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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Anna Meseguer Navarro

Anna Meseguer Navarro

Head of group
Kidney Physiopathology
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Carla Burballa Tàrrega

Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
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Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
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Gema Ariceta Iraola

Gema Ariceta Iraola

Main researcher
Kidney Physiopathology
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Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
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Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
Read more
Anna Meseguer Navarro

Anna Meseguer Navarro

Head of group
Kidney Physiopathology
Read more
Carla Burballa Tàrrega

Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
Read more
Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
Read more
Gema Ariceta Iraola

Gema Ariceta Iraola

Main researcher
Kidney Physiopathology
Read more
Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
Read more

Research lines

Rare inhirited renal diseases

Our group is focused in research in primary or inherited tubular renal diseases, such as Dent’s Disease, Bartter syndrome, Tubular Acidosis, Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, among others. Currently we are collaborating  with other groups in Spain, within a research project named Renaltube the main purpose of which is to build a database while facilitating access to genotyping in order to improve the clinical and molecular knowledge of primary tubulopathies. Renaltube has a web-based approach with multilateral collaboration scheme that enhances the recruitment of data and promotes the understanding of underlying mechanisms of rare inherited diseases, defines more accurate diagnostic and follow-up criteria, develops new molecular techniques and will improve the overall care of the patients. Currently we are offering the analysis of 22 genes corresponding to 23 primary tubulopathies. After two years of activity Renaltube has collected data from 222 patients, the mayority from Spain and Latin America (85.3%). The most common tubulopathies are distal renal tubular acidosis (22.5%), and classical Bartter syndrome (19.3%) followed by familial hypomagesemia with hipercalciuria and nephrocalcinosis (15.7%), and Gitelman syndrome (15%).

IP: Gema Ariceta Iraola, Anna Meseguer Navarro

Role of HAVRC/KIM-1 in the development and progression of the renal clear cell carcinoma (ccRCC) and in the damage/regeneration renal tubular processes

Overexpression of this protein in 60% of the ccRCCs has already been described. HAVR/KIM-1 overexpression in human ccRCC cell lines blocks cell differentiation and promotes cell scattering. We aim to determine the role of HAVR/KIM-1 in the development and progression of ccRCC, and its possible value as a diagnostic and prognostic biomarker. We also focus on KIM-1’s role in ischemia/reperfusion- or nephrotoxic-induced renal tubular injury. Overexpression of this protein in kidney injury has been described. However, whether its involvement is associated with processes enabling to recover tubular epithelium or potentially increasing damage is not known to this date. With the assistance of cultured renal tubular cell models, we are now investigating whether KIM-1 expression shifts are correlated with renal proximal tubule regeneration ability and, as a consequence, investigating its potential therapeutic application.

IP: Anna Meseguer Navarro

Projects

La variabilidad fenotípica en pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC) como oportunidad para entender las bases fisiopatológicas de la enfermedad y para la búsqueda de soluciones terapéuticas

IP: Anna Meseguer Navarro
Collaborators: Gema Ariceta Iraola, Gerard Cantero Recasens
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/MESEGUER
Duration: 27/11/2023 - 26/11/2025

Fucosylation in Clear Cell Renal Cell Carcinoma. STATing novel biomarkers and therapeutic strategies

IP: Anna Meseguer Navarro
Collaborators: Gerard Cantero Recasens, Miriam Izquierdo Sans
Funding agency: Asociación Española Contra el Cáncer
Funding: 150000
Reference: INVES234762CANT
Duration: 15/11/2023 - 14/11/2026

Unravelling CIC-5 role on glycosylation and its link with proximal tubule functioning

IP: Gerard Cantero Recasens
Collaborators: -
Funding agency: Mizutani Foundation for Glycoscience
Funding: 45000
Reference: MIZUTANI FOUNDATION FOR GLYCOSCIENCE - 2022
Duration: 01/04/2023 - 31/03/2025

Patologia Cel·lular

IP: Anna Meseguer Navarro
Collaborators: Gema Ariceta Iraola, Alejandro Cruz Gual, Gerard Cantero Recasens, David Lorente García, Marina Muñoz López, Hector Rios Duro, Luis Augusto Castro Sáder, Gloria Mª Fraga Rodriguez, Julieta Torchia
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 01600
Duration: 01/01/2022 - 30/06/2025

Publications

Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia.

PMID: 38707823
Journal: Kidney International Reports
Year: 2024
Reference: Kidney Int Rep. 2024 Feb 22;9(5):1419-1428. doi: 10.1016/j.ekir.2024.02.1403. eCollection 2024 May.
Impact factor:
Publication type: Paper in international publication
Authors: Bagi, Per; Bettiga, Arianna; Bevc, Sebastjan; Carro, Clara Garcia; Cases Corona, Clara Maria; Cruzado, Josep Maria; Diaz, Maruja Navarro; Feldt-Rasmussen, Bo; Fernandez, Gema; Fernandez-Fernandez, Beatriz et al.
DOI: 10.1016/j.ekir.2024.02.1403

Lung Function and Symptoms of Exposure to the Volcanic Eruption in the Canary Islands: First Follow-Up of the ASHES Study.

