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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Joana Rita Marques Soares

Joana Rita Marques Soares

Predoctoral researcher
Systemic Diseases
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José Manuel Rodríguez Moreno

José Manuel Rodríguez Moreno

Systemic Diseases
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Mari Carmen Pérez Bocanegra

Mari Carmen Pérez Bocanegra

Systemic Diseases
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Maria Cecilia Juárez Dobjanschi

Maria Cecilia Juárez Dobjanschi

Predoctoral researcher
Systemic Diseases
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Mònica Faro Colomés

Mònica Faro Colomés

Junior researcher
Systemic Diseases
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Neus Prades Gimeno

Neus Prades Gimeno

Research assistant
Systemic Diseases
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Joana Rita Marques Soares

Joana Rita Marques Soares

Predoctoral researcher
Systemic Diseases
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José Manuel Rodríguez Moreno

José Manuel Rodríguez Moreno

Systemic Diseases
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Mari Carmen Pérez Bocanegra

Mari Carmen Pérez Bocanegra

Systemic Diseases
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Maria Cecilia Juárez Dobjanschi

Maria Cecilia Juárez Dobjanschi

Predoctoral researcher
Systemic Diseases
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Mònica Faro Colomés

Mònica Faro Colomés

Junior researcher
Systemic Diseases
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Neus Prades Gimeno

Neus Prades Gimeno

Research assistant
Systemic Diseases
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Research lines

Infection and Autoimmunity: relevance of Human Endogenous Retrovirus (HERV) in Systemic Lupus Erythematosus (SLE).

Antibodies against HERVs have been detected in patients suffering from some autoimmune diseases such as SLE, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. We mainly focus our research on trying to detect these antibodies in our patients affected with SLE. We have recently cloned some recombinant proteins specific for HERVs. We are simultaneously evaluating the transcription levels of several HERV proteins in T CD4+ lymphocytes from SLE patients.

IP: -

International Classification Criteria project for neuro-Behçet disease.

We are currently enrolled in this multicentre study coordinated by Dr. Seema Kalra from University Hospital of North Staffordshire (UK). The study aims to define new diagnostic criteria for neuro-Behçet disease. A set of neurologists, rheumatologists and specialists in Internal Medicine from different countries, experts in the diagnosis and management of this disease, will try to define a new set of diagnostic criteria based on clinical expertise, and in the most new laboratory and radiology modern tests.

IP: Roser Solans Laque

International Classification Criteria Project.

This is a multicentric study aimed at defining new diagnosis criteria for muscular inflammatory diseases. Although criteria given by Bohan and Peter are still used in clinical practice, some inflammatory diseases such as inclusion body myositis are not included. The hytopathological classification performed by Dalakas includes the latter entity but it does not take into account neither the paraneoplastic myositis nor those associated to systemic diseases.

IP: Albert Selva O'Callaghan

Lung involvement in inflammatory myopathies.

With this study we want to study the natural history of this syndrome mediated by anti-synthetase antibodies, the characterization of new antibodies that may be used as markers for lung involvement, as well as we aim at understanding better the etiopathogenicity and the treatment of this organic illness in patients with myositis.

IP: Albert Selva O'Callaghan

Publications

The role of TAPSE/sPAP ratio in predicting pulmonary hypertension and mortality in the systemic sclerosis EUSTAR cohort.

PMID: 36746368
Journal: AUTOIMMUNITY REVIEWS
Year: 2023
Reference: Autoimmun Rev. 2023 Apr;22(4):103290. doi: 10.1016/j.autrev.2023.103290. Epub 2023 Feb 4.
Impact factor:
Publication type: Review in international publication
Authors: Airo, Paolo; Castellvi, Ivan; Colalillo, Amalia; Distler, Oliver; Gabrielli, Armando; Hachulla, Eric; Hoffmann-Vold, Anna-Maria; Pellicano, Chiara; Romaniello, Antonella; Rosato, Edoardo et al.
DOI: 10.1016/j.autrev.2023.103290

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.

PMID: 36799120
Journal: ALLERGY
Year: 2023
Reference: Allergy. 2023 May;78(5):1169-1203. doi: 10.1111/all.15679. Epub 2023 Apr 10.
Impact factor:
Publication type: Review in international publication
Authors: Abdul Latiff, A H; Aberer, W; Agache, I; Aguilar, D; Akdis, C A; Akdis, M; Al-Ahmad, M; Alobid, I; Ansotegui, I J; Anto, J M et al.
DOI: 10.1111/all.15679

Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis.

