Fabrizio; Dagna, Lorenzo; Egan, Allyson; Emmi, Giacomo et al.
DOI: 10.1136/ard-2022-222776

Proteomics and enriched biological processes in Antiphospholipid syndrome: A systematic review.

PMID: 34718168
Journal: AUTOIMMUNITY REVIEWS
Year: 2021
Reference: Autoimmun Rev. 2021 Dec;20(12):102982. doi: 10.1016/j.autrev.2021.102982. Epub 2021 Oct 27.
Impact factor:
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume; Anunciacion-Llunell, Ariadna; Esteve-Valverde, Enrique; Marques-Soares, Joana; Miro-Mur, Francesc; Pardos-Gea, Josep et al.
DOI: 10.1016/j.autrev.2021.102982

Why Choose Cyclosporin A as First-line Therapy in COVID-19 Pneumonia.

PMID: 32354685
Journal: Reumatologia clinica
Year: 2021
Reference: Reumatol Clin. 2021 Nov;17(9):555-557. doi: 10.1016/j.reuma.2020.03.001. Epub 2020 Apr 16.
Impact factor:
Publication type: Letter or abstract
Authors: Romero-Bueno, Fredeswinda I; Sanchez-Pernaute, Olga; Selva-O'Callaghan, Albert et al.
DOI: 10.1016/j.reuma.2020.03.001

Chronic Villitis of unknown etiology (VUE): Obstetrical features, outcome and treatment.

PMID: 34710823
Journal: JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Year: 2021
Reference: J Reprod Immunol. 2021 Nov;148:103438. doi: 10.1016/j.jri.2021.103438. Epub 2021 Oct 23.
Impact factor:
Publication type: Review in international publication
Authors: Abisror, Noemie; Alijotas-Reig, Jaume; Arsene, Mekinian; Bornes, Marie; Cheloufi, Meryam; Cohen, Jonathan; Coulomb, Aurore; Fain, Olivier; Kayem, Gilles; Kolanska, Kamila et al.
DOI: 10.1016/j.jri.2021.103438

Tumour Markers in the Differential Diagnosis of Patients With Isolated Involuntary Weight Loss.

PMID: 34697170
Journal: IN VIVO
Year: 2021
Reference: In Vivo. 2021 Nov-Dec;35(6):3361-3367. doi: 10.21873/invivo.12634.
Impact factor:
Publication type: Paper in international publication
Authors: Abril, Andres; Aligue, Jordi; Arnau, Anna; Bonet, Mariona; El-Boutrouki, Omar; Figols, Cristina; Gonzalez-Fernandez, Carolina; Gonzalez-Garcia, Elisabeth; Montsant, Lourdes; Ordeig, Josep et al.
DOI: 10.21873/invivo.12634

Systemic phenotype related to primary Sjogren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies.

PMID: 33095152
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2020
Reference: Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):85-94. Epub 2020 Oct 22.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Armagan, Berkan; Atzeni, Fabiola; Baldini, Chiara; Bartoloni, Elena; Bootsma, Hendrika; Brito-Zeron, Pilar; Carsons, Steven E; de Miguel Campo, Borja; Devauchelle-Pensec, Valerie et al.
DOI:

Angiogenic Factors and Long-Term Cardiovascular Risk in Women That Developed Preeclampsia During Pregnancy.

PMID: 33012203
Journal: HYPERTENSION
Year: 2020
Reference: Hypertension. 2020 Dec;76(6):1808-1816. doi: 10.1161/HYPERTENSIONAHA.120.15830. Epub 2020 Oct 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Cabero-Roura, Lluis; Carreras-Moratonas, Elena; Cruz-Lemini, Monica; Galian-Gay, Laura; Garrido-Gimenez, Carmen; Granato, Chiara; Llurba, Elisa; Mendoza, Manel; Rodriguez-Palomares, Jose et al.
DOI: 10.1161/HYPERTENSIONAHA.120.15830

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.

