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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Team

José García Arumí

José García Arumí

Head of group
Ophtalmology
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Ana Boixadera Espax

Ana Boixadera Espax

Ophtalmology
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Miguel Angel Zapata Victori

Miguel Angel Zapata Victori

Main researcher
Ophtalmology
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Olivia Pujol Carreras

Olivia Pujol Carreras

Main researcher
Ophtalmology
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Miguel Ángel Arcediano Sánchez

Miguel Ángel Arcediano Sánchez

Postdoctoral researcher
Ophtalmology
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Laura Natalia Distefano

Laura Natalia Distefano

Predoctoral researcher
Ophtalmology
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José García Arumí

José García Arumí

Head of group
Ophtalmology
Read more
Ana Boixadera Espax

Ana Boixadera Espax

Ophtalmology
Read more
Miguel Angel Zapata Victori

Miguel Angel Zapata Victori

Main researcher
Ophtalmology
Read more
Olivia Pujol Carreras

Olivia Pujol Carreras

Main researcher
Ophtalmology
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Miguel Ángel Arcediano Sánchez

Miguel Ángel Arcediano Sánchez

Postdoctoral researcher
Ophtalmology
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Laura Natalia Distefano

Laura Natalia Distefano

Predoctoral researcher
Ophtalmology
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Research lines

Active fractions of PEDF in the treatment of choroidal neovascularization in an animal model of AMD

IP: -

Cell therapy with Retinal Pigment Epithelium cells and Photoreceptors differentiated from human pluripotent stem cells in a rat model of retinitis pigmentosa

IP: -

CeO2 Nanoparticles-assisted stem-based cell therapy: an innovative nanopharmaceutical approach to treat retinal degenerative diseases

Chronic inflammation is now regarded as a major pathogenic pathway common in many different pathologies. This is the case of Age-related Macular Degeneration (AMD), a disease currently inevitable, orphan of treatment that represents a major cause of blindness in people over 50, and affects millions of people worldwide. The progression of AMD is associated to an increase of oxidative stress and inflammatory response in the eye leading to retinal cell death. Current studies suggest that antioxidant therapies for chronic inflammation treatment are a feasible objective to stop disease progression and represent a promising strategy to improve the therapeutic benefits of regenerative medicine to restore vision (since inflammation impedes proper regeneration). CeO2nanoparticles have a unique electronic structure that when reduced to the nanoscale, oxygen defects appear at their surface, behaving as sites for free radical scavenging. Thus, the main objective of CELLUX is to develop a novel pharmaceutical-based CeO2 nanoparticles eye drops to treat AMD that in combination with stem cell-based therapeutic strategies, will not only stop degeneration but restore vision. The accomplishment of the objectives will represent a significant advance in the current concept of nanomedicine to treat degenerative diseases.

IP: Anna Duarri Piqué

New approaches of an antiangiogenic non-viral gene therapy in the treatment of diabetic retinopathy

IP: -

Projects

BIOBANCOS Y BIOMODELOS

IP: Isabel Novoa Garcia
Collaborators: Joaquim Vives Armengol, Anna Duarri Piqué, Eva Colas Ortega, Oriol Bestard Matamoros, Marta Rosal Fontana, Carmen Espejo Ruiz, Marielle Esteves Coelho, Juan Jose Gonzalez Lopez, Sheyla Pascual Martín, Alejandro Tomasello Weitz
Funding agency: Instituto de Salud Carlos III
Funding: 137460
Reference: PT23/00040
Duration: 01/01/2024 - 31/12/2026

Oftalmologia

IP: José García Arumí
Collaborators: Javier José Puig Galy, Anna Duarri Piqué, Ana Boixadera Espax, Jaume Rigo Quera, Helena Isla Magrané, Claudia Garcia-Arumí Fusté, Miguel Angel Zapata Victori, Sara Martin Nalda, Laura Natalia Distefano
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 00994
Duration: 01/01/2022 - 30/06/2025

Administración tópica (colirio) de sitagliptina como tratamiento para la retinopatía diabética proliferativa (TopSit@)

IP: Rafael Simó Canonge
Collaborators: Anna Duarri Piqué, Cristina Hernández Pascual, Hugo Ramos Abellan, Patricia Bogdanov Baruj
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 128570
Reference: PDC2022-133991-I00
Duration: 01/12/2022 - 30/11/2024

Ministerio de Ciencia

(DIGITAL RETINA) - Análisis masivo de datos de bioimagen para el desarrollo de terapias celulares para enfermedades degenerativas de la retina

IP: Miguel Angel Zapata Victori
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 188760
Reference: PID2021-122807OB-C32
Duration: 01/09/2022 - 01/09/2025

Ministerio de Ciencia

Publications

Serum glial fibrillary acidic protein and neurofilament light chain as biomarkers of retinal neurodysfunction in early diabetic retinopathy: results of the EUROCONDOR study.

PMID: 36959506
Journal: ACTA DIABETOLOGICA
Year: 2023
Reference: Acta Diabetol. 2023 Jun;60(6):837-844. doi: 10.1007/s00592-023-02076-1. Epub 2023 Mar 23.
Impact factor:
Publication type: Paper in international publication
Authors: Cunha-Vaz, Jose; Frydkjaer-Olsen, Ulrik; Garcia-Arumi, Jose; Grauslund, Jakob; Harding, Simon P; Hernandez, Cristina; Hernandez, Cristina; Porta, Massimo; Ribeiro, Luisa; Scanlon, Peter et al.
DOI: 10.1007/s00592-023-02076-1

Delayed suprachoroidal hemorrhage after descemet stripping automated endothelial keratoplasty (DSAEK).