PMID: 36801811
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2023
Reference: Ann Rheum Dis. 2023 Jun;82(6):829-836. doi: 10.1136/ard-2022-223792. Epub 2023 Feb 17.
Impact factor:
Publication type: Paper in international publication
Authors: Casal-Dominguez, Maria; Christopher-Stine, Lisa; Dell'Orso, Stefania; Derfoul, Assia; Duque-Jaimez, Yaiza; Garrabou, Gloria; Grau-Junyent, Josep Maria; Gutierrez-Cruz, Gustavo; Liewluck, Teerin; Lloyd, Thomas E et al.
DOI: 10.1136/ard-2022-223792

Expert review and consensus on the t2t management of hereditary angioedema: from the scientific evidence to clinical practice.

PMID: 36811842
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2023
Reference: J Investig Allergol Clin Immunol. 2023 Jul 27;33(4):238-249. doi: 10.18176/jiaci.0875. Epub 2023 Feb 23.
Impact factor:
Publication type: Review in international publication
Authors: Caballero, T; Ferrer, L; Guilarte, M; Lleonart-Bellfill, R; Pedrosa, M et al.
DOI: 10.18176/jiaci.0875

Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management.

PMID: 35847803
Journal: Frontiers in Medicine
Year: 2022
Reference: Front Med (Lausanne). 2022 Jun 30;9:906098. doi: 10.3389/fmed.2022.906098. eCollection 2022.
Impact factor:
Publication type: Review in international publication
Authors: Borruel, Natalia; Martinez-Valle, Fernando; Robles-Alonso, Virginia et al.
DOI: 10.3389/fmed.2022.906098

Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study.

PMID: 35844497
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Jun 29;13:902837. doi: 10.3389/fimmu.2022.902837. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Antonio; Alvarez, Antonio; Alvarez-Sierra, Daniel; Anton, Andres; Arrese-Munoz, Iria; Bas-Minguet, Jordi; Blanco-Grau, Albert; Blanco-Grau, Albert; Bosch-Nicolau, Pau; Buzon, Maria Jose et al.
DOI: 10.3389/fimmu.2022.902837

Transforming a public university hospital and its area of influence into a comprehensive resource in response to the COVID-19 pandemic.

PMID: 35780057
Journal: Journal of healthcare quality research
Year: 2022
Reference: J Healthc Qual Res. 2022 Sep-Oct;37(5):335-342. doi: 10.1016/j.jhqr.2022.02.006. Epub 2022 Mar 10.
Impact factor:
Publication type: Paper in international publication
Authors: Abadias, M-J; Aguileta, B L D; Aller, M-B; Almirante, B; Arranz, M; Barba, M-A; Bravo, I; Campins, M; Carbonell, M; Cebrian, R et al.
DOI: 10.1016/j.jhqr.2022.02.006

Development and validation of combined symptom-medication scores for allergic rhinitis.

PMID: 34932829
Journal: ALLERGY
Year: 2022
Reference: Allergy. 2022 Jul;77(7):2147-2162. doi: 10.1111/all.15199. Epub 2022 Jan 15.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, Ioana; Almeida Fonseca, Joao; Almeida, Rute; Anto, Aram; Anto, Josep M; Bedbrook, Anna; Bergmann, Karl-Christian; Bosnic-Anticevich, Sinthia; Bousquet, Jean; Brough, Helen A et al.
DOI: 10.1111/all.15199

Corrigendum to: A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies.

PMID: 34689208
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Nov 3;60(11):5483. doi: 10.1093/rheumatology/keab616.
Impact factor:
Publication type: Letter or abstract
Authors: Aggarwal, Rohit; Allard, Andrew B; Callen, Jeffrey P; Chinoy, Hector; Chung, Lorinda; Fiorentino, David; George, Michael D; Gordon, Patrick; Kolstad, Kate; Kurtzman, Drew J B et al.
DOI: 10.1093/rheumatology/keab616

Corrigendum to: Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from EUROAPS registry.

PMID: 34672326
Journal: RHEUMATOLOGY
Year: 2021
Reference: Rheumatology (Oxford). 2021 Dec 1;60(12):5883. doi: 10.1093/rheumatology/keab659.
Impact factor:
Publication type: Letter or abstract
Authors: Alijotas-Reig, Jaume; Arnau, Anna; Belizna, Cristina; Canti, Valentina; Cervera, Ricard; Chighizola, Cecilia Beatrice; De Carolis, Sara; Espinosa, Gerard; Esteve-Valverde, Enrique; Farran-Codina, Inmaculada et al.
DOI: 10.1093/rheumatology/keab659

Pharmacologic Treatment of Anti-MDA5 Rapidly Progressive Interstitial Lung Disease.

