Skip to main content

Rheumatology

The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.

At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.

Team

Raul Tortosa Mendez

Raul Tortosa Mendez

Main researcher
Rheumatology
Read more
Cristina Solé Marce

Cristina Solé Marce

Main researcher
Rheumatology
Read more
Jesus Castro Marrero

Jesus Castro Marrero

Main researcher
Rheumatology
Read more
Josefina Cortes  Hernandez

Josefina Cortes Hernandez

Main researcher
Rheumatology
Read more
Juan Jose De Agustin De Oro

Juan Jose De Agustin De Oro

Senior researcher
Rheumatology
Read more
Maria America Lopez Lasanta

Maria America Lopez Lasanta

Senior researcher
Rheumatology
Read more
Raul Tortosa Mendez

Raul Tortosa Mendez

Main researcher
Rheumatology
Read more
Cristina Solé Marce

Cristina Solé Marce

Main researcher
Rheumatology
Read more
Jesus Castro Marrero

Jesus Castro Marrero

Main researcher
Rheumatology
Read more
Josefina Cortes  Hernandez

Josefina Cortes Hernandez

Main researcher
Rheumatology
Read more
Juan Jose De Agustin De Oro

Juan Jose De Agustin De Oro

Senior researcher
Rheumatology
Read more
Maria America Lopez Lasanta

Maria America Lopez Lasanta

Senior researcher
Rheumatology
Read more

Projects

Caracterización por single cell RNA-seq de las células T patogénicas en la artritis idiopática juvenil oliogarticular, estudio de aplicabilidad translacional.

IP: Mireia Lopez Corbeto
Collaborators: -
Funding agency: Sociedad Española de Reumatología Pediátrica SERP
Funding: 8000
Reference: SERPE/REUMAPED/2022/LOPEZ
Duration: 30/12/2022 - 29/12/2024

Valorización de una terapia antígeno-específica para el tratamiento disruptivo de la diabetes tipo 1; esclerosis múltiple, miastenia gravis, enfermedad celíaca y artritis reumatoide.

IP: Carmen Espejo Ruiz
Collaborators: Sara Marsal Barril, Herena Eixarch Ahufinger, Helena Borrell Paños
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 217313.9
Reference: CPP2021-008475
Duration: 10/02/2022 - 09/02/2025

Ministerio de Ciencia

Estratificación de la severidad de la fatiga en el síndrome de COVID persistente: nuevas estrategias terapéuticas

IP: -
Collaborators: -
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 109998
Reference: MUTUA_MADRILEÑA/2022/ALEGRE
Duration: 20/07/2022 - 19/07/2025

Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudio de aplicabilidad traslacional.

IP: Ernesto Trallero Araguas
Collaborators: Albert Selva O'Callaghan, Raul Tortosa Mendez, Albert Gil Vila, Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudi, Gloria Aparicio Español, Adria Aterido Ballonga, Hugo Fernando Avalos Bogado
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI22/00708
Duration: 01/01/2023 - 31/12/2025

Publications

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.

PMID: 34861974
Journal: BIOLOGICAL PSYCHIATRY
Year: 2022
Reference: Biol Psychiatry. 2022 Feb 1;91(3):313-327. doi: 10.1016/j.biopsych.2021.05.029. Epub 2021 Sep 9.
Impact factor: 13.382
Publication type: Paper in international publication
Authors: Anjorin, Adebayo; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan D; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo et al.
DOI: 10.1016/j.biopsych.2021.05.029

Multidisciplinary models for pregnancy care in patients with rheumatic diseases: Clinical experiences and experts opinion.

PMID: 35156620
Journal: European journal of rheumatology
Year: 2022
Reference: Eur J Rheumatol. 2022 Feb 14. doi: 10.5152/eujrheum.2022.20012.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vela, Paloma; Trujillo, Elisa; Pego Reigosa, Jose Maria; Polo, Ana; Pluma, Andrea; Alsina, Laia; Baniandres, Ofelia; Caliz, Rafael; Casellas, Manel; Grados, Dolors et al.
DOI: 10.5152/eujrheum.2022.20012

Identifying mindfulness and acceptance as mediators between negative affect, functional disability and emotional distress in patients with fibromyalgia.

PMID: 34796836
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2022
Reference: Clin Exp Rheumatol. 2022 Jun;40(6):1102-1111. doi: 10.55563/clinexprheumatol/uzzejn. Epub 2021 Nov 18.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Maurel, Sara; Saez-Francas, Naia; Calvo, Natalia; Alegre-Martin, Jose; Castro-Marrero, Jesus et al.
DOI:

Trajectories in early rheumatoid arthritis related fatigue over 10 years: results from the ESPOIR cohort.