PMID: 37023849
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2023
Reference: Arch Soc Esp Oftalmol (Engl Ed). 2023 Apr 4:S2173-5794(23)00044-0. doi: 10.1016/j.oftale.2023.04.001.
Impact factor:
Publication type: Letter or abstract
Authors: Bisbe, L; Buck, P; Martin Nalda, S; Oliver-Gutierrez, D; Ros-Sanchez, E; Segura-Duch, G et al.
DOI: 10.1016/j.oftale.2023.04.001

Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy.

PMID: 37722135
Journal: DIABETES
Year: 2023
Reference: Diabetes. 2023 Sep 18:db230027. doi: 10.2337/db23-0027.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanov, Patricia; Duarri, Anna; Garcia-Arumi, Jose; Garcia-Arumi, Jose; Hernandez, Cristina; Hernandez, Cristina; Huerta, Jordi; Isla-Magrane, Helena; Ramos, Hugo; Sabater, David et al.
DOI: 10.2337/db23-0027

Neovascular Progression and Retinal Dysfunction in the Laser-Induced Choroidal Neovascularization Mouse Model.

PMID: 37760886
Journal: Biomedicines
Year: 2023
Reference: Biomedicines. 2023 Sep 2;11(9):2445. doi: 10.3390/biomedicines11092445.
Impact factor:
Publication type: Paper in international publication
Authors: Badia, Anna; Duarri, Anna; Fontrodona, Laura; Garcia-Arumi, Jose; Garcia-Arumi, Jose; Salas, Anna; Salas, Anna; Zapata, Miguel; Zapata, Miguel et al.
DOI: 10.3390/biomedicines11092445

A Screening Tool for Self-Evaluation of Risk for Age-Related Macular Degeneration: Validation in a Spanish Population.

PMID: 35749108
Journal: Translational Vision Science & Technology
Year: 2022
Reference: Transl Vis Sci Technol. 2022 Jun 1;11(6):23. doi: 10.1167/tvst.11.6.23.
Impact factor: 3.283
Publication type: Paper in international publication
Authors: Seddon, Johanna M; de Dios Hernandez, Jose M; Ibanez, Isabel Lopez; Aslam, Tariq M; Sedano-Gil, German; Sayar-Beristain, Onintza; Marin-Mendez, Juan J; Gea-Sanchez, Alfredo; Arias, Luis; Garcia-Arumi, Jose et al.
DOI: 10.1167/tvst.11.6.23

Validation of an autonomous artificial intelligence-based diagnostic system for holistic maculopathy screening in a routine occupational health checkup context.

PMID: 35567610
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTALMOLOGY
Year: 2022
Reference: Graefes Arch Clin Exp Ophthalmol. 2022 May 14. pii: 10.1007/s00417-022-05653-2. doi: 10.1007/s00417-022-05653-2.
Impact factor: 3.117
Publication type: Paper in international publication
Authors: Font, Octavi, Torrents-Barrena, Jordina, Royo, Didac, Garcia, Sandra Banderas, Zarranz-Ventura, Javier, Bures, Anniken, Salinas, Cecilia, Zapata, Miguel Angel et al.
DOI: 10.1007/s00417-022-05653-2

Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity.

PMID: 33328184
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2022
Reference: Br J Ophthalmol. 2022 Apr;106(4):559-563. doi: 10.1136/bjophthalmol-2020-317953. Epub 2020 Dec 16.
Impact factor: 4.638
Publication type: Paper in international publication
Authors: Sanchez, Adrian, Zapata, Miguel Angel, Banderas Garcia, Sandra, Arcos, Gabriel, Velazquez-Villoria, Daniel, Garcia-Arumi, Jose, Otero-Romero, Susana, Falco, Anna et al.
DOI: 10.1136/bjophthalmol-2020-317953

Orbital filariasis.

PMID: 35282899
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jul 8;159(1):56. doi: 10.1016/j.medcli.2022.02.004. Epub 2022 Mar 10.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Sanchez-Vela, Laura, Garrido-Marin, Marta, Sanchez-Dalmau, Bernardo F et al.
DOI: 10.1016/j.medcli.2022.02.004

Palytoxin-Related Keratoconjunctivitis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography.

PMID: 34963267
Journal: Turkish journal of ophthalmology
Year: 2021
Reference: Turk J Ophthalmol. 2021 Dec 28;51(6):393-397. doi: 10.4274/tjo.galenos.2021.93384.
Impact factor: 0
Publication type: Letter whit IF
Authors: Nalda, Sara Martin, Oliveres, Joan, Garrido-Marin, Marta, Marti, Monica Berges, Aragon-Roca, David, Trejo-Velasco, Fernando et al.
DOI: 10.4274/tjo.galenos.2021.93384

Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages.

PMID: 34809716
Journal: Stem Cell Research & Therapy
Year: 2021
Reference: Stem Cell Res Ther. 2021 Nov 22;12(1):581. doi: 10.1186/s13287-021-02651-9.
Impact factor: 6.832
Publication type: Paper in international publication
Authors: Isla-Magrane, Helena, Veiga, Anna, Garcia-Arumi, Jose, Duarri, Anna et al.
DOI: 10.1186/s13287-021-02651-9

Ex-Press P50 device filtering failure due to non-visible intraluminal blockages.