PMID: 34603940
Journal: Current treatment options in rheumatology
Year: 2021
Reference: Curr Treatm Opt Rheumatol. 2021;7(4):319-333. doi: 10.1007/s40674-021-00186-x. Epub 2021 Sep 28.
Impact factor:
Publication type: Review in international publication
Authors: Gil-Vila, A; Pinal-Fernandez, I; Romero-Bueno, F; Ruiz-Rodriguez, J C; Sanchez-Pernaute, O; Selva-O'Callaghan, A; Trallero-Araguas, E et al.
DOI: 10.1007/s40674-021-00186-x

Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA).

PMID: 34582103
Journal: Clinical and Translational Allergy
Year: 2021
Reference: Clin Transl Allergy. 2021 Aug;11(7):e12052. doi: 10.1002/clt2.12052.
Impact factor:
Publication type: Review in international publication
Authors: Bartra, Joan; Davila, Ignacio; Labrador, Moises; Luengo, Olga; Moreno, Carmen; Pascal, Mariona; Tabar, Ana I et al.
DOI: 10.1002/clt2.12052

A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020.

PMID: 32180890
Journal: World Allergy Organization Journal
Year: 2020
Reference: World Allergy Organ J. 2020 Mar 7;13(2):100091. doi: 10.1016/j.waojou.2019.100091. eCollection 2020 Feb.
Impact factor:
Publication type: Paper in international publication
Authors: Ansotegui, Ignacio J; Asero, Riccardo; Bernstein, Jonathan; Bousquet, Jean; Canonica, Giorgio Walter; Caraballo, Luis; Cardona, Victoria; Cox, Lindo; Demoly, Pascal; Ebisawa, Motohiro et al.
DOI: 10.1016/j.waojou.2019.100091

Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing.

PMID: 32009320
Journal: Allergy Asthma & Immunology Research
Year: 2020
Reference: Allergy Asthma Immunol Res. 2020 Mar;12(2):238-258. doi: 10.4168/aair.2020.12.2.238.
Impact factor:
Publication type: Review in international publication
Authors: ARIA-MASK study group; Bousquet, J; Cardona Dahl, Victòria; Farrell, J; Illario, M et al.
DOI: 10.4168/aair.2020.12.2.238

Toxicities from immunotherapy: From clinical trials to real-world clinical practice.

PMID: 32868034
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Dec 24;155(12):541-547. doi: 10.1016/j.medcli.2020.06.057. Epub 2020 Aug 28.
Impact factor:
Publication type: Review in national publication
Authors: Barreira-Diaz, Ana; Martinez-Valle, Fernando; Munoz-Couselo, Eva; Riveiro-Barciela, Mar; Roca-Herrera, Maria; Trallero-Araguas, Ernesto; Zamora, Ester et al.
DOI: 10.1016/j.medcli.2020.06.057

Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjogren's syndrome.

PMID: 31873754
Journal: RHEUMATOLOGY
Year: 2020
Reference: Rheumatology (Oxford). 2020 Sep 1;59(9):2350-2359. doi: 10.1093/rheumatology/kez578.
Impact factor:
Publication type: Paper in international publication
Authors: Acar-Denizli, Nihan; Armagan, Berkan; Atzeni, Fabiola; Baldini, Chiara; Bombardieri, Michele; Bombardieri, Stefano; Bootsma, Hendrika; Brito-Zeron, Pilar; Danda, Debashish; De Vita, Salvatore et al.
DOI: 10.1093/rheumatology/kez578

Agreement between results of meta-analyses from case reports and clinical studies, regarding efficacy and safety of idursulfase therapy in patients with mucopolysaccharidosis type II (MPS-II). A new tool for evidence-based medicine in rare diseases.

PMID: 31639024
Journal: Orphanet Journal of Rare Diseases
Year: 2019
Reference: Orphanet J Rare Dis. 2019 Oct 21;14(1):230. doi: 10.1186/s13023-019-1202-6.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes, Javier; Llombart-Cussac, Antonio; Malfettone, Andrea; Miguel-Huguet, Bernat; Molto-Abad, Marc; Munoz-Delgado, Cecilia; Pardo-Mateos, Almudena; Perez-Garcia, Jose; Perez-Lopez, Jordi; Perez-Quintana, Marta et al.
DOI: 10.1186/s13023-019-1202-6

Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.