PMID: 32977850
Journal: Genome Medicine
Year: 2020
Reference: Genome Med. 2020 Sep 25;12(1):81. doi: 10.1186/s13073-020-00779-6.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Leon, Eduardo; Ballestar, Esteban; Ciudad, Laura; Guillen-Del-Castillo, Alfredo; Javierre, Biola M; Li, Tianlu; Lopez-Isac, Elena; Martin, Javier; Ortiz-Fernandez, Lourdes; Simeon-Aznar, Carmen Pilar et al.
DOI: 10.1186/s13073-020-00779-6

Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic.

PMID: 32947588
Journal: JOURNAL OF ORTHOPAEDIC TRAUMA
Year: 2020
Reference: J Orthop Trauma. 2020 Oct;34(10):e377-e381. doi: 10.1097/BOT.0000000000001903.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Peiro, Jose V; Bhandari, Mohit; Garcia-Sanchez, Yaiza; Guerra-Farfan, Ernesto; Mestre-Torres, Jaume; Minguell-Monyart, Joan; Molero-Garcia, Vicente; Porcel-Vazquez, Juan A; Selga Marsa, Jordi; Teixidor-Serra, Jordi et al.
DOI: 10.1097/BOT.0000000000001903

Therapeutic strategy according to the differing patient response profiles to omalizumab in chronic spontaneous urticaria.

PMID: 30222111
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Investig Allergol Clin Immunol. 2019;29(5):338-348. doi: 10.18176/jiaci.0323. Epub 2018 Sep 17.
Impact factor:
Publication type: Review in international publication
Authors: Bartra Tomas, J; Ferrer Puga, M; Gimenez Arnau, A M; Jauregui Presa, I; Labrador-Horrillo, M; Miquel Miquel, F J; Ortiz de Frutos, J; Sastre, J; Silvestre Salvador, F J; Valero Santiago, A et al.
DOI: 10.18176/jiaci.0323

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

PMID: 31672989
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Oct 31;10(1):4955. doi: 10.1038/s41467-019-12760-y.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Aguirre, M A; Airo, P; Alegre-Sancho, J J; Allanore, Yannick; Andreu, J L; Assassi, Shervin; Beltran, E; Beretta, Lorenzo; Blanco-Garcia, F J et al.
DOI: 10.1038/s41467-019-12760-y

Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 2).

PMID: 31656683
Journal: Journal of Thoracic Disease
Year: 2019
Reference: J Thorac Dis. 2019 Sep;11(9):4072-4084. doi: 10.21037/jtd.2019.09.38.
Impact factor:
Publication type: Review in international publication
Authors: Agache, Ioana; Annesi-Maesano, Isabella; Ansotegui, Ignacio; Anto, Josep M; Bachert, Claus; Bedbrook, Anna; Benveniste, Samuel; Bewick, Mike; Billo, Nils; Bosnic-Anticevich, Sinthia et al.
DOI: 10.21037/jtd.2019.09.38

Malignancy and myositis, from molecular mimicry to tumor infiltrating lymphocytes.

PMID: 31635909
Journal: NEUROMUSCULAR DISORDERS
Year: 2019
Reference: Neuromuscul Disord. 2019 Nov;29(11):819-825. doi: 10.1016/j.nmd.2019.09.014. Epub 2019 Sep 26.
Impact factor:
Publication type: Review in international publication
Authors: Gil-Vila, Albert; Pinal-Fernandez, Iago; Ros, Javier; Ros, Javier; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vila-Pijoan, Gemma et al.
DOI: 10.1016/j.nmd.2019.09.014

Comparative study between obstetric antiphospholipid syndrome and obstetric morbidity related with antiphospholipid antibodies.

PMID: 29274674
Journal: MEDICINA CLINICA
Year: 2018
Reference: Med Clin (Barc). 2018 Sep 21;151(6):215-222. doi: 10.1016/j.medcli.2017.11.017. Epub 2017 Dec 20.
Impact factor:
Publication type: Paper in national publication
Authors: Alijotas-Reig, Jaume; Bertero, M feminine Tiziana; de Carolis, Sara; Espinosa, Gerard; Esteve-Valverde, Enrique; Ferrer-Oliveras, Raquel; Lefkou, Elmina; LLurba, Elisa; Lundelin, Krista; Mekinian, Arsene et al.
DOI: 10.1016/j.medcli.2017.11.017

How immunological profile drives clinical phenotype of primary Sjogren's syndrome at diagnosis: analysis of 10,500 patients (Sjogren Big Data Project).

