About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.
Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.
We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function.
PMID: 33670508 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Feb 18;13(2). pii: nu13020658. doi: 10.3390/nu13020658. Impact factor: 5.719 Publication type: Paper in international publication Authors: Livovsky, Dan M, Barber, Claudia, Barba, Elizabeth, Accarino, Anna, Azpiroz, Fernando et al. DOI: 10.3390/nu13020658
PMID: 33655764 Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Year: 2021 Reference: Am J Physiol Gastrointest Liver Physiol. 2021 May 1;320(5):G768-G779. doi: 10.1152/ajpgi.00047.2021. Epub 2021 Mar 3. Impact factor: 4.052 Publication type: Paper in international publication Authors: Giordano, Carla, Accarino, Anna, Malagelada, Carolina, Clavenzani, Paolo, Tugnoli, Vitaliano, Caio, Giacomo, Righi, Valeria, Garone, Caterina, D'Errico, Antonietta, Cenacchi, Giovanna et al. DOI: 10.1152/ajpgi.00047.2021
PMID: 33652061 Journal: Gastroenterologia y Hepatologia Year: 2021 Reference: Gastroenterol Hepatol. 2021 Aug-Sep;44(7):519-535. doi: 10.1016/j.gastrohep.2021.01.009. Epub 2021 Feb 27. Impact factor: 2.102 Publication type: Review in national publication Authors: Alvarez, Julia, Manuel Fernandez Real, Jose, Guarner, Francisco, Gueimonde, Miguel, Rodriguez, Juan Miguel, Saenz de Pipaon, Miguel, Sanz, Yolanda et al. DOI: 10.1016/j.gastrohep.2021.01.009
PMID: 33642094 Journal: Gastroenterologia y Hepatologia Year: 2021 Reference: Gastroenterol Hepatol. 2021 Apr;44(4):320. doi: 10.1016/j.gastrohep.2021.02.001. Epub 2021 Feb 25. Impact factor: 2.102 Publication type: Letter or abstract Authors: Beltran, Belen, Barreiro-de Acosta, Manuel, Marin-Jimenez, Ignacio, Rodriguez-Lago, Iago, Guarner, Francisco, Espin, Eloy, Ferrer Bradley, Isabel, Gutierrez, Ana, Nos, Pilar, Gisbert, Javier P et al. DOI: 10.1016/j.gastrohep.2021.02.001
PMID: 31991794 Journal: Nutrients Year: 2020 Reference: Nutrients. 2020 Jan 25;12(2). pii: nu12020320. doi: 10.3390/nu12020320. Impact factor: 4.546 Publication type: Paper in international publication Authors: Cotillard, Aurelie, Barba, Elizabeth, Mego, Marianela, Nieto Ruiz, Adoracion, Hernandez-Palet, Laura, Dornic, Quentin, Faurie, Jean-Michel, Butler, John, Merino, Xavi, Lobo, Beatriz et al. DOI: 10.3390/nu12020320
PMID: 31997116 Journal: Patient-Patient Centered Outcomes Research Year: 2020 Reference: Patient. 2020 Jun;13(3):317-325. doi: 10.1007/s40271-019-00407-5. Impact factor: 3.226 Publication type: Paper in international publication Authors: Novak, Kerri, Donnet, Xavier, Easton, David, Saldana, Roberto, Protze, Katja, Tzur, Eyal, Alperovich, Gabriela, Casellas, Francesc, Hart, Ailsa, Bettenworth, Dominik et al. DOI: 10.1007/s40271-019-00407-5
PMID: 31901867 Journal: EBioMedicine Year: 2020 Reference: EBioMedicine. 2020 Jan;51:102611. doi: 10.1016/j.ebiom.2019.102611. Epub 2020 Jan 2. Impact factor: 5.736 Publication type: Paper in international publication Authors: Varela, Encarna, Clark, Allison, Campos, David, Herrera, Claudia, Santiago, Alba, Machiels, Kathleen, Vermeire, Severine, Marti, Marc, Espin, Eloy, Manichanh, Chaysavanh et al. DOI: 10.1016/j.ebiom.2019.102611
PMID: 31523867 Journal: JOURNAL OF ANIMAL BREEDING AND GENETICS Year: 2020 Reference: J Anim Breed Genet. 2020 Jan;137(1):103-120. doi: 10.1111/jbg.12441. Epub 2019 Sep 16. Impact factor: 1.822 Publication type: Paper in international publication Authors: Costa, Marcio, Massacci, Francesca Romana, Clark, Allison, Ruet, Alice, Lansade, Lea, Mach, Nuria et al. DOI: 10.1111/jbg.12441