PMID: 31610549
Journal: ANNALS OF INTERNAL MEDICINE
Year: 2019
Reference: Ann Intern Med. 2019 Nov 19;171(10):685-694. doi: 10.7326/M19-0291. Epub 2019 Oct 15.
Impact factor:
Publication type: Paper in international publication
Authors: Castro-Salomo, Antoni; Cortes-Hernandez, Josefina; Cuquet-Pedragosa, Jordi; Mauri-Plana, Montserrat; Ordi-Ros, Josep; Ortiz-Santamaria, Vera; Perez-Conesa, Mercedes; Riera-Mestre, Antoni; Saez-Comet, Luis; Sole, Cristina et al.
DOI: 10.7326/M19-0291

Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA project.

PMID: 30620291
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2019
Reference: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):731-739. Epub 2019 Jan 3.
Impact factor:
Publication type: Paper in international publication
Authors: Avila Pedretti, Maria Gabriela; Babio-Herraiz, Jesus; Castaneda, Santos; Fabregas-Canales, Dolores; Garcia-Gomez, Carmen; Gonzalez-Gay, Miguel A; Gonzalez-Juanatey, Carlos; Juan-Mas, Antonio; Llorca, Javier; Lopez-Gonzalez, Ruth et al.
DOI:

Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 1).

PMID: 31559071
Journal: Journal of Thoracic Disease
Year: 2019
Reference: J Thorac Dis. 2019 Aug;11(8):3633-3642. doi: 10.21037/jtd.2019.08.64.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, Ioana; Annesi-Maesano, Isabella; Ansotegui, Ignacio; Anto, Josep M; Bachert, Claus; Bedbrook, Anna; Benveniste, Samuel; Bewick, Mike; Billo, Nils; Bosnic-Anticevich, Sinthia et al.
DOI: 10.21037/jtd.2019.08.64

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage.

PMID: 30092836
Journal: Acta Neuropathologica Communications
Year: 2018
Reference: Acta Neuropathol Commun. 2018 Aug 9;6(1):76. doi: 10.1186/s40478-018-0581-6.
Impact factor:
Publication type: Paper in international publication
Authors: Brianso, Ferran; Chamorro, Angel; Cugota, Roger; Gallizioli, Mattia; Gieryng, Anna; Justicia, Carles; Kaminska, Bozena; Marquez-Kisinousky, Leonardo; Miro-Mur, Francesc; Pedragosa, Jordi et al.
DOI: 10.1186/s40478-018-0581-6

Microbiome and Allergic Diseases.

PMID: 30065721
Journal: Frontiers in Immunology
Year: 2018
Reference: Front Immunol. 2018 Jul 17;9:1584. doi: 10.3389/fimmu.2018.01584. eCollection 2018.
Impact factor:
Publication type: Review in national publication
Authors: Caballero, Teresa; Escribese, Maria M; Labrador, Moises; Lopez Longo, M Natividad; Luengo, Olga; Manso, Luis; Matheu, Victor; Mayorga, Cristobalina; Pascal, Mariona; Perez-Gordo, Marina et al.
DOI: 10.3389/fimmu.2018.01584

Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study.

PMID: 30061979
Journal: World Allergy Organization Journal
Year: 2018
Reference: World Allergy Organ J. 2018 Jul 16;11(1):15. doi: 10.1186/s40413-018-0194-3. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Agache, I; Almeida, R; Almeida, R; Angles, R; Annesi-Maesano, I; Annesi-Maesano, I; Anto, J M; Anto, J M; Arnavielhe, S; Arnavielhe, S et al.
DOI: 10.1186/s40413-018-0194-3

Phenotypes, endotypes and biomarkers in anaphylaxis: current insights.

PMID: 30048251
Journal: Current Opinion in Allergy and Clinical Immunology
Year: 2018
Reference: Curr Opin Allergy Clin Immunol. 2018 Oct;18(5):370-376. doi: 10.1097/ACI.0000000000000472.
Impact factor:
Publication type: Review in international publication
Authors: Cardona, Victoria; Guilarte, Mar; Sala-Cunill, Anna et al.
DOI: 10.1097/ACI.0000000000000472

2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups.

