About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.
At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.
IP: Mireia Lopez Corbeto Collaborators: - Funding agency: Sociedad Española de Reumatología Pediátrica SERP Funding: 8000 Reference: SERPE/REUMAPED/2022/LOPEZ Duration: 30/12/2022 - 29/12/2024
IP: Carmen Espejo Ruiz Collaborators: Sara Marsal Barril, Herena Eixarch Ahufinger, Helena Borrell Paños Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 217313.9 Reference: CPP2021-008475 Duration: 10/02/2022 - 09/02/2025
IP: - Collaborators: - Funding agency: Fundación Invest. Médica Mutua Madrileña Funding: 109998 Reference: MUTUA_MADRILEÑA/2022/ALEGRE Duration: 20/07/2022 - 19/07/2025
IP: Ernesto Trallero Araguas Collaborators: Albert Selva O'Callaghan, Raul Tortosa Mendez, Albert Gil Vila, Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudi, Gloria Aparicio Español, Adria Aterido Ballonga, Hugo Fernando Avalos Bogado Funding agency: Instituto de Salud Carlos III Funding: 135520 Reference: PI22/00708 Duration: 01/01/2023 - 31/12/2025
PMID: 34861974 Journal: BIOLOGICAL PSYCHIATRY Year: 2022 Reference: Biol Psychiatry. 2022 Feb 1;91(3):313-327. doi: 10.1016/j.biopsych.2021.05.029. Epub 2021 Sep 9. Impact factor: 13.382 Publication type: Paper in international publication Authors: Anjorin, Adebayo; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan D; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo et al. DOI: 10.1016/j.biopsych.2021.05.029
PMID: 35156620 Journal: European journal of rheumatology Year: 2022 Reference: Eur J Rheumatol. 2022 Feb 14. doi: 10.5152/eujrheum.2022.20012. Impact factor: 0 Publication type: Paper in international publication Authors: Vela, Paloma; Trujillo, Elisa; Pego Reigosa, Jose Maria; Polo, Ana; Pluma, Andrea; Alsina, Laia; Baniandres, Ofelia; Caliz, Rafael; Casellas, Manel; Grados, Dolors et al. DOI: 10.5152/eujrheum.2022.20012
PMID: 34796836 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 Jun;40(6):1102-1111. doi: 10.55563/clinexprheumatol/uzzejn. Epub 2021 Nov 18. Impact factor: 4.473 Publication type: Paper in international publication Authors: Maurel, Sara; Saez-Francas, Naia; Calvo, Natalia; Alegre-Martin, Jose; Castro-Marrero, Jesus et al. DOI:
PMID: 34596027 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 Jul;40(7):1361-1367. doi: 10.55563/clinexprheumatol/kk1ndf. Epub 2021 Sep 21. Impact factor: 4.473 Publication type: Paper in international publication Authors: Marsal, Sara; Olive, Alejandro; Fautrel, Bruno; Guillemin, Francis; Combe, Bernard; Rodriguez-Muguruza, Samantha; Valero, Oliver; Lukas, Cedric et al. DOI: 10.55563/clinexprheumatol/kk1ndf
PMID: 34444817 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082658. doi: 10.3390/nu13082658. Impact factor: 5.719 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Segundo, Maria Jose, Lacasa, Marcos, Martinez-Martinez, Alba, Sentanes, Ramon Sanmartin, Alegre-Martin, Jose et al. DOI: 10.3390/nu13082658
PMID: 34075090 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Jun 1;11(1):11462. doi: 10.1038/s41598-021-90797-0. Impact factor: 4.38 Publication type: Paper in international publication Authors: Julia, Antonio, Bonafonte-Pardas, Irene, Gomez, Antonio, Lopez-Lasanta, Maria, Lopez-Corbeto, Mireia, Martinez-Mateu, Sergio H, Llados, Jordi, Rodriguez-Nunez, Ivan, Myers, Richard M, Marsal, Sara et al. DOI: 10.1038/s41598-021-90797-0
PMID: 33081069 Journal: Journal of Clinical Medicine Year: 2020 Reference: J Clin Med. 2020 Oct 18;9(10). pii: jcm9103348. doi: 10.3390/jcm9103348. Impact factor: 3.303 Publication type: Paper in international publication Authors: Serrat, Mayte, Almirall, Miriam, Muste, Marta, Sanabria-Mazo, Juan P, Feliu-Soler, Albert, Mendez-Ulrich, Jorge L, Luciano, Juan V, Sanz, Antoni et al. DOI: 10.3390/jcm9103348
PMID: 32425260 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2020 Reference: Semin Arthritis Rheum. 2020 May 16. doi: 10.1016/j.semarthrit.2020.05.001. Impact factor: 4.751 Publication type: Paper in international publication Authors: Moreno, EstefanÃa, Michelena, Xabier, Borrell, Helena, López-Corbeto, Mireia, López-Lasanta, MarÃa, Serrat, Mayte, Espartal, Esther, Antón, Susana, Añez, Gustavo Adolfo, Caparrós-Ruiz, Raquel et al. DOI: 10.1016/j.semarthrit.2020.05.001
PhD student: Miriam Almirall Bernabé Director/s: Sara Marsal Barril, Francesc Casellas Jordá University: Year: 2022
PhD student: Andrea Pluma Sanjurjo Director/s: Sara Marsal Barril University: Year: 2022
PhD student: Eloy Garcia Vives Director/s: Josefina Cortes Hernandez University: Universitat Autònoma de Barcelona Year: 2019
PhD student: M Alba Erra Duran Director/s: Vicenç Fonollosa Pla University: Universitat Autònoma de Barcelona Year: 2017
PhD student: Ernesto Trallero Araguas Director/s: Albert Selva O'Callaghan, Moisés Labrador Horrillo University: Universitat Autònoma de Barcelona Year: 2011
PhD student: Antonio Julia Cano Director/s: Sara Marsal Barril University: Universitat Autònoma de Barcelona Year: 2010
It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.
Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.
Lesions present low levels of miR-885-5p, and this increases keratinocyte proliferation, the attraction of inflammatory cells and also the production of inflammatory mediators.