PMID: 28104319 Journal: Revista de gastroenterologia de Mexico Year: 2017 Reference: Rev Gastroenterol Mex. 2017 Apr - Jun;82(2):156-178. doi: 10.1016/j.rgmx.2016.08.004. Epub 2017 Jan 16. Impact factor: 0 Publication type: Paper in national publication Authors: Murata, C, Valdovinos, M A, Montijo, E, Abreu, A T, Heller, S, Gonzalez-Garay, A, Bacarreza, D, Bielsa-Fernandez, M, Bojorquez-Ramos, M C, Bosques-Padilla, F et al. DOI: 10.1016/j.rgmx.2016.08.004
PMID: 28090679 Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Year: 2017 Reference: J Gastroenterol Hepatol. 2017 Aug;32(8):1457-1462. doi: 10.1111/jgh.13733. Impact factor: 3.452 Publication type: Paper in international publication Authors: Nieto, Adoracion, Malagelada, Carolina, Santos, Javier, Malagelada, Juan-R, Azpiroz, Fernando, Accarino, Anna, Mendez, Sara et al. DOI: 10.1111/jgh.13733
PMID: 28082316 Journal: GUT Year: 2017 Reference: Gut. 2017 Sep;66(9):1537-1538. doi: 10.1136/gutjnl-2016-311477. Epub 2017 Jan 12. Impact factor: 16.658 Publication type: Paper in international publication Authors: Martinez, Cristina, Rodino-Janeiro, Bruno K, Lobo, Beatriz, Stanifer, Megan L, Klaus, Bernd, Granzow, Martin, Gonzalez-Castro, Ana M, Salvo-Romero, Eloisa, Alonso-Cotoner, Carmen, Pigrau, Marc et al. DOI: 10.1136/gutjnl-2016-311477
PMID: 26628509 Journal: GUT Year: 2017 Reference: Gut. 2017 Feb;66(2):314-322. doi: 10.1136/gutjnl-2015-310442. Epub 2015 Dec 1. Impact factor: 16.658 Publication type: Paper in international publication Authors: Marquez, Mirari, Sharp, Linda, Hidalgo, Manuel, Carrato, Alfredo, Ilzarbe, Lucas, Michalski, Christoph, Molero, Xavier, Farre, Antoni, Perea, Jose, Greenhalf, William et al. DOI: 10.1136/gutjnl-2015-310442
PMID: 27230869 Journal: PSYCHOTHERAPY AND PSYCHOSOMATICS Year: 2016 Reference: Psychother Psychosom. 2016;85(4):244-5. doi: 10.1159/000443899. Epub 2016 May 27. Impact factor: 7.632 Publication type: Paper in international publication Authors: Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose, Accarino, Anna, Malagelada, Carolina, Azpiroz, Fernando et al. DOI: 10.1159/000443899
PMID: 27211518 Journal: Scientific Reports Year: 2016 Reference: Sci Rep. 2016 May 23;6:26447. doi: 10.1038/srep26447. Impact factor: 5.228 Publication type: Paper in international publication Authors: Martinez, Xavier, Pozuelo, Marta, Pascal, Victoria, Campos, David, Gut, Ivo, Gut, Marta, Azpiroz, Fernando, Guarner, Francisco, Manichanh, Chaysavanh et al. DOI: 10.1038/srep26447
PMID: 27185077 Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Year: 2016 Reference: Am J Gastroenterol. 2016 Jul;111(7):1007-13. doi: 10.1038/ajg.2016.197. Epub 2016 May 17. Impact factor: 10.383 Publication type: Paper in international publication Authors: Barba, Elizabeth, Accarino, Anna, Soldevilla, Alfredo, Malagelada, Juan-R, Azpiroz, Fernando et al. DOI: 10.1038/ajg.2016.197
PMID: 27144619 Journal: GASTROENTEROLOGY Year: 2016 Reference: Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00221-3. doi: 10.1053/j.gastro.2016.02.030. Impact factor: 18.187 Publication type: Paper in international publication Authors: Boeckxstaens, Guy, Camilleri, Michael, Sifrim, Daniel, Houghton, Lesley A, Elsenbruch, Sigrid, Lindberg, Greger, Azpiroz, Fernando, Parkman, Henry P et al. DOI: 10.1053/j.gastro.2016.02.030
A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.
Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.
The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.