PMID: 32838551
Journal: EUROPEAN JOURNAL OF OPHTHALMOLOGY
Year: 2021
Reference: Eur J Ophthalmol. 2021 Jul;31(4):1822-1828. doi: 10.1177/1120672120952032. Epub 2020 Aug 24.
Impact factor: 2.597
Publication type: Paper in international publication
Authors: Dou Saenz De Vizmanos, Antonio, Azarfane, Brahim, Castany Aregall, Marta, Rigo Quera, Jaume, Banderas Garcia, Sandra, Garcia Arumi, Josep et al.
DOI: 10.1177/1120672120952032

Interobserver and Intertest Agreement in Telemedicine Glaucoma Screening with Optic Disk Photos and Optical Coherence Tomography.

PMID: 34362120
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jul 28;10(15). pii: jcm10153337. doi: 10.3390/jcm10153337.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Anton, Alfonso, Nolivos, Karen, Pazos, Marta, Fatti, Gianluca, Herranz, Alejandra, Ayala-Fuentes, Miriam Eleonora, Martinez-Prats, Elena, Peral, Oscar, Vega-Lopez, Zaida, Monleon-Getino, Antoni et al.
DOI: 10.3390/jcm10153337

Differential response to intravitreal dexamethasone implant in naive and previously treated diabetic macular edema eyes.

PMID: 33176749
Journal: BMC Ophthalmology
Year: 2020
Reference: BMC Ophthalmol. 2020 Nov 11;20(1):443. doi: 10.1186/s12886-020-01716-2.
Impact factor: 1.413
Publication type: Paper in international publication
Authors: Zarranz-Ventura, Javier, Romero-Nunez, Barbara, Bernal-Morales, Carolina, Velazquez-Villoria, Daniel, Sala-Puigdollers, Anna, Figueras-Roca, Marc, Copete, Sergio, Zarranz-Ventura, Javier, Distefano, Laura, Boixadera, Anna et al.
DOI: 10.1186/s12886-020-01716-2

Remote screening of retinal and optic disc diseases using handheld nonmydriatic cameras in programmed routine occupational health checkups onsite at work centers.

PMID: 32728935
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2020
Reference: Graefes Arch Clin Exp Ophthalmol. 2020 Jul 29. pii: 10.1007/s00417-020-04860-z. doi: 10.1007/s00417-020-04860-z.
Impact factor: 2.396
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Martin, Ruth, Garcia-Arumi, Claudia, Fonollosa, Alex, Flores-Moreno, Ignacio, Gallego-Pinazo, Roberto, Gutierrez, Estanislao, Abraldes, Maximino, Zarranz-Ventura, Javier et al.
DOI: 10.1007/s00417-020-04860-z

[Ocular leprosy: A case report].

PMID: 32778351
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2020
Reference: J Fr Ophtalmol. 2020 Nov;43(9):963-966. doi: 10.1016/j.jfo.2020.03.004. Epub 2020 Aug 7.
Impact factor: 0.636
Publication type: Letter or abstract
Authors: Berges, M, Cilveti, E, Kirkegaard, E, Azarfane, B, Bisbe, L et al.
DOI: 10.1016/j.jfo.2020.03.004

Delay in diagnosis resulting in corneal perforation: nucleic acid amplification tests for a rapid identification of ocular Neisseria gonorrhoeae infection.

PMID: 32703844
Journal: SEXUALLY TRANSMITTED INFECTIONS
Year: 2020
Reference: Sex Transm Infect. 2020 Dec;96(8):562. doi: 10.1136/sextrans-2020-054549. Epub 2020 Jul 23.
Impact factor: 3.396
Publication type: Letter or abstract
Authors: Sevilla, Nerea, Martin, Sara, Serra-Pladevall, Judit, Kirkegaard, Eric, Bisbe, Laia, Puig, Javier Jose et al.
DOI: 10.1136/sextrans-2020-054549

Diabetic retinopathy as an independent predictor of subclinical cardiovascular disease: baseline results of the PRECISED study.

PMID: 31908800
Journal: BMJ Open Diabetes Research & Care
Year: 2019
Reference: BMJ Open Diabetes Res Care. 2019 Dec 29;7(1):e000845. doi: 10.1136/bmjdrc-2019-000845. eCollection 2019.
Impact factor: 5.067
Publication type: Paper in international publication
Authors: Simo, Rafael, Baneras, Jordi, Hernandez, Cristina, Rodriguez-Palomares, Jose, Valente, Filipa, Gutierrez, Laura, Gonzalez-Alujas, Teresa, Ferreira, Ignacio, Aguade-Bruix, Santiago, Seron, Daniel et al.
DOI: 10.1136/bmjdrc-2019-000845

Possible Intraluminal Obstruction of the XEN45 Gel Stent Observed With Anterior Segment Optical Coherence Tomography.

