Skip to main content

Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Publications

Optimization of Statin-Loaded Delivery Nanoparticles for Treating Chronic Liver Diseases by Targeting Liver Sinusoidal Endothelial Cells.

PMID: 37896223
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 Oct 14;15(10):2463. doi: 10.3390/pharmaceutics15102463.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Agarwal, Neeraj; Andrade, Fernanda; Azad, Arun A; Chakrabarti, Jayeta; Chen, Hsiang-Chun; Fizazi, Karim; Genesca, Joan; Gil, Mar; Hide, Diana et al.
DOI: 10.3390/pharmaceutics15102463

The Need for the Closer Monitoring of Novel Drugs in MS: A Siponimod Retrospective Cohort Study (Realhes Study).

PMID: 37892611
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Oct 11;12(20):6471. doi: 10.3390/jcm12206471.
Impact factor:
Publication type: Paper in international publication
Authors: Abe, Hiroshi; Ahn, Sang Bong; Aldea-Perona, Ana; An, Jihyun; Arai, Taeang; Atsukawa, Masanori; Avendano-Sola, Cristina; Blasco Quilez, Maria Rosario; Bonilla-Toyos, Elvira; Bosch Ferrer, Montserrat et al.
DOI: 10.3390/jcm12206471

Impact of hepatitis D reflex testing on the future disease burden: A modelling analysis.

PMID: 37916574
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Nov 2. doi: 10.1111/liv.15776.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar-Riera, Cristina; Aguilar-Riera, Cristina; Biagetti, Betina; Buti, Maria; Campos-Martorell, Ariadna; Casado, Miguel Angel; Clemente, Maria; Dominguez-Hernandez, Raquel; Esteban, Rafael; Fabregas, Anna et al.
DOI: 10.1111/liv.15776

Phase Ia/b Study of Giredestrant +/-Palbociclib and +/-Luteinizing Hormone-releasing Hormone Agonists in Estrogen Receptor-positive, HER2-negative, Locally Advanced/Metastatic Breast Cancer.

PMID: 37921755
Journal: CLINICAL CANCER RESEARCH
Year: 2023
Reference: Clin Cancer Res. 2023 Nov 3. doi: 10.1158/1078-0432.CCR-23-1796.
Impact factor:
Publication type: Paper in international publication
Authors: Bardia, Aditya; Bellet-Ezquerra, Meritxell; Bond, John W; Boni, Valentina; Buti, Maria; Casado, Miguel Angel; Chang, Ching-Wei; Dominguez-Hernandez, Raquel; Eng-Wong, Jennifer; Esteban, Rafael et al.
DOI: 10.1158/1078-0432.CCR-23-1796

Relationship among Streptococcus gallolyticus Subsp. gallolyticus, Enterococcus faecalis and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series.

PMID: 35456274
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Apr 13;11(8). pii: jcm11082181. doi: 10.3390/jcm11082181.
Impact factor:
Publication type: Paper in international publication
Authors: Almela, Manel; Alonso-Garcia, Pilar; Ayuso, Blanca; Corredoira, Juan; Falces, Carles; Garces-Duran, Rodrigo Vicente; Garcia-Garrote, Fernando; Garcia-Gonzalez, Javier; Garcia-Pais, Maria Jose; Hernandez-Meneses, Marta et al.
DOI: 10.3390/jcm11082181

Transplantation, HIV Serostatus and Registry Data, Room for Improvement.

PMID: 35429220
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2022
Reference: Am J Transplant. 2022 Sep;22(9):2283-2284. doi: 10.1111/ajt.17062. Epub 2022 Apr 25.
Impact factor:
Publication type: Letter or abstract
Authors: Campos-Varela, Isabel; Dodge, Jennifer L; Price, Jennifer C; Terrault, Norah A et al.
DOI: 10.1111/ajt.17062

Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals.

PMID: 35434589
Journal: JHEP Reports
Year: 2022
Reference: JHEP Rep. 2022 Feb 24;4(5):100462. doi: 10.1016/j.jhepr.2022.100462. eCollection 2022 May.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Antonio; Alados-Arboledas, Juan Carlos; Aldamiz-Echevarria, Teresa; Aleman, Soo; Alonso, Roberto; Andreoni, Massimo; Angelico, Mario; Antequera, Pedro; Anton, Jose Joaquin; Applegate, Tanya et al.
DOI: 10.1016/j.jhepr.2022.100462

High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation.