PMID: 38760276
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2024
Reference: Arch Bronconeumol. 2024 May 4:S0300-2896(24)00140-6. doi: 10.1016/j.arbres.2024.05.002.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta, Orlando; Barreiro, Esther; Canas, Ana; Candal-Pedreira, Cristina; Casanova, Ciro; Castano, Argelia; Cruz Carmona, Maria Jesus; Diaz-Perez, David; Diego, Carmen; Garcia-Aymerich, Judith et al.
DOI: 10.1016/j.arbres.2024.05.002

Clinical and molecular spectrum of v-lesion.

PMID: 39084462
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2024
Reference: Am J Transplant. 2024 Jul 29:S1600-6135(24)00448-9. doi: 10.1016/j.ajt.2024.07.025.
Impact factor:
Publication type: Paper in international publication
Authors: Adam, Benjamin A; Burballa, Carla; Buxeda, Anna; Chamoun, Betty; Crespo, Marta; Gimeno, Javier; Mengel, Michael; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores et al.
DOI: 10.1016/j.ajt.2024.07.025

Diagnosis and Treatment of Renal ANCA Vasculitis: A Summary of the Consensus Document of the Catalan Group for the Study of Glomerular Diseases (GLOMCAT).

PMID: 39597938
Journal: Journal of Clinical Medicine
Year: 2024
Reference: J Clin Med. 2024 Nov 12;13(22):6793. doi: 10.3390/jcm13226793.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Arcal, Carola; Barros, Xoana; Cabrera, Victoria; Da Silva, Iara; Diaz, Montserrat; Draibe, Juliana Bordignon; Fulladosa, Xavier; Guillen, Elena; Ibernon, Meritxell et al.
DOI: 10.3390/jcm13226793

Hyperparathyroidism Is an Independent Risk Factor for Allograft Dysfunction in Pediatric Kidney Transplantation.

PMID: 36644359
Journal: Kidney International Reports
Year: 2023
Reference: Kidney Int Rep. 2022 Oct 28;8(1):81-90. doi: 10.1016/j.ekir.2022.10.018. eCollection 2023 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Awan, Atif; Bacchetta, Justine; Benetti, Elisa; Berta, Laszlo; Buscher, Anja; Carraro, Andrea; Christian, Martin; Dello Strologo, Luca; Deschepper, Ellen et al.
DOI: 10.1016/j.ekir.2022.10.018

Peritoneal transformation shortly after kidney transplantation in pediatric patients with preceding chronic peritoneal dialysis.

PMID: 36754369
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2023
Reference: Nephrol Dial Transplant. 2023 Sep 29;38(10):2170-2181. doi: 10.1093/ndt/gfad031.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Bartosova, Maria; Buscher, Rainer; Marinovic, Iva; Mehrabi, Arianeb; Oh, Jun; Ranchin, Bruno; Schaefer, Betti; Schmitt, Claus Peter; Schwab, Constantin et al.
DOI: 10.1093/ndt/gfad031

Stress and coping strategies of families of pediatric solid organ transplant recipients in times of pandemic.

PMID: 36777197
Journal: Frontiers in Psychology
Year: 2023
Reference: Front Psychol. 2023 Jan 26;14:1067477. doi: 10.3389/fpsyg.2023.1067477. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Castell-Panisello, Eudald; Espanol-Martin, Gemma; Forner-Puntonet, Mireia; Garcia-Moran, Annabella; Garcia-Moran, Annabella; Gisbert-Gustemps, Laura; Gran, Ferran; Ibanez-Jimenez, Pol; Iglesias-Serrano, Ignacio et al.
DOI: 10.3389/fpsyg.2023.1067477

Endothelin Receptor Antagonists in Kidney Disease.

PMID: 36834836
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Feb 8;24(4):3427. doi: 10.3390/ijms24043427.
Impact factor:
Publication type: Review in international publication
Authors: Alvarez, Francisco J; Alvarez, Francisco J; Bedard, Patricia W; Jacobs-Cacha, Conxita; Llorens-Cebria, Carmen; Martinez-Diaz, Irene; Martos, Nerea; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.3390/ijms24043427

Clinical and genetic characterization of a cohort of proteinuric patients with biallelic CUBN variants.

PMID: 34610128
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Sep 22;37(10):1906-1915. doi: 10.1093/ndt/gfab285.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Ars, Elisabet; Domingo-Gallego, Andrea; Ejarque-Vila, Laia; Gall, Emilie Cornec-Le; Gonzalez-Pastor, Sara; Guirado, Lluis; Lopez-Gonzalez, Mercedes; Madariaga, Leire; Matoses-Ruiperez, Maria Luisa et al.
DOI: 10.1093/ndt/gfab285

Refining Kidney Survival in 383 Genetically Characterized Patients With Nephronophthisis.