PMID: 30156539
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2018
Reference: Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):102-112. Epub 2018 Aug 14.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Armagan, Berkan; Atzeni, Fabiola; Baldini, Chiara; Bartoloni, Elena; Bombardieri, Michele; Bootsma, Hendrika; Brito-Zeron, Pilar; Danda, Debashish; De Vita, Salvatore et al.
DOI:

Severe, life-threatening phenotype of primary Sjogren's syndrome: clinical characterisation and outcomes in 1580 patients (GEAS-SS Registry).

PMID: 30156546
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2018
Reference: Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):121-129. Epub 2018 Aug 14.
Impact factor:
Publication type: Paper in international publication
Authors: Brito-Zeron, Pilar; Chamorro, Antonio-J; de-la-Red, Gloria; Duarte-Millan, Miguel-Angel; Fanlo, Patricia; Feijoo-Masso, Carlos; Flores-Chavez, Alejandra; Fonseca-Aizpuru, Eva; Fraile, Guadalupe; Garcia-Perez, Alicia et al.
DOI:

Classification and management of adult inflammatory myopathies.

PMID: 30129477
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Sep;17(9):816-828. doi: 10.1016/S1474-4422(18)30254-0.
Impact factor:
Publication type: Review in international publication
Authors: Grau-Junyent, Josep Maria; Mammen, Andrew L; Milisenda, Jose Cesar; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1016/S1474-4422(18)30254-0

[Characteristics of potentially inappropriate prescribing of drugs in elderly polypathological patients].

PMID: 27486035
Journal: Gaceta Sanitaria
Year: 2017
Reference: Gac Sanit. 2017 Jul - Aug;31(4):327-331. doi: 10.1016/j.gaceta.2016.06.013. Epub 2016 Jul 30.
Impact factor:
Publication type: Paper in national publication
Authors: Agusti, Antonia; Formiga, Francesc; Garcia, Juana; Gomez Hernandez, Mercedes; Lopez-Soto, Alfonso; Ramirez-Duque, Nieves; Rivas-Cobas, Paula Carlota; San-Jose, Antonio; Torres, Olga H; Vidal, Xavier et al.
DOI: 10.1016/j.gaceta.2016.06.013

New trends in anaphylaxis.

PMID: 29214141
Journal: Allergo journal international
Year: 2017
Reference: Allergo J Int. 2017;26(8):295-300. doi: 10.1007/s40629-017-0042-y. Epub 2017 Nov 15.
Impact factor:
Publication type: Review in national publication
Authors: Cardona, Victoria; Cichocka-Jarosz, Ewa; Dolle, Sabine; Kleine-Tebbe, Jorg; Maris, Ioana; Sturm, Gunter; Worm, Margitta et al.
DOI: 10.1007/s40629-017-0042-y

EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report.

PMID: 29177080
Journal: RMD open
Year: 2017
Reference: RMD Open. 2017 Nov 14;3(2):e000507. doi: 10.1136/rmdopen-2017-000507. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Aggarwal, Rohit; Alfredsson, Lars; Amato, Anthony A; Amoruso, Maria; Andersson, Helena; Arnardottir, Snjolaug; Barohn, Richard J; Bayat, Nastaran; Bhansing, Kavish J; Bottai, Matteo et al.
DOI: 10.1136/rmdopen-2017-000507

TNFalpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.

PMID: 29176033
Journal: Aging-US
Year: 2017
Reference: Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Kandhaya-Pillai, Renuka; Kirkland, James L; Miro-Mur, Francesc; Schwartz, Simo; Tchkonia, Tamara et al.
DOI: 10.18632/aging.101328

[Hiccups as an onset form of aortic dissection].