PMID: 29106061
Journal: Arthritis & Rheumatology
Year: 2017
Reference: Arthritis Rheumatol. 2017 Dec;69(12):2271-2282. doi: 10.1002/art.40320. Epub 2017 Oct 27.
Impact factor:
Publication type: Paper in international publication
Authors: Aggarwal, Rohit; Alfredsson, Lars; Amato, Anthony A; Arnardottir, Snjolaug; Barohn, Richard J; Bottai, Matteo; Chinoy, Hector; Cooper, Robert G; Danko, Katalin; de Visser, Marianne et al.
DOI: 10.1002/art.40320

CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report.

PMID: 29075437
Journal: Clinical and Translational Allergy
Year: 2017
Reference: Clin Transl Allergy. 2017 Oct 23;7:37. doi: 10.1186/s13601-017-0173-8. eCollection 2017.
Impact factor:
Publication type: Review in national publication
Authors: Agache, I; Annesi-Maesano, I; Anto, J M; Arnavielhe, S; Bachert, C; Barbolini, M; Bedbrook, A; Bergmann, K C; Bewick, M; Bindslev-Jensen, C et al.
DOI: 10.1186/s13601-017-0173-8

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups.

PMID: 29079590
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2017
Reference: Ann Rheum Dis. 2017 Dec;76(12):1955-1964. doi: 10.1136/annrheumdis-2017-211468. Epub 2017 Oct 27.
Impact factor:
Publication type: Editorail in international publication
Authors: Aggarwal, Rohit; Alfredsson, Lars; Amato, Anthony A; Arnardottir, Snjolaug; Barohn, Richard J; Bottai, Matteo; Chinoy, Hector; Cooper, Robert G; Danko, Katalin; Dimachkie, Mazen M et al.
DOI: 10.1136/annrheumdis-2017-211468

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study.

PMID: 29026603
Journal: United European Gastroenterology Journal
Year: 2017
Reference: United European Gastroenterol J. 2017 Oct;5(6):887-897. doi: 10.1177/2050640617691690. Epub 2017 Jan 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Azpiroz, Fernando; de Torres, Ines; Fortea, Marina; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pardo-Camacho, Cristina et al.
DOI: 10.1177/2050640617691690

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project.

PMID: 27895895
Journal: Clinical and Translational Allergy
Year: 2016
Reference: Clin Transl Allergy. 2016 Nov 23;6:41. doi: 10.1186/s13601-016-0131-x. eCollection 2016.
Impact factor:
Publication type: Review in international publication
Authors: Akdis, C A; Bachert, C; Bewick, M; Bilo, B M; Bohle, B; Bonini, S; Bousquet, J; Bush, A; Caimmi, D P; Calderon, M A et al.
DOI: 10.1186/s13601-016-0131-x

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

PMID: 27554814
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2016
Reference: J Allergy Clin Immunol. 2016 Dec;138(6):1752-1755. doi: 10.1016/j.jaci.2016.07.015. Epub 2016 Aug 20.
Impact factor:
Publication type: Letter whit IF
Authors: Bader-Meunier, Brigitte; Belot, Alexandre; Berteloot, Laureline; Bessis, Didier; Blanche, Stephane; Bodemer, Christine; Caballero, Consuelo Modesto; Charbit, Bruno; Cros, Guilhem; Crow, Yanick Joseph et al.
DOI: 10.1016/j.jaci.2016.07.015

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

PMID: 26338038
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Aug;75(8):1521-6. doi: 10.1136/annrheumdis-2015-208154. Epub 2015 Sep 2.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, M Angeles; Andreu, Jose Luis; Assassi, Shervin; Bellocchi, Chiara; Beltran, Emma; Beretta, Lorenzo; Bossini-Castillo, Lara; Callejas, Jose Luis; Campillo-Davo, Diana; Camps, Maria Teresa et al.
DOI: 10.1136/annrheumdis-2015-208154

[Study of prognostic factors and prevalence of post-thrombotic syndrome in Spain in patients with deep vein thrombosis].

PMID: 26198362
Journal: MEDICINA CLINICA
Year: 2016
Reference: Med Clin (Barc). 2016 Jan 15;146(2):49-54. doi: 10.1016/j.medcli.2015.04.030. Epub 2015 Jul 18.
Impact factor:
Publication type: Paper in national publication
Authors: Acosta, Fernando; Camacho, Isabel; Marin, Nuria; Ordi, Josep; Salmeron, Luis et al.
DOI: 10.1016/j.medcli.2015.04.030

Association of CCR5Delta32 and Behcet's disease: new data from a case-control study in the Spanish population and meta-analysis.