PMID: 31453896
Journal: JOURNAL OF GLAUCOMA
Year: 2019
Reference: J Glaucoma. 2019 Dec;28(12):1095-1101. doi: 10.1097/IJG.0000000000001351.
Impact factor: 1.661
Publication type: Paper in international publication
Authors: Rigo, Jaume, Castany, Marta, Banderas, Sandra, Pujol, Olivia, Amilburu, Manuel, Dou, Antoni et al.
DOI: 10.1097/IJG.0000000000001351

Editors' note: Novel ocular toxicity associated with fibroblast growth factor receptor (FGFR) inhibitors in cancer treatment: observational case series.

PMID: 29217514
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2019
Reference: Br J Ophthalmol. 2019 Aug;103(8):1200. doi: 10.1136/bjophthalmol-2017-311282. Epub 2017 Dec 7.
Impact factor: 3.615
Publication type: Letter or abstract
Authors: Velazquez-Villoria, Daniel, Azaro, Analia, Rodon, Jordi, Hierro, Cinta, Kyriakou, Danai, Garcia-Arumi, Jose, Zapata, Miguel Angel et al.
DOI: 10.1136/bjophthalmol-2017-311282

SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CHORIORETINAL CHANGES IN HYPERTENSIVE CHOROIDOPATHY RELATED TO HELLP SYNDROME.

PMID: 28067720
Journal: Retinal cases & brief reports
Year: 2019
Reference: Retin Cases Brief Rep. 2019 Winter;13(1):30-33. doi: 10.1097/ICB.0000000000000524.
Impact factor: 0
Publication type: Paper in international publication
Authors: Velazquez-Villoria, Daniel, Marti Rodrigo, Pablo, DeNicola, Maria L, Zapata Vitori, Miguel A, Segura Garcia, Antonio, Garcia-Arumi, Jose et al.
DOI: 10.1097/ICB.0000000000000524

Fibrin glue as agent for sealing corneal and conjunctival wound leaks.

PMID: 29075013
Journal: EYE
Year: 2018
Reference: Eye (Lond). 2018 Feb;32(2):463-466. doi: 10.1038/eye.2017.227. Epub 2017 Oct 27.
Impact factor: 2.478
Publication type: Paper in international publication
Authors: Scalcione, C, Ortiz-Vaquerizas, D, Said, D G, Dua, H S et al.
DOI: 10.1038/eye.2017.227

INTEROCULAR ASYMMETRY IN CHOROIDAL THICKNESS AND RETINAL SENSITIVITY IN HIGH MYOPIA.

PMID: 28682947
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2018
Reference: Retina. 2018 Aug;38(8):1620-1628. doi: 10.1097/IAE.0000000000001756.
Impact factor: 3.7
Publication type: Paper in international publication
Authors: Alzaben, Zeyad, Cardona, Genis, Zapata, Miguel A, Zaben, Ahmad et al.
DOI: 10.1097/IAE.0000000000001756

Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naive Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-Month, Single-Arm, Multicentre Trial.

PMID: 30405907
Journal: Journal of Ophthalmology
Year: 2018
Reference: J Ophthalmol. 2018 Oct 14;2018:8310350. doi: 10.1155/2018/8310350. eCollection 2018.
Impact factor: 1.68
Publication type: Paper in international publication
Authors: Manzanas, Lucia, Garcia-Arumi, Jose, Gomez-Ulla, Francisco, Amparo, Navea, Cervera, Enrique, Fonollosa, Alex, Arias, Luis, Araiz, Javier, Donate, Juan, de Figueroa, Marta Suarez et al.
DOI: 10.1155/2018/8310350

Keratitis secondary to Fusarium spp. in Spain 2012-2014.

PMID: 29150218
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2018
Reference: Arch Soc Esp Oftalmol. 2018 Jun;93(6):283-289. doi: 10.1016/j.oftal.2017.08.005. Epub 2017 Nov 14.
Impact factor: 0
Publication type: Paper in national publication
Authors: Mosquera Gordillo, M A, Baron Cano, N, Garralda Luquin, A, Lopez Gutierrez, C, Mengual Verdu, E, Trujillo Cabrera, G, Garrido Fierro, J M, Lamarca Mateu, J, Sanchez Espana, J C, Marticorena Alvarez, P et al.
DOI: 10.1016/j.oftal.2017.08.005

Anterior iris-claw intraocular lens implantation for the management of nontraumatic ectopia lentis: long-term outcomes in a paediatric cohort.

PMID: 27535343
Journal: ACTA OPHTHALMOLOGICA
Year: 2017
Reference: Acta Ophthalmol. 2017 Mar;95(2):170-174. doi: 10.1111/aos.13192. Epub 2016 Aug 18.
Impact factor: 3.157
Publication type: Paper in international publication
Authors: Catala-Mora, Jaume, Cuadras, Daniel, Diaz-Cascajosa, Jesus, Castany-Aregall, Marta, Prat-Bartomeu, Joan, Garcia-Arumi, Jose et al.
DOI: 10.1111/aos.13192

Prevalence of Vitreoretinal Interface Abnormalities on Spectral-Domain OCT in Healthy Participants over 45 Years of Age.

PMID: 31047428
Journal: Ophthalmology. Retina
Year: 2017
Reference: Ophthalmol Retina. 2017 May - Jun;1(3):249-254. doi: 10.1016/j.oret.2016.11.001. Epub 2016 Dec 28.
Impact factor: 0
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Figueroa, Marta S, Esteban Gonzalez, Eduardo, Huguet, Cristina, Giralt, Joan, Gallego Pinazo, Roberto, Abecia, Emilio, Donate, Juan, Fernandez Vigo, Jose, Zapata, Miguel Angel et al.
DOI: 10.1016/j.oret.2016.11.001

Early and intermediate age-related macular degeneration: update and clinical review.

