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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Publications

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial.

PMID: 37871604
Journal: LANCET
Year: 2023
Reference: Lancet. 2023 Oct 19:S0140-6736(23)02033-0. doi: 10.1016/S0140-6736(23)02033-0.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Ampuero, Javier; Andrade, Raul J; Angeli, Paolo; Arroyo, Vicente; Bai, Yuxian; Ballester, Maria Pilar; Belli, Luca; Berenguer, Marina; Berg, Thomas et al.
DOI: 10.1016/S0140-6736(23)02033-0

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Primary results from the phase 3 MARIPOSA-2 study.

PMID: 37879444
Journal: ANNALS OF ONCOLOGY
Year: 2023
Reference: Ann Oncol. 2023 Oct 17:S0923-7534(23)04281-3. doi: 10.1016/j.annonc.2023.10.117.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Azuma, K; Baneras, Jordi; Barala, P; Bauml, J M; Bearz, A; Boixadera, Anna; Bourla, A B; Califano, R; Campelo, R G et al.
DOI: 10.1016/j.annonc.2023.10.117

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis.

PMID: 37884354
Journal: GUT
Year: 2023
Reference: Gut. 2023 Oct 26:gutjnl-2023-329923. doi: 10.1136/gutjnl-2023-329923.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Agueras, Cajal; Agueras, Cajal; Alessandria, Carlo; Allegretti, Andrew S; Alonso, Sonia; Asrani, Sumeet K; Beuers, Ulrich; Campion, Daniela; Caraceni, Paolo et al.
DOI: 10.1136/gutjnl-2023-329923

Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study.

PMID: 37893239
Journal: Biomedicines
Year: 2023
Reference: Biomedicines. 2023 Oct 23;11(10):2867. doi: 10.3390/biomedicines11102867.
Impact factor:
Publication type: Paper in international publication
Authors: Aban, M; Abraldes, Juan G; Alegre-Martin, Jose; Alessandria, Carlo; Allegretti, Andrew S; Alonso, Sonia; Andrade, R; Angeli, P; Asrani, Sumeet K; Avitabile, E et al.
DOI: 10.3390/biomedicines11102867

Impact of HBeAg on Hepatocellular Carcinoma Risk During Oral Antiviral Treatment in Patients with Chronic Hepatitis B.

PMID: 34500103
Journal: Clinical Gastroenterology and Hepatology
Year: 2022
Reference: Clin Gastroenterol Hepatol. 2022 Jun;20(6):1343-1353.e16. doi: 10.1016/j.cgh.2021.09.001. Epub 2021 Sep 6.
Impact factor:
Publication type: Paper in international publication
Authors: Ahn, Sang Bong; Berg, Thomas; Buti, Maria; Calleja, Jose Luis; Cho, Yong Kyun; Dalekos, George N; Goulis, John; Idilman, Ramazan; Jang, Heejoon; Jang, Myoung-Jin et al.
DOI: 10.1016/j.cgh.2021.09.001

Correction to: The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.

PMID: 35501978
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2022
Reference: Am J Gastroenterol. 2022 May 1;117(5):818. doi: 10.14309/ajg.0000000000001704.
Impact factor:
Publication type: Letter or abstract
Authors: Abraldes, J G; Allison, M; Altamirano, J; Alvarado-Tapias, E; Arab, J P; Argemi, J; Atkinson, S R; Bataller, R; Brown, R S Jr; Charles, E A et al.
DOI: 10.14309/ajg.0000000000001704

Early predictors of corticosteroid response in acute severe autoimmune hepatitis: A nationwide multicenter study.

PMID: 35470447
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2022
Reference: Aliment Pharmacol Ther. 2022 Jul;56(1):131-143. doi: 10.1111/apt.16926. Epub 2022 Apr 25.
Impact factor:
Publication type: Paper in international publication
Authors: Abadia, Marta; Albillos, Agustin; Alvarez Lopez, Patricia; Amaral, Carla; Berenguer, Marina; Calleja, Jose Luis; Crespo, Javier; Diaz-Fontenla, Fernando; Ferre-Aracil, Carlos; Fortea, Jose Ignacio et al.
DOI: 10.1111/apt.16926

Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.

PMID: 34964311
Journal: Hepatology Communications
Year: 2022
Reference: Hepatol Commun. 2022 May;6(5):1100-1112. doi: 10.1002/hep4.1881. Epub 2021 Dec 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aban, M; Abraldes, Juan G; Alessandria, Carlo; Andrade, R; Angeli, P; Avitabile, E; Bassegoda, O; Beuers, Ulrich; Campion, Daniela; Caraceni, Paolo et al.
DOI: 10.1002/hep4.1881

Utility of the Cobas((R)) Plasma Separation Card as a Sample Collection Device for Serological and Virological Diagnosis of Hepatitis C Virus Infection.