PMID: 26393284
Journal: CLIN EXP RHEUMATOL
Year: 2015
Reference: Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S96-100. Epub 2015 Sep 22.
Impact factor:
Publication type: Review in national publication
Authors: Barnosi-Marin, Ana-Celia; Blanco, Ricardo; Camps, Teresa; Castaneda, Santos; Castillo-Palma, Maria-Jesus; Conde-Jaldon, Marta; Espinosa, Gerard; Fanlo, Patricia; Garcia-Lozano, Jose-Raul; Gonzalez-Escribano, Maria-Francisca et al.
DOI:

Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behcet disease.

PMID: 25641891
Journal: J RHEUMATOL
Year: 2015
Reference: J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1.
Impact factor:
Publication type: Paper in international publication
Authors: Barnosi-Marin, Ana-Celia; Blanco, Ricardo; Camps, Teresa; Castaneda, Santos; Conde-Jaldon, Marta; Espinosa, Gerard; Fanlo, Patricia; Garcia-Hernandez, Francisco-Jose; Garcia-Lozano, Jose-Raul; Gonzalez-Escribano, Maria-Francisca et al.
DOI: 10.3899/jrheum.140949

[Anemia in elderly patients admitted to an acute geriatric ward].

PMID: 25749584
Journal: Revista espanola de geriatria y gerontologia
Year: 2015
Reference: Rev Esp Geriatr Gerontol. 2015 May-Jun;50(3):122-5. doi: 10.1016/j.regg.2014.09.002. Epub 2015 Mar 4.
Impact factor:
Publication type: Paper in national publication
Authors: Barbe-Gil Ortega, Jose; Duran-Taberna, Montserrat; Perez-Bocanegra, Maria Carmen; Romero-Ruperto, Sheila; San Jose-Laporte, Antonio; Toscano-Rivera, Ainhoa et al.
DOI: 10.1016/j.regg.2014.09.002

A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

PMID: 25817017
Journal: AM J HUM GENET
Year: 2015
Reference: Am J Hum Genet. 2015 Apr 2;96(4):565-80. doi: 10.1016/j.ajhg.2015.02.009. Epub 2015 Mar 26.
Impact factor:
Publication type: Paper in international publication
Authors: Addimanda, Olga; Alegre-Sancho, Juan J; Barrett, Jennifer H; Beretta, Lorenzo; Blanco, Ricardo; Bossini-Castillo, Lara; Callejas, Jose L; Caminal-Montero, Luis; Carette, Simon; Carmona, F David et al.
DOI: 10.1016/j.ajhg.2015.02.009

Anti-SSA/Ro52 autoantibodies in scleroderma: results of an observational, cross-sectional study.

PMID: 25372801
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2014
Reference: Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-177-82. Epub 2014 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez-Luque, A; Fonollosa-Pla, V; Guillen, A; Marin, A; Sanchez-Montalva, A; Simeon, C P; Vilardell, M et al.
DOI:

A novel splice site mutation in the SERPING1 gene leads to haploinsufficiency by complete degradation of the mutant allele mRNA in a case of familial hereditary angioedema.

PMID: 24760113
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2014
Reference: J Clin Immunol. 2014 Jul;34(5):521-3. doi: 10.1007/s10875-014-0042-3. Epub 2014 Apr 24.
Impact factor:
Publication type: Paper in international publication
Authors: Colobran, Roger; Guilarte, Mar; Hernandez-Gonzalez, Manuel; Pujol-Borrell, Ricardo et al.
DOI: 10.1007/s10875-014-0042-3

"Pregnancy in adult-onset idiopathic inflammatory myopathy": report from a cohort of myositis patients from a single center.

PMID: 24906908
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2014
Reference: Semin Arthritis Rheum. 2014 Oct;44(2):234-40. doi: 10.1016/j.semarthrit.2014.05.004. Epub 2014 May 9.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez-Codina, Andreu; Martinez-Gomez, Xavier; Perez-Lopez, Jordi; Pinal-Fernandez, Iago; Rodrigo-Pendas, Jose; Selva-O'Callaghan, Albert; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.semarthrit.2014.05.004

Identification and characterization of a novel splice site mutation in the SERPING1 gene in a family with hereditary angioedema.

PMID: 24412907
Journal: CLINICAL IMMUNOLOGY
Year: 2014
Reference: Clin Immunol. 2014 Feb;150(2):143-8. doi: 10.1016/j.clim.2013.11.013. Epub 2013 Dec 4.
Impact factor:
Publication type: Paper in international publication
Authors: Colobran, Roger; de la Cruz, Xavier; Guilarte, Mar; Hernandez-Gonzalez, Manuel; Lois, Sergio; Pujol-Borrell, Ricardo et al.
DOI: 10.1016/j.clim.2013.11.013

Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.