PMID: 36090483
Journal: Kidney International Reports
Year: 2022
Reference: Kidney Int Rep. 2022 Jun 16;7(9):2016-2028. doi: 10.1016/j.ekir.2022.05.035. eCollection 2022 Sep.
Impact factor:
Publication type: Paper in international publication
Authors: Antczak, P; Ariceta, Gema; Bald, Martin; Bergmann, C; Bergmann, Carsten; Bertholet-Thomas, Aurelia; Birtel, J; Bockenhauer, Detlef; Boyer, Olivia; Cetiner, M et al.
DOI: 10.1016/j.ekir.2022.05.035

Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description.

PMID: 36082134
Journal: Therapeutic Advances in Chronic Disease
Year: 2022
Reference: Ther Adv Chronic Dis. 2022 Sep 5;13:20406223221117471. doi: 10.1177/20406223221117471. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Beck-Nielsen, Signe Sparre; Boot, Annemieke M; Brandi, Maria Luisa; Briot, Karine; de Lucas Collantes, Carmen; Emma, Francesco; Giannini, Sandro; Haffner, Dieter; Keen, Richard et al.
DOI: 10.1177/20406223221117471

Multiparametric MRI for Staging of Prostate Cancer: A Multicentric Analysis of Predictive Factors to Improve Identification of Extracapsular Extension before Radical Prostatectomy.

PMID: 36010963
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Aug 17;14(16). pii: cancers14163966. doi: 10.3390/cancers14163966.
Impact factor:
Publication type: Paper in international publication
Authors: Celma, Ana; Cuadras, Merce; Morote, Juan; Planas, Jacques; Regis, Lucas; Trilla, Enrique; Triquell, Marina; Valdes, Nicolas; Winkler, Mathias et al.
DOI: 10.3390/cancers14163966

Charcoal Hemoperfusion for Methotrexate Toxicity: A Safe and Effective Life-Rescue Alternative When Glucarpidase Is Not Available.

PMID: 34490152
Journal: Frontiers in Pediatrics
Year: 2021
Reference: Front Pediatr. 2021 Aug 19;9:635152. doi: 10.3389/fped.2021.635152. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Dapena, Jose Luis; Madrid, Alvaro; Munoz, Marina; Rosales, Alejandra et al.
DOI: 10.3389/fped.2021.635152

Impact of COVID-19 on Families of Pediatric Solid Organ Transplant Recipients.

PMID: 34313783
Journal: JOURNAL OF PEDIATRIC PSYCHOLOGY
Year: 2021
Reference: J Pediatr Psychol. 2021 Aug 19;46(8):927-938. doi: 10.1093/jpepsy/jsab058.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Castell-Panisello, Eudald; Daigre, Constanza; Delgado, Mercedes; Espanol-Martin, Gemma; Forner-Puntonet, Mireia; Gisbert-Gustemps, Laura; Gran, Ferran; Ibanez-Jimenez, Pol; Iglesias-Serrano, Ignacio et al.
DOI: 10.1093/jpepsy/jsab058

Prediction of clinically significant prostate cancer after negative prostate biopsy: The current value of microscopic findings.

PMID: 33160846
Journal: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Year: 2021
Reference: Urol Oncol. 2021 Jul;39(7):432.e11-432.e19. doi: 10.1016/j.urolonc.2020.10.016. Epub 2020 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Borque, Angel; Celma, Anna; de Torres, Ines M; Esteban, Luis M; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Santamaria, Anna et al.
DOI: 10.1016/j.urolonc.2020.10.016

An international cohort study spanning five decades assessed outcomes of nephropathic cystinosis.

PMID: 34237326
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Nov;100(5):1112-1123. doi: 10.1016/j.kint.2021.06.019. Epub 2021 Jul 6.
Impact factor:
Publication type: Paper in international publication
Authors: Antignac, Corinne; Ariceta, Gema; Bertholet-Thomas, Aurelia; Bettini, Chiara; Bockenhauer, Detlef; Collin, Suzanne; Cornelissen, Elisabeth; Deschenes, Georges; Devuyst, Olivier; Emma, Francesco et al.
DOI: 10.1016/j.kint.2021.06.019

Erratum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naive to complement inhibitor treatment" Kidney Int. 2020;97:1287-1296.

PMID: 33276869
Journal: KIDNEY INTERNATIONAL
Year: 2020
Reference: Kidney Int. 2020 Dec;98(6):1621. doi: 10.1016/j.kint.2020.11.001.
Impact factor:
Publication type: Letter or abstract
Authors: Antognoli, Guilia; Arepally, Gowthami; Ariceta, Gema; Babu, Sunil; Barbour, Tom; Boyer-Suavet, Sonia; Broeders, Nilufer; Brown, Fiona; Campbell, Philip; Cappuccilli, Maria et al.
DOI: 10.1016/j.kint.2020.11.001

Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 33244004
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Nov 26;10(1):20706. doi: 10.1038/s41598-020-77176-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Azpiroz, Fernando; de Torres, Ines; Exposito, Elba; Farre, Ricard; Fortea, Marina; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Lobo, Beatriz; Martinez, Cristina et al.
DOI: 10.1038/s41598-020-77176-x

Assessing the Limits in Kidney Transplantation: Use of Extremely Elderly Donors and Outcomes in Elderly Recipients.