PMID: 33800211
Journal: Diagnostics
Year: 2021
Reference: Diagnostics (Basel). 2021 Mar 8;11(3). pii: diagnostics11030473. doi: 10.3390/diagnostics11030473.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Esteban, Angels; Martinez-Camprecios, Joan; Najarro-Centeno, Adrian; Pumarola-Sune, Tomas; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Salmeron, Paula; Velasquez-Orozco, Fernando et al.
DOI: 10.3390/diagnostics11030473

ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity.

PMID: 33807672
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Mar 5;13(5). pii: cancers13051110. doi: 10.3390/cancers13051110.
Impact factor:
Publication type: Paper in international publication
Authors: Avila, Matias A; Balibrea, Jose Maria; Berasain, Carmen; Burgaya, Ferran; Gavalda-Navarro, Aleix; Higuera, Monica; Manso, Yasmina; Minguez, Beatriz; Mirra, Serena; Salcedo, Maria Teresa et al.
DOI: 10.3390/cancers13051110

Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM).

PMID: 33782108
Journal: Journal for ImmunoTherapy of Cancer
Year: 2021
Reference: J Immunother Cancer. 2021 Mar;9(3). pii: jitc-2020-001664. doi: 10.1136/jitc-2020-001664.
Impact factor:
Publication type: Paper in international publication
Authors: Berrocal, Alfonso; Carrera, Cristina; Cerezuela, Pablo; Clotet, Bonaventura; Espinosa, Enrique; Fancelli, Sara; Gonzalez-Cao, Maria; Mandala, Mario; Manzano, Jose Luis; Marquez, Ivan et al.
DOI: 10.1136/jitc-2020-001664

Hospital at home for the management of COVID-19: preliminary experience with 63 patients.

PMID: 32995970
Journal: INFECTION
Year: 2021
Reference: Infection. 2021 Apr;49(2):327-332. doi: 10.1007/s15010-020-01527-z. Epub 2020 Sep 29.
Impact factor:
Publication type: Paper in international publication
Authors: Agelet, Aleix; Alves, Eduarda; Alves, Elisenda; Bodro, Marta; Calvo, Julia; Cardozo, Celia; Castells, Eva; Coloma, Emmanuel; Cucchiari, David; Hernandez, Carme et al.
DOI: 10.1007/s15010-020-01527-z

Anti-HBc impacts on the risk of hepatitis B reactivation but not on survival of solid-organ transplant recipients.

PMID: 32118794
Journal: MEDICINE
Year: 2020
Reference: Medicine (Baltimore). 2020 Feb;99(9):e19407. doi: 10.1097/MD.0000000000019407.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Berastegui, Cristina; Buti, Maria; Castells, Lluis; Esteban, Rafael; Flores-Cortes, Claudia; Oleas-Vega, Diana; Perello, Manel; Riveiro-Barciela, Mar; Roman, Antonio et al.
DOI: 10.1097/MD.0000000000019407

Broad and dynamic diversification of infectious hepatitis C virus in a cell culture environment.

PMID: 31852791
Journal: JOURNAL OF VIROLOGY
Year: 2020
Reference: J Virol. 2020 Feb 28;94(6). pii: JVI.01856-19. doi: 10.1128/JVI.01856-19. Print 2020 Feb 28.
Impact factor:
Publication type: Paper in international publication
Authors: Briones, Carlos; Chen, Qian; de Avila, Ana Isabel; Domingo, Esteban; Esteban, Juan Ignacio; Gallego, Isabel; Garcia-Cehic, Damir; Garcia-Crespo, Carlos; Gomez, Jordi; Gregori, Josep et al.
DOI: 10.1128/JVI.01856-19

Unexpected long-lasting anti-HEV IgM positivity: Is HEV antigen a better serological marker for hepatitis E infection diagnosis?

PMID: 32106351
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2020
Reference: J Viral Hepat. 2020 Jul;27(7):747-753. doi: 10.1111/jvh.13285. Epub 2020 Mar 11.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Bes, Marta; Buti, Maria; Esteban, Rafael; Piron, Maria; Quer, Josep; Rando-Segura, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruzo, Sofia P et al.
DOI: 10.1111/jvh.13285

Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study.

PMID: 32087795
Journal: Lancet Gastroenterology & Hepatology
Year: 2020
Reference: Lancet Gastroenterol Hepatol. 2020 May;5(5):441-453. doi: 10.1016/S2468-1253(19)30421-2. Epub 2020 Feb 20.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Kosh; Ahn, Sang Hoon; Bae, Ho; Buti, Maria; Chan, Henry L Y; Chen, Chi-Yi; Chuang, Wan-Long; Flaherty, John F; Fung, Scott; Gaggar, Anuj et al.
DOI: 10.1016/S2468-1253(19)30421-2

Immune reconstitution inflammatory syndrome in HIV-infected patients with Pneumocystis jirovecii pneumonia.