PMID: 27143531
Journal: MEDICINA CLINICA
Year: 2016
Reference: Med Clin (Barc). 2016 Aug 5;147(3):e13. doi: 10.1016/j.medcli.2016.03.014. Epub 2016 Apr 30.
Impact factor:
Publication type: Letter or abstract
Authors: Callejas-Moraga, Eduardo L; Mestre-Torres, Jaume; Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.medcli.2016.03.014

Interdisciplinary recommendations document to improve adherence in patients with chronic inflammatory diseases: Adhing recommendations.

PMID: 27570990
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2016
Reference: Farm Hosp. 2016 Sep 1;40(5):394-411. doi: 10.7399/fh.2016.40.5.10180.
Impact factor:
Publication type: Review in international publication
Authors: Barcelo-Bru, Mireia Barcelo; Bermejo San Jose, Fernando; Poveda-Andres, Jose Luis; Ribera-Pibernat, Miquel; Sanroman-Alvarez, Luciano et al.
DOI: 10.7399/fh.2016.40.5.10180

Effects of rituximab in connective tissue disorders related interstitial lung disease.

PMID: 27749242
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2016
Reference: Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):181-185. Epub 2016 Oct 14.
Impact factor:
Publication type: Paper in international publication
Authors: Airo, Paolo; Allanore, Yannick; Anguita Santos, Francisco; Avouac, Jerome; Bellando-Randone, Silvia; Blagojevic, Jelena; Distler, Oliver; Garcia Hernandez, Francisco; Gonzalez Nieto, Jose Antonio; Guiducci, Serena et al.
DOI:

Clinical manifestations and long-term outcome of anti-Jo1 antisynthetase patients in a large cohort of Spanish patients from the GEAS-IIM group.

PMID: 27139168
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2016
Reference: Semin Arthritis Rheum. 2016 Oct;46(2):225-231. doi: 10.1016/j.semarthrit.2016.03.011. Epub 2016 Mar 30.
Impact factor:
Publication type: Paper in international publication
Authors: Fraile-Rodriguez, Guadalupe; Garcia-Hernandez, Francisco Jose; Grau-Junyent, Josep Maria; Labirua-Iturburu, Anne; Les-Bujanda, Inigo; Monteagudo-Jimenez, Manuel; Rodriguez-Carballeira, Monica; Saez-Comet, Luis; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1016/j.semarthrit.2016.03.011

[Association with IgG3 deficiency in chronic autoimmune neutropenia in adults: case report and literatura review].

PMID: 25865610
Journal: MED CLIN-BARCELONA
Year: 2015
Reference: Med Clin (Barc). 2015 Dec 21;145(12):553-4. doi: 10.1016/j.medcli.2015.03.002. Epub 2015 Apr 9.
Impact factor:
Publication type: Review in national publication
Authors: Artaza Minano, Gonzalo; Pardos-Gea, Jose; Sanjose, Antonio et al.
DOI: 10.1016/j.medcli.2015.03.002

Cardiac manifestations other than valvulopathy in antiphospholipid syndrome: long-time echocardiography follow-up study.

PMID: 24131635
Journal: INT J RHEUM DIS
Year: 2015
Reference: Int J Rheum Dis. 2015 Jan;18(1):76-83. doi: 10.1111/1756-185X.12191. Epub 2013 Oct 17.
Impact factor:
Publication type: Paper in international publication
Authors: Avegliano, Gonzalo; Evangelista, Arturo; Ordi-Ros, Jose; Pardos-Gea, Jose; Vilardell, Miguel et al.
DOI: 10.1111/1756-185X.12191

Management of urticaria: not too complicated, not too simple.

PMID: 25429900
Journal: CLIN EXP ALLERGY
Year: 2015
Reference: Clin Exp Allergy. 2015 Apr;45(4):731-43. doi: 10.1111/cea.12465.
Impact factor:
Publication type: Paper in international publication
Authors: Bartra, J; de Frutos, J Ortiz; Ferrer, M; Gimenez-Arnau, A; Jauregui, I; Labrador-Horrillo, M; Sastre, J; Silvestre, Jf; Valero, A; Velasco, M et al.
DOI: 10.1111/cea.12465

Inappropriate prescribing to the oldest old patients admitted to hospital: prevalence, most frequently used medicines, and associated factors.

