Childhood Cancer and Blood Disorders
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
Publications
Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study.
PMID: 35410925
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Apr 11;12(4):e054690. doi: 10.1136/bmjopen-2021-054690.
Impact factor:
Publication type: Paper in international publication
Authors: Ababneh, Hazim; Abantanga, Francis A; Abbas, Alzhraa Salah; Abdel-Maboud, Mohamed; Abdelhafeez, Hafeez; Abdelsalam, Sherief; Abdelwahab, Mohamed; Abdessamad, El Ouahabi; Abdul Qadir, Muskaan; Abdul-Mumin, Alhassan et al.
DOI: 10.1136/bmjopen-2021-054690
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
PMID: NOPMID0100
Journal: Advances in Laboratory Medicine
Year: 2022
Reference: Adv Lab Med / Av en Med Lab. 2022;3(3):263-271. doi:10.1515/almed-2022-0016
Impact factor:
Publication type: Paper in national publication
Authors: Barquin Del Pino , Raquel ; Benitez Carabante, Maria Isabel ; Casis Saenz, Ernesto; Castellote Bellés, Laura; Ferrer Costa, Roser; López Hellin, Joan; Martinez Sánchez, Luisa; Miarons Font , Marta; Paciucci Barzanti, Rosanna; Rodríguez Frias, Francisco et al.
DOI: 10.1515/almed-2022-0016
Localised rhabdomyosarcoma in infants (<12 months) and young children (12-36 months of age) treated on the EpSSG RMS 2005 study.
PMID: 34865946
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2022
Reference: Eur J Cancer. 2022 Jan;160:206-214. doi: 10.1016/j.ejca.2021.10.031. Epub 2021 Dec 2.
Impact factor: 9.162
Publication type: Paper in international publication
Authors: Slater, Olga; Gains, Jennifer E; Kelsey, Anna M; De Corti, Federica; Zanetti, Ilaria; Coppadoro, Beatrice; Jorgensen, Mette; Gallego, Soledad; Orbach, Daniel H; Glosli, Heidi et al.
DOI: 10.1016/j.ejca.2021.10.031
Congenital rhabdomyosarcoma: A report from the European paediatric Soft tissue sarcoma Study Group.
PMID: 34582098
Journal: PEDIATRIC BLOOD & CANCER
Year: 2022
Reference: Pediatr Blood Cancer. 2022 Feb;69(2):e29376. doi: 10.1002/pbc.29376. Epub 2021 Sep 28.
Impact factor: 3.167
Publication type: Paper in international publication
Authors: Smeulders, Naima; Mudry, Peter; Zin, Angelica; Merks, Johannes H M; Slater, Olga; Alaggio, Rita; Gallego, Soledad; Coppadoro, Beatrice; Daragjati, Julia; Bisogno, Gianni et al.
DOI: 10.1002/pbc.29376
Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours.
PMID: 33620682
Journal: Clinical & Translational Oncology
Year: 2021
Reference: Clin Transl Oncol. 2021 Aug;23(8):1529-1541. doi: 10.1007/s12094-021-02558-0. Epub 2021 Feb 23.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, R; Bautista, F; Colomer, R; de Alava, E; Garrido, P; Hladun, R; Lopez-Rios, F; Rojo, F et al.
DOI: 10.1007/s12094-021-02558-0
Usefulness of NGS for Diagnosis of Dominant Beta-Thalassemia and Unstable Hemoglobinopathies in Five Clinical Cases.
PMID: 33613322
Journal: Frontiers in Physiology
Year: 2021
Reference: Front Physiol. 2021 Feb 5;12:628236. doi: 10.3389/fphys.2021.628236. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Beneitez, David; Blanco-Alvarez, Adoracion; de Pagter, Anne J; Del Orbe, Rafael; Diaz de Heredia, Cristina; Elting, Mariet; Harteveld, Cornelis L; Idrizovic, Amira; Kerkhoffs, Jean-Louis H; Koopmann, Tamara T et al.
DOI: 10.3389/fphys.2021.628236
Whole-body MRI versus an FDG-PET/CT-based reference standard for staging of paediatric Hodgkin lymphoma: a prospective multicentre study.
PMID: 32880696
Journal: EUROPEAN RADIOLOGY
Year: 2021
Reference: Eur Radiol. 2021 Mar;31(3):1494-1504. doi: 10.1007/s00330-020-07182-0. Epub 2020 Sep 3.
Impact factor:
Publication type: Paper in international publication
Authors: Beishuizen, Auke; Bruin, Marrie C A; de Keizer, Bart; de Lange, Charlotte; Elias, Sjoerd G; Enriquez, Goya; Granata, Claudio; Greer, Mary-Louise C; Kwee, Thomas C; Littooij, Annemieke S et al.
DOI: 10.1007/s00330-020-07182-0
Matched sibling donor stem cell transplantation for sickle cell disease: results from the Spanish Group for Bone Marrow Transplantation in Children.
PMID: 33296531
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2021
Reference: Eur J Haematol. 2021 Mar;106(3):408-416. doi: 10.1111/ejh.13566. Epub 2021 Jan 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Belendez, Cristina; Benitez-Carabante, Maria Isabel; Cela, Elena; Diaz-de-Heredia, Cristina; Fuster, Jose Luis; Gonzalez-Vicent, Marta; Perez-Hurtado, Jose Maria; Torrent, Monserrat; Uria-Oficialdegui, Maria Luz et al.
DOI: 10.1111/ejh.13566
Results of Ovarian Sparing Surgery in Pediatric Patients: Is There a Place for Laparoscopy?