PMID: 35373449
Journal: CTS-Clinical and Translational Science
Year: 2022
Reference: Clin Transl Sci. 2022 Jun;15(6):1544-1555. doi: 10.1111/cts.13276. Epub 2022 Apr 19.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Campos-Varela, Isabel; Caralt, Mireia; Castells, Lluis; Charco, Ramon; Dopazo, Cristina; Garcia, Sonia; Gomez-Gavara, Concepcion; Hidalgo, Ernest; Montoro, Bruno et al.
DOI: 10.1111/cts.13276

A notable proportion of liver transplant candidates with alcohol-related cirrhosis can be delisted because of clinical improvement.

PMID: 33746085
Journal: JOURNAL OF HEPATOLOGY
Year: 2021
Reference: J Hepatol. 2021 Aug;75(2):275-283. doi: 10.1016/j.jhep.2021.02.033. Epub 2021 Mar 18.
Impact factor:
Publication type: Paper in international publication
Authors: Avitabile, Emma; Campos-Varela, Isabel; Castellote, Jose; Castells, Lluis; Colmenero, Jordi; Crespo, Gonzalo; Gines, Pere; Gratacos-Gines, Jordi; Perez-Campuzano, Valeria; Pose, Elisa et al.
DOI: 10.1016/j.jhep.2021.02.033

Non-viral Liver Disease is the Leading Indication for Liver Transplant in the U.S. in Persons Living with Human Immunodeficiency Virus.

PMID: 33749113
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2021
Reference: Am J Transplant. 2021 Sep;21(9):3148-3156. doi: 10.1111/ajt.16569. Epub 2021 Jul 8.
Impact factor:
Publication type: Paper in international publication
Authors: Brandman, Danielle; Campos-Varela, Isabel; Dodge, Jennifer L; Price, Jennifer C; Terrault, Norah A et al.
DOI: 10.1111/ajt.16569

Going 'trans-E-3-ve': Educational principles for a new generation of medical students.

PMID: 32529920
Journal: MEDICAL TEACHER
Year: 2021
Reference: Med Teach. 2021 Mar;43(3):358-360. doi: 10.1080/0142159X.2020.1774529. Epub 2020 Jun 12.
Impact factor:
Publication type: Letter or abstract
Authors: Bosch, Xavier; Pericas, Juan M et al.
DOI: 10.1080/0142159X.2020.1774529

Recommendations and guidance on nutritional supplementation in the liver transplant setting.

PMID: 33724244
Journal: TRANSPLANTATION
Year: 2021
Reference: Transplantation. 2021 Dec 1;105(12):2528-2537. doi: 10.1097/TP.0000000000003736.
Impact factor:
Publication type: Review in international publication
Authors: Augustin, Salvador; Campos-Varela, Isabel; Gomez-Gavara, Concepcion et al.
DOI: 10.1097/TP.0000000000003736

Optimal management of chronic hepatitis B patients receiving nucleos(t)ide analogues.

PMID: 32077604
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Feb;40 Suppl 1:15-21. doi: 10.1111/liv.14367.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Esteban, Rafael; Riveiro-Barciela, Mar; Roade, Luisa et al.
DOI: 10.1111/liv.14367

An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders.

PMID: 32080253
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 20;10(1):3038. doi: 10.1038/s41598-020-59476-4.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Bosch, Francesc; Buti, Maria; Carreras, Maria Jose; Esteban, Rafael; Farriols, Anna; Gubern, Paula; Riveiro-Barciela, Mar; Roade, Luisa et al.
DOI: 10.1038/s41598-020-59476-4

Non-invasive prediction of liver related events in HCV compensated advanced chronic liver disease patients after oral antivirals.

PMID: 31629779
Journal: JOURNAL OF HEPATOLOGY
Year: 2020
Reference: J Hepatol. 2020 Mar;72(3):472-480. doi: 10.1016/j.jhep.2019.10.005. Epub 2019 Oct 17.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Buti, Maria; Esteban, Juan Ignacio; Forns, Xavier; Genesca, Joan; Lens, Sabela; Marino, Zoe; Minguez, Beatriz; Pons, Monica; Rodriguez-Tajes, Sergio et al.
DOI: 10.1016/j.jhep.2019.10.005

The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease.

PMID: 31606552
Journal: JOURNAL OF HEPATOLOGY
Year: 2020
Reference: J Hepatol. 2020 Mar;72(3):391-400. doi: 10.1016/j.jhep.2019.09.029. Epub 2019 Oct 10.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Bosques-Padilla, Francisco; Chu, Huikuan; Duan, Yi; Hou, Xiaohua; Hube, Bernhard; Jiang, Lu; Lang, Sonja; Liu, Jinyuan; Llorente, Cristina et al.
DOI: 10.1016/j.jhep.2019.09.029

What have we learned from observational studies and clinical trials of mild to moderate COPD?