PMID: 25887546
Journal: BMC GERIATR
Year: 2015
Reference: BMC Geriatr. 2015 Apr 9;15:42. doi: 10.1186/s12877-015-0038-8.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cristina; Agusti, Antonia; Agusti, Antonia; Ballarin, Elena; Ballesteros, Isabel; Barbe, Jose; Barbe, Jose; Barroso, Xavier; Bocanegra, Carmen Perez; Bosch, Xavier et al.
DOI: 10.1186/s12877-015-0038-8

EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy.

PMID: 24909706
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Aug;69(8):1008-25. doi: 10.1111/all.12429. Epub 2014 Jun 9.
Impact factor:
Publication type: Clinical guide
Authors: Akdis, C A; Ballmer-Weber, B K; Beyer, K; Bindslev-Jensen, C; Cardona, V; de Jong, N W; de Silva, D; Dubois, A; duToit, G; Eigenmann, P et al.
DOI: 10.1111/all.12429

Primary prevention of food allergy in children and adults: systematic review.

PMID: 24433563
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 May;69(5):581-9. doi: 10.1111/all.12334. Epub 2014 Jan 16.
Impact factor:
Publication type: Review in international publication
Authors: Agache, I; Akdis, C A; Alvarez, R; Arshad, S H; Beyer, K; Bindslev-Jensen, C; Cardona, V; de Silva, D; Demoly, P; Dubois, A E J et al.
DOI: 10.1111/all.12334

Component resolved diagnosis: when should it be used?

PMID: 25250172
Journal: Clinical and Translational Allergy
Year: 2014
Reference: Clin Transl Allergy. 2014 Sep 8;4:28. doi: 10.1186/2045-7022-4-28. eCollection 2014.
Impact factor:
Publication type: Letter or abstract
Authors: Cardona, Victoria; Luengo, Olga et al.
DOI: 10.1186/2045-7022-4-28

IgE-mediated allergic reactions after the first administration of glatiramer acetate in patients with multiple sclerosis.

PMID: 25634237
Journal: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Year: 2014
Reference: Int Arch Allergy Immunol. 2014;165(4):244-6. doi: 10.1159/000371418. Epub 2015 Jan 29.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, Victoria; Corominas, Merce; Lleonart, Ramon; Martinez, Jorge; Postigo, Idoia; Romero-Pinel, Lucia et al.
DOI: 10.1159/000371418

Identification of thaumatin-like protein and aspartyl protease as new major allergens in lettuce (Lactuca sativa).

PMID: 23983075
Journal: MOLECULAR NUTRITION & FOOD RESEARCH
Year: 2013
Reference: Mol Nutr Food Res. 2013 Dec;57(12):2245-52. doi: 10.1002/mnfr.201300139. Epub 2013 Aug 25.
Impact factor:
Publication type: Paper in international publication
Authors: Cuesta-Herranz, Javier; de Las Heras Gozalo, Manuel; Diaz-Perales, Araceli; Haroun-Diaz, Elisa; Labrador-Horrillo, Moises; Luengo-Sanchez, Olga; Maroto, Aroa Sanz; Munoz-Garcia, Esther; Palacin, Arancha; Pastor-Vargas, Carlos et al.
DOI: 10.1002/mnfr.201300139

Efficacy of omalizumab in chronic spontaneous urticaria refractory to conventional therapy: analysis of 110 patients in real-life practice.

PMID: 23875845
Journal: EXPERT OPINION ON BIOLOGICAL THERAPY
Year: 2013
Reference: Expert Opin Biol Ther. 2013 Sep;13(9):1225-8. doi: 10.1517/14712598.2013.822484. Epub 2013 Jul 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bartra, Joan; Ferrer, Marta; Gimenez-Arnau, Ana; Jauregui, Ignacio; Labrador-Horrillo, Moises; Ortiz de Frutos, Javier; Sastre, Joaquin; Silvestre, Juan Francisco; Valero, Antonio; Velasco, Manuel et al.
DOI: 10.1517/14712598.2013.822484

Current concepts and new trends in the diagnosis and management of recurrent miscarriage.