PMID: 29187293
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2018
Reference: Enferm Infecc Microbiol Clin. 2018 Dec;36(10):621-626. doi: 10.1016/j.eimc.2017.11.002. Epub 2017 Nov 26.
Impact factor: 1.714
Publication type: Paper in national publication
Authors: Roade Tato, Luisa, Burgos Cibrian, Joaquin, Curran Fabregas, Adria, Navarro Mercade, Jordi, Willekens, Rein, Martin Gomez, Maria Teresa, Ribera Pascuet, Esteban, Falco Ferrer, Vicenc et al.
DOI: 10.1016/j.eimc.2017.11.002

Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

PMID: 30519058
Journal: Infection and Drug Resistance
Year: 2018
Reference: Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018.
Impact factor: 3.443
Publication type: Paper in international publication
Authors: Perales, Celia, Chen, Qian, Soria, Maria Eugenia, Gregori, Josep, Garcia-Cehic, Damir, Nieto-Aponte, Leonardo, Castells, Lluis, Imaz, Arkaitz, Llorens-Revull, Meritxell, Domingo, Esteban et al.
DOI: 10.2147/IDR.S172226

HDV evolution-will viral resistance be an issue in HDV infection?

PMID: 30415162
Journal: Current Opinion in Virology
Year: 2018
Reference: Curr Opin Virol. 2018 Oct;32:100-107. doi: 10.1016/j.coviro.2018.10.003. Epub 2018 Nov 8.
Impact factor: 5.644
Publication type: Review in national publication
Authors: Tabernero, David, Cortese, Maria Francesca, Buti, Maria, Rodriguez-Frias, Francisco et al.
DOI: 10.1016/j.coviro.2018.10.003

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor: 3.423
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Bes, Marta, Quer, Josep, Valcarcel, David, Piriz, Sofia, Gregori, Josep, Llorens, Meritxell, Salcedo, Maria-Teresa, Piron, Maria, Esteban, Rafael et al.
DOI: 10.1111/trf.14831

Sofosbuvir and daclatasvir in mono- and HIV-coinfected patients with recurrent hepatitis C after liver transplant.

PMID: 28051797
Journal: Annals of Hepatology
Year: 2017
Reference: Ann Hepatol. 2017 Jan-Feb 2017;16(1):86-93. doi: 10.5604/16652681.1226819.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Campos-Varela, Isabel; Castells, Lluis; Charco, Ramon; Crespo, Manel; Esteban, Juan Ignacio; Esteban-Mur, Rafael; Len, Oscar; Llaneras, Jordi; Rodriguez-Frias, Francisco et al.
DOI: 10.5604/16652681.1226819

The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey.

PMID: 28775763
Journal: World Journal of Emergency Surgery
Year: 2017
Reference: World J Emerg Surg. 2017 Aug 1;12:34. doi: 10.1186/s13017-017-0145-2. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Abbo, Lilian M; Abu-Zidan, Fikri M; Adesunkanmi, Abdulrashid K; Al-Dahir, Sara; Al-Hasan, Majdi N; Alis, Halil; Alves, Carlos; Ansaloni, Luca; Araujo da Silva, Andre R; Augustin, Goran et al.
DOI: 10.1186/s13017-017-0145-2

Deep sequencing in the management of hepatitis virus infections.

PMID: 28040474
Journal: VIRUS RESEARCH
Year: 2017
Reference: Virus Res. 2017 Jul 15;239:115-125. doi: 10.1016/j.virusres.2016.12.020. Epub 2016 Dec 28.
Impact factor: 2.526
Publication type: Review in national publication
Authors: Quer, Josep, Rodriguez-Frias, Francisco, Gregori, Josep, Tabernero, David, Soria, Maria Eugenia, Garcia-Cehic, Damir, Homs, Maria, Bosch, Albert, Pinto, Rosa Maria, Esteban, Juan Ignacio et al.
DOI: 10.1016/j.virusres.2016.12.020

Effectiveness and safety of ombitasvir, paritaprevir, ritonavir +/- dasabuvir +/- ribavirin: An early access programme for Spanish patients with genotype 1/4 chronic hepatitis C virus infection.

PMID: 27976491
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2017
Reference: J Viral Hepat. 2017 Mar;24(3):226-237. doi: 10.1111/jvh.12637. Epub 2016 Dec 15.
Impact factor: 4.179
Publication type: Paper in international publication
Authors: Perello, C, Real, Y, Jorquera, F, Calleja, J L, Rayuela, Federico Saez, Simon, Miguel Angel, Gonzalez, Jose Manuel, Munoz, Eduardo, Gonzalez, Marta, Jimenez, Miguel et al.
DOI: 10.1111/jvh.12637

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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