PMID: 30223834
Journal: RESPIRATORY RESEARCH
Year: 2018
Reference: Respir Res. 2018 Sep 17;19(1):177. doi: 10.1186/s12931-018-0882-0.
Impact factor: 3.751
Publication type: Review in international publication
Authors: Barrecheguren, Miriam, Gonzalez, Cruz, Miravitlles, Marc et al.
DOI: 10.1186/s12931-018-0882-0

Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus.

PMID: 30176817
Journal: BMC INFECTIOUS DISEASES
Year: 2018
Reference: BMC Infect Dis. 2018 Sep 3;18(1):446. doi: 10.1186/s12879-018-3356-6.
Impact factor: 2.62
Publication type: Paper in international publication
Authors: Domingo, Esteban, Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Beach, Nathan M, de Avila, Ana I, Llorens, Meritxell et al.
DOI: 10.1186/s12879-018-3356-6

Real world evaluation of a novel lateral flow assay (AlphaKit(R) QuickScreen) for the detection of alpha-1-antitrypsin deficiency.

PMID: 30103740
Journal: RESPIRATORY RESEARCH
Year: 2018
Reference: Respir Res. 2018 Aug 13;19(1):151. doi: 10.1186/s12931-018-0826-8.
Impact factor: 3.751
Publication type: Paper in international publication
Authors: Greulich, Timm, Rodriguez-Frias, Francisco, Belmonte, Irene, Miravitlles, Marc, Vogelmeier, Claus F, Klemmer, Andreas et al.
DOI: 10.1186/s12931-018-0826-8

Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.

PMID: 30059722
Journal: ANTIVIRAL RESEARCH
Year: 2018
Reference: Antiviral Res. 2018 Oct;158:34-44. doi: 10.1016/j.antiviral.2018.07.019. Epub 2018 Jul 29.
Impact factor: 4.307
Publication type: Review in international publication
Authors: Rodriguez-Frias, Francisco, Tabernero, David, Caballero, Andrea, Buti, Maria et al.
DOI: 10.1016/j.antiviral.2018.07.019

Assessment of a novel automatic real-time PCR assay on the Cobas4800 analyzer as a screening platform for HCV genotyping in clinical practice: comparison with massive sequencing.

PMID: 27927921
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2017
Reference: J Clin Microbiol. 2017 Feb;55(2):504-509. doi: 10.1128/JCM.01960-16. Epub 2016 Dec 7.
Impact factor: 3.631
Publication type: Paper in international publication
Authors: Nieto-Aponte, Leonardo, Quer, Josep, Ruiz-Ripa, Alicia, Tabernero, David, Gonzalez, Carolina, Gregori, Josep, Vila, Marta, Asensio, Miriam, Garcia-Cehic, Damir, Ruiz, Gerardo et al.
DOI: 10.1128/JCM.01960-16

Evaluation of Sensitivity and Specificity Performance of Elecsys HTLV-I/II Assay in a Multicenter Study in Europe and Japan.

PMID: 28468860
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2017
Reference: J Clin Microbiol. 2017 Jul;55(7):2180-2187. doi: 10.1128/JCM.00169-17. Epub 2017 May 3.
Impact factor: 3.712
Publication type: Paper in international publication
Authors: Laperche, Syria, Sauleda, Silvia, Piron, Maria, Muhlbacher, Annelies, Schennach, Harald, Queiros, Lucinda, Uno, Naoki, Yanagihara, Katsunori, Imdahl, Roland, Hey, Ariann et al.
DOI: 10.1128/JCM.00169-17

Sepsis code implementation at Vall d'Hebron University Hospital: rapid diagnostics key to success

PMID: NOPMID003
Journal: ICU Management
Year: 2017
Reference: ICU Management & Practice 2017:4
Impact factor: 0
Publication type: Paper in international publication
Authors: Ferrer Ricard, Juan Carlos Ruiz-Rodriguez, Larrosa Nieves, Llaneras J, Molas Emma, Juanjo Gonzalez-Lopez et al.
DOI:

Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.

PMID: 27785789
Journal: TRANSFUSION
Year: 2017
Reference: Transfusion. 2017 Feb;57(2):244-247. doi: 10.1111/trf.13876. Epub 2016 Oct 26.
Impact factor: 3.042
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Sauleda, Silvia, Quer, Josep, Salvador, Fernando, Gregori, Josep, Piron, Maria, Rodriguez-Frias, Francisco, Buti, Maria et al.
DOI: 10.1111/trf.13876

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

Més informació