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Melissa Bradbury Lobato

Instituciones de las que forman parte

Investigación Biomédica en Ginecología
Vall Hebron Institut de Recerca

Líneas de investigación

Ovarian Cancer Research

Research team:


Dr. Melissa Bardbury (Principal researcher)

Dr. Antonio Gil-Moreno (Principal researcher)

Dra. Anna Santamaría (Stable collaborator)

Dr. Eva Coll (PhD student)

Dr. Carlos López (PhD student)

Dr. Melek Denizli (Technician)

Dr. José Luís Sánchez Iglesias (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Assumpció Pérez-Benavente (Clinical associated investigator)

Dr. Vicente Bebia Conesa (Clinical associated investigator)

Dr. Natalia Rodríguez Gómez-Hidalgo (Clinical associated investigator)

Dr. Javier de la Torre Fernández de Vega (Clinical associated investigator)


Research focus


PERIOPERATIVE IMMUNOMODULATION IN OVARIAN CANCER

Surgery for advanced ovarian cancer is a stressful stimulus that results in a pro-catabolic hormonal and cytokine environment, which significantly impacts metabolism. This metabolic response is accompanied by immune system impairment, increasing the risk of post-operative complications. In this research line the group is working in a multidisplinary project within the ERAS® program at the Vall d’Hebron Hospital for the: 

Identification of inflammatory markers predicting improved recovery after surgery within an ERAS® protocol.


MOLECULAR DIAGNOSTICS AND PREDICTION OF TREATMENT RESPONSE IN OVARIAN CANCER

Ovarian cancer remains the leading cause of death from gynecological malignancies due to its late diagnosis and high recurrence rates following treatment. There is a need to improve the early detection of the disease and identify predictive markers of treatment response. These diagnostic and predictive markers are being identified in proximal body fluids and patient-tissue samples. In this research line, the group has 3 ongoing projects:

Proteomic biomarkers for an improved diagnosis in uterine aspirates and pap-smears.

Proteomic biomarkers for the prediction of treatment response.

SalivOmiX: A salivary miRNA-based test for ovarian cancer early diagnosis.


IP: Melissa Bradbury Lobato, Antonio Gil Moreno

Preinvasive and invasive disease of the lower genital tract research

Research team:


Dr. Melissa Bradbury (Principal researcher)

Dr. Cristina Centeno (Clinical associated investigator)

Dr. Antonio Gil-Moreno (Principal researcher)

Dr. Carme Dinarés (Clinical associated investigator)

Dr. Josep Castellví (Clinical associated investigator)

Dr. Armando Reques (Clinical associated investigator)

Dr. Angel Garcia (Clinical associated investigator)

Dra. Eva Colás (Translational associated researcher)

Dr. Melek Denizli (Technician)


Research focus


NEW MARKERS FOR THE DIAGNOSIS AND PROGRESSION OF INTRAEPITHELIAL NEOPLASIA OF THE LOWER GENITAL TRACT

Persistent infections with high-risk human papillomavirus (HPV) genotypes are necessary, but not sufficient, cause of preinvasive and invasive lesions of the cervix and the lower genital tract. Although cancer screening prevention is based on HPV screening and pap-smear tests, it is essential to identify new molecular markers that can predict the transformation of HPV-associated lesions.

In this research line our group is assessing: Identification of molecular markers associated to an increased risk of development, persistence and progression of preinvasive lesions of the lower genital tract.


IP: Melissa Bradbury Lobato

Proyectos

SalivOmiX: Test basado en el análisis de miRNAS en saliva para la detección precoz de cáncer de ovario.

IP: Anna Santamaria Margalef
Colaboradores: Leticia Suarez Cabrera, Maria Asuncion Perez Benavente, José Luis Sánchez Iglesias, Melissa Bradbury Lobato
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 159720
Referencia: PI18/01017
Duración: 01/01/2019 - 30/06/2023

Sol·licitud Melissa.

IP: Anna Santamaria Margalef
Colaboradores: Melissa Bradbury Lobato, Miriam Izquierdo Sans
Entidad financiadora: Fundació Institut de Recerca HUVH
Financiación: 107196
Referencia: PHD4MD/04/BRADBURY/2016
Duración: 01/10/2016 - 30/09/2019

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