PMID: 23172754
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 Jul;72(7):1233-8. doi: 10.1136/annrheumdis-2012-202357. Epub 2012 Nov 21.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, M Angeles; Airo, Paolo; Andreu, Jose Luis; Arnett, Frank C; Assasi, Shervin; Beltran, Emma; Beretta, Lorenzo; Broen, Jasper C; Callejas, Jose Luis; Camps, Maria Teresa et al.
DOI: 10.1136/annrheumdis-2012-202357

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

PMID: 23372721
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013;8(1):e54419. doi: 10.1371/journal.pone.0054419. Epub 2013 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Maria Angeles; Airo, Paolo; Andreu, Jose Luis; Beltran, Emma; Beretta, Lorenzo; Callejas, Jose Luis; Camps, Maria Teresa; Carballeira, Monica Rodriguez; Carmona, F David; Carreira, Patricia E et al.
DOI: 10.1371/journal.pone.0054419

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.

PMID: 22637702
Journal: GUT
Year: 2013
Reference: Gut. 2013 Aug;62(8):1160-8. doi: 10.1136/gutjnl-2012-302093. Epub 2012 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/gutjnl-2012-302093

Available evidence and outcome of off-label use of rituximab in clinical practice.

PMID: 23700188
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2013
Reference: Eur J Clin Pharmacol. 2013 Sep;69(9):1689-99. doi: 10.1007/s00228-013-1518-4. Epub 2013 May 23.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, A; Alerany, C; Bosch, J A; Cortes-Hernandez, J; Danes, I; Ferrer, A; Lopez, A; Martinez, J; Vallano, A et al.
DOI: 10.1007/s00228-013-1518-4

Development of a disease-specific quality of life questionnaire for adult patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-QOL): Spanish multi-centre research project.

PMID: 22817696
Journal: Health and Quality of Life Outcomes
Year: 2012
Reference: Health Qual Life Outcomes. 2012 Jul 20;10:82. doi: 10.1186/1477-7525-10-82.
Impact factor:
Publication type: Paper in international publication
Authors: Caballero, Teresa; Cabanas, Rosario; Campos, Angel; Cardona, Victoria; Cimbollek, Stefan; Contreras, Javier; de Rojas, Dolores Hernandez Fernandez; Gomez-Traseira, Carmen; Gonzalez-Quevedo, Teresa; Guilarte, Mar et al.
DOI: 10.1186/1477-7525-10-82

Risk Variants for Psoriasis Vulgaris in a Large Case-Control Collection and Association with Clinical Subphenotypes.

PMID: 22814393
Journal: HUMAN MOLECULAR GENETICS
Year: 2012
Reference: Hum Mol Genet. 2012 Oct 15;21(20):4549-57. Epub 2012 Jul 19.
Impact factor:
Publication type: Paper in international publication
Authors: Absher, Devin; Acosta, Isabel; Alonso, Arnald; Canete, Juan D; Dauden, Esteban; Erra, Alba; Fernandez-Nebro, Antonio; Fernandez-Sueiro, Jose Luis; Ferrandiz, Carlos; Fonseca, Eduardo et al.
DOI: 10.1093/hmg/dds295

Churg-Strauss Syndrome: An evolving paradigm.

PMID: 22796280
Journal: AUTOIMMUNITY REVIEWS
Year: 2012
Reference: Autoimmun Rev. 2012 Dec;12(2):235-40. doi: 10.1016/j.autrev.2012.07.009. Epub 2012 Jul 13.
Impact factor:
Publication type: Review in international publication
Authors: ; ; et al.
DOI: 10.1016/j.autrev.2012.07.009

A 79-year-old man with dyspnea, Dysphagia, and weakness.

PMID: 22796848
Journal: CHEST
Year: 2012
Reference: Chest. 2012 Jul 1;142(1):252-5.
Impact factor:
Publication type: Paper in international publication
Authors: Labirua-Iturburu, Ane; Riveiro-Barciela, Mar; Selva-O'Callaghan, Albert et al.
DOI: 10.1378/chest.11-2437

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy.