PMID: 30985579
Journal: TRANSPLANTATION
Year: 2020
Reference: Transplantation. 2020 Jan;104(1):176-183. doi: 10.1097/TP.0000000000002748.
Impact factor:
Publication type: Paper in international publication
Authors: ; Arcos, Emma; Calabia, Jordi; Cao, Higinio; Cases, Aleix; Comas, Jordi; Espinel, Eugenia; Gil-Vernet, Salvador; Lara, Enrique; Lloveras, Josep et al.
DOI: 10.1097/TP.0000000000002748

Emergence Delirium: Can Corticosteroids Contribute to It?

PMID: 33133750
Journal: Journal of pediatric intensive care
Year: 2020
Reference: J Pediatr Intensive Care. 2020 Dec;9(4):304-306. doi: 10.1055/s-0040-1709655. Epub 2020 Apr 17.
Impact factor:
Publication type: Letter or abstract
Authors: Andreu, Eva; Cruz, Alejandro; Esmel-Vilomara, Roger; Inoriza, Cristina; Munar, Francisca et al.
DOI: 10.1055/s-0040-1709655

Complement Activation and Thrombotic Microangiopathies.

PMID: 31694864
Journal: Clinical Journal of the American Society of Nephrology
Year: 2019
Reference: Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1719-1732. doi: 10.2215/CJN.05830519. Epub 2019 Nov 6.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Avila, Ana; Barros, Xoana; Blasco, Miquel; Cabello, Virginia; Campistol, Josep M; Cao, Mercedes; Carreras, Enric; Chocron, Sara; Cid, Joan et al.
DOI: 10.2215/CJN.05830519

Vascular access in children requiring maintenance haemodialysis: a consensus document by the European Society for Paediatric Nephrology Dialysis Working Group.

PMID: 30859187
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Oct 1;34(10):1746-1765. doi: 10.1093/ndt/gfz011.
Impact factor:
Publication type: Paper in international publication
Authors: Allinovi, M; Alpay, H; Ariceta, G; Aufricht, C; Bakkaloglu, S; Bakkaloglu, Sevcan; Bourquelot, Pierre; Calder, Francis; Caliskan, S; Do Sameiro Faria, M et al.
DOI: 10.1093/ndt/gfz011

Prediabetes is a risk factor for cardiovascular disease following renal transplantation.

PMID: 31611066
Journal: KIDNEY INTERNATIONAL
Year: 2019
Reference: Kidney Int. 2019 Dec;96(6):1374-1380. doi: 10.1016/j.kint.2019.06.026. Epub 2019 Aug 14.
Impact factor:
Publication type: Paper in international publication
Authors: Bayes-Genis, Beatriz; Diaz, Juan Manuel; Dominguez, Rosa; Gainza, Francisco J; Ibernon, Meritxel; Lauzurrica, Ricardo; Macias, Manuel; Mallen, Patricia Delgado; Miranda, Domingo Marrero; Moreso, Francesc et al.
DOI: 10.1016/j.kint.2019.06.026

Accuracy of Urinary Epidermal Growth Factor to Creatinine Ratio to Predict 24-Hour Urine Epidermal Growth Factor and Interstitial Kidney Fibrosis in Patients with IgA Nephropathy.

PMID: 31232037
Journal: Clinical Laboratory
Year: 2019
Reference: Clin Lab. 2019 Jun 1;65(6). doi: 10.7754/Clin.Lab.2018.181122.
Impact factor:
Publication type: Paper in international publication
Authors: Carnicer, Clara; Jatem, Elias; Martin, Marisa; Martinez, Cristina; Molina, Maria; Perich, Carme; Segarra, Alfonso et al.
DOI: 10.7754/Clin.Lab.2018.181122

Recovery of Kidney Function in Children Treated with Maintenance Dialysis.

PMID: 30237216
Journal: Clinical Journal of the American Society of Nephrology
Year: 2018
Reference: Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1510-1516. doi: 10.2215/CJN.01500218. Epub 2018 Sep 20.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Berard, Etienne; Bonthuis, Marjolein; Cransberg, Karlien; Duzova, Ali; Garneata, Liliana; Groothoff, Jaap W; Harambat, Jerome; Herthelius, Maria; Jager, Kitty J et al.
DOI: 10.2215/CJN.01500218

Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome.

PMID: 30179222
Journal: JOURNAL OF CLINICAL INVESTIGATION
Year: 2018
Reference: J Clin Invest. 2018 Oct 1;128(10):4313-4328. doi: 10.1172/JCI98688. Epub 2018 Sep 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alhasan, Khalid A; Alkuraya, Fowzan S; Altmuller, Janine; Antignac, Corinne; Antonin, Wolfram; Ariceta, Gema; Ashraf, Shazia; Asif, Maria; Baig, Shahid Mahmood; Braun, Daniela A et al.
DOI: 10.1172/JCI98688

A questionnaire survey of radiological diagnosis and management of renal dysplasia in children.