PMID: 29042759
Journal: Clinical Interventions in Aging
Year: 2017
Reference: Clin Interv Aging. 2017 Oct 3;12:1579-1587. doi: 10.2147/CIA.S142685. eCollection 2017.
Impact factor: 2.581
Publication type: Review in national publication
Authors: Garcia-Layana, Alfredo, Cabrera-Lopez, Francisco, Garcia-Arumi, Jose, Arias-Barquet, Lluis, Ruiz-Moreno, Jose M et al.
DOI: 10.2147/CIA.S142685

Incidence of cystoid macular edema after Descemet's stripping automated endothelial keratoplasty.

PMID: 28730110
Journal: International Journal of Ophthalmology
Year: 2017
Reference: Int J Ophthalmol. 2017 Jul 18;10(7):1081-1087. doi: 10.18240/ijo.2017.07.10. eCollection 2017.
Impact factor: 1.177
Publication type: Paper in international publication
Authors: Pedemonte-Sarrias, Eduard, Salvador Playa, Toni, Gris, Oscar, Ribas Martinez, Joan, Garcia-Arumi, Jose, Gimenez, Nuria, Sassot Cladera, Irene et al.
DOI: 10.18240/ijo.2017.07.10

Radius of curvature changes in spontaneous improvement of foveoschisis in highly myopic eyes.

PMID: 26130673
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2016
Reference: Br J Ophthalmol. 2016 Feb;100(2):222-6. doi: 10.1136/bjophthalmol-2015-306628. Epub 2015 Jun 30.
Impact factor: 3.036
Publication type: Paper in international publication
Authors: Sherwood, Pamela R, Chang, Stanley, Garcia-Arumi, Jose, Chen, Ching-Lung, Hoang, Quan V et al.
DOI: 10.1136/bjophthalmol-2015-306628

Pars Plana Vitrectomy Alone for the Management of Pseudophakic Rhegmatogenous Retinal Detachment with Only Inferior Breaks.

PMID: 27126928
Journal: OPHTHALMOLOGY
Year: 2016
Reference: Ophthalmology. 2016 Jul;123(7):1563-9. doi: 10.1016/j.ophtha.2016.03.032. Epub 2016 Apr 26.
Impact factor: 6.75
Publication type: Paper in international publication
Authors: Martinez-Castillo, Vicente J, Garcia-Arumi, Jose, Boixadera, Anna et al.
DOI: 10.1016/j.ophtha.2016.03.032

Comparative study of human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) as a treatment for retinal dystrophies.

PMID: 27006969
Journal: Molecular Therapy-Nucleic Acids
Year: 2016
Reference: Mol Ther Methods Clin Dev. 2016 Mar 16;3:16010. doi: 10.1038/mtm.2016.10. eCollection 2016.
Impact factor: 5.048
Publication type: Paper in international publication
Authors: Riera, Marina, Fontrodona, Laura, Albert, Silvia, Ramirez, Diana Mora, Seriola, Anna, Salas, Anna, Munoz, Yolanda, Ramos, David, Villegas-Perez, Maria Paz, Zapata, Miguel Angel et al.
DOI: 10.1038/mtm.2016.10

Acid-sensing ion channels detect moderate acidifications to induce ocular pain.

PMID: 25687542
Journal: PAIN
Year: 2015
Reference: Pain. 2015 Mar;156(3):483-95. doi: 10.1097/01.j.pain.0000460335.49525.17.
Impact factor: 5.213
Publication type: Paper in international publication
Authors: Callejo, Gerard, Castellanos, Aida, Castany, Marta, Gual, Arcadi, Luna, Carolina, Acosta, M Carmen, Gallar, Juana, Giblin, Jonathan P, Gasull, Xavier et al.
DOI: 10.1097/01.j.pain.0000460335.49525.17

[New perspectives in the approach to age-related macular degeneration].

PMID: 25925046
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2015
Reference: Arch Soc Esp Oftalmol. 2015 Mar;90 Suppl 1:11-4. doi: 10.1016/S0365-6691(15)30004-6.
Impact factor: 0
Publication type: Review in national publication
Authors: Gallego-Pinazo, R, Zapata, M A et al.
DOI: 10.1016/S0365-6691(15)30004-6

Individualized Therapy with Ranibizumab in Wet Age-Related Macular Degeneration.

PMID: 26491550
Journal: Journal of Ophthalmology
Year: 2015
Reference: J Ophthalmol. 2015;2015:412903. doi: 10.1155/2015/412903. Epub 2015 Sep 27.
Impact factor: 1.425
Publication type: Review in international publication
Authors: Garcia-Layana, Alfredo, Figueroa, Marta S, Arias, Luis, Araiz, Javier, Ruiz-Moreno, Jose Maria, Garcia-Arumi, Jose, Gomez-Ulla, Francisco, Lopez-Galvez, Maria Isabel, Cabrera-Lopez, Francisco, Garcia-Campos, Jose Manuel et al.
DOI: 10.1155/2015/412903

Transcorneal oxygen therapy in two patients with traumatic hyphema and sickle cell trait.