PMID: 21779181
Journal: PLoS Genetics
Year: 2011
Reference: PLoS Genet. 2011 Jul;7(7):e1002178. Epub 2011 Jul 14.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Sandeep; Airo, Paolo; Alizadeh, Behrooz Z; Amos, Christopher I; Arnett, Frank C; Assassi, Shervin; Beretta, Lorenzo; Broen, Jasper C; Carreira, Patricia; Chee, Meng May et al.
DOI: 10.1371/journal.pgen.1002178

Rates of and risk factors for severe infections in patients with systemic autoimmune diseases receiving biological agents off-label.

PMID: 21745378
Journal: ARTHRITIS RESEARCH & THERAPY
Year: 2011
Reference: Arthritis Res Ther. 2011 Jul 11;13(4):R112. doi: 10.1186/ar3397.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/ar3397

[Is the endothelial circulating microparticles analysis enough to assess the inflammatory status related to preeclampsia?]

PMID: 21196020
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Apr 30;136(12):531-533. Epub 2010 Dec 31.
Impact factor:
Publication type: Editorial in national publication
Authors: ; et al.
DOI: 10.1016/j.medcli.2010.10.010

Risk, Predictors, and Clinical Characteristics of Lymphoma Development in Primary Sjogren's Syndrome.

PMID: 21665245
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2011
Reference: Semin Arthritis Rheum. 2011 Dec;41(3):415-23. Epub 2011 Jun 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1016/j.semarthrit.2011.04.006

High doses of beta-blockers and alcohol abstinence improve long-term rebleeding and mortality in cirrhotic patients after an acute variceal bleeding.

PMID: 20536715
Journal: LIVER INTERNATIONAL
Year: 2010
Reference: Liver Int. 2010 Sep;30(8):1123-30. Epub 2010 Jun 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; et al.
DOI: 10.1111/j.1478-3231.2010.02287.x

Off-label use of rituximab in 196 patients with severe, refractory systemic autoimmune diseases.

PMID: 20525449
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2010
Reference: Clin Exp Rheumatol. 2010 Jul-Aug;28(4):468-76. Epub 2010 Aug 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI:

[Common variable immunodeficiency. Prognostic factors for lung damage]

PMID: 19811791
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Jan 30;134(2):64-7. Epub 2009 Oct 6.
Impact factor:
Publication type: Paper in national publication
Authors: Figueras Nadal, Concepcio; Labrador Horrillo, Moises; Luengo Sanchez, Olga; Martin De Vicente, Carlos; Sala Cunill, Anna; Soler-Palacin, Pere et al.
DOI: 10.1016/j.medcli.2009.06.050

Anti-beta(2)-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss.

PMID: 19296946
Journal: FERTILITY AND STERILITY
Year: 2010
Reference: Fertil Steril. 2010 May 1;93(7):2330-6.
Impact factor:
Publication type: Paper in international publication
Authors: Alijotas Reig, Jaume; Alijotas-Reig, Jaume; Cabero-Roura, Luis; Farran-Codina, Immaculada; Ferrer-Oliveras, Raquel; Rodrigo-Anoro, Maria Jose; Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.fertnstert.2009.01.089

NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain.

PMID: 19479837
Journal: ARTHRITIS AND RHEUMATISM
Year: 2009
Reference: Arthritis Rheum. 2009 Jun;60(6):1797-803.
Impact factor:
Publication type: Paper in international publication
Authors: Arostegui, Juan I; Carballo Silva, Maria Antonia; Cristina Arnal, Maria; Espada, Graciela; Garcia-Consuegra, Julia; Martin, Tammy M; Merino, Rosa; Modesto, Consuelo; Rose, Carlos D; Rosenbaum, James T et al.
DOI: 10.1002/art.24533

[Raynaud's phenomenon]

PMID: 19268319
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 May 16;132(18):712-8.
Impact factor:
Publication type: Paper in national publication
Authors: Gabarro Julia, Lourdes; Simeon Aznar, Carmen Pilar; Tolosa Vilella, Carles et al.
DOI: 10.1016/j.medcli.2008.11.017

[Internal Medicine continues its trajectory.]

PMID: 19889318
Journal: REVISTA CLINICA ESPANOLA
Year: 2009
Reference: Rev Clin Esp. 2009 Nov;209(10):483-4.
Impact factor:
Publication type: Review or editorial in national publication
Authors: Vilardell Tarres, M et al.
DOI:

Association of HLA Class II Genes with Systemic Sclerosis in Spanish Patients.

PMID: 19884273
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 Dec;36(12):2733-6.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.3899/jrheum.090377

Blog

News

The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.