PMID: 28647851
Journal: JOURNAL OF NEPHROLOGY
Year: 2018
Reference: J Nephrol. 2018 Feb;31(1):95-102. doi: 10.1007/s40620-017-0417-7. Epub 2017 Jun 24.
Impact factor:
Publication type: Paper in international publication
Authors: Alpay, Harika; Antic, Amira Peco; Ariceta, Gema; Bael, An; Bonthuis, Marjolein; Busutti, Marco; Caliskan, Salim; Gotsiridze, Elene; Gulleroglu, Kaan; Gunduz, Zubeyde et al.
DOI: 10.1007/s40620-017-0417-7

Th1-skewed profile and excessive production of proinflammatory cytokines in a NFKB1-deficient patient with CVID and severe gastrointestinal manifestations.

PMID: 30063981
Journal: CLINICAL IMMUNOLOGY
Year: 2018
Reference: Clin Immunol. 2018 Oct;195:49-58. doi: 10.1016/j.clim.2018.07.015. Epub 2018 Jul 29.
Impact factor:
Publication type: Paper in international publication
Authors: Antolin, Maria; Blasco, Laura; Colobran, Roger; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Fernandez, Antoni Alvarez; Franco-Jarava, Clara; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Molero, Xavier et al.
DOI: 10.1016/j.clim.2018.07.015

miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

PMID: 29089619
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Oct 31;7(1):14680. doi: 10.1038/s41598-017-13982-0.
Impact factor:
Publication type: Paper in international publication
Authors: Agreus, Lars; Andreasson, Anna; Assadi, Ghazaleh; Becker, Philip P; Bermejo, Justo Lorenzo; Boeckxstaens, Guy; Braun, Alexander; Burwinkel, Barbara; D'Amato, Mauro; Dlugosz, Aldona et al.
DOI: 10.1038/s41598-017-13982-0

Fascin-1 is released from proximal tubular cells in response to calcineurin inhibitors (CNIs) and correlates with isometric vacuolization in kidney transplanted patients.

PMID: 28979691
Journal: American Journal of Translational Research
Year: 2017
Reference: Am J Transl Res. 2017 Sep 15;9(9):4173-4183. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Azancot, Maria A; Azancot, Maria A; Cantarell, Carme; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Meseguer, Anna; Moreso, Francesc; Roman, Antonio; Sarro, Eduard; Seron, Daniel et al.
DOI:

Clinical practice recommendations for treatment with active vitamin D analogues in children with chronic kidney disease Stages 2-5 and on dialysis.

PMID: 28873971
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2017
Reference: Nephrol Dial Transplant. 2017 Jul 1;32(7):1114-1127. doi: 10.1093/ndt/gfx080.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Bacchetta, Justine; Bakkaloglu, Sevcan; Cozzolino, Mario; Edefonti, Alberto; Haffner, Dieter; Klaus, Gunter; Nagler, Evi V; Schmitt, Claus Peter; Shroff, Rukshana et al.
DOI: 10.1093/ndt/gfx080

Hyperinsulinaemic hypoglycaemia, renal Fanconi syndrome and liver disease due to a mutation in the HNF4A gene.

PMID: 28458902
Journal: Endocrinology, diabetes & metabolism case repo
Year: 2017
Reference: Endocrinol Diabetes Metab Case Rep. 2017 Mar 16;2017. pii: 16-0133. doi: 10.1530/EDM-16-0133. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Campos, Ariadna; Clemente, Maria; Martinez, Rosa; Vargas, Alejandro; Yeste, Diego et al.
DOI: 10.1530/EDM-16-0133

An international consensus approach to the management of atypical hemolytic uremic syndrome in children.

PMID: 25859752
Journal: PEDIATRIC NEPHROLOGY
Year: 2016
Reference: Pediatr Nephrol. 2016 Jan;31(1):15-39. doi: 10.1007/s00467-015-3076-8. Epub 2015 Apr 11.
Impact factor:
Publication type: Review in international publication
Authors: Ariceta, Gema; Besbas, Nesrin; Bitzan, Martin; Bjerre, Anna; Coppo, Rosanna; Emma, Francesco; Fakhouri, Fadi; Fremeaux-Bacchi, Veronique; Johnson, Sally; Karpman, Diana et al.
DOI: 10.1007/s00467-015-3076-8

Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease.

PMID: 27846250
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Nov 15;11(11):e0166050. doi: 10.1371/journal.pone.0166050. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Bartosova, Maria; Burkhardt, Dorothea; Cerkauskiene, Rimante; Degenhardt, Petra; Freise, Christian; Grabe, Niels; Lahrmann, Bernd; Lingnau, Anja; Malina, Michal et al.
DOI: 10.1371/journal.pone.0166050

Glomerular Pathology in Dent Disease and Its Association with Kidney Function.

PMID: 27697782
Journal: Clinical Journal of the American Society of Nephrology
Year: 2016
Reference: Clin J Am Soc Nephrol. 2016 Dec 7;11(12):2168-2176. Epub 2016 Oct 3.
Impact factor:
Publication type: Paper in international publication
Authors: Anglani, Franca; Ariceta, Gema; Beara-Lasic, Lada; Cogal, Andrea; Copelovitch, Lawrence; Del Prete, Dorella; Enders, Felicity T; Harris, Peter C; Herrera Hernandez, Loren; Isom, Robert et al.
DOI: 10.2215/CJN.03710416

A coordinated transition model for patients with cystinosis: from pediatrics to adult care.

