Clinical Neuroimmunology
The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches.
Publications
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness.
PMID: 37945711
Journal: Scientific Reports
Year: 2023
Reference: Sci Rep. 2023 Nov 9;13(1):19552. doi: 10.1038/s41598-023-46628-5.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelhak, Ahmed; Alvarez-Lafuente, Roberto; Areny, A; Arevalo, J; Bachhuber, Franziska; Benkert, Pascal; Berek, Klaus; Blanco, Yolanda; Campoy, I; Cantero-Recasens, G et al.
DOI: 10.1038/s41598-023-46628-5
Changes in physical activity participation during the COVID-19 pandemic in people with multiple sclerosis: An international survey study.
PMID: 37967488
Journal: Annals of Physical and Rehabilitation Medicine
Year: 2023
Reference: Ann Phys Rehabil Med. 2023 Nov 13;66(7):101798. doi: 10.1016/j.rehab.2023.101798.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Arntzen, Ellen Christin; Coote, Susan; de Oliveira, Ricardo Kaempf; Jonsdottir, Johanna; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne C; Moumdjian, Lousin; Nedeljkovic, Una; Novotna, Klara et al.
DOI: 10.1016/j.rehab.2023.101798
Improvements in quality of life over 2 years with cladribine tablets in people with relapsing multiple sclerosis: The CLARIFY-MS study.
PMID: 37978852
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Nov 18:13524585231205962. doi: 10.1177/13524585231205962.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Alexandri, Nektaria; Brieva, Luis; Brochet, Bruno; Callejas, Jose L; Guillen-Del-Castillo, Alfredo; Hupperts, Raymond; Keller, Birgit; Kubala Havrdova, Eva; Langdon, Dawn et al.
DOI: 10.1177/13524585231205962
Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course.
PMID: 37979966
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2023
Reference: J Neurol Neurosurg Psychiatry. 2023 Nov 18:jnnp-2023-332542. doi: 10.1136/jnnp-2023-332542.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel-Mannan, Omar; Barrabes, Jose A; Champsas, Dimitrios; Chitre, Manali; Ciccarelli, Olga; Desai, Ishita; Forsyth, Rob; Hacohen, Yael; Hemingway, Cheryl; Kneen, Rachel et al.
DOI: 10.1136/jnnp-2023-332542
Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal.
PMID: 34850641
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jan;28(1):16-28. doi: 10.1177/13524585211059766. Epub 2021 Dec 1.
Impact factor:
Publication type: Paper in international publication
Authors: Carroll, William; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Cross, Anne; Donnelly, Alexis; Feinstein, Anthony; Fox, Robert J; Helme, Anne; Hohlfeld, Reinhard et al.
DOI: 10.1177/13524585211059766
Fitbeat: COVID-19 Estimation Based on Wristband Heart Rate Using a Contrastive Convolutional Auto-Encoder.
PMID: 34720200
Journal: PATTERN RECOGNITION
Year: 2022
Reference: Pattern Recognit. 2022 Mar;123:108403. doi: 10.1016/j.patcog.2021.108403. Epub 2021 Oct 26.
Impact factor:
Publication type: Paper in international publication
Authors: Bailon, Raquel; Buron, Mathias; Comi, Giancarlo; Conde, Pauline; Consortium, Radar-Cns; Costa, Gloria Dalla; Cummins, Nicholas; Dineley, Judith; Dobson, Richard Jb; Folarin, Amos A et al.
DOI: 10.1016/j.patcog.2021.108403
Assessment of automatic decision-support systems for detecting active T2 lesions in multiple sclerosis patients.
PMID: 34859704
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jul;28(8):1209-1218. doi: 10.1177/13524585211061339. Epub 2021 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Juli; Auger, Cristina; Aymerich, Francesc Xavier; Corral, Juan Francisco; de Barros, Andrea; Llado, Xavier; Montalban, Xavier; Ng Wong, Yiken Karelys; Oliver, Arnau; Pareto, Deborah et al.
