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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort.

PMID: 35245746
Journal: BREAST
Year: 2022
Reference: Breast. 2022 Jun;63:1-8. doi: 10.1016/j.breast.2022.02.010. Epub 2022 Feb 22.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Gunda, Aparna, Basavaraj, Chetana, Serkad V, Chandra Prakash, Adinarayan, Manjula, Kolli, Ramu, Siraganahalli Eshwaraiah, Mallikarjuna, Saura, Cristina, Ruiz, Fiorella, Gomez, Patricia, Peg, Vicente et al.
DOI: 10.1016/j.breast.2022.02.010

Are Temporal Artery Biopsy Findings Related to PET/CT Findings in Giant Cell Arteritis?

PMID: 35234202
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2022
Reference: Clin Nucl Med. 2022 May 1;47(5):387-393. doi: 10.1097/RLU.0000000000004097.
Impact factor: 7.794
Publication type: Paper in international publication
Authors: Navales-Mateu, Ignacio, Mestre-Torres, Jaume, Martinez-Valle, Fernando, Gabaldon, Alejandra, Simo-Perdigo, Marc, Salcedo-Allende, M Teresa, Solans-Laque, Roser et al.
DOI: 10.1097/RLU.0000000000004097

Prognostic value of ctDNA detection in patients with early breast cancer undergoing neoadjuvant therapy: A systematic review and meta-analysis.

PMID: 35219090
Journal: CANCER TREATMENT REVIEWS
Year: 2022
Reference: Cancer Treat Rev. 2022 Mar;104:102362. doi: 10.1016/j.ctrv.2022.102362. Epub 2022 Feb 18.
Impact factor: 12.111
Publication type: Review in international publication
Authors: Peg, Vicente, Vivancos, Ana, Saura, Cristina, Villacampa, Guillermo, Oliveira, Mafalda, Espinosa-Bravo, Martin, Ortiz, Carolina, Zamora, Esther, Sunol, Anna, Papakonstantinou, Andri et al.
DOI: 10.1016/j.ctrv.2022.102362

Podocytopathy in patients with monoclonal gammopathy: three patients and literature review.

PMID: 35211301
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Sep 28;15(3):417-424. doi: 10.1093/ckj/sfab176. eCollection 2022 Mar.
Impact factor: 4.452
Publication type: Review in international publication
Authors: Crespo, Marta, Rodriguez, Eva, Gabaldon, Alejandra, Soler, Maria Jose, Lop, Joan, Ribas, Andres, Puche, Adrian, Gimeno, Javier, Sans, Laia, Barrios, Clara et al.
DOI: 10.1093/ckj/sfab176

Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise.

PMID: 34006935
Journal: MODERN PATHOLOGY
Year: 2021
Reference: Mod Pathol. 2021 Sep;34(9):1704-1709. doi: 10.1038/s41379-021-00827-5. Epub 2021 May 18.
Impact factor: 7.842
Publication type: Paper in international publication
Authors: Serrano, Berta, Garrido-Pontnou, Marta, Navarro, Alexandra, Camacho, Jessica, Crispi, Fatima, Alguacil-Guillen, Marina, Moreno-Baro, Anna, Hernandez-Losa, Javier, Sese, Marta, Ramon Y Cajal, Santiago et al.
DOI: 10.1038/s41379-021-00827-5

Incidences and Determinants of Functional Cure during Entecavir or Tenofovir Disoproxil Fumarate for Chronic Hepatitis B.

PMID: 33999179
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2021
Reference: J Infect Dis. 2021 Dec 1;224(11):1890-1899. doi: 10.1093/infdis/jiab241.
Impact factor: 5.226
Publication type: Paper in international publication
Authors: Hoang, Joseph, Huang, Chung-Feng, Riveiro-Barciela, Mar, Kozuka, Ritsuzo, Istratescu, Doina, Tsai, Pei-Chien, Accarino, Elena Vargas, Lee, Dong-Hyun, Wu, Jia-Ling, Huang, Jee Fu et al.
DOI: 10.1093/infdis/jiab241

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience.

