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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Acute kidney injury as a risk factor for mortality in oncological patients receiving check-point inhibitors.

PMID: 33547795
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Apr 25;37(5):887-894. doi: 10.1093/ndt/gfab034.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Garcia-Carro, Clara, Bolufer, Monica, Bury, Roxana, Cataneda, Zaira, Munoz, Eva, Felip, Enriqueta, Lorente, David, Josep Carreras, Maria, Gabaldon, Alejandra, Seron, Daniel et al.
DOI: 10.1093/ndt/gfab034

DigiPatICS: Digital Pathology Transformation of the Catalan Health Institute Network of 8 Hospitals-Planification, Implementation, and Preliminary Results.

PMID: 35453900
Journal: Diagnostics
Year: 2022
Reference: Diagnostics (Basel). 2022 Mar 30;12(4). pii: diagnostics12040852. doi: 10.3390/diagnostics12040852.
Impact factor: 3.706
Publication type: Paper in international publication
Authors: Matias-Guiu, Xavier, Ramon Y Cajal, Santiago, Bosch, Ramon, Temprana-Salvador, Jordi, Lopez-Garcia, Pablo, Castellvi Vives, Josep, de Haro, Lluis, Ballesta, Eudald, Rojas Abusleme, Matias, Arrufat, Miquel et al.
DOI: 10.3390/diagnostics12040852

Hepatic Rupture as the Initial Presentation of an EGFR-Mutated Lung Adenocarcinoma: A Case Report.

PMID: 35433405
Journal: Frontiers in Oncology
Year: 2022
Reference: Front Oncol. 2022 Mar 30;12:837630. doi: 10.3389/fonc.2022.837630. eCollection 2022.
Impact factor: 6.244
Publication type: Letter or abstract
Authors: Mirallas, Oriol, Bosch-Schips, Marc, Pardo, Nuria, Aubanell, Anton, Salcedo-Allende, Maria Teresa, Callejo, Ana, Iranzo, Patricia, Tabernero, Josep, Felip, Enriqueta et al.
DOI: 10.3389/fonc.2022.837630

Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification.

PMID: 35425960
Journal: CANCER RESEARCH
Year: 2022
Reference: Cancer Res. 2022 Apr 15;82(8):1646-1657. doi: 10.1158/0008-5472.CAN-21-2409.
Impact factor: 12.701
Publication type: Paper in international publication
Authors: Serres-Creixams, Xavier, Peg, Vicente, Espinosa-Bravo, Martin, Macarulla, Teresa, Oaknin, Ana, Mateo, Joaquin, Arribas, Joaquin, Dienstmann, Rodrigo, Bellet, Meritxell, Oliveira, Mafalda et al.
DOI: 10.1158/0008-5472.CAN-21-2409

Acute interstitial nephritis associated with immune checkpoint inhibitors: a single-centre experience.

PMID: 34221369
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Feb 10;14(5):1364-1370. doi: 10.1093/ckj/sfaa008. eCollection 2021 May.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Oleas, Diana, Bolufer, Monica, Agraz, Irene, Felip, Enriqueta, Munoz, Eva, Gabaldon, Alejandra, Bury, Roxana, Espinel, Eugenia, Seron, Daniel, Garcia-Carro, Clara et al.
DOI: 10.1093/ckj/sfaa008

GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma.

PMID: 34212338
Journal: Clinical & Translational Oncology
Year: 2021
Reference: Clin Transl Oncol. 2021 Dec;23(12):2460-2473. doi: 10.1007/s12094-021-02654-1. Epub 2021 Jul 1.
Impact factor: 3.405
Publication type: Paper in international publication
Authors: Ruano, D, Rubio, P, Verges, R, Valverde, C, Gallego, S, Bernabeu, D, Hindi, N, Mata, C, Marquez, C, Orcajo, J et al.
DOI: 10.1007/s12094-021-02654-1

Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor - an update on neuroendocrine neoplasm's treatment: A case report.

PMID: 34131474
Journal: World journal of hepatology
Year: 2021
Reference: World J Hepatol. 2021 May 27;13(5):611-619. doi: 10.4254/wjh.v13.i5.611.
Impact factor: 0
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Mirallas, Oriol, Saoudi, Nadia, Gomez-Puerto, Diego, Landolfi, Stefania, Blanco, Laia, Garcia-Burillo, Amparo, Molero, Xavier, Salcedo-Allende, Maria Teresa, Capdevila, Jaume et al.
DOI: 10.4254/wjh.v13.i5.611

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma.

PMID: 34150764
Journal: Frontiers in Cell and Developmental Biology
Year: 2021
Reference: Front Cell Dev Biol. 2021 Jun 3;9:670185. doi: 10.3389/fcell.2021.670185. eCollection 2021.
Impact factor: 6.684
Publication type: Paper in international publication
Authors: Noguera, Rosa, Matias-Guiu, Xavier, de Alava, Enrique, Sanegre, Sabina, Eritja, Nuria, Diaz-Martin, Juan, Diaz-Lagares, Angel, Jacome, Maria Amalia, Salguero-Aranda, Carmen, Garcia Ros, David et al.
DOI: 10.3389/fcell.2021.670185

Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.