DOI: 10.1177/13524585211061339
Cognitive assessment in patients with multiple sclerosis: A Spanish consensus.
PMID: 36605095
Journal: Frontiers in rehabilitation sciences
Year: 2022
Reference: Front Rehabil Sci. 2022 Dec 20;3:1006699. doi: 10.3389/fresc.2022.1006699. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Anglada, Elisenda; Aparicio-Mingueza, Ana; Arevalo, Maria Jesus; Arrabal-Gomez, Carlos; Balaguer-Marmana, Marta; Borges, Monica; Conde, Cristina; Garcia-Vaz, Fabiola; Gich-Fulla, Jordi; Gil-Sanchez, Anna et al.
DOI: 10.3389/fresc.2022.1006699
Quantification of Cervical Cord Cross-Sectional Area: Which Acquisition, Vertebra Level, and Analysis Software? A Multicenter Repeatability Study on a Traveling Healthy Volunteer.
PMID: 34421797
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Aug 4;12:693333. doi: 10.3389/fneur.2021.693333. eCollection 2021.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: Gandini Wheeler-Kingshott, Claudia A M, Kappos, Ludwig, Rocca, Maria A, Filippi, Massimo, Yiannakas, Marios, Barkhof, Frederik, Vrenken, Hugo, Sastre-Garriga, Jaume, Rovira, Alex, Brouwer, Iman et al.
DOI: 10.3389/fneur.2021.693333
Myelin-oligodendrocyte glycoprotein antibody-associated disease.
PMID: 34418402
Journal: LANCET NEUROLOGY
Year: 2021
Reference: Lancet Neurol. 2021 Sep;20(9):762-772. doi: 10.1016/S1474-4422(21)00218-0.
Impact factor: 44.182
Publication type: Review in international publication
Authors: Linington, Christopher, Meinl, Edgar, Palace, Jacqueline, Paul, Friedemann, Petzold, Axel, Pittock, Sean, Reindl, Markus, Sato, Douglas Kazutoshi, Selmaj, Krzysztof, Siva, Aksel et al.
DOI: 10.1016/S1474-4422(21)00218-0
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.
PMID: 34400655
Journal: Scientific Data
Year: 2021
Reference: Sci Data. 2021 Aug 16;8(1):219. doi: 10.1038/s41597-021-00941-8.
Impact factor: 6.444
Publication type: Paper in international publication
Authors: Lagana, Maria Marcella, Cohen-Adad, Julien, Alonso-Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles et al.
DOI: 10.1038/s41597-021-00941-8
Generic acquisition protocol for quantitative MRI of the spinal cord.
PMID: 34400839
Journal: Nature protocols
Year: 2021
Reference: Nat Protoc. 2021 Oct;16(10):4611-4632. doi: 10.1038/s41596-021-00588-0. Epub 2021 Aug 16.
Impact factor: 0
Publication type: Review in international publication
Authors: Kinany, Nawal, Freund, Patrick, Finsterbusch, Jurgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia A M Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico et al.
DOI: 10.1038/s41596-021-00588-0
Assessing life balance of European people with multiple sclerosis: A multicenter clinimetric study within the RIMS network.
PMID: 31915118
Journal: Multiple Sclerosis and Related Disorders
Year: 2020
Reference: Multiple Sclerosis and Related Disorders. 2020 Apr;39:101879.
Impact factor: 2.889
Publication type: Paper in international publication
Authors: Kos, Daphne, Ferdinand, Sofie, Duportail, Marijke, Eijssen, Isaline, Schouteden, Sofie, Kerkhofs, Lore, Jansa, Jelka, Fillo, Núria, Matuska, Kathleen, Beckerman, Heleen et al.
DOI: 10.1016/j.msard.2019.101879
New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab.
PMID: 33408681
Journal: Frontiers in Neurology
Year: 2020
Reference: Front Neurol. 2020 Dec 17;11:579438. doi: 10.3389/fneur.2020.579438. eCollection 2020.
