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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

A faecal microbiota signature with high specificity for pancreatic cancer.

PMID: 35260444
Journal: GUT
Year: 2022
Reference: Gut. 2022 Jul;71(7):1359-1372. doi: 10.1136/gutjnl-2021-324755. Epub 2022 Mar 8.
Impact factor: 23.059
Publication type: Paper in international publication
Authors: Maistrenko, Oleksandr M, Kartal, Ece, Schmidt, Thomas S B, Molina-Montes, Esther, Rodriguez-Perales, Sandra, Wirbel, Jakob, Malats, Nuria, Bork, Peer, Malats, Nuria, Real, Francisco X et al.
DOI: 10.1136/gutjnl-2021-324755

Safety of Obtaining an Extra Biobank Kidney Biopsy Core.

PMID: 35268550
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Mar 7;11(5). pii: jcm11051459. doi: 10.3390/jcm11051459.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Mast, Richard, Vergara, Ander, Agraz, Irene, Leon, Juan Carlos, Bolufer, Monica, Gabaldon, Maria-Alejandra, Seron, Daniel, Bestard, Oriol, Soler, Maria Jose, Garcia-Carro, Clara et al.
DOI: 10.3390/jcm11051459

Histological Findings in Transbronchial Cryobiopsies Obtained From Patients After COVID-19.

PMID: 34582842
Journal: CHEST
Year: 2022
Reference: Chest. 2022 Mar;161(3):647-650. doi: 10.1016/j.chest.2021.09.016. Epub 2021 Sep 25.
Impact factor: 9.41
Publication type: Letter whit IF
Authors: Alvarez, Antonio, Andreu, Jordi, Arjona, Marta, Berastegui, Cristina, Barrecheguren, Miriam, Cardoso, Jose, Cruz, Ma Jesus, De Souza, Ma Luiza, Espejo, David, Granados, Galo et al.
DOI: 10.1016/j.chest.2021.09.016

Sinusoidal Obstruction Syndrome after Liver Transplantation: A Multicenter Observational Study.

PMID: 35255179
Journal: LIVER TRANSPLANTATION
Year: 2022
Reference: Liver Transpl. 2022 Jul;28(7):1257-1261. doi: 10.1002/lt.26452. Epub 2022 Apr 28.
Impact factor: 5.799
Publication type: Paper in international publication
Authors: Romero-Cristobal, Mario, Caballero-Marcos, Aranzazu, Peligros, Isabel, Perez-Rojas, Judith, Campos-Varela, Isabel, Colmenero, Jordi, Gomez-Bravo, Miguel Angel, Justo, Iago, Otero, Alejandra, Molina-Perez, Esther et al.
DOI: 10.1002/lt.26452

Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project.

PMID: 34074264
Journal: BMC Pulmonary Medicine
Year: 2021
Reference: BMC Pulm Med. 2021 Jun 1;21(1):184. doi: 10.1186/s12890-021-01522-6.
Impact factor: 3.317
Publication type: Paper in international publication
Authors: Camp, Robert, Smith, Maxwell L, Larsen, Brandon T, Roden, Anja C, Farver, Carol, Moreira, Andre L, Attanoos, Richard, Pillappa, Raghavendra, Sansano, Irene, Fabro, Alexandre Todorovic et al.
DOI: 10.1186/s12890-021-01522-6

Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.

PMID: 34059954
Journal: HUMAN GENETICS
Year: 2021
Reference: Hum Genet. 2021 Aug;140(8):1241-1252. doi: 10.1007/s00439-021-02296-x. Epub 2021 May 31.
Impact factor: 4.132
Publication type: Paper in international publication
Authors: Romagosa, Cleofe, Estival, Anna, Perez Sidelnikova, Diana, Salvador, Hector, Villanueva, Alberto, Blanco, Ignacio, Carrio, Meritxell, Lazaro, Conxi, Serra, Eduard, Gel, Bernat et al.
DOI: 10.1007/s00439-021-02296-x

Peripheral and lung resident memory T cell responses against SARS-CoV-2.

PMID: 34021148
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 May 21;12(1):3010. doi: 10.1038/s41467-021-23333-3.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Perea, David, Rosado, Joel, Falco, Anna, Kirkegaard, Cristina, Torrella, Ariadna, Planas, Bibiana, Navarro, Jordi, Suanzes, Paula, Alvarez-Sierra, Daniel, Ayora, Alfonso et al.
DOI: 10.1038/s41467-021-23333-3

Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH.

PMID: 34014280
Journal: Disease Models & Mechanisms
Year: 2021
Reference: Dis Model Mech. 2021 May 1;14(5). pii: 268318. doi: 10.1242/dmm.048884. Epub 2021 May 20.
Impact factor: 5.758
Publication type: Paper in international publication
Authors: Bravo, Miren, Raurell, Imma, Barbera, Aurora, Hide, Diana, Gil, Mar, Estrella, Federico, Salcedo, Maria Teresa, Augustin, Salvador, Genesca, Joan, Martell, Maria et al.
DOI: 10.1242/dmm.048884

Parvovirus B19 Myocarditis: Looking Beyond the Heart.

PMID: 31335286
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Year: 2020
Reference: Pediatr Dev Pathol. 2020 Mar-Apr;23(2):158-162. doi: 10.1177/1093526619865641. Epub 2019 Jul 23.
Impact factor: 0.885
Publication type: Paper in international publication
Authors: Izquierdo-Blasco, Jaume, Salcedo Allende, Maria Teresa, Codina Grau, Maria Gemma, Gran, Ferran, Martinez Saez, Elena, Balcells, Joan et al.
DOI: 10.1177/1093526619865641

The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1.

PMID: 32183023
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Mar 13;12(3). pii: cancers12030670. doi: 10.3390/cancers12030670.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Nadal-Serrano, Mercedes, Morancho, Beatriz, Escriva-de-Romani, Santiago, Morales, Cristina Bernado, Luque, Antonio, Escorihuela, Marta, Espinosa Bravo, Martin, Peg, Vicente, Dijcks, Fred A, Dokter, Wim H A et al.
DOI: 10.3390/cancers12030670

Cyclophilins A and B Oppositely Regulate Renal Tubular Epithelial Cell Phenotype.

PMID: 32162654
Journal: Journal of Molecular Cell Biology
Year: 2020
Reference: J Mol Cell Biol. 2020 Jul 1;12(7):499-514. doi: 10.1093/jmcb/mjaa005.
Impact factor: 4
Publication type: Paper in international publication
Authors: Gundelach, Justin H, Sarro, Eduard, Duran, Monica, Rico, Ana, Bou-Teen, Diana, Fernandez-Majada, Vanesa, Croatt, Anthony J, Nath, Karl A, Salcedo, Maria Teresa, Meseguer, Anna et al.
DOI: 10.1093/jmcb/mjaa005

Insights into new mechanisms and models of cancer stem cell multidrug resistance.

PMID: 31369817
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2020
Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
Impact factor: 11.09
Publication type: Review in international publication
Authors: Garcia-Mayea, Y, Mir, C, Masson, F, Paciucci, R, LLeonart, M E et al.
DOI: 10.1016/j.semcancer.2019.07.022

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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