Speaker: Dr. Andelo Beletic,  he is a lead researcher at Genos Ltd in Zagreb, a global leader in glycomics, and serves as an Assistant Editor for Biochemia Medica, the official journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine.

Abstract: IgG antibodies are the most abundant antibody isotype in circulation and play key roles in numerous humoral immune processes. As glycoproteins, they carry complex carbohydrates, termed glycans, covalently attached to the protein backbone in the enzymatic process known as glycosylation, ongoing during IgG synthesis and maturation in the endoplasmic reticulum and Golgi apparatus. The composition of IgG glycome influences antibody stability, conformation, half-life, and effector functions, including antigen neutralization, opsonization, antibody-dependent cell-mediated (ADC) cytotoxicity, and ADC phagocytosis, as well as complement-dependent cytotoxicity. 

Host: Dr. Joaquin Seras Franzoso, Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT). Vall d'Hebron Institut de Recerca (VHIR) -Vall d’Hebron Barcelona Hospital Campus.

Online assistance: https://gencat.zoom.us/j/82041153684