PMID: 33986388
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 May 13;11(1):10171. doi: 10.1038/s41598-021-89562-0.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Ramon, Maria Antonia, Gomez-Olles, Susana, Roman, Antonio, Bello, Irene, Burgos, Rosa, Escobar, Roser, Ferrandiz-Pulido, Carla, Gomez, Alba, Pallisa, Esther, Palomares, Gloria et al.
DOI: 10.1038/s41598-021-89562-0

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.

PMID: 33983674
Journal: Molecular Oncology
Year: 2021
Reference: Mol Oncol. 2021 Dec;15(12):3691-3705. doi: 10.1002/1878-0261.12996. Epub 2021 Jun 30.
Impact factor: 6.603
Publication type: Paper in international publication
Authors: Valverde, Claudia, Ramos, Rafael, Ortega-Medina, Luis, Martin-Davila, Francisco, Castilla-Ramirez, Carolina, Hernandez-Leon, Carmen Nieves, Romagosa, Cleofe, Vaz Salgado, Maria Angeles, Lavernia, Javier, Bague, Silvia et al.
DOI: 10.1002/1878-0261.12996

Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation OF OF 783 cases with Emphasis on histological features.

PMID: 32145220
Journal: HUMAN PATHOLOGY
Year: 2020
Reference: Hum Pathol. 2020 Apr;98:98-109. doi: 10.1016/j.humpath.2020.02.005. Epub 2020 Mar 5.
Impact factor: 2.735
Publication type: Paper in international publication
Authors: Dalurzo, Liliana, Langman, Gerald, Jang, Se Jin, Spagnolo, Dominic, Chai, Siaw Ming, Laycock, Andrew, Falconieri, Giovanni, Pizzolitto, Stefano, de Pellegrin, Alessandro, Medeiros, Filomena et al.
DOI: 10.1016/j.humpath.2020.02.005

A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation.

PMID: 31383960
Journal: MODERN PATHOLOGY
Year: 2020
Reference: Mod Pathol. 2020 Mar;33(3):404-419. doi: 10.1038/s41379-019-0323-8. Epub 2019 Aug 5.
Impact factor: 5.988
Publication type: Paper in international publication
Authors: Baud, Jessica, Le Loarer, Francois, Cleven, Arjen H G, Bouvier, Corinne, Castex, Marie-Pierre, Romagosa, Cleofe, Moreau, Anne, Salas, Sebastien, Bonhomme, Benjamin, Gomez-Brouchet, Anne et al.
DOI: 10.1038/s41379-019-0323-8

A Multidisciplinary Proposal for a Diagnostic Algorithm in Idiopathic Pulmonary Fibrosis: The Role of Transbronchial Cryobiopsy.

PMID: 31420183
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2020
Reference: Arch Bronconeumol. 2020 Feb;56(2):99-105. doi: 10.1016/j.arbres.2019.07.001. Epub 2019 Aug 13.
Impact factor: 4.957
Publication type: Paper in national publication
Authors: Llatjos, Roger, Sansano, Irene, Sellares, Jacobo, Centeno, Carmen, Fibla, Juan J, Sanchez, Marcelo, Ramirez, Jose, Moreno, Amalia, Trujillo-Reyes, Juan Carlos, Barbeta, Enric et al.
DOI: 10.1016/j.arbres.2019.07.001

Pulmonary Adenofibromas: A Clinicopathologic Correlation of 13 Cases.

PMID: 32091433
Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Year: 2020
Reference: Am J Surg Pathol. 2020 Jul;44(7):917-921. doi: 10.1097/PAS.0000000000001456.
Impact factor: 4.958
Publication type: Paper in international publication
Authors: Lindholm, Kaleigh E, Sansano-Valero, Irene, Rodriguez, Jorge L, Ramon Y Cajal, Santiago, Moran, Cesar A et al.
DOI: 10.1097/PAS.0000000000001456

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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