PMID: 25546137
Journal: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2015
Reference: Clin Exp Ophthalmol. 2015 Jul;43(5):488-90. doi: 10.1111/ceo.12492. Epub 2015 Feb 19.
Impact factor: 2.347
Publication type: Letter or abstract
Authors: Carceller, Amadeu, Castany-Aregall, Marta, Padron-Perez, Noel, Pueyo, Alfredo et al.
DOI: 10.1111/ceo.12492

Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.

PMID: 25110679
Journal: Biomed Research International
Year: 2014
Reference: Biomed Res Int. 2014;2014:458631. doi: 10.1155/2014/458631. Epub 2014 Jul 7.
Impact factor: 0
Publication type: Paper in international publication
Authors: Sabater, Alfonso L, Velazquez-Villoria, Alvaro, Zapata, Miguel A, Figueroa, Marta S, Suarez-Leoz, Marta, Arrevola, Luis, Teijeiro, Maria-Angeles, Garcia-Layana, Alfredo et al.
DOI: 10.1155/2014/458631

Dexamethasone intravitreal implant for treatment of patients with persistent diabetic macular edema.

PMID: 24356099
Journal: OPHTHALMOLOGICA
Year: 2014
Reference: Ophthalmologica. 2014;231(3):141-6. doi: 10.1159/000356413. Epub 2013 Dec 19.
Impact factor: 1.867
Publication type: Paper in international publication
Authors: Dutra Medeiros, Marco, Postorino, Maurizio, Navarro, Rafael, Garcia-Arumi, Jose, Mateo, Carlos, Corcostegui, Borja et al.
DOI: 10.1159/000356413

A delphi study to detect deficiencies and propose actions in real life treatment of neovascular age-related macular degeneration.

PMID: 25587438
Journal: J OPHTHALMOL
Year: 2014
Reference: J Ophthalmol. 2014;2014:595132. doi: 10.1155/2014/595132. Epub 2014 Dec 21.
Impact factor: 1.935
Publication type: Paper in international publication
Authors: Lopez-Galvez, Maria Isabel, Cabrera-Lopez, Francisco, Garcia-Campos, Jose Manuel, Mones, Jordi, Cervera, Enrique, Armada, Felix, Gallego-Pinazo, Roberto, Pinero-Bustamante, Antonio, Serrano-Garcia, Miguel Angel, Gomez-Ulla, Francisco et al.
DOI: 10.1155/2014/595132

Dexamethasone intravitreal implant in vitrectomized versus nonvitrectomized eyes for treatment of patients with persistent diabetic macular edema.

PMID: 25259834
Journal: J OCUL PHARMACOL TH
Year: 2014
Reference: J Ocul Pharmacol Ther. 2014 Nov;30(9):709-16. doi: 10.1089/jop.2014.0010. Epub 2014 Sep 26.
Impact factor: 1.42
Publication type: Paper in international publication
Authors: Medeiros, Marco Dutra, Alkabes, Micol, Navarro, Rafael, Garcia-Arumi, Jose, Mateo, Carlos, Corcostegui, Borja et al.
DOI: 10.1089/jop.2014.0010

Correspondence to: Intravitreal tumor necrosis factor inhibitors in the treatment of refractory diabetic macular edema: a pilot study from the Pan-American Collaborative Retina Study Group.

PMID: 23624520
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2013
Reference: Retina. 2013 Jun;33(6):1285-7. doi: 10.1097/IAE.0b013e31828bcb15.
Impact factor: 2.825
Publication type: Letter whit IF
Authors: Zapata, Miguel A, Suarez, Joel, Minoves, Teresa, Moncho, Dulce, Farriols, Anna, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0b013e31828bcb15

Spectral-domain optical coherence tomography study of macular structure as prognostic and determining factor for macular hole surgery outcome.

PMID: 23584694
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2013
Reference: Retina. 2013 Jun;33(6):1117-22. doi: 10.1097/IAE.0b013e318285cc3b.
Impact factor: 2.825
Publication type: Paper in international publication
Authors: Ruiz-Moreno, Jose M, Arias, Luis, Araiz, Javier, Garcia-Arumi, Jose, Montero, Javier A, Pinero, David P et al.
DOI: 10.1097/IAE.0b013e318285cc3b

Dexamethasone intravitreal implant for treatment of patients with recalcitrant macular edema resulting from Irvine-Gass syndrome.

PMID: 23599334
Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Year: 2013
Reference: Invest Ophthalmol Vis Sci. 2013 May 7;54(5):3320-4. doi: 10.1167/iovs.12-11463.
Impact factor: 3.441
Publication type: Paper in international publication
Authors: Dutra Medeiros, Marco, Mateo, Carlos, Corcostegui, Borja, Garcia-Arumi, Jose, Navarro, Rafael et al.
DOI: 10.1167/iovs.12-11463

Rhegmatogenous retinal detachment treatment guidelines.

PMID: 23414946
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2013
Reference: Arch Soc Esp Oftalmol. 2013 Jan;88(1):11-35. doi: 10.1016/j.oftal.2011.10.013. Epub 2012 Sep 20.
Impact factor:
Publication type: Letter or abstract
Authors: Zambrano, A, Garcia-Arumi, J, Martinez-Castillo, V, Boixadera, A, Blasco, H, Marticorena, J, Zapata, M A, Macia, C, Badal, J, Distefano, L et al.
DOI: 10.1016/j.oftal.2011.10.013

Variations in Functional and Anatomical Outcomes and in Proliferative Vitreoretinopathy Rate along a Prospective Collaborative Study on Primary Rhegmatogenous Retinal Detachments: The Retina 1 Project-Report 4.