PMID: 27595514
Journal: NEFROLOGIA
Year: 2016
Reference: Nefrologia. 2016 Nov - Dec;36(6):616-630. doi: 10.1016/j.nefro.2016.05.012. Epub 2016 Aug 30.
Impact factor:
Publication type: Paper in national publication
Authors: Ariceta, Gema; Camacho, Juan Antonio; Fernandez-Obispo, Matilde; Fernandez-Polo, Aurora; Gamez, Josep; Garcia-Villoria, Judit; Guell, Ana; Lara, Enrique; Leyes, Pere; Martin-Begue, Nieves et al.
DOI: 10.1016/j.nefro.2016.05.012

The global aHUS registry: methodology and initial patient characteristics.

PMID: 26654630
Journal: BMC NEPHROL
Year: 2015
Reference: BMC Nephrol. 2015 Dec 10;16:207. doi: 10.1186/s12882-015-0195-1.
Impact factor:
Publication type: Clinical guide
Authors: Ardissino, Gianluigi; Ariceta, Gema; Cohen, David; Cole, J Alexander; Fremeaux-Bacchi, Veronique; Gasteyger, Christoph; Greenbaum, Larry A; Johnson, Sally; Licht, Christoph; Ogawa, Masayo et al.
DOI: 10.1186/s12882-015-0195-1

Effectiveness of mycophenolate mofetil in C3 glomerulonephritis.

PMID: 26221755
Journal: KIDNEY INT
Year: 2015
Reference: Kidney Int. 2015 Nov;88(5):1153-60. doi: 10.1038/ki.2015.227. Epub 2015 Jul 29.
Impact factor:
Publication type: Letter or abstract
Authors: Alegre, Raquel; Anton, Monserrat; Ariceta, Gema; Avila, Ana; Baltar, Jose Maria; Barroso, Sergio; Bernis, Carmen; Blasco, Miguel; Cabello, Virginia; Campistol, Jose Maria et al.
DOI: 10.1038/ki.2015.227

Risk factors for loss of residual renal function in children treated with chronic peritoneal dialysis.

PMID: 25874598
Journal: KIDNEY INT
Year: 2015
Reference: Kidney Int. 2015 Sep;88(3):605-13. doi: 10.1038/ki.2015.108. Epub 2015 Apr 15.
Impact factor:
Publication type: Letter or abstract
Authors: Aguirre, M; Al Ryami, M; Al-Akash, A; Alconcher, L; Antonio, Z; Antonio, Zenaida L; Ariceta, G; Askenazi, D; Bagga, A; Bakkaloglu, A S et al.
DOI: 10.1038/ki.2015.108

Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study.

PMID: 25902753
Journal: EUR J PEDIATR
Year: 2015
Reference: Eur J Pediatr. 2015 Oct;174(10):1373-85. doi: 10.1007/s00431-015-2534-4. Epub 2015 Apr 23.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Mireia; Aguirre, Mireia; Alvarez, Victoria; Ariceta, Gema; Ariceta, Gema; Camacho, Juan Antonio; Castano, Luis; Castano, Luis; Chocron, Sara; Claverie, Felix et al.
DOI: 10.1007/s00431-015-2534-4

Renal replacement therapy for rare diseases affecting the kidney: an analysis of the ERA-EDTA Registry.

PMID: 25165174
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2014
Reference: Nephrol Dial Transplant. 2014 Sep;29 Suppl 4:iv1-8. doi: 10.1093/ndt/gfu030.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Bjerre, Anna K; Duneau, Gabrielle; Heaf, James Goya; Hoitsma, Andries J; Jager, Kitty J; Palsson, Runolfur; Ravani, Pietro; Schaefer, Franz; van Stralen, Karlijn J et al.
DOI: 10.1093/ndt/gfu030

An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome.

PMID: 24817340
Journal: PEDIATRIC NEPHROLOGY
Year: 2014
Reference: Pediatr Nephrol. 2014 Oct;29(10):1967-78. doi: 10.1007/s00467-014-2817-4. Epub 2014 May 11.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Besbas, Nesrin; Bitzan, Martin; Frieling, Michelle; Johnson, Sally; Karpman, Diana; Landau, Daniel; Langman, Craig; Licht, Christoph; Loirat, Chantal et al.
DOI: 10.1007/s00467-014-2817-4

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

PMID: 23474421
Journal: GUT
Year: 2014
Reference: Gut. 2014 Feb;63(2):262-71. doi: 10.1136/gutjnl-2012-303857. Epub 2013 Mar 8.
Impact factor:
Publication type: Paper in international publication
Authors: Farre, Ricard; Keita, Asa V; Martinez, Cristina; Pardon, Nicolas; Santos, Javier; Soderholm, Johan D; Tack, Jan; Van Oudenhove, Lukas; Vanheel, Hanne; Vanuytsel, Tim et al.
DOI: 10.1136/gutjnl-2012-303857

Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood.