PMID: 32013689
Journal: Journal of Laparoendoscopic & Advanced Surgical Techniques
Year: 2020
Reference: J Laparoendosc Adv Surg Tech A. 2020 Apr;30(4):458-463. doi: 10.1089/lap.2019.0515. Epub 2020 Feb 3.
Impact factor:
Publication type: Paper in international publication
Authors: Guillen, Gabriela; Lopez, Manuel; Lopez-Fernandez, Sergio; Martin-Gimenez, Marta Pilar; Molino, Jose Andres et al.
DOI: 10.1089/lap.2019.0515
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
PMID: 32015347
Journal: Cell Death & Disease
Year: 2020
Reference: Cell Death Dis. 2020 Feb 3;11(2):82. doi: 10.1038/s41419-020-2282-x.
Impact factor:
Publication type: Paper in international publication
Authors: Badillos-Rodriguez, Raquel; Barneda-Zahonero, Bruna; Coccia, Elena; Comella, Joan X; Fernandez-Hernandez, Rita; Gari, Eloi; Lopez-Soriano, Joaquin; Moubarak, Rana S; Pascual, Marta; Perez-Garcia, M Jose et al.
DOI: 10.1038/s41419-020-2282-x
Inflammatory myofibroblastic tumor: The experience of the European pediatric Soft Tissue Sarcoma Study Group (EpSSG).
PMID: 32007712
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2020
Reference: Eur J Cancer. 2020 Mar;127:123-129. doi: 10.1016/j.ejca.2019.12.021. Epub 2020 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Bisogno, Gianni; Brennan, Bernadette; Casanova, Michela; Corradini, Nadege; De Salvo, Gian Luca; Ferrari, Andrea; Gallego, Soledad; Kelsey, Anna; Merks, Johannes H M et al.
DOI: 10.1016/j.ejca.2019.12.021
IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults.
PMID: 31738823
Journal: BLOOD
Year: 2020
Reference: Blood. 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699.
Impact factor:
Publication type: Paper in international publication
Authors: Andion, Maitane; Andres, Mara; Astigarraga, Itziar; Azorin, Daniel; Balague, Olga; Barcena, Carmen; Campo, Elias; Celis, Veronica; Clot, Guillem; Dlouhy, Ivan et al.
DOI: 10.1182/blood.2019002699
Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.
PMID: 30995915
Journal: Orphanet Journal of Rare Diseases
Year: 2019
Reference: Orphanet J Rare Dis. 2019 Apr 17;14(1):82. doi: 10.1186/s13023-019-1046-0.
Impact factor: 3.687
Publication type: Paper in international publication
Authors: Arias-Salgado, Elena G, Galvez, Eva, Planas-Cerezales, Lurdes, Vallespin, Elena, Pintado-Berninches, Laura, Sastre, Leandro, Molina-Molina, Maria, Martinez, Pilar, Carrillo, Jaime, Iarriccio, Laura et al.
DOI: 10.1186/s13023-019-1046-0
Frequency, characteristics and outcome of PTLD after allo-SCT: a multicenter study from the Spanish group of blood and marrow transplantation (GETH).
PMID: 30828868
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2019
Reference: Eur J Haematol. 2019 Jun;102(6):465-471. doi: 10.1111/ejh.13226. Epub 2019 Apr 10.
Impact factor: 2.217
Publication type: Paper in international publication
Authors: Heras, Inmaculada, Viguria, M, Batlle, M, Vazquez, L, Lopez, J, Solano, C, Gonzalez Vicent, M, Suarez-Lledo, M, Alonso, L, Garcia, E et al.
DOI: 10.1111/ejh.13226
Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in high-risk populations, Spain, 2016.
PMID: 30782268
Journal: Eurosurveillance
Year: 2019
Reference: Euro Surveill. 2019 Feb;24(7). doi: 10.2807/1560-7917.ES.2019.24.7.1700857.
Impact factor: 7.421
Publication type: Review in international publication
Authors: Martinez-Gomez, Xavier, Curran, Adrian, Campins, Magda, Alemany, Laia, Rodrigo-Pendas, Jose Angel, Borruel, Natalia, Castellsague, Xavier, Diaz-de-Heredia, Cristina, Moraga-Llop, Fernando A, Del Pino, Marta et al.
DOI: 10.2807/1560-7917.ES.2019.24.7.1700857
Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.
PMID: 30770954
Journal: CELLULAR AND MOLECULAR LIFE SCIENCES
Year: 2019
Reference: Cell Mol Life Sci. 2019 Jun;76(11):2231-2243. doi: 10.1007/s00018-019-03041-4. Epub 2019 Feb 15.
Impact factor: 7.014
Publication type: Paper in international publication
Authors: Soriano, Aroa, Masanas, Marc, Boloix, Ariadna, Masia, Nuria, Paris-Coderch, Laia, Piskareva, Olga, Jimenez, Carlos, Henrich, Kai-Oliver, Roma, Josep, Westermann, Frank et al.
DOI: 10.1007/s00018-019-03041-4
Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.
PMID: 27811020
Journal: BLOOD
Year: 2017
Reference: Blood. 2017 Jan 26;129(4):525-532. doi: 10.1182/blood-2016-06-722249. Epub 2016 Nov 3.
Impact factor: 13.164
Publication type: Paper in international publication
Authors: Rocha, Vanderson, Cunha, Renato, Zago, Marco A, Querol, Sergio, Volt, Fernanda, Ruggeri, Annalisa, Sanz, Guillermo, Pouthier, Fabienne, Kogler, Gesine, Vicario, Jose L et al.
DOI: 10.1182/blood-2016-06-722249
News
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.