PMID: 32418154
Journal: Clinical & Translational Oncology
Year: 2020
Reference: Clin Transl Oncol. 2020 Nov;22(11):1976-1991. doi: 10.1007/s12094-020-02357-z. Epub 2020 May 16.
Impact factor: 2.737
Publication type: Paper in international publication
Authors: Garcia-Alfonso, P, Garcia-Carbonero, R, Garcia-Foncillas, J, Perez-Segura, P, Salazar, R, Vera, R, Ramon Y Cajal, S, Hernandez-Losa, J, Landolfi, S, Musulen, E et al.
DOI: 10.1007/s12094-020-02357-z

A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas.

PMID: 31399857
Journal: Clinical & Translational Oncology
Year: 2020
Reference: Clin Transl Oncol. 2020 Jun;22(6):798-801. doi: 10.1007/s12094-019-02199-4. Epub 2019 Aug 9.
Impact factor: 2.737
Publication type: Editorail in international publication
Authors: Schuhmacher, A J, Anton, A, Ramon Y Cajal, S, Sancho, P, Soucek, L, Peinado, H, Abad, M, Valiente, M, Efeyan, A, Pardo, J et al.
DOI: 10.1007/s12094-019-02199-4

Pedro Ramon Y Cajal: The legacy of a neurohistologist, a medical doctor and a pathologist.

PMID: 30993912
Journal: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
Year: 2020
Reference: Anat Rec (Hoboken). 2020 May;303(5):1189-1202. doi: 10.1002/ar.24137. Epub 2019 Apr 29.
Impact factor: 1.634
Publication type: Paper in international publication
Authors: Ramon Y Cajal, Santiago, de Carlos, Juan A et al.
DOI: 10.1002/ar.24137

Transient elastography in direct acting antiviral era. Relation between liver stiffness measurement after sustained virological response and histology.

PMID: 31816146
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2020
Reference: J Viral Hepat. 2020 Apr;27(4):453-455. doi: 10.1111/jvh.13245. Epub 2019 Dec 18.
Impact factor: 3.561
Publication type: Paper in international publication
Authors: Martinez-Camprecios, Joan, Bonis Puig, Sara, Pons Delgado, Monica, Salcedo Allende, Maria Teresa, Minguez Rosique, Beatriz, Genesca Ferrer, Joan et al.
DOI: 10.1111/jvh.13245

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.

PMID: 29463754
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Year: 2018
Reference: Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2202-E2209. doi: 10.1073/pnas.1717439115. Epub 2018 Feb 20.
Impact factor: 9.504
Publication type: Paper in international publication
Authors: Istomine, Roman, Robichaud, Nathaniel, Hsu, Brian E, Ma, Eric H, Morales, Sebastian V, Dai, David L, Li, Glenn, Souleimanova, Margarita, Guo, Qianyu, Del Rincon, Sonia V et al.
DOI: 10.1073/pnas.1717439115

Beyond molecular tumor heterogeneity: protein synthesis takes control.

PMID: 29463861
Journal: ONCOGENE
Year: 2018
Reference: Oncogene. 2018 May;37(19):2490-2501. doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21.
Impact factor: 6.854
Publication type: Review in national publication
Authors: Ramon Y Cajal, Santiago, Castellvi, Josep, Hummer, Stefan, Peg, Vicente, Pelletier, Jerry, Sonenberg, Nahum et al.
DOI: 10.1038/s41388-018-0152-0

Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.

PMID: 29464030
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2017 Dec 19;9(5):5736-5751. doi: 10.18632/oncotarget.23422. eCollection 2018 Jan 19.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vilardell, Jordi, Alcaraz, Estefania, Sarro, Eduard, Trilla, Enric, Cuadros, Thais, de Torres, Ines, Plana, Maria, Ramon Y Cajal, Santiago, Pinna, Lorenzo A, Ruzzene, Maria et al.
DOI: 10.18632/oncotarget.23422

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis.

PMID: 29433983
Journal: EBioMedicine
Year: 2018
Reference: EBioMedicine. 2018 Mar;29:112-127. doi: 10.1016/j.ebiom.2018.02.001. Epub 2018 Feb 5.
Impact factor: 6.183
Publication type: Paper in international publication
Authors: Karachaliou, Niki, Chaib, Imane, Cardona, Andres Felipe, Rosell, Rafael, Cao, Peng, Cajal, Santiago Ramon Y, Cui, Jean, Berenguer, Jordi, Bracht, Jillian Wilhelmina Paulina, Yang, Jie et al.
DOI: 10.1016/j.ebiom.2018.02.001

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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