PMID: 24178977
Journal: Clinical Journal of the American Society of Nephrology
Year: 2014
Reference: Clin J Am Soc Nephrol. 2014 Jan;9(1):92-9. doi: 10.2215/CJN.00890113. Epub 2013 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Battelino, Nina; Bjerre, Anna; Bonthuis, Marjolein; Combe, Christian; Groothoff, Jaap W; Harambat, Jerome; Jager, Kitty J; Jahnukainen, Timo; Leroy, Valerie et al.
DOI: 10.2215/CJN.00890113

Claudin-19 mutations and clinical phenotype in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

PMID: 23301036
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013;8(1):e53151. doi: 10.1371/journal.pone.0053151. Epub 2013 Jan 3.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre Menica, Mireia; Alvarez, Victoria; Anton-Gamero, Montserrat; Ariceta, Gema; Ariceta, Gema; Avila, Africa; Castano, Luis; Claverie-Martin, Felix; Claverie-Martin, Felix; Cordoba-Lanus, Elizabeth et al.
DOI: 10.1371/journal.pone.0053151

Genetics of type III Bartter syndrome in Spain, proposed diagnostic algorithm.

PMID: 24058621
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Sep 18;8(9):e74673. doi: 10.1371/journal.pone.0074673. eCollection 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Mireia; Aguirre, Mireia; Alvarez, Victoria; Ariceta, Gema; Ariceta, Gema; Castano, Luis; Castano, Luis; Claverie, Felix; Cordoba, Elizabeth; Coto, Eliecer et al.
DOI: 10.1371/journal.pone.0074673

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.

PMID: 22637702
Journal: GUT
Year: 2013
Reference: Gut. 2013 Aug;62(8):1160-8. doi: 10.1136/gutjnl-2012-302093. Epub 2012 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/gutjnl-2012-302093

Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients.

PMID: 23692602
Journal: PEDIATRIC TRANSPLANTATION
Year: 2013
Reference: Pediatr Transplant. 2013 Jun;17(4):403-6. doi: 10.1111/petr.12084.
Impact factor:
Publication type: Paper in international publication
Authors: Aydillo, T; Cabral, E; Campins, M; Charco, R; Cordero, E; Gavalda, J; Len, O; Nieto, J; Pahissa, A; Peghin, M et al.
DOI: 10.1111/petr.12084

The EMT signaling pathways in endometrial carcinoma.

PMID: 22911547
Journal: Clinical & Translational Oncology
Year: 2012
Reference: Clin Transl Oncol. 2012 Oct;14(10):715-20. doi: 10.1007/s12094-012-0866-3. Epub 2012 Aug 22.
Impact factor:
Publication type: Review in international publication
Authors: Abal, Miguel; Alameda, Francesc; Cabrera, Silvia; Campoy, Irene; Castellvi, Josep; Colas, Eva; Devis, Laura; Dolcet, Xavier; Doll, Andreas; Ertekin, Tugce et al.
DOI: 10.1007/s12094-012-0866-3

Spanish study of anticoagulation in haemodialysis.

PMID: 22425796
Journal: NEFROLOGIA
Year: 2012
Reference: Nefrologia. 2012;32(2):143-52. doi: 10.3265/Nefrologia.pre2011.Nov.11106. Epub 2012 Jan 27.
Impact factor:
Publication type: Paper in national publication
Authors: Agar, Irene; Ahijado, Francisco J; Alba, Perez; Albert Balaguer, Enrique; Alcazar, Jose Maria; Alonso Melgar, Angel; Alvarez de Lara Sanchez, Maria Antonia; Amoedo, Maria Luisa; Andres Ribes, Enric; Arcona, Victor et al.
DOI: 10.3265/Nefrologia.pre2011.Nov.11106

Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome.

PMID: 22844557
Journal: Gut and Liver
Year: 2012
Reference: Gut Liver. 2012 Jul;6(3):305-15. Epub 2012 Jul 12.
Impact factor:
Publication type: Review in international publication
Authors: Gonzalez-Castro, Ana; Martinez, Cristina; Santos, Javier; Vicario, Maria et al.
DOI: 10.5009/gnl.2012.6.3.305

Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability.

PMID: 22625665
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2012
Reference: Neurogastroenterol Motil. 2012 Aug;24(8):740-6, e348-9. doi: 10.1111/j.1365-2982.2012.01928.x. Epub 2012 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2982.2012.01928.x

Genetic diagnosis of X-linked dominant hypophosphatemic rickets in a cohort study: Tubular reabsorption of phosphate and 1,25(OH)2D serum levels are associated with PHEX mutation type.

PMID: 21902834
Journal: BMC Medical Genetics
Year: 2011
Reference: BMC Med Genet. 2011 Sep 8;12:116. doi: 10.1186/1471-2350-12-116.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/1471-2350-12-116

Clinical value of NPHS2 analysis in early- and adult-onset steroid-resistant nephrotic syndrome.