PMID: 24527230
Journal: ISRN ophthalmology
Year: 2012
Reference: ISRN Ophthalmol. 2012 Oct 8;2012:206385. doi: 10.5402/2012/206385. eCollection 2012.
Impact factor: 0
Publication type: Paper in international publication
Authors: Pastor, J Carlos, Fernandez, Itziar, Coco, Rosa M, Sanabria, Maria R, Rodriguez de la Rua, Enrique, Pinon, Rosa M, Sala-Puigdollers, Anna, Gallardo, Jose M, Velilla, Sara, Martinez, Vicente et al.
DOI: 10.5402/2012/206385

Posterior scleritis resembling acute retinal necrosis syndrome.

PMID: 25390725
Journal: Retinal cases & brief reports
Year: 2012
Reference: Retin Cases Brief Rep. 2012 Winter;6(1):102-4. doi: 10.1097/ICB.0b013e318209da6e.
Impact factor: 0
Publication type: Letter or abstract
Authors: Badal, Josep, Lobato, Carlos, Fonollosa, Alex, Segura, Antonio, Garcia-Arumi, Jose et al.
DOI: 10.1097/ICB.0b013e318209da6e

[From scientific evidence to clinical practice: treatment regimens for macular edema secondary to retinal vein occlusion].

PMID: 24278990
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2012
Reference: Arch Soc Esp Oftalmol. 2012 Dec;87 Suppl 1:54-62.
Impact factor: 0.21
Publication type: Paper in national publication
Authors: Abraldes, M J, Zapata, M A, Gomez-Ulla, F, Garcia-Arumi, J et al.
DOI:

Vitreous levels of somatostatin in patients with chronic uveitic macular oedema.

PMID: 22878444
Journal: EYE
Year: 2012
Reference: Eye (Lond). 2012 Oct;26(10):1378-83. doi: 10.1038/eye.2012.161. Epub 2012 Aug 10.
Impact factor: 1.851
Publication type: Paper in international publication
Authors: Fonollosa, A, Coronado, E, Catalan, R, Gutierrez, M, Macia, C, Zapata, M A, Martinez-Alday, N, Simo, R, Garcia-Arumi, J et al.
DOI: 10.1038/eye.2012.161

Myopic choroidal neovascularization.

PMID: 22136676
Journal: OPHTHALMOLOGY
Year: 2011
Reference: Ophthalmology. 2011 Dec;118(12):2521-3.
Impact factor: 5.017
Publication type: Letter or abstract
Authors: Ruiz-Moreno, Jose M, Lopez-Galvez, Maria I, Donate, Juan, Gomez-Ulla, Francisco, Garcia-Arumi, Jose, Garcia-Layana, Alfredo, Selles, Inmaculada, Reche, Juan, Montero, Javier A, Pazos, Belen et al.
DOI: 10.1016/j.ophtha.2011.07.029

MACULAR HOLES AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR: Surgical Management and Functional Outcome.

PMID: 21606891
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2011
Reference: Retina. 2011 Oct;31(9):1777-82.
Impact factor: 2.774
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Boixadera, Anna, Martinez-Castillo, Vicente, Zapata, Miguel Angel, Fonollosa, Alex, Corcostegui, Borja et al.
DOI: 10.1097/IAE.0b013e31820a69c3

Visian toric implantable collamer lens for correction of compound myopic astigmatism.

PMID: 20415321
Journal: JOURNAL OF REFRACTIVE SURGERY
Year: 2010
Reference: J Refract Surg. 2010 Apr;26(4):251-8. doi: 10.3928/1081597X-20100218-02. Epub 2010 Apr 7.
Impact factor: 2.32
Publication type: Paper in international publication
Authors: Elies, Daniel, Alonso, Tirso, Puig, Javier, Gris, Oscar, Guell, Jose Luis, Coret, Andreu et al.
DOI: 10.3928/1081597X-20100218-02

Evaluation of an intravitreal fluocinolone acetonide implant versus standard systemic therapy in noninfectious posterior uveitis.

PMID: 20079922
Journal: OPHTHALMOLOGY
Year: 2010
Reference: Ophthalmology. 2010 Mar;117(3):567-75, 575.e1. Epub 2010 Jan 15.
Impact factor: 5.491
Publication type: Paper in international publication
Authors: Pavesio, Carlos, Zierhut, Manfred, Bairi, Khaled, Comstock, Timothy L, Usner, Dale W, Abboud, Emad, Amoaku, Winfried, Becker, Matthias, Brancato, Rosario, Benitez del Castillo, Jose M et al.
DOI: 10.1016/j.ophtha.2009.11.027

A Strong Genetic Association between the Tumor Necrosis Factor Locus and Proliferative Vitreoretinopathy: The Retina 4 Project.

PMID: 20663564
Journal: OPHTHALMOLOGY
Year: 2010
Reference: Ophthalmology. 2010 Dec;117(12):2417-2423.e1-2. Epub 2010 Jul 21.
Impact factor: 5.491
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.ophtha.2010.03.059

Effect of intensive insulin therapy on macular biometrics, plasma VEGF and its soluble receptor in newly diagnosed diabetic patients.

