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Diana Fernandes de Rafael

I possess a Master in Pharmaceutical Sciences (2010) granted by the Faculty of Pharmacy from the Lisbon University, and a PhD degree in Pharmaceutical Technology (2017) from the same University. During my PhD I had the opportunity to do research stays at Ludwig Maximillian University (LMU), Munich, Bellvitge Biomedical Research Institute (IDIBELL) and Vall D'Hebron Research Institute (VHIR), Barcelona. Actually, I am a post-doctoral researcher at Drug Delivery and Targeting Group, VHIR working in the field of nanotechnology-based drug delivery systems applied to several diseases.

Instituciones de las que forman parte

Investigador/a principal
Bioquímica Clínica, Vehiculización de Fármacos y Terapia
Vall Hebron Institut de Recerca
Diana Fernandes de Rafael

Diana Fernandes de Rafael

Diana Fernandes de Rafael

Instituciones de las que forman parte

Investigador/a principal
Bioquímica Clínica, Vehiculización de Fármacos y Terapia
Vall Hebron Institut de Recerca

I possess a Master in Pharmaceutical Sciences (2010) granted by the Faculty of Pharmacy from the Lisbon University, and a PhD degree in Pharmaceutical Technology (2017) from the same University. During my PhD I had the opportunity to do research stays at Ludwig Maximillian University (LMU), Munich, Bellvitge Biomedical Research Institute (IDIBELL) and Vall D'Hebron Research Institute (VHIR), Barcelona. Actually, I am a post-doctoral researcher at Drug Delivery and Targeting Group, VHIR working in the field of nanotechnology-based drug delivery systems applied to several diseases.

Being a multidisciplinary scientist, during 10 years of research career I acquired expertise in different areas of knowledge such as Pharmaceutical Technology, Nanomedicine, Chemistry, Molecular Biology, Cancer Signalling Pathways, Preclinical Validation, etc. My board knowledge in the field of biomedical sciences granted by my training as pharmacist and my research experience, allowed me to have a comprehensive and integrative view of the different stages of drug development from the bench to the bedside. My career has been fully dedicated to the design, development, and preclinical validation of innovative delivery systems for a wide range of challenging diseases with a special attention to oncology.
My active participation at different international projects (12) and collaborations with a variety of research groups have resulted in the authorship of several publications in high impact peer-reviewed journals (35 publications, 15 as corresponding/first author, h-index 18). Also, she is co-inventor of two patents about delivery systems for gene delivery and the creation of cell penetrating peptides. Moreover, I am truly active in science dissemination both to share the knowhow with the pairs at international conferences, and also in citizenship dissemination actions. Additionally, due to her experience in the fields of Pharmaceutical Technology and Molecular Biology, I am giving classes at the Master of Molecular Biotechnology from the University of Barcelona. Most importantly, I was responsible for the supervision of the thesis of different pre-graduated, master and PhD students (14).

Proyectos

Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia (Clinical Biochemistry, Drug Delivery & Therapy, CB-DDT)

IP: Abasolo Olaortua, Ibane
Colaboradores: Arranz Amo, José Antonio, Barquin Del Pino , Raquel , Laura Conesa Milian, Clara Ramírez Serra, Yolanda Villena Ortiz, Joan López Hellin, Albert Blanco Grau, Francisco Rodríguez Frias, Roser Ferrer Costa, Joaquin Seras Franzoso, Diego Baranda Martínez-Abasca, Laura Castillo Ribelles, Clara Carnicer Cáceres, Marina Giralt Arnaiz, Ana Gomez Garcia, Simon Schwartz Navarro, Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia (Clinical Biochemistry, Drug Delivery & Therapy, CB-DDT), Pablo Gabriel Medina, Rosanna Paciucci Barzanti, Zamira Vanessa Diaz Riascos, Marc Miquel Moltó Abad, Laura Castellote Bellés, Daniel Bravo Nieto, Luz María Cruz Carlos, Clara Sanz Gea, Alba Estela García Fernández, Maria del Pilar Reimundo Diaz-Fierros, Belen Garcia Prats, Noelia Díaz Troyano, JAUME VIMA BOFARULL, Pacín Ruíz, Beatriz, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Cortese , Maria Francesca
Entidad financiadora: AGAUR no fer servir-correcte 4301-37
Financiación: 60000
Referencia: 2021 SGR 01173
Duración: 01/01/2022 - 31/12/2024

Personal Técnico de Apoyo 2021

IP: Abasolo Olaortua, Ibane
Colaboradores: Diana Fernandes de Rafael, Izquierdo Sans , Miriam
Entidad financiadora: Ministerio de Ciencia e Innovación-MICINN
Financiación: 42600
Referencia: PTA2021-021005-I
Duración: 01/01/2023 - 31/12/2025

Ministerio de Ciencia

NanoDIRE-CT - Uso de nanobodies para terapia dirigida contra células madre tumorales

IP: Abasolo Olaortua, Ibane
Colaboradores: Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Simon Schwartz Navarro
Entidad financiadora: Ministerio de Ciencia e Innovación-MICINN
Financiación: 322172.61
Referencia: RTC2019-006809-1
Duración: 01/09/2020 - 31/12/2023

Ministerio de Ciencia

BIODEGRADABLE NANOPARTICLES OF SIMVASTATIN AS NEW THERAPEUTIC TOOL FOR CHRONIC LIVER DISEASE (NANOSIM)

IP: Genescà Ferrer, Joan
Colaboradores: Martell Pérez-Alcalde, Maria Nieves, Diana Fernandes de Rafael
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 199946.45
Referencia: AC18/00033
Duración: 01/01/2019 - 31/12/2022

Noticias relacionadas

En total se impulsarán diferentes proyectos de seis grupos de investigación que se centrarán en la medicina de precisión y las terapias avanzadas.

Durante el último año, la colaboración entre Vall d'Hebron y ZeClinics ha encontrado tres candidatos a nanocuerpos con potentes propiedades anticancerígenas en el modelo de pez cebra.

El equipo de investigación utilizó nanotecnología para administrar el medicamento directamente a las células hepáticas, lo que elimina efectos secundarios sin reducir la efectividad

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