Impact factor: 2.889
Publication type: Paper in international publication
Authors: Romero, Fernando, Laroni, Alicia, Uccelli, Antonio, Perez-Sempere, Angel, Saiz, Albert, Blanco, Yolanda, Galimberti, Daniela, Scarpini, Elio, Espejo, Carmen, Montalban, Xavier et al.
DOI: 10.3389/fneur.2020.579438
Palliative care in multiple sclerosis: European guideline.
PMID: 32513039
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1009-1011. doi: 10.1177/1352458520926467. Epub 2020 Jun 9.
Impact factor: 5.412
Publication type: Paper in international publication
Authors: Solari, Alessandra, Oliver, David, Solari, Alessandra, Giordano, Andrea, Sastre-Garriga, Jaume, Kopke, Sascha, Rahn, Anne C, Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A et al.
DOI: 10.1177/1352458520926467
Modelling multiple sclerosis using induced pluripotent stem cells.
PMID: 33130461
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2020
Reference: J Neuroimmunol. 2020 Dec 15;349:577425. doi: 10.1016/j.jneuroim.2020.577425. Epub 2020 Oct 17.
Impact factor: 3.125
Publication type: Review in international publication
Authors: Matute-Blanch, Clara, Martinez-Larrosa, Julia, Comabella, Manuel, Montalban, Xavier et al.
DOI: 10.1016/j.jneuroim.2020.577425
Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor.
PMID: 28301287
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Mar;24(3):301-312. doi: 10.1177/1352458517697830. Epub 2017 Mar 16.
Impact factor: 5.28
Publication type: Paper in international publication
Authors: Arrambide, Georgina, Rovira, Alex, Sastre-Garriga, Jaume, Tur, Carmen, Castillo, Joaquin, Rio, Jordi, Vidal-Jordana, Angela, Galan, Ingrid, Rodriguez-Acevedo, Breogan, Midaglia, Luciana et al.
DOI: 10.1177/1352458517697830
Disability progression markers over 6-12 years in interferon-beta-treated multiple sclerosis patients.
PMID: 28287331
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Mar;24(3):322-330. doi: 10.1177/1352458517698052. Epub 2017 Mar 13.
Impact factor: 5.28
Publication type: Paper in international publication
Authors: Castillo, Joaquin, Arrambide, Georgina, Nos, Carlos, Tur, Carmen, Pujal, Berta, Auger, Cristina, Sastre-Garriga, Jaume, Montalban, Xavier, Galan, Ingrid, Vidal-Jordana, Angela et al.
DOI: 10.1177/1352458517698052
The value of oligoclonal bands in the multiple sclerosis diagnostic criteria.
PMID: 29462277
Journal: BRAIN
Year: 2018
Reference: Brain. 2018 Apr 1;141(4):1075-1084. doi: 10.1093/brain/awy006.
Impact factor: 10.84
Publication type: Paper in international publication
Authors: Castillo, Joaquin, Vidal-Jordana, Angela, Galan, Ingrid, Nos, Carlos, Mitjana, Raquel, Mulero, Patricia, de Barros, Andrea, Rodriguez-Acevedo, Breogan, Midaglia, Luciana, Sastre-Garriga, Jaume et al.
DOI: 10.1093/brain/awy006
Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome.
PMID: 29452342
Journal: BRAIN
Year: 2018
Reference: Brain. 2018 Apr 1;141(4):1085-1093. doi: 10.1093/brain/awy021.
Impact factor: 10.84
Publication type: Paper in international publication
Authors: Tintore, Mar, Sanchez, Alex, Montalban, Xavier, Comabella, Manuel, Rio, Jordi, Deisenhammer, Florian, Hegen, Harald, Quintana, Ester, Matute-Blanch, Clara, Villar, Luisa M et al.
DOI: 10.1093/brain/awy021
News
In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.
Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.
The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.
We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis
We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.