PMID: 20578202
Journal: DIABETES-METABOLISM RESEARCH AND REVIEWS
Year: 2010
Reference: Diabetes Metab Res Rev. 2010 Jul;26(5):386-92.
Impact factor: 2.762
Publication type: Paper in international publication
Authors: Hernandez, Cristina, Zapata, Miguel A, Losada, Eladio, Villarroel, Marta, Garcia-Ramirez, Marta, Garcia-Arumi, Jose, Simo, Rafael et al.
DOI: 10.1002/dmrr.1093

Total regression of extensive conjunctival intraepithelial neoplasia with superficial corneal invasion treated with topical mitomycin C 0.02%.

PMID: 22140408
Journal: BMJ case reports
Year: 2009
Reference: BMJ Case Rep. 2009;2009. pii: bcr04.2009.1765. doi: 10.1136/bcr.04.2009.1765. Epub 2009 Dec 3.
Impact factor: 0
Publication type: Paper in international publication
Authors: Calatayud, Marta, Badal, Josep, Bisbe, Laia, Martin, Sara, Puig, Javier et al.
DOI: 10.1136/bcr.04.2009.1765

[Study of pathogenic mediators in diabetic macular edema by analysis of the vitreous humour. Role of erythropoietin and somatostatin.]

PMID: 20049662
Journal: Arch Soc Esp Oftalmol
Year: 2009
Reference: Arch Soc Esp Oftalmol. 2009 Dec;84(12):591-4.
Impact factor:
Publication type: Letter or abstract
Authors: Fonollosa, A, Garcia-Arumi, J et al.
DOI:

Delay in treating age-related macular degeneration in Spain is associated with progressive vision loss.

PMID: 18202712
Journal: EYE
Year: 2009
Reference: Eye (Lond). 2009 Feb;23(2):326-33.
Impact factor: 2.064
Publication type: Paper in international publication
Authors: Arias, L, Armada, F, Donate, J, Garcia-Arumi, J, Giralt, J, Pazos, B, Pinero, A, Martinez, F, Mondejar, J J, Ortega, I et al.
DOI: 10.1038/sj.eye.6703053

Vitreous levels of erythropoietin in patients with macular oedema secondary to retinal vein occlusions: a comparative study with diabetic macular oedema.

PMID: 18670462
Journal: EYE
Year: 2009
Reference: Eye (Lond). 2009 May;23(5):1066-71.
Impact factor: 2.064
Publication type: Paper in international publication
Authors: Garci-Arumi, J, Fonollosa, A, Macia, C, Hernandez, C, Martinez-Castillo, V, Boixadera, A, Zapata, M A, Simo, R et al.
DOI: 10.1038/eye.2008.230

Thesis

Estudio comparativo de calidad de vida entre pacientes operados mediante lente implantable intraocular fáquica (ICL) y queratomiulesis por láser (LASIK), utilizando un cuestionario validado específico (QIRC) para miopía entre 5 y 10 dioptrías

PhD student: Marta López Fortuny
Director/s: José García Arumí
University: Universidad Autònoma de Barcelona
Year: 2020

Terapia celular con epitelio pigmentario de la retina y precursores de fotorreceptores como nueva estrategia terapéutica para la retinosis pigmentaria

PhD student: Diana Paola Mora Ramírez, Diana Paola Mora Ramírez, Diana Paola Mora Ramírez
Director/s: Laura Fontrodona Montals, Miguel Angel Zapata Victori, Vicente Jesús Martínez Castillo, Vicente Jesús Martínez Castillo
University: Universidad Autònoma de Barcelona
Year: 2019

Terapia celular con epitelio pigmentario de la retina y precursores de fotorreceptores como nueva estrategia terapéutica para la retinosis pigmentaria

PhD student: Diana Paola Mora Ramírez, Diana Paola Mora Ramírez, Diana Paola Mora Ramírez
Director/s: Miguel Angel Zapata Victori
University: Universidad Autònoma de Barcelona
Year: 2019

Supervivencia a largo plazo de las lentes intraoculares de cámara posterior suturadas a esclera

PhD student: María Montserrat Bausili Portabella
Director/s: José García Arumí
University: Universidad Autònoma de Barcelona
Year: 2019

Antioxidant nanoparticles for the treatment of Age-related Macular Degeneration: preclinical studies in the DKOrd8 mouse model

PhD student: Anna Badia Pérez
Director/s: José García Arumí, Laura Fontrodona Montals
University: Universidad Autònoma de Barcelona
Year: 2019

Desarrollo de modelos celulares y animales para el estudio de terapia gènica no viral anti-angiogénica en retina

PhD student: Anna Salas Torras
Director/s: José García Arumí, Simon Schwartz Navarro, Ibane Abasolo Olaortua
University: Universidad Autònoma de Barcelona
Year: 2017

Vitrectomía vía pars plana sin indentación escleral y sin taponamiento postoperatorio en el tratamiento del desprendimiento de retina rhegmatógeno primario.

PhD student: Miguel Angel Zapata Victori
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2007

descripción y análisis de los hallazgos con tomografía de coherencia óptica en el desprendimiento de la retina rhegmatógeno primario con afectación macular

PhD student: Ana Boixadera Espax
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2003

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.