PMID: 23942472
Journal: OBSTETRICAL & GYNECOLOGICAL SURVEY
Year: 2013
Reference: Obstet Gynecol Surv. 2013 Jun;68(6):445-66. doi: 10.1097/OGX.0b013e31828aca19.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Alijotas-Reig, Jaume; Garrido-Gimenez, Carmen et al.
DOI: 10.1097/OGX.0b013e31828aca19

A 72 year-old man with dyspnea, circumferential aortic thickening and weight loss.

PMID: 23925898
Journal: ARTHRITIS CARE & RESEARCH
Year: 2013
Reference: Arthritis Care Res (Hoboken). 2013 Dec;65(12):2056-61. doi: 10.1002/acr.22100.
Impact factor:
Publication type: Paper in international publication
Authors: Arcos-Bertiz, Ibai Los; Bujan-Rivas, Segundo; Juanos-Iborra, Montserrat; Martinez-Valle, Fernando; Palomares, Jose Rodriguez; Santos-Ortega, Alba; Tornos-Mas, Pilar et al.
DOI: 10.1002/acr.22100

Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade.

PMID: 22952322
Journal: LUPUS
Year: 2012
Reference: Lupus. 2012;21(12):1326-34. Epub 2012 Sep 5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; Alijotas-Reig, J; Garcia-Gimenez, V; Llurba, E; Vilardell-Tarres, M et al.
DOI: 10.1177/0961203312458838

Screening for the presence of FMR1 premutation alleles in a Spanish population with fibromyalgia.

PMID: 22903700
Journal: CLINICAL RHEUMATOLOGY
Year: 2012
Reference: Clin Rheumatol. 2012 Nov;31(11):1611-5. doi: 10.1007/s10067-012-2052-y. Epub 2012 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre, Cayetano; Gamez, Josep; Garcia-Fructuoso, Ferran; Genoves, Jordi; Martorell, Loreto; Naudo, Montserrat; Poo, Pilar; Tondo, Mireia et al.
DOI: 10.1007/s10067-012-2052-y

Unveiling Case-Control Relationships in Designing a Simple and Powerful Method for Detecting Gene-Gene Interactions.

PMID: 22886951
Journal: GENETIC EPIDEMIOLOGY
Year: 2012
Reference: Genet Epidemiol. 2012 Nov;36(7):710-6. doi: 10.1002/gepi.21665. Epub 2012 Aug 7.
Impact factor:
Publication type: Paper in international publication
Authors: Canela-Xandri, Oriol; Gelpi, Josep Lluis; Julia, Antonio; Marsal, Sara et al.
DOI: 10.1002/gepi.21665

Co-factor-enhanced food allergy.

PMID: 22845005
Journal: ALLERGY
Year: 2012
Reference: Allergy. 2012 Oct;67(10):1316-8. doi: 10.1111/j.1398-9995.2012.02877.x.. Epub 2012 Jul 30.
Impact factor:
Publication type: Paper in international publication
Authors: Cardona, V; Garriga, T; Guilarte, M; Izquierdo, A; Labrador-Horrillo, M; Luengo, O; Sala-Cunill, A; Soto, L et al.
DOI: 10.1111/j.1398-9995.2012.02877.x.

Venous thromboembolism in patients with dermatomyositis and polymyositis.

PMID: 21962007
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2011
Reference: Clin Exp Rheumatol. 2011 Sep-Oct;29(5):846-9. Epub 2011 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI:

The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population.

PMID: 21923648
Journal: International Journal of Immunogenetics
Year: 2011
Reference: Int J Immunogenet. 2011 Dec;38(6):529-31. doi: 10.1111/j.1744-313X.2011.01038.x. Epub 2011 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1111/j.1744-313X.2011.01038.x

Effect of mycophenolate sodium in scleroderma-related interstitial lung disease.