PMID: 34596027
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2022
Reference: Clin Exp Rheumatol. 2022 Jul;40(7):1361-1367. doi: 10.55563/clinexprheumatol/kk1ndf. Epub 2021 Sep 21.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Marsal, Sara; Olive, Alejandro; Fautrel, Bruno; Guillemin, Francis; Combe, Bernard; Rodriguez-Muguruza, Samantha; Valero, Oliver; Lukas, Cedric et al.
DOI: 10.55563/clinexprheumatol/kk1ndf

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

PMID: 34444817
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082658. doi: 10.3390/nu13082658.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Castro-Marrero, Jesus, Segundo, Maria Jose, Lacasa, Marcos, Martinez-Martinez, Alba, Sentanes, Ramon Sanmartin, Alegre-Martin, Jose et al.
DOI: 10.3390/nu13082658

Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19.

PMID: 34075090
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Jun 1;11(1):11462. doi: 10.1038/s41598-021-90797-0.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Julia, Antonio, Bonafonte-Pardas, Irene, Gomez, Antonio, Lopez-Lasanta, Maria, Lopez-Corbeto, Mireia, Martinez-Mateu, Sergio H, Llados, Jordi, Rodriguez-Nunez, Ivan, Myers, Richard M, Marsal, Sara et al.
DOI: 10.1038/s41598-021-90797-0

Effectiveness of a Multicomponent Treatment for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): A Pragmatic Randomized Controlled Trial.

PMID: 33081069
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Oct 18;9(10). pii: jcm9103348. doi: 10.3390/jcm9103348.
Impact factor: 3.303
Publication type: Paper in international publication
Authors: Serrat, Mayte, Almirall, Miriam, Muste, Marta, Sanabria-Mazo, Juan P, Feliu-Soler, Albert, Mendez-Ulrich, Jorge L, Luciano, Juan V, Sanz, Antoni et al.
DOI: 10.3390/jcm9103348

Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs.

PMID: 32425260
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2020
Reference: Semin Arthritis Rheum. 2020 May 16. doi: 10.1016/j.semarthrit.2020.05.001.
Impact factor: 4.751
Publication type: Paper in international publication
Authors: Moreno, Estefanía, Michelena, Xabier, Borrell, Helena, López-Corbeto, Mireia, López-Lasanta, María, Serrat, Mayte, Espartal, Esther, Antón, Susana, Añez, Gustavo Adolfo, Caparrós-Ruiz, Raquel et al.
DOI: 10.1016/j.semarthrit.2020.05.001

Thesis

Prevalencia de la sensibilidad al gluten no celíaca y valoración de la respuesta a una dieta sin gluten en una cohorte de pacientes con fibromialgia.

PhD student: Miriam Almirall Bernabé
Director/s: Sara Marsal Barril, Francesc Casellas Jordá
University:
Year: 2022

Identification of differential biological mechanisms between pregnancy and postpartum in Rheumatoid Arthritis

PhD student: Andrea Pluma Sanjurjo
Director/s: Sara Marsal Barril
University:
Year: 2022

Exosomas urinarios: Identificación de biomarcadores de respuesta clínica en la nefritis lúpica

PhD student: Eloy Garcia Vives
Director/s: Josefina Cortes Hernandez
University: Universitat Autònoma de Barcelona
Year: 2019

Factores predictores de la respuesta clínica al tratamiento con fármacos biológicos en la artritis reumatoide

PhD student: M Alba Erra Duran
Director/s: Vicenç Fonollosa Pla
University: Universitat Autònoma de Barcelona
Year: 2017

Nuevas estrategias en el diagnóstico del cáncer asociado a las dermatomiositis y polimiositis.

PhD student: Ernesto Trallero Araguas
Director/s: Albert Selva O'Callaghan, Moisés Labrador Horrillo
University: Universitat Autònoma de Barcelona
Year: 2011

Genomic approaches for the indentification of risk loci for Rheumatoid Arthritis.

PhD student: Antonio Julia Cano
Director/s: Sara Marsal Barril
University: Universitat Autònoma de Barcelona
Year: 2010

Blog

News

It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Lesions present low levels of miR-885-5p, and this increases keratinocyte proliferation, the attraction of inflammatory cells and also the production of inflammatory mediators.

Job offers

PhD Student - Rheumatology Unit
Start date:
11/04/2023
End date:
25/04/2023
Document: Download
Research associate in Biobanking - Rheumatology Research Group and the IMID-Biobank
Start date:
11/04/2023
End date:
01/05/2023
Document: Download
Licensed Technician - LUPUS Research Unit
Start date:
04/04/2023
End date:
30/04/2023
Document: Download