PMID: 20947785
Journal: Clinical Journal of the American Society of Nephrology
Year: 2011
Reference: Clin J Am Soc Nephrol. 2011 Feb;6(2):344-54. Epub 2010 Oct 14.
Impact factor:
Publication type: Paper in international publication
Authors: Alexandra, Simona; Aparicio, Cristina; Ars, Elisabet; Ballarin, Jose; Barajas de Frutos, David; Bernis, Carmen; Camacho, Juan Antonio; Caramelo, Carlos; Chocron, Sara; Cobo, Maria Angeles et al.
DOI: 10.2215/CJN.03770410

Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.

PMID: 21382338
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Year: 2011
Reference: Biochem Biophys Res Commun. 2011 Apr 8;407(2):333-8. Epub 2011 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.bbrc.2011.03.018

Subclinical rejection in renal transplants is associated with low serum mannose-binding lectin levels.

PMID: 25018901
Journal: Kidney international supplements
Year: 2011
Reference: Kidney Int Suppl (2011). 2011 Aug;1(2):36-39. doi: 10.1038/kisup.2011.10.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1038/kisup.2011.10

[Pathophysiology of CADASIL disease]

PMID: 20036399
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Jul 10;135(5):222-30. Epub 2009 Dec 29.
Impact factor:
Publication type: Review in national publication
Authors: Del Rio Espinola, Alberto; Montaner, Joan; Sole, Esther et al.
DOI: 10.1016/j.medcli.2009.10.034

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress.

PMID: 20600818
Journal: BRAIN BEHAVIOR AND IMMUNITY
Year: 2010
Reference: Brain Behav Immun. 2010 Oct;24(7):1166-75. Epub 2010 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Azpiroz, Fernando; Gonzalez, Ana; Guila, Meritxell; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pigrau, Marc; Ramos, Laura; Santos, Javier et al.
DOI: 10.1016/j.bbi.2010.06.002

Role of microRNA in IBS with increased gut permeability.

PMID: 20551452
Journal: GUT
Year: 2010
Reference: Gut. 2010 Jun;59(6):710-2.
Impact factor:
Publication type: Editorail in international publication
Authors: Martinez, Cristina; Santos, Javier; Vicario, Maria et al.
DOI: 10.1136/gut.2009.203695

Post-transplant lymphoproliferative disorders in children: the role of chemotherapy in the era of rituximab.

PMID: 19344338
Journal: PEDIATRIC TRANSPLANTATION
Year: 2010
Reference: Pediatr Transplant. 2010 Feb;14(1):61-6. Epub 2009 Mar 31.
Impact factor:
Publication type: Paper in international publication
Authors: Bueno, J; Gallego, S; Gros, L; Llort, A; Moreno, A; Nieto, J; Sanchez de Toledo, J; Sanchez de Toledo, J Jr et al.
DOI: 10.1111/j.1399-3046.2009.01181.x

Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.

PMID: 19332469
Journal: CIRCULATION
Year: 2009
Reference: Circulation. 2009 Apr 14;119(14):1908-17.
Impact factor:
Publication type: Paper in international publication
Authors: Bardaji, B; Barreiro, M L; Carretero, A; Garcia-Arumi, E; Gonzalez-Nunez, M; Grande, M T; Lopez-Novoa, J M; Meseguer, A; Montero, M A; Pascual, G et al.
DOI: 10.1161/CIRCULATIONAHA.108.808543

Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.

PMID: 19265691
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 May 1;315(8):1429-38.
Impact factor:
Publication type: Paper in international publication
Authors: de Bolos, Carme; Hirano, Michio; Meseguer, Anna; Vila, Maya R; Villarroya, Joan et al.
DOI: 10.1016/j.yexcr.2009.02.018

CADASIL management or what to do when there is little one can do.

PMID: 19210195
Journal: Expert Rev Neurother
Year: 2009
Reference: Expert Rev Neurother. 2009 Feb;9(2):197-210.
Impact factor:
Publication type: Letter or abstract
Authors: del Rio-Espinola, Alberto; Domingues-Montanari, Sophie; Fernandez-Cadenas, Israel; Fernandez-Morales, Jessica; Mendioroz, Maite; Montaner, Joan; Pozo Rosich, Patricia; Pozo-Rosich, Patricia; Sole, Esther et al.
DOI: 10.1586/14737175.9.2.197

Very Low-Molecular-Mass Fragments of Albumin in the Plasma of Patients With Focal Segmental Glomerulosclerosis.

PMID: 19781833
Journal: AMERICAN JOURNAL OF KIDNEY DISEASES
Year: 2009
Reference: Am J Kidney Dis. 2009 Nov;54(5):871-80.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1053/j.ajkd.2009.07.011

Blog

News

The communication is part of a study aimed at identifying the mechanisms of progression of Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, a rare disease that affects the kidneys.

"Patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis present miRNA profiles in urinary extracellular vesicles associated with disease progression" was the awarded work.

Researchers at the VHIR have carried out a study showing that the ClC-5 protein regulates collagen levels through the β-catenin pathway and lysosomal degradation.