PMID: 21881859
Journal: CLINICAL RHEUMATOLOGY
Year: 2011
Reference: Clin Rheumatol. 2011 Nov;30(11):1393-8. Epub 2011 Sep 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1007/s10067-011-1823-1

Generalised delayed desquamative exanthema after intradermal testing with betalactam antibiotics.

PMID: 21470241
Journal: ALLERGY
Year: 2011
Reference: Allergy. 2011 May;66(5):702-3. doi: 10.1111/j.1398-9995.2010.02495.x. Epub 2010 Oct 26.
Impact factor:
Publication type: Editorail in international publication
Authors: Cardona, V; Guilarte, M; Labrador-Horrillo, M; Luengo, O; Sala Cunill, A et al.
DOI: 10.1111/j.1398-9995.2010.02495.x

Malignancy and myositis: novel autoantibodies and new insights.

PMID: 20827204
Journal: CURRENT OPINION IN RHEUMATOLOGY
Year: 2010
Reference: Curr Opin Rheumatol. 2010 Nov;22(6):627-32.
Impact factor:
Publication type: Review in international publication
Authors: Grau-Junyent, Josep M; Labrador-Horrillo, Moises; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1097/BOR.0b013e32833f1075

Bioengineered hyaluronic acid elicited a nonantigenic T cell activation: Implications from cosmetic medicine and surgery to nanomedicine.

PMID: 20564542
Journal: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Year: 2010
Reference: J Biomed Mater Res A. 2010 Oct;95(1):180-90.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; Alijotas Reig, Jaume et al.
DOI: 10.1002/jbm.a.32794

Conventional cancer screening versus PET/CT in dermatomyositis/polymyositis.

PMID: 20569766
Journal: AMERICAN JOURNAL OF MEDICINE
Year: 2010
Reference: Am J Med. 2010 Jun;123(6):558-62.
Impact factor:
Publication type: Paper in international publication
Authors: Andia-Navarro, Eduard; Gamez-Cenzano, Cristina; Grau, Josep M; Martinez-Gomez, Xavier; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vidaller-Palacin, Antonio; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.amjmed.2009.11.012

Long-term outcomes--mycophenolate mofetil treatment for lupus nephritis with addition of tacrolimus for resistant cases.

PMID: 20538787
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2010
Reference: Nephrol Dial Transplant. 2010 Dec;25(12):3939-48. Epub 2010 Jun 10.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1093/ndt/gfq322

The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype.

PMID: 18713787
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2009
Reference: Ann Rheum Dis. 2009 Feb;68(2):253-6.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Zamorano, M A; Broen, J; Camps, M T; Coenen, M J H; Fonollosa, V; Garcia-Portales, R; Gonzalez-Gay, M A; Martin, J; Ortego-Centeno, N; Pros, A et al.
DOI: 10.1136/ard.2008.096719

[Serotonin syndrome associated with linezolid]

PMID: 19211077
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Feb 7;132(4):157-8.
Impact factor:
Publication type: Letter or abstract
Authors: Broto, Pilar Lalueza; Brumos, Lourdes Girona; Hernandez-Lorente, Eva; Simeon Aznar, Carmen P et al.
DOI: 10.1016/j.medcli.2008.09.007

Obstructive sleep apnea in patients with inflammatory myopathies.

PMID: 19145652
Journal: MUSCLE & NERVE
Year: 2009
Reference: Muscle Nerve. 2009 Feb;39(2):144-9.
Impact factor:
Publication type: Paper in international publication
Authors: Lloberes, Patricia; Romero, Odile; Sampol, Gabriel; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Vilardell-Tarres, Miquel et al.
DOI: 10.1002/mus.21204

Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells.

PMID: 19145631
Journal: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Year: 2009
Reference: J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):510-20.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas-Reig, Jaume; Hindie, Mathilde; Kandhaya-Pillai, Renuka; Miro-Mur, Francesc; Schwartz, Simo Jr; Tobajas, Vanessa et al.
DOI: 10.1002/jbm.b.31312

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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.